A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo

Genes and Development

Volumn 19, Issue 20, 2005, Pages 2458-2465

  Araki, Marito ^a   Yu, Hongtao ^b   Asano, Maki ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

APC; Cell cycle; ORC1; Proteolysis; Replication

Indexed keywords

ORIGIN RECOGNITION COMPLEX PROTEIN 1; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; DROSOPHILA; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; REGULATORY MECHANISM; SCHIZOSACCHAROMYCES POMBE; UBIQUITINATION;

AMINO ACID MOTIFS; ANIMALS; CELL CYCLE PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; G1 PHASE; ORIGIN RECOGNITION COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

SCHIZOSACCHAROMYCES POMBE;

EID: 26944487640     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1361905     Document Type: Article

References (42)

1. Araki, M., Wharton, R.P., Tang, Z., Yu, H., and Asano, M. 2003. Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. EMBO J. 22: 6115-6126.
2. Asano, M. and Wharton, R.P. 1999. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila. EMBO J. 18: 2435-2448.
3. Bell, S.P. 2002. The origin recognition complex: From simple origins to complex functions. Genes & Dev. 16: 659-672.
4. Bell, S.P. and Dutta, A. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71: 333-374.
5. Brandeis, M. and Hunt, T. 1996. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J. 15: 5280-5289.
6. Burton, J.L. and Solomon, M.J. 2001. D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes & Dev. 15: 2381-2395.
7. Burton, J.L., Tsakraklides, V., and Solomon, M.J. 2005. Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box. Mol. Cell 18: 533-542.
8. Castro, A., Vigneron, S., Bernis, C., Labbe, J.C., and Lorca, T. 2003. Xkid is degraded in a D-box, KEN-box, and A-boxindependent pathway. Mol. Cell. Biol. 23: 4126-4138.
9. Ciechanover, A. 1994. The ubiquitin-proteasome proteolytic pathway. Cell 79: 13-21.
10. DePamphilis, M.L. 2003. The 'ORC cycle': A novel pathway for regulating eukaryotic DNA replication. Gene 310: 1-15.
11. Diffley, J.F. 2004. Regulation of early events in chromosome replication. Curr. Biol. 14: R778-R786.
12. do Carmo Avides, M. and Glover, D.M. 1999. Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. Science 283: 1733-1735.
13. Ferreira, M.F., Santocanale, C., Drury, L.S., and Diffley, J.F. 2000. Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex. Mol. Cell. Biol. 20: 242-248.
14. Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T., and Yanagida, M. 1996. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381: 438-441.
15. Funabiki, H., Yamano, H., Nagao, K., Tanaka, H., Yasuda, H., Hunt, T., and Yanagida, M. 1997. Fission yeast Cut2 required for anaphase has two destruction boxes. EMBO J. 16: 5977-5987.
16. Glotzer, M., Murray, A.W., and Kirschner, M.W. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349: 132-138.
17. Harper, J.W., Burton, J.L., and Solomon, M.J. 2002. The anaphase-promoting complex: It's not just for mitosis any more. Genes & Dev. 16: 2179-2206.
18. Hilioti, Z., Chung, Y.S., Mochizuki, Y., Hardy, C.F., and Cohen-Fix, O. 2001. The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. Curr. Biol. 11: 1347-1352.
19. Hochstrasser, M. 1996. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30: 405-439.
20. Kearsey, S.E. and Cotterill, S. 2003. Enigmatic variations: Divergent modes of regulating eukaryotic DNA replication. Mol. Cell 12: 1067-1075.
21. Kraft, C., Vodermaier, H.C., Maurer-Stroh, S., Eisenhaber, F., and Peters, J.M. 2005. The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol. Cell 18: 543-553.
22. Littlepage, L.E. and Ruderman, J.V. 2002. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes & Dev. 16: 2274-2285.
23. Loupart, M.L., Krause, S.A., and Heck, M.S. 2000. Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants. Curr. Biol. 10: 1547-1556.
24. McGarry, T.J. and Kirschner, M.W. 1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93: 1043-1053.
25. Mendez, J., Zou-Yang, X.H., Kim, S.Y., Hidaka, M., Tansey, W.P., and Stillman, B. 2002. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol. Cell 9: 481-491.
26. Neufeld, T.P., de la Cruz, A.F., Johnston, L.A., and Edgar, B.A. 1998. Coordination of growth and cell division in the Drosophila wing. Cell 93: 1183-1193.
27. Pak, D.T., Pflumm, M., Chesnokov, I., Huang, D.W., Kellum, R., Marr, J., Romanowski, P., and Botchan, M.R. 1997. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell 91: 311-323.
28. Peters, J.M. 2002. The anaphase-promoting complex: Proteolysis in mitosis and beyond. Mol. Cell 9: 931-943.
29. Petersen, B.O., Wagener, C., Marinoni, F., Kramer, E.R., Melixetian, M., Denchi, E.L., Gieffers, C., Matteucci, C., Peters, J.M., and Helin, K. 2000. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes & Dev. 14: 2330-2343.
30. Pfleger, C.M. and Kirschner, M.W. 2000. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1. Genes & Dev. 14: 655-665.
31. Pinto, S., Quintana, D.G., Smith, P., Mihalek, R.M., Hou, Z.H., Boynton, S., Jones, C.J., Hendricks, M., Velinzon, K., Wohlschlegel, J.A., et al. 1999. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron 23: 45-54.
32. Quinn, L.M., Herr, A., McGarry, T.J., and Richardson, H. 2001. The Drosophila Geminin homolog: Roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis. Genes & Dev. 15: 2741-2754.
33. Rohrbough, J., Pinto, S., Mihalek, R.M., Tully, T., and Broadie, K. 1999. latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron 23: 55-70.
34. Rudner, A.D. and Murray, A.W. 2000. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J. Cell Biol. 149: 1377-1390.
35. Sigrist, S., Jacobs, H., Stratmann, R., and Lehner, C.F. 1995. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J. 14: 4827-4838.
36. Stillman, B. 2005. Origin recognition and the chromosome cycle. FEBS Lett. 579: 877-884.
37. Tang, Z. and Yu, H. 2004. Functional analysis of the spindlecheckpoint proteins using an in vitro ubiquitination assay. Methods Mol. Biol. 281: 227-242.
38. Thrower, J.S., Hoffman, L., Rechsteiner, M., and Pickart, C.M. 2000. Recognition of the polyubiquitin proteolytic signal. EMBO J. 19: 94-102.
39. Yamano, H., Tsurumi, C., Gannon, J., and Hunt, T. 1998. The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: Defining the D-box receptor. EMBO J. 17: 5670-5678.
40. Yamano, H., Gannon, J., Mahbubani, H., and Hunt, T. 2004. Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts. Mol. Cell 13: 137-147.
41. Zachariae, W. and Nasmyth, K. 1999. Whose end is destruction: Cell division and the anaphase-promoting complex. Genes & Dev. 13: 2039-2058.
42. Zur, A. and Brandeis, M. 2002. Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes. EMBO J. 21: 4500-4510.