Abi1 is essential for the formation and activation of a WAVE2 signalling complex

Nature Cell Biology

Volumn 6, Issue 4, 2004, Pages 319-327

  Innocenti, Metello ^a,c   Zucconi, Adriana ^a,c   Disanza, Andrea ^a,c   Frittoli, Emanuela ^a,c   Areces, Liliana B ^a,c   Steffen, Anika ^e   Stradal, Theresia E B ^e   Di Fiore, Pier Paolo ^a,b,c   Carlier, Marie France ^d   Scita, Giorgio ^a,c  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^d CNRS   (France)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ACTIN; ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; BINDING PROTEIN; CELL PROTEIN; PROTEIN ABI1; PROTEIN NAP1; PROTEIN PIR121; PROTEIN WAVE2; RAC PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; LAMELLIPODIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY;

ACTIN-RELATED PROTEIN 2; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARRIER PROTEINS; CELL MOVEMENT; CYTOSKELETAL PROTEINS; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; MICROFILAMENT PROTEINS; MICROFILAMENTS; PROTEIN STRUCTURE, TERTIARY; PSEUDOPODIA; RAC GTP-BINDING PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY;

EID: 2342483041     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1105     Document Type: Article

References (30)

1. Pollard, T. D. The cytoskeleton, cellular motility and the reductionist agenda. Nature 422, 741-745 (2003).
2. Takenawa, T. & Miki, H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 114, 1801-1809 (2001).
3. Miki, H., Yamaguchi, H., Suetsugu, S. & Takenawa, T. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature 408, 732-735 (2000).
4. Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M. & Kirschner, M. W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418, 790-793 (2002).
5. Shi, Y., Alin, K. & Goff, S. P. Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 9, 2583-2597 (1995).
6. Dai, Z. & Pendergast, A. M. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev. 9, 2569-2582 (1995).
7. Scita, G. et al. EPS8 and E3B1 transduce signals from Ras to Rac. Nature 401, 290-293 (1999).
8. Soderling, S. H. et al. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nature Cell Biol. 4, 970-975 (2002).
9. Rogers, S. L., Wiedemann, U., Stuurman, N. & Vale, R. D. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J. Cell Biol. 162, 1079-1088 (2003).
10. Saller, E. et al. Increased apoptosis induction by 121F mutant p53. EMBO J. 18, 4424-4437 (1999).
11. Nagase, T. et al. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5, 355-364 (1998).
12. Schenck, A., Bardoni, B., Moro, A., Bagni, C. & Mandel, J. L. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc. Natl Acad. Sci. USA 98, 8844-8849 (2001).
13. Witke, W. et al. In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. EMBO J. 17, 967-976 (1998).
14. Kobayashi, K. et al. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J. Biol. Chem. 273, 291-295 (1998).
15. Kitamura, T. et al. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. Biochem. Biophys. Res. Commun. 219, 509-514 (1996).
16. Suzuki, T. et al. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease. Genomics 63, 246-254 (2000).
17. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. & Hall, A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410 (1992).
18. Kitamura, Y. et al. Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. Biochem. J. 322, 873-878 (1997).
19. Soto, M. C. et al. The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev. 16, 620-632 (2002).
20. Soderling, S. H. et al. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc. Natl Acad. Sci. USA 100, 1723-1728 (2003).
21. Benachenhou, N., Massy, I. & Vacher, J. Characterization and expression analyses of the mouse Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar. Gene 290, 131-140 (2002).
22. Hall, A. Rho GTPases and the actin cytoskeleton. Science 279, 509-514 (1998).
23. Adams, J. C. Regulation of protrusive and contractile cell-matrix contacts. J. Cell Sci. 115, 257-265 (2002).
24. Steffen, A. K. R., Ehinger, J., Innocenti, M., Scita, G., Wehland, J. & Stradal, T. E. B. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J. 23, 749-759 (2004).
25. Allen, P. G. Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles. Nature Cell Biol. 5, 972-979 (2003).
26. Ichetovkin, I., Grant, W. & Condeelis, J. Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr. Biol. 12, 79-84 (2002).
27. Yamamoto, A., Suzuki, T. & Sakaki, Y. Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. Gene 271, 159-169 (2001).
28. Biesova, Z., Piccoli, C. & Wong, W. T. Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. Oncogene 14, 233-241 (1997).
29. Shevchenko, A., Wilm, M., Vorm, O. & Mann, M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68, 850-858 (1996).
30. Pantaloni, D., Boujemaa, R., Didry, D., Gounon, P. & Carlier, M. F. The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins. Nature Cell Biol. 2, 385-391 (2000).