Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1488, Issue 3, 2000, Pages 189-210

  Hevonoja, Tiia ^a   Pentikäinen, Markku O ^a   Hyvönen, Marja T ^a   Kovanen, Petri T ^a   Ala Korpela, Mika ^a  

^a WIHURI RESEARCH INSTITUTE   (Finland)

Author keywords

Apolipoprotein B 100; Computer models domain formation; Low density lipoprotein; Modified low density lipoprotein; Molecular interaction

Indexed keywords

APOLIPOPROTEIN B100; LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE;

ATHEROGENESIS; COMPUTER MODEL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN STRUCTURE; REVIEW;

APOLIPOPROTEIN B-100; APOLIPOPROTEINS B; CHOLESTEROL; CHOLESTEROL ESTERASE; ENDOPEPTIDASES; LIPOPROTEINS, LDL; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OXIDATION-REDUCTION; PARTICLE SIZE; PHOSPHOLIPASE C; PHOSPHOLIPASES A; PHOSPHOLIPIDS; PROTEIN CONFORMATION; SPECIFIC GRAVITY; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; TEMPERATURE; X-RAY DIFFRACTION;

EID: 0034669402     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(00)00123-2     Document Type: Review

References (133)

1. A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein
2. Structure and function of apolipoprotein A-I and high-density lipoprotein
3. Structure of human serum lipoproteins nuclear magnetic resonance supports a micellar model
4. Lipoprotein structure and metabolism
5. Effects of orientational order and particle size on the NMR line positions of lipoproteins
6. The role of lipid peroxidation and antioxidants in oxidative modification of LDL
7. Packing of cholesterol molecules in human low-density lipoprotein
8. Organization of phosphatidylcholine and sphingomyelin in the surface monolayer of low density lipoprotein (a) as determined by time-resolved fluorometry
9. Distribution of diacylglycerols among plasma lipoproteins in control subjects and in patients with non-insulin-dependent diabetes
10. Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins
11. Glycated phosphatidylethanolamine promotes macrophage uptake of low density lipoprotein and accumulation of cholesteryl esters and triacylglycerols
12. Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit
13. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching
14. Intimal thickenings of human aorta contain modified reassembled lipoproteins
15. The response-to-retention hypothesis of atherogenesis reinforced
16. Modified LDL-trigger of atherosclerosis and inflammation in the arterial intima
17. Microemulsions of phospholipids and cholesterol esters. Protein-free models of low density lipoprotein
18. Dynamic structure of the lower density lipoproteins. II. Deuterium NMR studies of the monolayer of very low and low density lipoproteins
19. 31P NMR study
20. The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells
21. Secondary structure and thermal behavior of trypsin-treated low-density lipoproteins from human serum, studied by circular dichroism
22. Physical states of surface and core lipids in lipid emulsions and apolipoprotein binding to the emulsion surface
23. Fluorescence study of the motional states of core and surface lipids in native and reconstituted low density lipoproteins
24. The order-disorder transition of the core cholesteryl esters of human plasma low density lipoprotein. A proton nuclear magnetic resonance study
25. 1H NMR
26. Structure and interactions of lipids in human plasma low density lipoproteins
27. Physical studies on cholesterol-phospholipid interactions
28. Cholesterol and the cell membrane
29. 1H) nuclear Overhauser effect study
30. 31P nuclear magnetic resonance
31. 13C-NMR
32. Acyl chain organization and protein secondary structure in cholesterol-modified erythrocyte membranes
33. High-sensitivity scanning calorimetric study of mixtures of cholesterol with dimyristoyl- and dipalmitoylphosphatidylcholines
34. Phospholipid head-group conformations; intermolecular interactions and cholesterol effects
35. Influence of cholesterol on the polar region of phosphatidylcholine and phosphatidylethanolamine bilayers
36. 1H-NMR
37. Factors contributing to the distribution of cholesterol among phospholipid vesicles
38. Effects of sphingomyelin and phosphatidylcholine degradation on cyclodextrin-mediated cholesterol efflux in cultures fibroblasts
39. Does cholesterol discriminate between sphingomyelin and phosphatidylcholine in mixed monolayers containing both phospholipids
40. Interaction of cholesterol with sphingomyelin and acyl-chain-matched phosphatidylcholines: a comparative study of the effect of the chain length
41. Interaction of cholesterol with sphingomyelin in bilayer membranes evidence that the hydroxy group of sphingomyelin does not modulate the rate of cholesterol exchange between vesicles
42. Influence of molecular packing and phospholipid type on rates of cholesterol exchange
43. 13C-NMR study
44. Effect of free cholesterol on incorporation of triolein in phospholipid bilayers
45. Effect of unesterified cholesterol on the compartmentation of a fluorescent cholesteryl ester in a lipoprotein-like lipid microemulsion
46. Conformational analysis of the polar headgroup in phosphatidylcholine bilayers a structural change induced by cations
47. The headgroup conformation of phospholipids in membranes
48. Preferred conformation and molecular packing of phosphatidylethanolamine and phosphatidylcholine
49. Orientation and flexibility of the choline head group in phophatidylcholine bilayers
50. Lipid conformation in model membranes and biological membranes
51. A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems
52. Atomic-scale molecular dynamics simulations of lipid membranes
53. Structure and dynamic properties of diunsaturated 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine lipid bilayer from molecular dynamics simulation
54. Electric charge effects on phospholipid headgroups. Phosphatidylcholine in mixtures with cationic and anionic amphiphiles
55. Structure of human low-density lipoprotein subfractions, determined by X-ray small-angle scattering
56. Oxidation of cholesterol in low density and high density lipoproteins by cholesterol oxidase
57. Molecular packing of high-density and low-density lipoprotein surface lipids and apolipoprotein A-I binding
58. Effects of sphingomyelin and cholesterol on lipoprotein lipase-mediated lipolysis in lipid emulsions
59. Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans
60. Low density lipoprotein particle size and core cholesteryl ester physical state affect the proton NMR magnetic environment of fatty acid methylene and methyl nuclei
61. Microphase separation in low density lipoproteins. Evidence for a fluid triglyceride core below the lipid melting transition
62. 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates
63. Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins
64. Complete protein sequence and identification of structural domains of human apolipoprotein B
65. Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100
66. Apolipoprotein B and low-density lipoprotein structure: implications for biosynthesis of triglyceride-rich lipoproteins
67. Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100
68. An amino-terminal fragment of apolipoprotein B binds to lipoprotein lipase and may facilitate its binding to endothelial cells
69. Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein
70. Human apolipoprotein B-100 heparin-binding sites
71. Isolation and characterization of four heparin-binding cyanogen bromide peptides of human plasma apolipoprotein B
72. Identification of apoB-100 segments mediating the interaction of low density lipoproteins with arterial proteoglycans
73. Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding
74. Immunoelectron microscopy of low density lipoproteins yields a ribbon and bow model for the conformation of apolipoprotein B on the lipoprotein surface
75. Cryo-electron microscopy of low density lipoprotein and reconstituted discoidal high density lipoprotein: imaging of the apolipoprotein moiety
76. apoB-100 has a pentapartite structure composed of three amphipathic α-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE
77. Apolipoprotein B-100: conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates
78. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E
79. Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
80. Secondary structure of the particle associating domain of apolipoprotein B-100 in low-density lipoprotein by attenuated total reflection infrared spectroscopy
81. NMR studies of pig low- and high-density serum lipoproteins. Molecular motions and morphology
82. 31P nuclear magnetic resonance
83. Apoprotein-phospholipid interactions in Lp(a)
84. Evidence for distinct behaviour of phosphatidylcholine and sphingomyelin at the low density lipoprotein surface
85. Modification of the core lipids of low density lipoproteins produces selective alterations in the expression of apoB-100 epitopes
86. Plasma triglycerides determine low density lipoprotein composition, physical properties, and cell-specific binding in cultured cells
87. Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B
88. Surface-core relationships in human low density lipoprotein as studied by infrared spectroscopy
89. Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas
90. Not the mature 56 kDa lipoprotein lipase protein but a 37 kDa protein copurifying with the lipase mediates the binding of low density lipoproteins to J774 macrophages
91. Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization
92. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
93. Microscopic localization of active proteases by in situ zymography detection of matrix metalloproteinase activity in vascular tissue
94. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
95. Macrophage proteases can modify low density lipoproteins to increase their uptake by macrophages
96. Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix
97. 2 in human atherosclerotic plaques
98. 2 in normal and atherosclerotic arteries. Activity of the isolated enzyme on low-density lipoproteins
99. Purification and properties of cholesterol ester hydrolase from human aortic intima and media
100. Pancreatic carboxyl ester lipase: a circulating enzyme that modifies normal and oxidized lipoproteins in vitro
101. Low density lipoprotein oxidation and its pathobiological significance
102. Aggregation, fusion, and vesicle formation of modified LDL particles: molecular mechanisms and effects on matrix interactions
103. Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages
104. Proteolysis and fusion of low density lipoprotein particles independently strengthen their binding to exocytosed mast cell granules
105. Aggregation and fusion of modified low density lipoprotein
106. 2 induces particle aggregation in the absence and fusion in the presence of heparin
107. Fusion of proteolyzed low-density lipoprotein in the fluid phase: a novel mechanism generating atherogenic lipoprotein particles
108. Human arterial proteoglycans increase the rate of proteolytic fusion of low density lipoprotein particles
109. Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy
110. Lipid dynamics in human low density lipoproteins and human aortic tissue with fibrous plaques
111. 2 only aggregation, of low density lipoprotein (LDL) particles. Two distinct mechanisms leading to incresed binding strenght of LDL to human aortic proteoglycans
112. Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
113. Ceramides in phospholipid membranes: effects on bilayer stability and transition to nonlamellar phases
114. The mechanism of lamellar-to-inverted hexagonal phase transitions in phosphatidylethanolamine: implications for membrane fusion mechanisms
115. Morphological changes induced by phospholipase C and by sphingomyelinase on large unilamellar vesicles: a cryo-transmission electron microscopy study of liposome fusion
116. On the geometrical arrangement of the protein subunits of human serum low-density lipoprotein: evidence for a dodecahedral model
117. Phagosytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation
118. Prevention of phospholipase-C-induced aggregation of low density lipoprotein by amphipathic apolipoproteins
119. 13C NMR
120. Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I
121. 2 alters the expression of selected apoB-100 epitopes and the interaction of LDL with cells
122. 2
123. Enzymatic probes of lipoprotein structure
124. The structural stability of low-density lipoprotein. A kinetic X-ray scattering study of its interaction with arterial proteoglycans
125. Effect of proteoglycans on lipoprotein-cell interactions: possible contribution to atherogenesis
126. Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6-sulfate
127. Modifications of low density lipoprotein induced by the interaction with human plasma glycosaminoglycan-protein complexes
128. Cellular consequences of the association of apoB lipoproteins with proteoglycans. Potential contribution to atherogenesis
129. Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells
130. Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome
131. On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety
132. Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation
133. Structural models of human apolipoprotein A-I