Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative

Journal of Biochemistry

Volumn 138, Issue 3, 2005, Pages 263-275

  Tanaka, Yoko ^a   Nakagawa, Noriko ^a,b   Kuramitsu, Seiki ^a,b,c   Yokoyama, Shigeyuki ^b,c,d   Masui, Ryoji ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b RIKEN HARIMA INSTITUTE   (Japan)

^c RIKEN YOKOHAMA INSTITUTE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

8 oxogu anine; GTP cyclohydrolase I; Thermus thermophilus hb8; Transition state analogue; Zinc enzyme

Indexed keywords

8 HYDROXYGUANINE; CYSTEINE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HISTIDINE; IMIDAZOLE; RIBOSE; ZINC ION;

ARTICLE; CHEMICAL REACTION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; NONHUMAN; PROTON TRANSPORT; THERMUS THERMOPHILUS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GTP CYCLOHYDROLASE; GUANOSINE TRIPHOSPHATE; HISTIDINE; HUMANS; HYDROGEN BONDING; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE ALIGNMENT; THERMUS THERMOPHILUS; WATER; ZINC;

THERMUS THERMOPHILUS;

EID: 26644444335     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvi120     Document Type: Article

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