2,2′-dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (Connexin43) and inhibition of myometrial gap junctions

Biology of Reproduction

Volumn 73, Issue 5, 2005, Pages 974-982

  Chung, Daesuk ^a   Caruso, Rita Loch ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Kinases; Parturition; Signal transduction; Toxicology; Uterus

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CONNEXIN 43; DICHLOROBIPHENYL; LUCIFER YELLOW; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; POLYCHLORINATED BIPHENYL; PROTEIN GJA1; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG; 2,2'-DICHLOROBIPHENYL; ENZYME INHIBITOR; FLAVONOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SYNCHRONIZATION; CHILDBIRTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GAP JUNCTION; GESTATIONAL AGE; HYPOTHESIS; MYOMETRIUM; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SCORING SYSTEM; SIGNAL TRANSDUCTION; UTERUS; UTERUS CONTRACTION; WESTERN BLOTTING; ANIMAL; CELL JUNCTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; CONNEXIN 43; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; GAP JUNCTIONS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MYOMETRIUM; PHOSPHORYLATION; POLYCHLORINATED BIPHENYLS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; UTERINE CONTRACTION;

EID: 27144523471     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.105.043505     Document Type: Article

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