Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione

Biochemistry

Volumn 42, Issue 34, 2003, Pages 10238-10245

  Kavana, Michael ^a   Moran, Graham R ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATABOLISM;

AMINO ACIDS; BENZENE; CATALYSIS; ENZYME INHIBITION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PH EFFECTS; RATE CONSTANTS;

ENZYMES;

(4 HYDROXYPHENYL)PYRUVATE; (4 HYDROXYPHENYL)PYRUVATE DIOXYGENASE; 2 [2 NITRO 4 (TRIFLUOROMETHYL)BENZOYL] 1,3 CYCLOHEXANEDIONE; CYCLOHEXANE DERIVATIVE; HEME DERIVATIVE; HOMOGENTISIC ACID; IRON; KETONE DERIVATIVE; OXYGENASE; PYRUVIC ACID DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ABSORPTION; AMINO ACID METABOLISM; ARTICLE; CATABOLISM; CATALYSIS; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; ISOTOPE LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PH; PRIORITY JOURNAL; TYROSINEMIA;

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; CYCLOHEXANONES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; ENZYME STABILITY; FERROUS COMPOUNDS; HOLOENZYMES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; NITRIC OXIDE; NITROBENZOATES; OXIDATION-REDUCTION; OXYGEN; PROTEIN BINDING; SPECTROPHOTOMETRY, ULTRAVIOLET; STREPTOMYCES;

EID: 0042825545     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034658b     Document Type: Article

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