Biology and application of alphaviruses in gene therapy

Gene Therapy

Volumn 12, Issue , 2005, Pages S92-S97

  Lundstrom, K ^a  

^a BioXtal   (Switzerland)

Author keywords

Alphavirus; Cancer therapy; Gene delivery; Gene expression; Neuron specific expression; Tumor targeting

Indexed keywords

BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN G; IMMUNOSTIMULATING AGENT; INTERLEUKIN 12; INTERLEUKIN 12P40; LAMININ RECEPTOR; MEMBRANE PROTEIN; PLASMID DNA; PROTEIN BAX; PROTEIN E7; RECOMBINANT PROTEIN; TUMOR ANTIGEN; VIRUS VECTOR;

ALPHA VIRUS; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; CELL CULTURE; CELL SURVIVAL; CONFERENCE PAPER; ENCAPSULATION; GENE EXPRESSION; HIPPOCAMPUS; IN VITRO STUDY; MELANOMA; MICROBIOLOGY; NEUROSCIENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SEMLIKI FOREST ALPHAVIRUS; SINDBIS VIRUS; TISSUE CULTURE; TUMOR REGRESSION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS ENVELOPE; VIRUS PARTICLE;

ALPHAVIRUS; ANIMALS; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; IMMUNOTHERAPY; NERVOUS SYSTEM DISEASES; RECOMBINANT FUSION PROTEINS;

ALPHAVIRUS; ANIMALIA; PRIMATES; RODENTIA; SEMLIKI FOREST VIRUS; SINDBIS VIRUS;

EID: 27544433736     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302620     Document Type: Article

References (34)

1. Strauss JH, Strauss EG. The alphaviruses: gene expression, replication, and evolution. Microbiol Rev 1994; 58: 491-562.
2. Mathiot CC et al. An outbreak of human Semliki Forest virus infections in Central African Republic. Am J Trop Med Hyg 1990; 4: 386-393.
3. Liljestrom P, Garoff H. A new generation of animal cell expression vectors based on the Semliki Forest virus replicon. BiolTechnology 1991; 9: 1356-1361.
4. Xiong C et al. Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 1989; 243: 1189-1191.
5. Davis NL, Brown KW, Johnston RE. In vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: Analysis of a viable deletion mutant. Virology 1989; 171: 189-204.
6. DiCiommo DP, Bremner R. Rapid, high level protein production using DNA-based Semliki Forest virus vectors. J Biol Chem 1998; 273: 18060-18066.
7. Lundstrom K. Semliki Forest virus vectors for rapid and high- level expression of integral membrane proteins. Biochim Biophys Acta 2003; 1610: 90-96.
8. Lundstrom K et al. Semliki Forest virus vectors: efficient vehicles for in vitro and in vivo gene delivery. FEBS Lett 2001; 504: 99-103.
9. Blasey HD et al. Large scale transient 5-HT3 reecptor production with the Semliki Forest virus system. Cytotechnology 2000; 32: 199-208.
10. Lundstrom K. Structural genomics on membrane proteins: the MePNet approach. Curr Opin Drug Discov Devel 2004; 7: 342-346.
11. Olkkonen VM et al. Expression of heterologous proteins in cultured rat hippocampal neurons using the Semliki Forest virus vector. J Neurosci Res 1993; 35: 445-451.
12. Ehrengruber MU et al. Recombinant Semliki Forest virus and Sindbis virus efficiently infect neurons in hippocampal slice cultures. Proc Natl Acad Sci USA 1999; 96: 7041-7046.
13. Ehrengruber MU et al. Gene transfer into neurons from hippocampal slices: comparison of recombinant Semliki Forest Virus, adenovirus, adeno-associated virus, lentivirus, and measles virus. Mol Cell Neurosci 2001; 17: 855-871.
14. Hennou S et al. Homer-1alVesl-1S enhances hippocampal synaptic transmission. Eur J Neurosci 2003; 18: 811-819.
15. Altman-Hamamdzic S et al. Expression of beta-galactosidase in mouse brain: utilization of a novel nonreplicative Sindbis virusvector as a neuronal gene delivery system. Gene Therapy 1997; 4: 815-822.
16. Lundstrom K, Richards JG, Pink JR, Jenck F. Efficient in vivo expression of a reporter gene in rat brain after injection of recombinant replication-deficient Semliki Forets virus. Gene Ther Mol Biol 1999; 3: 15-23.
17. Hardy PA et al. Recombinant Semliki forest virus infects and kills human prostate cancer cell lines and prostatic duct epithelial cells ex vivo. Int J Mol Med 2000; 5: 241-245.
18. Loimas S et al. Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy. Cancer Gene Ther 2001; 8: 137-144.
19. Lundstrom K. Alphavirus vectors for vaccine production and gene therapy. Expert Rev Vaccines 2003; 2: 447-459.
20. Ying H et al. Cancer therapy using a self-replicating RNA vaccine. Nat Med 1999; 5: 823-827.
21. Leitner WW et al. Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat Med 2003; 9: 33-39.
22. Velders MP et al. Eradication of established tumors by vaccination with Venezuelan equine encephalitis virus replicon particles delivering human papillomavirus 16 E7 RNA. Cancer Res 2001; 61: 7861-7867.
23. Asselin-Paturel C et al. Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography. Gene Therapy 1999; 6: 606-615.
24. Murphy AM, Morris-Downes MM, Sheahan BJ, Atkins GJ. Inhibition of human lung carcinoma cell growth by apoptosis induction using Semliki Forest virus recombinant particles. Gene Therapy 2000; 7: 1477-1482.
25. Murphy AM, Sheahan BJ, Atkins GJ. Induction of apoptosis in BCL-2-expressing rat prostate cancer cells using the Semliki Forest virus vector. Int J Cancer 2001; 94: 572-578.
26. Ohno K et al. Cell-specific targeting of Sindbis virus vectors displaying IgG binding domains of protein A. Nat Biotechnol 1997; 15: 763-767.
27. Tseng JC et al. Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol 2004; 22: 70-77.
28. Lundstrom K, Boulikas T. Viral and non-viral vectors in gene therapy: technology development and clinical trials. Technol Cancer Res Treatment 2003; 2: 471-486.
29. Ren H et al. Immunogene therapy of recurrent glioblastoma multiforme with a liposomally encapsulated replication-incompetent Semliki forest virus vector carrying the human interleukin-12 gene—a phase IlII clinical protocol. J Neurooncol 2003; 64: 147-154.
30. Agapov EV et al. Non-cytopathogenic Sindbis RNA vectors for heterologous gene expression. Proc Natl Acad Sci USA 1998; 95: 12989-12994.
31. Boorsma M et al. A temperature-regulated replicon-based DNA expression system. Nat Biotechnol 2000; 18: 429-432.
32. Lundstrom K, Abenavoli A, Malgaroli A, Ehrengruber MU. Novel Semliki Forest virus vectors with reduced cytotoxicity and temperature sensitive for long-term enhancement of transgene expression. Mol Ther 2003; 7: 202-209.
33. Ehrengruber MU et al. Semliki Forest virus A7(74) transduces hippocampal neurons and glial cells in a temperature-dependent dual manner. J Neurovirol 2003; 9: 16-28.
34. Kim J et al. Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons. J Neurosci Methods 2004; 133: 81-90.