A new procedure for deconvolution of inter-/intramolecular intrinsic primary and α-secondary deuterium isotope effects from enzyme steady-state kinetic data

Journal of the American Chemical Society

Volumn 121, Issue 25, 1999, Pages 5865-5880

  McIntire, William S ^a,b,c   Everhart, E Thomas ^c   Craig, John C ^c   Kuusk, Vladislav ^a,b,d  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d OREAD Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTERIUM; ISOTOPE; PARA CRESOL;

ARTICLE; COMPLEX FORMATION; COVALENT BOND; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ISOTOPE LABELING; MOLECULAR INTERACTION; NONHUMAN; OXIDATION; STEADY STATE;

EID: 0033618106     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja984214g     Document Type: Article

References (50)

1. Kurz, L. C.; Freiden, C. J. Am. Chem. Soc. 1980, 102, 4198-4203. Kohen, A.; Klinman J. P. Acc. Chem Res. 1998, 31, 397-404.
2. Kurz, L. C.; Freiden, C. J. Am. Chem. Soc. 1980, 102, 4198-4203. Kohen, A.; Klinman J. P. Acc. Chem Res. 1998, 31, 397-404.
3. (a) Klinman, J. P. In Enzyme Mechanisms from Isotope Effects; Cook, P. F., Ed.; CRC Press: Boca Raton, FL, 1991; pp 127-148.
4. (b) Bahnson, B. J.; Klinman, J. P. Methods Enzymol. 1995, 249, 373-397.
5. Fisher, H. F.; Saha, S. K. Biochemistry 1996, 35, 83-88.
6. Enzyme Mechanisms from Isotope Effects; Cook, P. F., Ed.; CRC Press: Boca Raton, FL, 1991.
7. Hanzilik, R. P.; Hogberg, K.; Moon, J. P.; Judson, C. M. J. Am. Chem. Soc. 1985, 107, 7164-7167.
8. Hanzlik, R. P.; Schaefer, A. R.; Moon, J. B.; Judson, C. M. J. Am. Chem. Soc. 1987, 109, 4926-4930.
9. Jones, J. P.; Trager, W. F. J. Am. Chem. Soc. 1987, 109, 2171-2173.
10. Miller, V. P.; Tschirret-Guth, R. A.; Ortiz de Montellano, P. R. Arch. Biochem. Biophys. 1995, 319, 333-340.
11. McIntire, W. S.; Singer, T. P.; Smith, A. J.; Mathews, F. S. Biochemistry 1986, 25, 5975-5981.
12. McIntire, W. S.; Edmondson, D. E.; Hopper, D. J.; Singer, T. P. Biochemistry 1981, 20, 3068-3075.
13. Singer, T. P.; McIntire, W. S. Methods Enzymol. 1984, 106, 369-378.
14. Mewies, M.; McIntire, W. S.; Scrutton, N. S. Protein Sci. 1998, 7, 7-20.
15. McIntire, W. S.; Hopper, D. J.; Singer, T. P. Biochem. J. 1985, 228, 325-335.
16. McIntire, W. S.; Hopper, D. J.; Singer, T. P. Biochemistry 1987, 26, 4107-4117.
17. McIntire, W. S.; Koerber, S. C.; Bohmont, C.; Singer, T. P. In Flavins and Flavoproteins; Bray, R. C., Engel, P. C., Mayhew, S. G., Eds.; Walter de Gruyter: Berlin and New York, 1984; pp 643-658.
18. McIntire, W. S.; Hopper, D. J.; Craig, J. C.; Everhart, E. T.; Webster, R. V.; Causer, M. J.; Singer, T. P. Biochem. J. 1984, 224, 617-621.
19. Northrop, D. B. Anal. Biochem. 1983, 132, 457-461.
20. Northrop, D. B. In Isotope Effects on Enzyme Catalyzed Reactions; Cleland, W. W., O'Leary, M. H., Northrop, D. B., Eds.; University Park Press: Baltimore, MD, 1977; pp 122-152.
21. Northrop, D. B. In Enzyme Mechanisms from Isotope Effects; Cook, P. F., Ed.; CRC Press: Boca Raton, FL, 1991; pp 181-202.
22. Sherril, D. C.; Tucker, E. E. Am. Lab. 1983, 15, 78-85.
23. McIntire, W. S.; Bohmont, C. In Flavins and Flavoproteins; Edmondson, D. E., McCormick, D. B., Eds.; Walter de Gruyter: Berlin and New York, 1987; pp 677-686.
24. Pirkle, W. H.; Finn, J. M. J. Org. Chem. 1981, 46, 2935-2938.
25. Kasai, M.; Froussios, C.; Ziffer, H. J. Org. Chem. 1983, 48, 459-464.
26. Technical Brochure No. 3 (Chiralcel); Diacel (USA), Inc., Los Angeles, CA.
27. Okamoto, Y.; Aburatani, R.; Hatada, K. J. Chromatogr. 1987, 389, 95-102.
28. Estabrook, R. W. Methods Enzymol. 1967, 10, 41-47.
29. Cornish-Bowden, A. Fundamentals of Enzyme Kinetics; Portland Press: London, 1995; pp 105-110.
30. Melander, L.; Saunders: W. H. Reactions Rates of Isotopic Molecules; John Wiley & Sons: New York, 1980.
31. Shiner, V. L. In Isotope Effects in Chemical Reactions; Collins, C. J., Bowman, N. S., Eds.; Van Nostrand Reinhold: New York, 1970; Chapter 2, pp 90-159.
32. Kresge, A. J. In Isotope Effects on Enzyme Catalyzed Reactions; Cleland, W. W., O'Leary, M. H., Northrop, D. B., Eds.; University Park Press: Baltimore, MD, 1977; pp 37-63.
33. Sühnel, J.; Schowen, R. I. In Enzyme Mechanisms from Isotope Effects; Cook, P. F., Ed.; CRC Press: Boca Raton, FL, 1991; pp 3-35.
34. Saunders, W. H. J. Am. Chem. Soc. 1985, 107, 164-169.
35. Anderson, V. E. In Enzyme Mechanisms from Isotope Effects; Cook, P. F., Ed.; CRC Press: Boca Raton, FL, 1991; pp 389-417.
36. Reutov, O. A.; Beletskaya, I. P.; Butin, K. P. CH-Acids; Pergamon Press: New York, 1978.
37. Sim, B. A.; Griller, D.; Wayner, D. D. M. J. Am. Chem. Soc. 1989, 111, 754-755.
38. Nonhebel, D. C.; Tedder, J. M.; Walton, J. C. Radicals; Cambridge University Press: Cambridge, England, 1979.
39. Bhattacharyya, A.; Tollin, G.; McIntire, W. S.; Singer, T. P. Biochem. J. 1985, 228, 337-345.
40. Kim, J.; Fuller, J. H.; Kuusk, V.; Cunan, L.; Chen, Z.-w.; Mathews, F. S.; McIntire, W. S. J. Biol. Chem. 1995, 270, 31202-31209.
41. Hopper, D. J. FEBS Lett. 1983, 161, 100-102.
42. Lind, J.; Shen, X.; Eriksen, T. E.; Merényi, G. J. Am. Chem. Soc. 1990, 112, 479-482.
43. Walker, M. C.; Edmondon, D. E. Biochemistry 1994, 33, 7088-7098.
44. Van Hook, W. A. Isotope Effects in Chemical Reactions; Collins, C. J., Bowman, N. S., Eds.; Van Nostrand Reinhold: New York, 1979; Chapter 1, pp 1-89.
45. Koerber, S. C.; McIntire, W. S.; Bohmont, C.; Singer, T. P. Biochemistry 1985, 24, 5276-5280.
46. Wharton, D. C.; Tzagloff, A. Methods Enzymol. 1967, 10, 245-250.
47. Dale, W. J.; Hennis, H. E. J. Am. Chem. Soc. 1958, 80, 3645-3649.
48. Everhart, E. T.; Craig, J. C. J. Chem. Soc., Perkins Trans. 1 1991, 1701-1707.
49. Everhart, E. T.; McIntire, W. S.; Craig, J. C., manuscript in preparation.
50. Ramsay, R. R.; Koerber, S. C.; Singer, T. P. Biochemistry 1987, 26, 3045-3050.