A mechanism in epstein-barr virus oncogenesis: Inhibition of transforming growth factor-β1-mediated induction of MAPK/p21 by LMP1

Virology

Volumn 302, Issue 2, 2002, Pages 310-320

  Fukuda, Makoto ^a   Kurosaki, Wataru ^a   Yanagihara, Kazuyoshi ^b   Kuratsune, Hirohiko ^c   Sairenji, Takeshi ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENT MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN P21; PYRROLIDINE DITHIOCARBAMATE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; EPSTEIN BARR VIRUS; EXPRESSION VECTOR; FEMALE; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

HUMAN HERPESVIRUS 4;

EID: 0036440312     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1619     Document Type: Article

References (56)

1. Abdellatif, M., MacLellan, W. R., and Schneider, M. D. (1994). p21 Ras as a governor of global gene expression. J. Biol. Chem. 269, 15423-15426.
2. Arsura, M., Mercurio, F., Oliver, A. L., Thorgeirsson, S. S., and Sonen-shein, G. E. (2000). Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. Mol. Cell. Biol. 20, 5381-5391.
3. Arvanitakis, L., Yaseen, N., and Sharma, S. (1995). Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells. J. Immunol. 155, 1047-1056.
4. Blanchette, F., Rivard, N., Rudd, P., Grondin, F., Attisano, L., and Dubois, C. M. (2001). Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation. J. Biol. Chem. 276, 33986-33994.
5. Coppa, A., Mincione, G., Lazzereschi, D., Ranieri, A., Turco, A., Lucig-nano, B., Scarpa, S., RaganoCaracciolo, M., and Colletta, G. (1997). Restored expression of transforming growth factor beta type II receptor in k-ras-transformed thyroid cells, TGF beta-resistant, reverts their malignant phenotype. J. Cell. Physiol. 172, 200-208.
6. Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y., and Wang, X. F. (1995). Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92, 5545-5549.
7. Davies, S. P., Reddy, H., Caivano, M., and Cohen, P. (2000). Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105.
8. el Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.
9. Fahmi, H., Cochet, C., Hmama, Z., Opolon, P., and Joab, I. (2000). Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. J. Virol. 74, 5810-5818.
10. Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., VanDyk, D. E., Pitts, W. J., Earl, R. A., Hobbs, F., Copeland, R. A., Magolda, R. L., Scherle, P. A., and Trzaskos, J. M. (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273, 18623-18632.
11. Fukayama, M., Hayashi, Y., Iwasaki, Y., Chong, J., Ooba, T., Takizawa, T., Koike, M., Mizutani, S., Miyaki, M., and Hirai, K. (1994). Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab. Invest. 71, 73-81.
12. Fukuda, M., Ikuta, K., Yanagihara, K., Tajima, M., Kuratsune, H., Kurata, T., and Sairenji, T. (2001). Effect of transforming growth factor-beta 1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines. Virology 288, 109-118.
13. Gilmore, T. D., Koedood, M., Piffat, K. A., and White, D. W. (1996). Rel/NF-kappaB/IkappaB proteins and cancer. Oncogene 13, 1367-1378.
14. Greulich, H., and Erikson, R. L. (1998). An analysis of Mek1 signaling in cell proliferation and transformation. J. Biol. Chem. 273, 13280-13288.
15. Hannon, G. J., and Beach, D. (1994). p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371, 257-261.
16. Hartsough, M. T., Frey, R. S., Zipfel, P. A., Buard, A., Cook, S. J., McCormick, F., and Mulder, K. M. (1998). Altered transforming growth factor signaling in epithelial cells when ras activation is blocked. J. Biol. Chem. 271, 22368-22375.
17. Hartsough, M. T., and Mulder, K. M. (1996). Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells. J. Biol. Chem. 270, 7117-7124.
18. Hartsough, M. T., and Mulder, K. M. (1997). Transforming growth factor-beta signaling in epithelial cells. Pharmacol. Ther. 75, 21-41.
19. He, Z., Xin, B., Yang, X., Chan, C., and Cao, L. (2000). Nuclear factor-kappaB activation is involved in LMP1-mediated transformation and tumorigenesis of rat-1 fibroblasts. Cancer Res. 60, 1845-1848.
20. Hu, P. P., Shen, X., Huang, D., Liu, Y., Counter, C., and Wang, X. F. (1999). The MEK pathway is required for stimulation of p21 (WAF1/CIP1) by transforming growth factor-beta. J. Biol. Chem. 274, 35381-35387.
21. Huen, D. S., Henderson, S. A., Croom Carter, D., and Rowe, M. (1995). The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene 10, 549-560.
22. Imai, S., Koizumi, S., Sugiura, M., Tokunaga, M., Uemura, Y., Yamamoto, N., Tanaka, S., Sato, E., and Osato, T. (1994). Gastric carcinoma: Monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc. Natl. Acad. Sci. USA 91, 9131-9135.
23. Inman, G. J., and Allday, M. J. (2000). Resistance to TGF-beta1 correlates with a reduction of TGF-beta type II receptor expression in Burkitt's lymphoma and Epstein-Barr virus-transformed B lymphoblastoid cell lines. J. Gen. Virol. 2000, 61567-61578.
24. Izumi, K. M., and Kieff, E. D. (1997). The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappa B. Proc. Natl. Acad. Sci. USA 94, 12592-12597.
25. Kaye, K. M., Izumi, K. M., and Kieff, E. (1993). Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA 90, 9150-9154.
26. Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kolch, W., and Hammerschmidt, W. (1997). Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J. 16, 6478-6485.
27. Kretzschmar, M., Doody, J., Timokhina, I., and Massague, J. (1999). A mechanism of repression of TGF beta/Smad signaling by oncogenic Ras. Genes Dev. 13, 804-816.
28. Kumar, A., Rogers, T., Maizel, A., and Sharma, S. (1991). Loss of transforming growth factor beta 1 receptors and its effects on the growth of EBV-transformed human B cells. J. Immunol. 147, 998-1006.
29. Lenormand, P., Sardet, C., Pages, G., L'Allemain, G., Brunet, A., and Pouyssegur, J. (1993). Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J. Cell. Biol. 122, 1079-1088.
30. Levine, P. H., Stemmermann, G., Lennette, E. T., Hildesheim, A., Shibata, D., and Nomura, A. (1995). Elevated antibody titers to Epstein-Barr virus prior to the diagnosis of Epstein-Barr-virus-associated gastric adenocarcinoma. Int. J. Cancer 60, 642-644.
31. Longstreet, M., Miller, B., and Howe, P. H. (1992). Loss of transforming growth factor beta 1 (TGF-beta 1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells. Oncogene 7, 1549-1556.
32. Malliri, A., Yeudall, W. A., Nikolic, M., Crouch, D. H., Parkinson, E. K., and Ozanne, B. (1996). Sensitivity to transforming growth factor beta 1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC down-regulation and p21waf1 induction are important early events. Cell. Growth Differ. 7, 1291-1304.
33. Massague, J., Blain, S. W., and Lo, R. S. (2000). TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309.
34. Mitchell, T., and Sugden, B. (1995). Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus. J. Virol. 69, 2968-2976.
35. Mosialos, G., Birkenbach, M., Yalamanchili, R., VanArsdale, T., Ware, C., and Kieff, E. (1995). The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80, 389-399.
36. Murakami, M., Hoshikawa, Y., Satoh, Y., Ito, H., Tajima, M., Okinaga, K., Miyazawa, Y., Kurata, T., and Sairenji, T. (2000). Tumorigenesis of Epstein-Barr virus-positive epithelial cell lines derived from gastric tissues in the SCID mouse. Virology 277, 20-26.
37. Nadkarni, J. S., Nadkarni, J. J., Clifford, P., Manolov, G., Fenyo, E. M., and Klein, E. (1969). Characteristics of new cell lines derived from Burkitt lymphomas. Cancer 23, 64-79.
38. Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., and Reichmann, E. (1996). TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 10, 2462-2477.
39. Olson, M. F., Paterson, H. F., and Marshall, C. J. (1998). Signals from Ras and Rho GTPases interact to regulate expression of p21 (Waf1/Cip1). Nature 394, 295-299.
40. Pages, G., Lenormand, P., L'Allemain, G., Chambard, J. C., Meloche, S., and Pouyssegur, J. (1993). Mitogen activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. USA 90, 8319-8323.
41. Reynisdottir, I., Polyak, K., Iavarone, A., and Massague, J. (1995). Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9, 1831-1845.
42. Rickinson, A. B., and Kieff, E. (1996). Epstein-Barr virus. In "Fields Virology" (B. N. Field, D. M. Knipe, P. M. Howley, et al., Eds.), 3rd ed., pp. 2397-2445. Raven Press, New York.
43. Roberts, M. L., and Cooper, N. R. (1998). Activation of a Ras-MAPK-dependent pathway by Epstein-Barr virus latent membrane protein 1 is essential for cellular transformation. Virology 240, 93-99.
44. Rowe, M., Peng Pilon, M., Huen, D. S., Hardy, R., Croom Carter, D., Lundgren, E., and Rickinson, A. B. (1994). Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: A B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers. J. Virol. 68, 5602-5612.
45. Satoh, T., Fukuda, M., and Sairenji, T. (2002). Distinct patterns of mito-gen-activated protein kinase phosphorylation and Epstein-Barr virus gene expression in Burkitt's lymphoma cell lines versus B lymphoblastoid cell lines. Virus Genes 25, 15-21.
46. Seger, R., and Krebs, E. G. (1995). The MAPK signaling cascade. FASEB J. 9, 726-735.
47. Shibata, D., and Weiss, L. M. (1992). Epstein-Barr virus-associated gastric adenocarcinoma. Am. J. Pathol. 140, 769-774.
48. Sugiura, M., Imai, S., Tokunaga, M., Koizumi, S., Uchizawa, M., Oka-moto, K., and Osato, T. (1996). Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: Unique viral latency in the tumour cells. Br. J. Cancer 74, 625-631.
49. Tajima, M., Komuro, M., and Okinaga, K. (1998). Establishment of Ep-stein-Barr virus-positive human gastric epithelial cell lines. Jpn. J. Cancer Res. 89, 262-268.
50. Takanashi, M., Li, J., Shirakata, M., Mori, S., and Hirai, K. (1999). Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-beta 1-mediated growth inhibition. Arch. Virol. 144, 241-257.
51. Takasaka, N., Tajima, M., Okinaga, K., Satoh, Y., Hoshikawa, Y., Ka-tsumoto, T., Kurata, T., and Sairenji, T. (1998). Productive infection of Epstein-Barr virus (EBV) in EBV-genome-positive epithelial cell lines (GT38 and GT39) derived from gastric tissues. Virology 247, 152-159.
52. Takeshita, H., Yoshizaki, T., Miller, W. E., Sato, H., Furukawa, M., Pagano, J. S., and Raab Traub, N. (1999). Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. J. Virol. 73, 5548-5555.
53. Webb, C. P., Van Aelst, L., Wigler, M. H., and Woude, G. F. (1998). Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc. Natl. Acad. Sci. USA 95, 8773-8778.
54. Yanagihara, K., Kamada, N., Tsumuraya, M., and Amano, F. (1991). Establishment and characterization of a human gastric scirrhous carcinoma cell line in serum-free chemically defined medium. Int. J. Cancer 54, 200-207.
55. Yue, J. B., Buard, A., and Mulder, K. M. (1998). Blockade of TGF beta(3) up-regulation of p27(Kip1) and p21(Cip1) by expression of RasN17 in epithelial cells. Oncogene 17, 47-55.
56. Zeng, Y. X., and el Deiry, W. S. (1996). Regulation of p21WAF1/CIP1 expression by p53-independent pathways. Oncogene 12, 1557-1564.