Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm

Molecular Microbiology

Volumn 58, Issue 2, 2005, Pages 613-622

  Douthwaite, Stephen ^a   Jalava, Jari ^b   Jakobsen, Lene ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; CLINDAMYCIN; ERYTHROMYCIN; KETOLIDE; MACROLIDE; RNA 23S; TELITHROMYCIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BINDING SITE; DEMETHYLATION; GENE IDENTIFICATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; STREPTOCOCCUS PYOGENES;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; KETOLIDES; METHYLATION; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, RIBOSOMAL; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STREPTOCOCCUS PYOGENES;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

EID: 26944438340     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04863.x     Document Type: Article

References (49)

1. Andersen, I.E., Porse, B.T., and Kirpekar, F. (2004) A novel partial modification at 2501 in Escherichia coli 23S ribosomal RNA. RNA 10: 907-913.
2. Berisio, R., Harms, J., Schluenzen, F., Zarivach, R., Hansen, H.A., Fucini, P., and Yonath, A. (2003) Structural insight into the antibiotic action of telithromycin against resistant mutants. J Bacteriol 185: 4276-4279.
3. B resistance phenotype. J Antimicrob Chemother 40: 85-90.
4. Bryskier, A. (2000) Ketolides - telithromycin, an example of a new class of antibacterial agents. Clin Microbial Infect 6: 661-669.
5. Champney, W.S., Chittum, H.S., and Tober, C.L. (2003) A 50S ribosomal subunit precursor particle is a substrate for the ErmC methyltransferase in Staphylococcus aureus cells. Curr Microbiol 46: 453-460.
6. Champney, W.S., Mentens, N., and Zurawick, K. (2004) An examination of the differential sensitivity to ketolide antibiotics in erm(B) strains of Streptococcus pyogenes and Streptococcus pneumoniae. Curr Microbiol 49: 239-247.
7. Corpet, F. (1988) Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 16: 10881-10890.
8. Denoya, C., and Dubnau, D. (1989) Mono- and dimethylating activities and kinetic studies of the ermC 23S rRNA methyltransferase. J Biol Chem 264: 2615-2624.
9. Douthwaite, S., Hansen, L.H., and Mauvais, P. (2000) Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. Mol Microbiol 36: 183-193.
10. Farrell, D.J., and Felmingham, D. (2004) Activities of telithromycin against 13 874 Streptococcus pneumoniae isolates collected between 1999 and 2003. Antimicrob Agents Chemother 48: 1882-1884.
11. Farrell, D.J., Douthwaite, S., Morrissey, I., Bakker, S., Poehlsgaard, J., Jakobsen, L., and Felmingham, D. (2003) Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study. Antimicrob Agents Chemother 47: 1777-1783.
12. Farrell, D.J., Morrissey, I., Bakker, S., Morris, L., Buckridge, S., and Felmingham, D. (2004) Molecular epidemiology of multiresistant Streptococcus pneumoniae with both erm(B)- and mef(A)-mediated macrolide resistance. J Clin Microbiol 42: 764-768.
13. Felmingham, D. (2002) Evolving resistance patterns in community-acquired respiratory tract pathogens: first results from the PROJEKT global surveillance study. J Infect 44: 3-10.
14. Gutell, R.R. (1996) Comparative sequence analysis and the structure of 16S rRNA and 23S rRNA. In Ribosomal RNA. Zimmermann, R.A., and Dahlberg, A.E. (eds). New York: CRC Press, pp. 111-128.
15. Hansen, L.H., Mauvais, P., and Douthwaite, S. (1999) The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Mol Microbiol 31:623-631.
16. Hoban, D.J., Doern, G.V., Fluit, A.C., Roussel-Delvallez, M., and Jones, R.N. (2001) Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 32 (Suppl. 2): S81-S93.
17. Jalava, J., Kataja, J., Seppala, H., and Huovinen, P. (2001) In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species. Antimicrob Agents Chemother 45: 789-793.
18. Jalava, J., Vaara, M., and Huovinen, P. (2004) Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes. Ann Clin Microbiol Antimicrob 3: 5.
19. Kasbekar, N., and Acharya, P.S. (2005) Telithromycin: the first ketolide for the treatment of respiratory infections. Am J Health Syst Pharm 62: 905-916.
20. Kirpekar, F., Nordhoff, E., Larsen, L.K., Kristiansen, K., Roepstorff, P., and Hillenkamp, F. (1998) DNA sequence analysis by MALDI mass spectrometry. Nucleic Acids Res 26: 2554-2559.
21. Lai, C.J., and Weisblum, B. (1971) Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus. Proc Natl Acad Sci USA 68:856-860.
22. Leclercq, R., and Courvalin, P. (2002) Resistance to macrolides and related antibiotics in Streptococcus pneumoniae. Antimicrob Agents Chemother 46: 2727-2734.
23. Liu, M., and Douthwaite, S. (2002) Activity of the ketolide antibiotic telithromycin is refractory to Erm monomethylation of bacterial rRNA. Antimicrob Agents Chemother 46: 1629-1633.
24. Malbruny, B., Nagai, K., Coquemont, M., Bozdogan, B., Andrasevic, A.T., Hupkova, H., et al. (2002) Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations. J Antimicrob Chemother 49: 935-939.
25. Mengel-Jorgensen, J., and Kirpekar, F. (2002) Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry. Nucleic Acids Reses 30:E135-E135.
26. Morosini, M.I., Canton, R., Loza, E., del Campo, R., Almaraz, F., and Baquero, F. (2003) Streptococcus pyogenes isolates with characterized macrolide resistance mechanisms in Spain: in vitro activities of telithromycin and cethromycin. J Antimicrob Chemother 52: 50-55.
27. Nicolau, D.P. (2004) Clinical use of antimicrobial pharmacodynamic profiles to optimise treatment outcomes in community-acquired bacterial respiratory tract infections: application to telithromycin. Expert Opin Pharmacother 5: 229-235.
28. Noller, H.F. (1984) Structure of ribosomal RNA. Annu Rev Biochem 53: 119-162.
29. Pihlajamaki, M., Kataja, J., Seppala, H., Elliot, J., Leinonen, M., Huovinen, P., and Jalava, J. (2002) Ribosomal mutations in Streptococcus pneumoniae clinical isolates. Antimicrob Agents Chemother 46: 654-658.
30. Reinert, R.R. (2004) Clinical efficacy of ketolides in the treatment of respiratory tract infections. J Antimicrob Chemother 53: 918-927.
31. Roberts, M.C. (2004) Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics. Mol Biotechnol 28: 47-62.
32. Roberts, M.C., Sutcliffe, J., Courvalin, P., Jensen, L.B., Rood, J., and Seppala, H. (1999) Nomenclature for macrolide and macrolide-lincosamide- streptogramin B resistance determinants. Antimicrob Agents Chemother 43: 2823-2830.
33. Schiunzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., et al. (2001) Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413: 814-821.
34. Seppala, H., Haanpera, M., Al-Juhaish, M., Jarvinen, H., Jalava, J., and Huovinen, P. (2003) Antimicrobial susceptibility patterns and macrolide resistance genes of viridans group streptococci from normal flora. J Antimicrob Chemother 52: 636-644.
35. Shortridge, V.D., Zhong, P., Cao, Z., Beyer, J.M., Almer, L.S., Ramer, N.C., et al. (2002) Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci. Antimicrob Agents Chemother 46: 783-786.
36. Sigmund, C.D., Ettayebi, M., Borden, A., and Morgan, E.A. (1988) Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coll. Methods Enzymol 164: 673-690.
37. Skinner, R., Cundliffe, E., and Schmidt, F. (1983) Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics. J Biol Chem 258:12702-12706.
38. Stahl, D.A., Flesher, B., Mansfield, H.R., and Montgomery, L. (1988) Use of phylogenetically based hybridization probes for studies of ruminal microbial ecology. Appl Environ Microbiol 54: 1079-1084.
39. Syrogiannopoulos, G.A., Grivea, I.N., Ednie, L.M., Bozdogan, B., Katopodis, G.D., Beratis, N.G., et al. (2003) Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A). Antimicrob Agents Chemother 47: 2699-2702.
40. Szczypa, K., Sadowy, E., Izdebski, R., and Hryniewicz, W. (2004) A rapid increase in macrolide resistance in Streptococcus pyogenes isolated in Poland during 1996-2002. J Antimicrob Chemother 54: 828-831.
41. Tait-Kamradt, A., Clancy, J., Cronan, M., Dib-Hajj, F., Wondrack, L., Yuan, W., and Sutcliffe, J. (1997) mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumoniae. Antimicrob Agents Chemother 41: 2251-2255.
42. Tait-Kamradt, A., Davies, T., Cronan, M., Jacobs, M.R., Appelbaum, P.C., and Sutcliffe, J. (2000) Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage. Antimicrob Agents Chemother 44: 2118-2125.
43. BK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell 121: 257-270.
44. Usary, J., and Champney, W.S. (2001) Erythromycin inhibition of 50S ribosomal subunit formation in Escherichia coli cells. Mol Microbiol 40: 951-962.
45. Walsh, F., Willcock, J., and Amyes, S. (2003) High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. J Antimicrob Chemother 52: 345-353.
46. Weisblum, B. (1995a) Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother 39: 577-585.
47. Weisblum, B. (1995b) Insights into erythromycin action from studies of its activity as inducer of resistance. Antimicrob Agents Chemother 39: 797-805.
48. Xiong, L, Shah, S., Mauvais, P., and Mankin, A.S. (1999) Ketolide resistance mutation in domain II of 23S rRNA reveals rRNA folding required for formation of macrolide-binding site. Mol Microbiol 31: 633-639.
49. Zalacain, M., and Cundliffe, E. (1990) Methylation of 23S ribosomal RNA due to carB, an antibiotic-resistance determinant from the carbomycin producer, Streptomyces thermotolerans. Eur J Biochem 189: 67-72.