Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino4(3H)-pyrimidinone triphosphate

Journal of Biological Chemistry

Volumn 274, Issue 24, 1999, Pages 16727-16735

  Bracher, Andreas ^a   Fischer, Markus ^a   Eisenreich, Wolfgang ^a   Ritz, Harald ^a   Schramek, Nicholas ^a   Boyle, Peter ^b   Gentili, Patrizia ^b   Huber, Robert ^c   Nar, Herbert ^c   Auerbach, Günter ^c   Bacher, Adelbert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 FORMYLAMINO 6 RIBOFURANOSYLAMINO 4(3H) PYRIMIDINONE TRIPHOSPHATE; DIHYDRONEOPTERIN TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME MECHANISM; ISOMERISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

CATALYTIC DOMAIN; ESCHERICHIA COLI; GTP CYCLOHYDROLASE; GUANOSINE TRIPHOSPHATE; HISTIDINE; MODELS, CHEMICAL; MUTATION; NEOPTERIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PTERIDINES; PYRIMIDINE NUCLEOTIDES;

EID: 0033546186     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.24.16727     Document Type: Article

References (29)

1. Brown, G. M., and Williamson, J. M. (1987) in Escherichia coli and Salmonella typhimurium (Neidhardt, F. C., ed) Vol. 1, pp. 521-538, American Society for Microbiology, Washington, D. C.
2. Nichol, C. A., Smith, G. K., and Duch, D. S. (1985) Annu. Rev. Biochem. 54, 729-764
3. Tayeh, M. A., and Marletta, M. A. (1989) J. Biol. Chem. 264, 19654-19658
4. Kwon, N. S., Nathan, C. F., and Stuehr, D. J. (1989) J. Biol. Chem. 264, 20496-20501
5. Thony, B., and Blau, N. (1997) Hum. Mutat. 10, 11-20
6. Nagatsu, T., and Ichinose, H. (1997) J. Neural. Transm. Suppl. 49, 203-209
7. Bandmann, O., Nygaard, T. G., Surtees, R., Marsden, C. D., Wood, N. W., and Harding, A. E. (1996) Hum. Mol. Gen. 5, 403-406
8. Bandmann, O., Daniel, S., Marsden, C. D. Wood, N. W., and Harding, A. E. (1996) J. Neurol. Sci. 141, 27-32
9. Schmid, C., Meining, W., Weinkauf, S., Bachmann, L., Ritz, H., Eberhardt, S., Gimbel, W., Werner, T., Lahm, H.-W., Nar, H., and Bacher, A. (1993) in Chemistry and Biology of Pteridines and Folates (Ayling, J. B., Nair, M., and Baugh, C. M., eds) pp. 157-162, Plenum Press, New York
10. Nar, H., Huber, R., Meining, W., Schmid, C., Weinkauf, S., and Bacher, A. (1995a) Structure (Lond.) 3, 459-466
11. Nar, H., Huber, R., Auerbach, G., Fischer, M., Hösl, C., Ritz, H., Bracher, A., Meining, W., Eberhardt, S., and Bacher, A. (1995b) Proc. Natl. Acad. Sci. U. S. A. 92, 12120-12125
12. Burg, A. W., and Brown, G. M. (1968) J. Biol. Chem. 243, 2349-2358
13. Shiota, T., Palumbo, M. P., and Tsai, L. (1967) J. Biol. Chem. 242, 1961-1969
14. Shiota, T., Baugh, C. M., and Myrick, J. (1969) Biochim. Biophys. Acta 192, 205-210
15. Perricandet, M., and Pullman, A. (1973) Int. J. Pept. Protein Res. 5, 99-107
16. Richter, G., Ritz, H., Katzenmeier, G., Volk, R., Kohnle, A., Lottspeich, F., Allendorf, D., and Bacher, A. (1993) J. Bacteriol. 175, 4045-4051
17. Rieder, C., Eisenreich, W., O'Brien, J., Richter, G., Götze, E., Boyle, P., Blanchard, S., Bacher, A., and Simon, H. (1998) Eur. J. Biochem. 255, 24-36
18. Zou, R., and Robins, M. J. (1987) Can. J. Chem. 65, 1436-1437
19. Yoshikawa, M., Kato, T., and Takenishi, T. (1967) Tetrahedron Lett. 50, 5065-5068
20. Ludwig, J. (1981) Acta Biochim. Biophys. Acad. Sci. Hung. 16, 131-133
21. Bracher, A., Eisenreich, W., Schramek, N., Ritz, H., Götze, E., Herrmann, A., Gütlich, M., and Bacher, A. (1998) J. Biol. Chem. 273, 28132-28141
22. Pfleiderer, W. (1957) Chem. Ber. 90, 2272-2276
23. Fischer, M. (1997) Efficient Methods for in Vitro Mutagenesis: Studies on the Mechanisms of Lumazine Synthase and GTP Cyclohydrolase I. Ph.D. Thesis, Technische Universität München, Munchen, Germany
24. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
25. Read, S. M., and Northcote, D. H. (1981) Anal. Biochem. 116, 63-64
26. Breitmaier, E., and Voelter, W. (1987) Carbon-13 NMR Spectroscopy, 3rd Ed., pp. 229-231, VCH, Weinheim, Germany
27. Kenne, L., Unger, P., and Wehler, T. (1988) J. Chem. Soc. Perkin Trans. I 4, 1183-1186
28. Newmann, R. C., Jonas, V., Anderson, K., and Barry, R. (1971) Biochem. Biophys. Res. Commun. 44, 1156-1161
29. Radom, L., Lathan, W. A., Hehre, W. J., and Pople, J. A. (1972) Aust. J. Chem. 25, 1601-1612