Ankylosing spondylitis susceptibility loci defined by genome-search meta-analysis

Journal of Human Genetics

Volumn 50, Issue 9, 2005, Pages 453-459

  Lee, Young Ho ^a   Rho, Young Hee ^a   Choi, Seong Jae ^a   Ji, Jong Dae ^a   Song, Gwan Gyu ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Ankylosing spondylitis; Genome scan; Linkage; Meta analysis; Spondyloarthropathy

Indexed keywords

HLA B27 ANTIGEN;

ANKYLOSING SPONDYLITIS; ARTICLE; CAUCASIAN; CHROMOSOME 16Q; CHROMOSOME 17P; CHROMOSOME 19; CHROMOSOME 6; CHROMOSOME 6P; CHROMOSOME 9Q; CONTROLLED STUDY; DISEASE PREDISPOSITION; FAMILY; GENE LOCUS; GENE REPLICATION; GENETIC LINKAGE; GENOME ANALYSIS; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; SPONDYLOARTHROPATHY;

CHROMOSOMES, HUMAN, PAIR 6; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HUMANS; LINKAGE (GENETICS); SPONDYLITIS, ANKYLOSING;

EID: 26944470820     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-005-0277-1     Document Type: Article

References (22)

1. Altmuller J, Palmer LJ, Fischer G, Scherb H, Wjst M (2001) Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet 69:936-950
2. Braun J, Bollow M, Remlinger G, Eggens U, Rudwaleit M, Distler A, Sieper J (1998) Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum 41:58-67
3. Breban M, Said-Nahal R, Hugot JP, Miceli-Richard C (2003) Familial and genetic aspects of spondyloarthropathy. Rheum Dis Clin North Am 29:575-594
4. Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DC, Sturrock RD (1973) Ankylosing spondylitis and HL-A 27. Lancet 1:904-907
5. Brown MA, Kennedy LG, MacGregor AJ, Darke C, Duncan E, Shatford JL, Taylor A, Calin A, Wordsworth P (1997) Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40:1823-1828
6. Brown MA, Kennedy LG, Darke C, Gibson K, Pile KD, Shatford JL, Taylor A, Calin A, Wordsworth BP (1998) The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis Rheum 41:460-465
7. Brown MA, Laval SH, Brophy S, Calin A (2000) Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rheum Dis 59:883-886
8. Brown MA, Wordsworth BP, Reveille JD (2002) Genetics of ankylosing spondylitis. Clin Exp Rheumatol 20:S43-S49
9. Brown MA, Brophy S, Bradbury L, Hamersma J, Timms A, Laval S, Cardon L, Calin A, Wordsworth BP (2003) Identification of major loci controlling clinical manifestations of ankylosing spondylitis. Arthritis Rheum 48:2234-2239
10. Calin A, Marder A, Becks E, Burns T (1983) Genetic differences between B27 positive patients with ankylosing spondylitis and B27 positive healthy controls. Arthritis Rheum 26:1460-1464
11. Cordell HJ (2001) Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs. Ann Hum Genet 65:491-502
12. Goring HH, Terwilliger JD, Blangero J (2001) Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 69:1357-1369
13. Guerra R, Etzel CJ, Goldstein DR, Sain SR (1999) Meta-analysis by combining p-values: simulated linkage studies. Genet Epidemiol (Suppl 1):S605-S609
14. Jaakkola E, Crane AM, Laiho K, Herzberg I, Sims AM, Bradbury L, Calin A, Brophy S, Kauppi M, Kaarela K, Wordsworth BP, Tuomilehto J, Brown MA (2004) The effect of transforming growth factor beta1 gene polymorphisms in ankylosing spondylitis. Rheumatology 43:32-38
15. Jarvinen P (1995) Occurrence of ankylosing spondylitis in a nationwide series of twins. Arthritis Rheum 38:381-383
16. Laval SH, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, Rubin L, Siminovitch KA, Weeks DE, Calin A, Wordsworth BP, Brown MA (2001) Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet 68:918-926
17. Levinson DF, Levinson MD, Segurado R, Lewis CM (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: methods and power analysis. Am J Hum Genet 73:17-33
18. Miceli-Richard C, Zouali H, Said-Nahal R, Lesage S, Merlin F, De Toma C, Blanche H, Sahbatou M, Dougados M, Thomas G, Breban M, Hugot JP (2004) Significant linkage to spondyloarthropathy on 9q31-34. Hum Mol Genet 13:1641-1648
19. Province MA (2001) The significance of not finding a gene. Am J Hum Genet 69:660-663
20. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
21. Wise LH, Lanchbury JS, Lewis CM (1999) Meta-analysis of genome searches. Ann Hum Genet 63:263-272
22. Zhang G, Luo J, Bruckel J, Weisman MA, Schumacher HR, Khan MA, Inman RD, Mahowald M, Maksymowych WP, Martin TM, Yu DT, Stone M, Rosenbaum JT, Newman P, Lee J, McClain JA, West OC, Jin L, Reveille JD (2004) Genetic studies in familial ankylosing spondylitis susceptibility. Arthritis Rheum 50:2246-2254