A New Approach to the Rapid Parallel Development of Four Neurokinin Antagonists. Part 5. Preparation of ZM374979 Cyanoacid and Selective Crystallisation of ZM374979 Atropisomers

Organic Process Research and Development

Volumn 8, Issue 1, 2004, Pages 45-50

  Parker, Jeremy S ^a   Smith, Neil A ^a   Welham, Matthew J ^a   Moss, William O ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ESTER DERIVATIVE; NEUROKININ ANTAGONIST; NITRILE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ZD 2249; ZD 4974; ZD 6021; ZM 374979;

ARTICLE; CRYSTALLIZATION; DERIVATIZATION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; GRIGNARD REACTION; ISOMERISM; PROCESS DEVELOPMENT; REACTION ANALYSIS;

EID: 0842349056     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op030041q     Document Type: Article

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