메뉴 건너뛰기




Volumn 49, Issue 6, 2005, Pages 737-749

Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala

Author keywords

Cocaine; Dopamine; Polymorphism; Protein kinase C; Regulation; Transporter

Indexed keywords

ALANINE; DOPAMINE TRANSPORTER; VALINE;

EID: 26944469588     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.08.012     Document Type: Article
Times cited : (37)

References (59)
  • 1
    • 0032465989 scopus 로고    scopus 로고
    • Acute regulation of norepinephrine transport: I. PKC-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells
    • S. Apparsundaram, A. Galli, L.J. DeFelice, H.C. Hartzell, and R.D. Blakely Acute regulation of norepinephrine transport: I. PKC-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells Journal of Pharmacology and Experimental Therapeutics 287 1998 733 743
    • (1998) Journal of Pharmacology and Experimental Therapeutics , vol.287 , pp. 733-743
    • Apparsundaram, S.1    Galli, A.2    Defelice, L.J.3    Hartzell, H.C.4    Blakely, R.D.5
  • 2
    • 0034757985 scopus 로고    scopus 로고
    • Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells
    • S. Apparsundaram, U. Sung, R.D. Price, and R.D. Blakely Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells Journal of Pharmacology and Experimental Therapeutics 299 2001 666 677
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.299 , pp. 666-677
    • Apparsundaram, S.1    Sung, U.2    Price, R.D.3    Blakely, R.D.4
  • 10
    • 1242295211 scopus 로고    scopus 로고
    • Synaptic uptake and beyond: The sodium- and chloride-dependent neurotransmitter transporter family SLC6
    • N.H. Chen, M.E. Reith, and M.W. Quick Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6 Pflugers Archiv: European Journal of Physiology 447 2004 519 531
    • (2004) Pflugers Archiv: European Journal of Physiology , vol.447 , pp. 519-531
    • Chen, N.H.1    Reith, M.E.2    Quick, M.W.3
  • 14
    • 0032910655 scopus 로고    scopus 로고
    • Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children
    • G. Daly, Z. Hawi, M. Fitzgerald, and M. Gill Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children Molecular Psychiatry 4 1999 192 196
    • (1999) Molecular Psychiatry , vol.4 , pp. 192-196
    • Daly, G.1    Hawi, Z.2    Fitzgerald, M.3    Gill, M.4
  • 15
    • 0033582097 scopus 로고    scopus 로고
    • Dopamine transporter density in patients with attention deficit hyperactivity disorder
    • D.D. Dougherty, A.A. Bonab, T.J. Spencer, S.L. Rauch, B.K. Madras, and A.J. Fischman Dopamine transporter density in patients with attention deficit hyperactivity disorder Lancet 354 1999 2132 2133
    • (1999) Lancet , vol.354 , pp. 2132-2133
    • Dougherty, D.D.1    Bonab, A.A.2    Spencer, T.J.3    Rauch, S.L.4    Madras, B.K.5    Fischman, A.J.6
  • 17
    • 0033555898 scopus 로고    scopus 로고
    • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
    • R.R. Gainetdinov, W.C. Wetsel, S.R. Jones, E.D. Levin, M. Jaber, and M.G. Caron Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity Science 283 1999 397 401
    • (1999) Science , vol.283 , pp. 397-401
    • Gainetdinov, R.R.1    Wetsel, W.C.2    Jones, S.R.3    Levin, E.D.4    Jaber, M.5    Caron, M.G.6
  • 18
    • 0030844034 scopus 로고    scopus 로고
    • Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism
    • M. Gill, G. Daly, S. Heron, Z. Hawi, and M. Fitzgerald Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism Molecular Psychiatry 2 1997 311 313
    • (1997) Molecular Psychiatry , vol.2 , pp. 311-313
    • Gill, M.1    Daly, G.2    Heron, S.3    Hawi, Z.4    Fitzgerald, M.5
  • 20
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    • B. Giros, M. Jaber, S.R. Jones, R.M. Wightman, and M.G. Caron Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter Nature 379 1996 606 612
    • (1996) Nature , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 21
    • 0037775994 scopus 로고    scopus 로고
    • N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
    • C. Granas, J. Ferrer, C.J. Loland, J.A. Javitch, and U. Gether N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization Journal of Biological Chemistry 278 2003 4990 5000
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 4990-5000
    • Granas, C.1    Ferrer, J.2    Loland, C.J.3    Javitch, J.A.4    Gether, U.5
  • 23
    • 0036046157 scopus 로고    scopus 로고
    • Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders
    • M.K. Hahn, and R.D. Blakely Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders The Pharmacogenomics Journal 2 2002 217 235
    • (2002) The Pharmacogenomics Journal , vol.2 , pp. 217-235
    • Hahn, M.K.1    Blakely, R.D.2
  • 24
    • 0038118243 scopus 로고    scopus 로고
    • A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters
    • M.K. Hahn, D. Robertson, and R.D. Blakely A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters Journal of Neuroscience 23 2003 4470 4478
    • (2003) Journal of Neuroscience , vol.23 , pp. 4470-4478
    • Hahn, M.K.1    Robertson, D.2    Blakely, R.D.3
  • 25
    • 23044457293 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the human norepinephrine transporter gene impact expression, trafficking, antidepressant interaction and protein kinase C regulation
    • M.K. Hahn, M. Mazei-Robison, and R.D. Blakely Single nucleotide polymorphisms in the human norepinephrine transporter gene impact expression, trafficking, antidepressant interaction and protein kinase C regulation Molecular Pharmacology 68 2005 457 466
    • (2005) Molecular Pharmacology , vol.68 , pp. 457-466
    • Hahn, M.K.1    Mazei-Robison, M.2    Blakely, R.D.3
  • 26
    • 0035964192 scopus 로고    scopus 로고
    • Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment
    • H. Hastrup, A. Karlin, and J.A. Javitch Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment Proceedings of the National Academy of Sciences of the United States of America 98 2001 10055 10060
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , pp. 10055-10060
    • Hastrup, H.1    Karlin, A.2    Javitch, J.A.3
  • 28
    • 21744442114 scopus 로고    scopus 로고
    • Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation
    • L.D. Jayanthi, D.J. Samuvel, R.D. Blakely, and S. Ramamoorthy Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation Molecular Pharmacology 67 2005 2077 2087
    • (2005) Molecular Pharmacology , vol.67 , pp. 2077-2087
    • Jayanthi, L.D.1    Samuvel, D.J.2    Blakely, R.D.3    Ramamoorthy, S.4
  • 31
    • 0042343721 scopus 로고    scopus 로고
    • A human serotonin transporter mutation causes constitutive activation of transport activity
    • F. Kilic, D.L. Murphy, and G. Rudnick A human serotonin transporter mutation causes constitutive activation of transport activity Molecular Pharmacology 64 2003 440 446
    • (2003) Molecular Pharmacology , vol.64 , pp. 440-446
    • Kilic, F.1    Murphy, D.L.2    Rudnick, G.3
  • 32
    • 0034640146 scopus 로고    scopus 로고
    • Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomography
    • K.H. Krause, S.H. Dresel, J. Krause, H.F. Kung, and K. Tatsch Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography Neuroscience Letters 285 2000 107 110
    • (2000) Neuroscience Letters , vol.285 , pp. 107-110
    • Krause, K.H.1    Dresel, S.H.2    Krause, J.3    Kung, H.F.4    Tatsch, K.5
  • 33
    • 3442895932 scopus 로고    scopus 로고
    • Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter
    • K.H. Lee, M.Y. Kim, D.H. Kim, and Y.S. Lee Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter Neurochemical Research 29 2004 1405 1409
    • (2004) Neurochemical Research , vol.29 , pp. 1405-1409
    • Lee, K.H.1    Kim, M.Y.2    Kim, D.H.3    Lee, Y.S.4
  • 35
    • 0037481699 scopus 로고    scopus 로고
    • Human dopamine transporter gene variation: Effects of protein coding variants V55A and V382A on expression and uptake activities
    • Z. Lin, and G.R. Uhl Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities The Pharmacogenomics Journal 3 2003 159 168
    • (2003) The Pharmacogenomics Journal , vol.3 , pp. 159-168
    • Lin, Z.1    Uhl, G.R.2
  • 36
    • 0037805721 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites
    • Z. Lin, P.W. Zhang, X. Zhu, J.M. Melgari, R. Huff, R.L. Spieldoch, and G.R. Uhl Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites Journal of Biological Chemistry 278 2003 20162 20170
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 20162-20170
    • Lin, Z.1    Zhang, P.W.2    Zhu, X.3    Melgari, J.M.4    Huff, R.5    Spieldoch, R.L.6    Uhl, G.R.7
  • 37
    • 0037820586 scopus 로고    scopus 로고
    • The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines
    • M.K. Loder, and H.E. Melikian The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines Journal of Biological Chemistry 278 2003 22168 22174
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 22168-22174
    • Loder, M.K.1    Melikian, H.E.2
  • 38
    • 0037022356 scopus 로고    scopus 로고
    • Generation of an activating Zn(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
    • C.J. Loland, L. Norregaard, T. Litman, and U. Gether Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle Proceedings of the National Academy of Sciences of the United States of America 99 2002 1683 1688
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , pp. 1683-1688
    • Loland, C.J.1    Norregaard, L.2    Litman, T.3    Gether, U.4
  • 39
    • 26944484406 scopus 로고    scopus 로고
    • Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder
    • Mazei-Robison, M.S., Couch, R.S., Shelton, R.C., Stein, M.A., Blakely, R.D., 2005. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology 49 (6) 724-736.
    • (2005) Neuropharmacology , vol.49 , Issue.6 , pp. 724-736
    • Mazei-Robison, M.S.1    Couch, R.S.2    Shelton, R.C.3    Stein, M.A.4    Blakely, R.D.5
  • 40
    • 0033568870 scopus 로고    scopus 로고
    • Membrane trafficking regulates the activity of the human dopamine transporter
    • H. Melikian, and K. Buckley Membrane trafficking regulates the activity of the human dopamine transporter Journal of Neuroscience 19 1999 7699 7710
    • (1999) Journal of Neuroscience , vol.19 , pp. 7699-7710
    • Melikian, H.1    Buckley, K.2
  • 47
    • 0030936274 scopus 로고    scopus 로고
    • Synaptic-like microvesicles of neuroendocrine cells originate from a novel compartment that is continuous with the plasma membrane and devoid of transferrin receptor
    • A. Schmidt, M.J. Hannah, and W.B. Huttner Synaptic-like microvesicles of neuroendocrine cells originate from a novel compartment that is continuous with the plasma membrane and devoid of transferrin receptor Journal of Cell Biology 137 1997 445 458
    • (1997) Journal of Cell Biology , vol.137 , pp. 445-458
    • Schmidt, A.1    Hannah, M.J.2    Huttner, W.B.3
  • 49
    • 0031036030 scopus 로고    scopus 로고
    • Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants
    • M.S. Sonders, S.J. Zhu, N.R. Zahniser, M.P. Kavanaugh, and S.G. Amara Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants Journal of Neuroscience 17 1997 960 974
    • (1997) Journal of Neuroscience , vol.17 , pp. 960-974
    • Sonders, M.S.1    Zhu, S.J.2    Zahniser, N.R.3    Kavanaugh, M.P.4    Amara, S.G.5
  • 51
    • 0035829974 scopus 로고    scopus 로고
    • No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins
    • R.D. Todd, Y.J. Jong, E.A. Lobos, W. Reich, A.C. Heath, and R.J. Neuman No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins American Journal of Medical Genetics 105 2001 745 748
    • (2001) American Journal of Medical Genetics , vol.105 , pp. 745-748
    • Todd, R.D.1    Jong, Y.J.2    Lobos, E.A.3    Reich, W.4    Heath, A.C.5    Neuman, R.J.6
  • 52
    • 0035026044 scopus 로고    scopus 로고
    • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1
    • G.E. Torres, W.D. Yao, R.R. Mohn, H. Quan, K. Kim, A.I. Levey, J. Staudinger, and M.G. Caron Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1 Neuron 30 2001 121 134
    • (2001) Neuron , vol.30 , pp. 121-134
    • Torres, G.E.1    Yao, W.D.2    Mohn, R.R.3    Quan, H.4    Kim, K.5    Levey, A.I.6    Staudinger, J.7    Caron, M.G.8
  • 53
    • 0037462827 scopus 로고    scopus 로고
    • Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter
    • G.E. Torres, A. Carneiro, K. Seamans, C. Fiorentini, A. Sweeney, W.D. Yao, and M.G. Caron Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter Journal of Biological Chemistry 278 2003 2731 2739
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 2731-2739
    • Torres, G.E.1    Carneiro, A.2    Seamans, K.3    Fiorentini, C.4    Sweeney, A.5    Yao, W.D.6    Caron, M.G.7
  • 54
    • 0032476768 scopus 로고    scopus 로고
    • Ca(2+)-dependent enhancement of [3H]noradrenaline uptake in PC12 cells through calmodulin-dependent kinases
    • J. Uchida, Y. Kiuchi, M. Ohno, A. Yura, and K. Oguchi Ca(2+)-dependent enhancement of [3H]noradrenaline uptake in PC12 cells through calmodulin-dependent kinases Brain Research 809 1998 155 164
    • (1998) Brain Research , vol.809 , pp. 155-164
    • Uchida, J.1    Kiuchi, Y.2    Ohno, M.3    Yura, A.4    Oguchi, K.5
  • 56
    • 3042648050 scopus 로고    scopus 로고
    • Phosphorylation and regulation of psychostimulant-sensitive neurotransmitter transporters
    • R.A. Vaughan Phosphorylation and regulation of psychostimulant-sensitive neurotransmitter transporters Journal of Pharmacology and Experimental Therapeutics 310 2004 1 7
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.310 , pp. 1-7
    • Vaughan, R.A.1
  • 58
    • 2442650231 scopus 로고    scopus 로고
    • Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation
    • C.B. Zhu, W.A. Hewlett, I. Feoktistov, I. Biaggioni, and R.D. Blakely Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation Molecular Pharmacology 65 2004 1462 1474
    • (2004) Molecular Pharmacology , vol.65 , pp. 1462-1474
    • Zhu, C.B.1    Hewlett, W.A.2    Feoktistov, I.3    Biaggioni, I.4    Blakely, R.D.5
  • 59
    • 18144373742 scopus 로고    scopus 로고
    • P38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process
    • C.B. Zhu, A.M. Carneiro, W.R. Dostmann, W.A. Hewlett, and R.D. Blakely p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process Journal of Biological Chemistry 280 2005 15649 15658
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 15649-15658
    • Zhu, C.B.1    Carneiro, A.M.2    Dostmann, W.R.3    Hewlett, W.A.4    Blakely, R.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.