Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 3, 2002, Pages 783-786

  Shortridge, Virginia D ^a   Zhong, Ping ^a   Cao, Zhensheng ^a   Beyer, Jill M ^a   Almer, Laurel S ^a   Ramer, Nancy C ^a   Doktor, Stella Z ^a   Flamm, Robert K ^a  

^a Bldg AP52N ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CETHROMYCIN; KETOLIDE; MACROLIDE; MACROLIDE EFFLUX PROTEIN; METHYLTRANSFERASE; MUTANT PROTEIN; RIBOSOME PROTEIN; RIBOSOME RNA; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; ERYTHROMYCIN; HUMANS; KETOLIDES; MACROLIDES; MICROBIAL SENSITIVITY TESTS; RESPIRATORY TRACT INFECTIONS; RIBOSOMES; STAPHYLOCOCCUS; STREPTOCOCCUS;

EID: 0036171320     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.3.783-786.2002     Document Type: Article

References (15)

1. In vitro activities of the ketolide HMR 3647 against recent gram-positive clinical isolates and Haemophilus influenzae
2. Ketolides lack inducibility properties of MLS(B) resistance phenotype
3. In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streprococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis
4. Studies of the novel ketolide ABT-773: Transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae
5. Antiprieurnococcal activity of ABT-773 compared to those of 10 other agents
6. Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae
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8. Occurrence of macrolide-lincosamide-streptogramin resistances among staphylococcal clinical isolates at a university medical center. Is false susceptibility to new macrolides and clindamycin a contemporary clinical and in vitro testing problem?
9. Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995
10. Novel mechanism of macrolide resistance in Streptococcus pneumoniae
11. Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America
12. Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage
13. A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre
14. Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides