In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10- tetrahydrobenzo[b][1,8]naphthyridin-5(7h)-one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites

Biopharmaceutics and Drug Disposition

Volumn 19, Issue 5, 1998, Pages 315-332

  Zbaida, S ^a   Du, Y ^a   Shannon, D ^a   Laudicina, D ^a   Thonoor, C M ^a   Ng, K ^a   Blumenkrantz, N ^a   Patrick, J E ^a   Cayen, M N ^a   Friary, R ^a   Seidl, V ^a   Chan, T M ^a   Pramanik, B ^a   Spangler, M ^a   McPhail, A T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antipsoriatic drug; In vitro metabolism; Liver slices; SCH 40120

Indexed keywords

10 (3 CHLOROPHENYL) 6,8,9,10 TETRAHYDROBENZO[B][1,8]NAPHTHYRIDIN 5(7H) ONE; ANTIPSORIASIS AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DOG; DRUG CONFORMATION; DRUG METABOLISM; HUMAN; HUMAN TISSUE; LIVER METABOLISM; MONKEY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPECIES DIFFERENCE; STEREOISOMERISM; STRUCTURE ANALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD, PRESCHOOL; DOGS; HUMANS; HYDROXYLATION; LIVER; MACACA FASCICULARIS; MALE; NAPHTHYRIDINES; PSORIASIS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 0031811101     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199807)19:5<315::AID-BDD107>3.0.CO;2-N     Document Type: Article

References (30)