Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs

Annals of Human Genetics

Volumn 65, Issue 5, 2001, Pages 491-502

  Cordell, H J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANALYTICAL ERROR; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL; SIBLING; SIMULATION; STATISTICAL ANALYSIS; VARIANCE;

EID: 0035208755     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-1809.2001.6550491.x     Document Type: Article

References (24)

1. Babron, M.C., et al. (2000). Homogeneity tests for genome scans of multifactorial diseases. Genet. Epid. 19, 237.
2. Begleiter, H., et al. (1999). Description of the Genetic Analysis Workshop 11 Collaborative Study on the Genetics of Alcoholism. Genet. Epid. 17 Suppl 1, S25-30.
3. Blackwelder, W. G. & Eiston, R. C. (1985). A comparison of sib-pair linkage tests for disease susceptibility loci. Genet. Epid. 2, 85-97.
4. Camp, N. J. (1997). Genomewide transmission/disequilibrium testing: consideration of the genotypic relative risks at disease loci. Am. J. Hum. Genet. 61, 1424-1430.
5. Camp, N. J. (1999). Genomewide transmission/ disequilibrium testing: a correction. Am. J. Hum. Genet. 64, 1485-1487.
6. Cao, Q., et al. (1997). Suggestive evidence for a schizophrenia susceptibility locus on chromosomes 6q and a confirmation in an independent series of pedigrees. Genomics 43, 1-8.
7. Clerget-Darpoux, R, et al. (2000). Why are genome scans of multifactorial diseases so discordant? Genet. Epid. 19, 241.
8. Cordell, H. J., et al. (2000). Multilocus linkage tests based on affected relative pairs. Am. J. Hum. Genet. 66, 1273-1286.
9. Cox, N. J., et al. (1999). Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat. Genet. 21, 213-215.
10. Gudbjartsson, D. F. et al. (2000). Allegro, a new computer program for multipoint linkage analysis. Nat. Genet. 25, 12-13.
11. Hauser, E. R. & Boehnke, M. (1997). Confirmation of linkage results in affected-sib-pair linkage analysis for complex traits. Am. J. Hum. Genet. 61, A278.
12. Holmans, P. (1993). Asymptotic properties of affected-sib-pair linkage analysis. Am. J. Hum. Genet. 52, 362-374.
13. Horikawa, Y., et al. (2000). Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26, 103-175.
14. Kong, A. & Cox, N. J. (1997). Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet. 61, 1179-1188.
15. Kruglyak, L., et al. (1996). Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 46, 229-241.
16. Lander, E. & Kruglyak, L. (1995). Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11, 241-247.
17. Levinson, D. F., et al. (2000). Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: Schizophrenia Linkage Collaborative Group III. Am. J. Hum. Genet. 67, 652-663.
18. Martinez, M., et al. (1999). Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q. Am. J. Med. Genet. 88, 337-343.
19. Risch, N. (1990). Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am. J. Hum. Genet. 46, 229-241.
20. Risch, X. & Merikengas, K. (1996). The future of genetic studies of complex diseases. Science 273, 1510-1517.
21. Roberts, S. B., et al. (1999). Replication of linkage studies of complex traits: an examination of variation in location estimates. Am. J. Hum. Genet. 65, 870-884.
22. Slager, S. L., et al. (2000). Effect of allelic heterogeneity on the power of the transmission disequilibrium test. Genet. Epid. 18, 143-156.
23. Suarez, B. K., et al. (1994). Problems of replicating linkage claims in psychiatry. In: Genetic approaches to mental disorders (eds E. S. Gershon & C. R. Cloninger), pp. 23-40. Washington DC: American Psychiatric Press.
24. Whittemore, A. S. & Halpern, J. (1994). A class of tests of linkage using affected pedigree members. Biometrics 50, 118-127.