Identification of major loci controlling clinical manifestations of ankylosing spondylitis

Arthritis and Rheumatism

Volumn 48, Issue 8, 2003, Pages 2234-2239

  Brown, Matthew A ^a   Brophy, Sinead ^b   Bradbury, Linda ^a   Hamersma, Jasmin ^a   Timms, Andrew ^a   Laval, Steven ^a   Cardon, Lon ^a   Calin, Andrei ^b   Wordsworth, B Paul ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ROYAL NATIONAL HOSPITAL FOR RHEUMATIC DISEASES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYLOSING SPONDYLITIS; ARTICLE; BATH ANKYLOSING SPONDYLITIS DISEASE ACTIVITY INDEX; BATH ANKYLOSING SPONDYLITIS FUNCTIONAL INDEX; CHROMOSOME 11P; CHROMOSOME 18P; CHROMOSOME 2Q; CLINICAL FEATURE; DISEASE ACTIVITY; FAMILY STUDY; FUNCTIONAL ASSESSMENT; GENE LOCUS; GENETIC LINKAGE; HERITABILITY; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; ONSET AGE; PRIORITY JOURNAL; SIBLING; SPONDYLOARTHROPATHY; SYMPTOMATOLOGY;

CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 6; FAMILY HEALTH; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOTYPE; HUMANS; LOD SCORE; SPONDYLITIS, ANKYLOSING;

EID: 0042072981     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11106     Document Type: Article

References (27)

1. Calin A. Ankylosing spondylitis. In: Maddison PJ, Isenberg DA, Woo P, Glass DN, editors. Oxford textbook of rheumatology. Vol. 2. Oxford: Oxford University Press; 1998. p. 1058-70.
2. Brown MA, Laval SH, Brophy S, Calin A. Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rheum Dis 2000;59:883-6.
3. Laval SH, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, et al. Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet 2001;68:918-26.
4. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994;21:2286-91.
5. Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, et al. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 1994;21:2281-5.
6. Hamersma J, Cardon LR, Bradbury L, Brophy S, van der Horst-Bruinsma I, Calin A, et al. Is disease severity in ankylosing spondylitis genetically determined? Arthritis Rheum 2001;44:1396-400.
7. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984;27:361-8.
8. Nyholt DR. All LODs are not created equal. Am J Hum Genet 2000;67:282-8.
9. Sham PC, Purcell S, Cherny SS, Abecasis GR. Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet 2002;71:238-53.
10. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin: rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97-101.
11. O'Connell JR, Weeks DE. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance. Nat Genet 1995;11:402-8.
12. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-211.
13. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997;61:1179-88.
14. Hauser ER, Boehnke M, Guo SW, Risch N. Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol 1996;13:117-37.
15. Taylor AL, Balakrishnan C, Calin A. Reference centile charts for measures of disease activity, functional impairment, and metrology in ankylosing spondylitis. Arthritis Rheum 1998;41:1119-25.
16. Brown MA, Kennedy LG, Darke C, Gibson K, Pile KD, Shatford JL, et al. The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis Rheum 1998;41:460-5.
17. Ploski R, Flato B, Vinje O, Maksymowych W, Forre O, Thorsby E. Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis. Hum Immunol 1995;44:88-96.
18. Khan MA, Kushner I, Braun WE, Zachary AA, Steinberg AG. HLA-B27 homozygosity in ankylosing spondylitis: relationship to risk and severity. Tissue Antigens 1978;11:434-8.
19. Suarez-Almazor ME, Russell AS. B27 homozygosity and ankylosing spondylitis. J Rheumatol 1987;14:302-4.
20. Arnett FC Jr, Schacter BZ, Hochberg MC, Hsu SH, Bias WB. Homozygosity for HLA-B27: impact on rheumatic disease expression in two families. Arthritis Rheum 1977;20:797-804.
21. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
22. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
23. Van der Paardt M, Crusius JB, de Koning MH, Murillo LS, van de Stadt RJ, Dijkmans BA, et al. CARD15 gene mutations are not associated with ankylosing spondylitis. Genes Immun 2003;4:77-8.
24. D'Amato M. The Crohn's associated NOD2 3020InsC frameshift mutation does not confer susceptibility to ankylosing spondylitis. J Rheumatol 2002;29:2470-1.
25. Ferreiros-Vidal I, Amarelo J, Barros F, Carracedo A, Gomez-Reino JJ, Gonzalez A. Lack of association of ankylosing spondylitis with the most common NOD2 susceptibility alleles to Crohn's disease. J Rheumatol 2003;30:102-4.
26. Miceli-Richard C, Zouali H, Lesage S, Thomas G, Hugot J-P, Said-Nahal R, et al. CARD15/NOD2 analyses in spondylarthropathy. Arthritis Rheum 2002;46:1405-6.
27. Crane AM, Bradbury L, van Heel DA, McGovern DPB, Brophy S, Rubin L, et al. Role of NOD2 variants in spondylarthritis. Arthritis Rheum 2002;46:1629-33.