Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro

Xenobiotica

Volumn 30, Issue 10, 2000, Pages 971-982

  Emoto, C ^a   Yamazaki, H ^a   Yamasaki, S ^a   Shimada, N ^b   Nakajima, M ^a   Yokoi, T ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUFURALOL; CHLORZOXAZONE; CYTOCHROME P450; KETOCONAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE; TOLBUTAMIDE; WARFARIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSPORT; ENZYME ACTIVITY; FIRST PASS EFFECT; FREEZING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IN VITRO STUDY; MALE; MICROSOME; MOUSE; NONHUMAN; SMALL INTESTINE; THAWING;

ANIMALIA;

EID: 0033712106     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250050200122     Document Type: Article

References (34)

1. Expression of a human liver cytochrome P450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
2. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
3. Human cytochrome P450 enzymes
4. Cytochrome P-450 3A4: Regulation and role in drug metabolism
5. Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures
6. Effects of intestinal and hepatic metabolism on the bioavailability of tacrolimus in rats
7. Radiolabeling of methylphosphonate and phosphorothioate oligonucleotides and evaluation of their transport in everted rat jejunum sacs
8. Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents
9. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin
10. Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human
11. Absorption of methochlorpromazine in rat small intestinal everted sac
12. Extrahepatic metabolism of drugs in humans
13. High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P450 isozymes of human liver
14. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
15. Highly sensitive and specific high-performance liquid chromatographic analysis of 7-hydroxywarfarin, a marker for human cytochrome P450 2C9 activity
16. Protein measurement with the Folin phenol reagent
17. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
18. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
19. First-pass metabolism of midazolam by the human intestine
20. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIE1
21. Induction of cyp2e-1 protein in mouse colon
22. A novel female-specific member of the CYP3A gene subfamily in the mouse liver
23. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
24. Cytochrome P450 activity and distribution in the human colon mucosa
25. Sites of biotransformation for the cyclosporin derivative SDZ IMM 125 using human liver and kidney slices and intestine. Comparison with rat liver slices and cyclosporin A metabolism
26. Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines
27. Identification of glucocorticoid-inducible cytochromes P450 in the intestinal mucosa of rats and man
28. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface
29. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes
30. Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P450 2C9 in the oxidation of tolbutamide and warfarin by human liver microsomes
31. Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes
32. 1
33. Characterization of human small intestinal cytochromes P450