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Volumn 57, Issue 3, 2005, Pages 142-153

The bisphosponates: Chemical characteristics, skeletal biological effects and extra-skeletal effects;I bisfosfonati: Caratteristiche chimiche, effetti biologici scheletrici ed effetti extra-scheletrici

Author keywords

Arthritis; Bisphosponates; Inflammation; Osteoarthritis; Osteoclasts

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; ETIDRONIC ACID; IBANDRONIC ACID; INCADRONIC ACID; PAMIDRONIC ACID; PYROPHOSPHATE; RISEDRONIC ACID; TILUDRONIC ACID; ZOLEDRONIC ACID;

EID: 26644436246     PISSN: 00487449     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (17)

References (94)
  • 1
    • 0013916391 scopus 로고
    • Effect of pyrophosphate on dissolution of hydroxyapatite and its possible importance in calcium homeostasis
    • Fleisch H, Maerki J, Russell RG. Effect of pyrophosphate on dissolution of hydroxyapatite and its possible importance in calcium homeostasis. Proc Soc Exp Biol Med 1966; 122: 317-20.
    • (1966) Proc Soc Exp Biol Med , vol.122 , pp. 317-320
    • Fleisch, H.1    Maerki, J.2    Russell, R.G.3
  • 2
    • 0014345836 scopus 로고
    • Inhibition by pyrophosphate and polyphosphate of aortic calcification induced by vitamin D3 in rats
    • Schibler D, Russell RG, Fleisch H. Inhibition by pyrophosphate and polyphosphate of aortic calcification induced by vitamin D3 in rats. Clin Sci 1968; 35: 363-72.
    • (1968) Clin Sci , vol.35 , pp. 363-372
    • Schibler, D.1    Russell, R.G.2    Fleisch, H.3
  • 3
    • 0014759515 scopus 로고
    • The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo
    • Fleisch HA, Russell RG, Bisaz S, Muhlbauer RC, Williams DA. The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. Eur J Clin Invest 1970; 1: 12-8.
    • (1970) Eur J Clin Invest , vol.1 , pp. 12-18
    • Fleisch, H.A.1    Russell, R.G.2    Bisaz, S.3    Muhlbauer, R.C.4    Williams, D.A.5
  • 4
    • 0017682977 scopus 로고
    • The effects of various diphosphonates on a rat model of cardiac calciphylaxis
    • Rosenblum IY, Black HE, Ferrell JF. The effects of various diphosphonates on a rat model of cardiac calciphylaxis. Calcif Tissue Res 1977; 23: 151-9.
    • (1977) Calcif Tissue Res , vol.23 , pp. 151-159
    • Rosenblum, I.Y.1    Black, H.E.2    Ferrell, J.F.3
  • 5
    • 0015025092 scopus 로고
    • The control of dental calculus in experimental animals
    • Briner WW, Francis MD, Widder JS. The control of dental calculus in experimental animals. Int Dent J 1971; 21: 61-72.
    • (1971) Int Dent J , vol.21 , pp. 61-72
    • Briner, W.W.1    Francis, M.D.2    Widder, J.S.3
  • 8
    • 0019136797 scopus 로고
    • Kinetic studies of bone and mineral metabolism during treatment with (3- amino-1-hydroxypropylidene)-1,1-bisphosphonate-(APD) in rats
    • Reitsma PH, Bijvoet OL, Verlinden-Ooms H, Wee-Pals LJ. Kinetic studies of bone and mineral metabolism during treatment with (3- amino-1- hydroxypropylidene)-1,1-bisphosphonate-(APD) in rats. Calcif Tissue Int 1980; 32: 145-57.
    • (1980) Calcif Tissue Int , vol.32 , pp. 145-157
    • Reitsma, P.H.1    Bijvoet, O.L.2    Verlinden-Ooms, H.3    Wee-Pals, L.J.4
  • 11
    • 0024477815 scopus 로고
    • Dichloromethylenebisphosphonate (C12MBP) inhibits bone resorption through injury to osteoclasts that resorb C12MBP-coated bone
    • Flanagan AM, Chambers TJ. Dichloromethylenebisphosphonate (C12MBP) inhibits bone resorption through injury to osteoclasts that resorb C12MBP-coated bone. Bone Miner 1989; 6: 33-43.
    • (1989) Bone Miner , vol.6 , pp. 33-43
    • Flanagan, A.M.1    Chambers, T.J.2
  • 12
    • 0029097506 scopus 로고
    • A possible mechanism of specific action of bisphosphonates on osteoosteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffler borders
    • Murakami H, Takahashi N, Sasaki T, Udagawa N, Tanaka S. A possible mechanism of specific action of bisphosphonates on osteoosteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffler borders. Bone 1995; 17: 137-44.
    • (1995) Bone , vol.17 , pp. 137-144
    • Murakami, H.1    Takahashi, N.2    Sasaki, T.3    Udagawa, N.4    Tanaka, S.5
  • 13
    • 0030424359 scopus 로고    scopus 로고
    • Different effects of three bisphosphonates on nitric oxide production by raw 264 macrophage-like cells in vitro
    • Makkonen N, Hirvonen MR, Teravainen T, Savolainen K, Monkkonen J. Different effects of three bisphosphonates on nitric oxide production by raw 264 macrophage-like cells in vitro. J Pharmacol Exp Ther 1996; 277: 1097-102.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1097-1102
    • Makkonen, N.1    Hirvonen, M.R.2    Teravainen, T.3    Savolainen, K.4    Monkkonen, J.5
  • 14
    • 0027408426 scopus 로고
    • Osteoclast recruitment in mice is stimulated by 83-amino-1- hydroxypropylidene-1,1-bisphosphonate
    • Marshall MJ, Holt I, Davie MV. Osteoclast recruitment in mice is stimulated by 83-amino-1-hydroxypropylidene)-1,1-bisphosphonate. Calcif Tissue Int 1993; 52: 21-5.
    • (1993) Calcif Tissue Int , vol.52 , pp. 21-25
    • Marshall, M.J.1    Holt, I.2    Davie, M.V.3
  • 15
    • 0029934545 scopus 로고    scopus 로고
    • Bisphosphonate induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption
    • Vitte C, Fleisch H, Guenther HL. Bisphosphonate induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 1996; 137: 2324-33.
    • (1996) Endocrinology , vol.137 , pp. 2324-2333
    • Vitte, C.1    Fleisch, H.2    Guenther, H.L.3
  • 16
    • 0024451093 scopus 로고
    • Effects of a bisphosphonate (1-hydroxy ethylene-1,1-bisphosphonic acid) on osteoclast number durin prolonged bed rest in healthy humans
    • Chappard D, Alexandre C, Palle S, Vico L, Morukov BV, Rodinova SS, et al. Effects of a bisphosphonate (1-hydroxy ethylene-1,1-bisphosphonic acid) on osteoclast number durin prolonged bed rest in healthy humans. Metabolism 1989; 38: 822-5.
    • (1989) Metabolism , vol.38 , pp. 822-825
    • Chappard, D.1    Alexandre, C.2    Palle, S.3    Vico, L.4    Morukov, B.V.5    Rodinova, S.S.6
  • 17
    • 0026329441 scopus 로고
    • Inhibition of bone resorption by bisphosphonates: Interaction between bisphosphonates, osteoclasts, and bone
    • Flanagan AM, Chambers TJ. Inhibition of bone resorption by bisphosphonates: interaction between bisphosphonates, osteoclasts, and bone. Calcif Tissue Int 1991; 49: 407-15.
    • (1991) Calcif Tissue Int , vol.49 , pp. 407-415
    • Flanagan, A.M.1    Chambers, T.J.2
  • 18
    • 0024406012 scopus 로고
    • Inhibition of osteoclast-like cell formation by bisphosphonates in long-term culture of human bone marrow
    • Hughes DE, MacDonald BR, Russel RGG, Gowen M. Inhibition of osteoclast-like cell formation by bisphosphonates in long-term culture of human bone marrow. J Clin Invest 1989; 83: 1939-5.
    • (1989) J Clin Invest , vol.83 , pp. 1939-1945
    • Hughes, D.E.1    MacDonald, B.R.2    Russel, R.G.G.3    Gowen, M.4
  • 20
    • 26644434081 scopus 로고
    • Dose rsponse study od laendronate sodium for the treatment of cancer-associated hypercalcemia
    • Nussbaum SR, Warrell RP Jr, Rude R, Glusman J, Bilezikian JP, et al. Dose rsponse study od laendronate sodium for the treatment of cancer-associated hypercalcemia. J Clin Oncol 1993; 14: 268-76.
    • (1993) J Clin Oncol , vol.14 , pp. 268-276
    • Nussbaum, S.R.1    Warrell Jr., R.P.2    Rude, R.3    Glusman, J.4    Bilezikian, J.P.5
  • 21
    • 0023928381 scopus 로고
    • Osteoclast-like cell formation and its regulation bi osteotropic hormones in mouse marrow cultures
    • Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, et al. Osteoclast-like cell formation and its regulation bi osteotropic hormones in mouse marrow cultures. Endocrinology 1988; 122: 1373-82.
    • (1988) Endocrinology , vol.122 , pp. 1373-1382
    • Takahashi, N.1    Yamana, H.2    Yoshiki, S.3    Roodman, G.D.4    Mundy, G.R.5    Jones, S.J.6
  • 22
    • 0030028473 scopus 로고    scopus 로고
    • Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures
    • Nishikawa M, Akatsu T, Katayama Y, Yasutomo Y, Kado S, Kugai N, et al. Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures. Bone 1996; 18: 9-14.
    • (1996) Bone , vol.18 , pp. 9-14
    • Nishikawa, M.1    Akatsu, T.2    Katayama, Y.3    Yasutomo, Y.4    Kado, S.5    Kugai, N.6
  • 23
    • 0027193759 scopus 로고
    • Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
    • Sahni M, Guenther HL, Fleisch H, Collin P, Martin TJ. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 1993; 91: 2004-11.
    • (1993) J Clin Invest , vol.91 , pp. 2004-2011
    • Sahni, M.1    Guenther, H.L.2    Fleisch, H.3    Collin, P.4    Martin, T.J.5
  • 24
    • 0002924778 scopus 로고
    • Osteoblasts mediate the bisphosphonate inhibition of bone resorption through synthesis of an osteoclast-inhibiting activity
    • Vitte C, Fleisch H, Guenther HL. Osteoblasts mediate the bisphosphonate inhibition of bone resorption through synthesis of an osteoclast-inhibiting activity. J Bone Miner Res 1994; 9 (Suppl 1): S142.
    • (1994) J Bone Miner Res , vol.9 , Issue.SUPPL. 1
    • Vitte, C.1    Fleisch, H.2    Guenther, H.L.3
  • 25
    • 0024494133 scopus 로고
    • Diphosphonates inhibit human osteoblast secretion and proliferation
    • Khokher MA, Dandona P. Diphosphonates inhibit human osteoblast secretion and proliferation. Metabolism 1989; 38: 184-7.
    • (1989) Metabolism , vol.38 , pp. 184-187
    • Khokher, M.A.1    Dandona, P.2
  • 26
    • 0031974325 scopus 로고    scopus 로고
    • Structurally different bisphosphonates exert opposing effects on alkaline phosphatase and mineralization in marrow osteoprogenitors
    • Klein B, Ben-Bassat H, Breuer E, Solomon V, Golomb G. Structurally different bisphosphonates exert opposing effects on alkaline phosphatase and mineralization in marrow osteoprogenitors. J Cell Biochem 1998; 68: 186-94.
    • (1998) J Cell Biochem , vol.68 , pp. 186-194
    • Klein, B.1    Ben-Bassat, H.2    Breuer, E.3    Solomon, V.4    Golomb, G.5
  • 28
    • 0031979896 scopus 로고    scopus 로고
    • Bisphosphonates stimulate formation of osteoblasts precursor and mineralized nodules in murine and human bone marrow culture in vitro and promote early osteoblastogenesis in young and aged mice in vivo
    • Giuliani N, Pedrazzoni M, Negri G, Passeri G, Impicciatore M, Girasole G. Bisphosphonates stimulate formation of osteoblasts precursor and mineralized nodules in murine and human bone marrow culture in vitro and promote early osteoblastogenesis in young and aged mice in vivo. Bone 1998; 22: 455-61.
    • (1998) Bone , vol.22 , pp. 455-461
    • Giuliani, N.1    Pedrazzoni, M.2    Negri, G.3    Passeri, G.4    Impicciatore, M.5    Girasole, G.6
  • 30
    • 0024494133 scopus 로고
    • Diphosphonates inhibit human osteoblast secretion and proliferation
    • Khokher MA, Dandona P. Diphosphonates inhibit human osteoblast secretion and proliferation. Metabolism 1989; 38: 184-7.
    • (1989) Metabolism , vol.38 , pp. 184-187
    • Khokher, M.A.1    Dandona, P.2
  • 31
    • 0021797302 scopus 로고
    • Effect of bisphosphonates on prostagalandin synthesis by rat bone cells and mouse calvaria in culture
    • Ohya K, Yamada S, Felix R, Fleisch H. Effect of bisphosphonates on prostagalandin synthesis by rat bone cells and mouse calvaria in culture. Clin Sci 1985; 69: 403-11.
    • (1985) Clin Sci , vol.69 , pp. 403-411
    • Ohya, K.1    Yamada, S.2    Felix, R.3    Fleisch, H.4
  • 33
    • 0031907663 scopus 로고    scopus 로고
    • Bisphosphonates inhibit IL-6 production by human osteoblast-like cells
    • Giuliani N, Pedrazzoni M, Passeri G, Girasole G. Bisphosphonates inhibit IL-6 production by human osteoblast-like cells. Scand J Rheumatol 1998; 27: 38-41.
    • (1998) Scand J Rheumatol , vol.27 , pp. 38-41
    • Giuliani, N.1    Pedrazzoni, M.2    Passeri, G.3    Girasole, G.4
  • 34
    • 0001869451 scopus 로고    scopus 로고
    • Bone formation: Osteoblast lineage cells, growth factors, matrix proteins, and the mineralization process
    • M.J. Favus (ed). Philadelphia: Lippincott Williams and Wilkins
    • Lian JB, Stein GS, Canalis E, Robey PG, Boskey AD. Bone formation: osteoblast lineage cells, growth factors, matrix proteins, and the mineralization process. In: M.J. Favus (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Philadelphia: Lippincott Williams and Wilkins 1999; 14-29.
    • (1999) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , pp. 14-29
    • Lian, J.B.1    Stein, G.S.2    Canalis, E.3    Robey, P.G.4    Boskey, A.D.5
  • 35
    • 0034326253 scopus 로고    scopus 로고
    • Bisphosphonates directly regulate cell proliferation, differentiation and gene expression in human osteoblasts
    • Rehinolz GG, Getz B, Pederson L, Sanders ES, Subramaniam M, Ingle JN, et al. Bisphosphonates directly regulate cell proliferation, differentiation and gene expression in human osteoblasts. Cancer Res 2000; 60: 6001-7.
    • (2000) Cancer Res , vol.60 , pp. 6001-6007
    • Rehinolz, G.G.1    Getz, B.2    Pederson, L.3    Sanders, E.S.4    Subramaniam, M.5    Ingle, J.N.6
  • 36
    • 0033065233 scopus 로고    scopus 로고
    • Bisphosphonates: From the laboratory to the clinic and back again
    • Russel RGG, Rogers MJ. Bisphosphonates: from the laboratory to the clinic and back again. Bone 1999; 97: 97-106.
    • (1999) Bone , vol.97 , pp. 97-106
    • Russel, R.G.G.1    Rogers, M.J.2
  • 38
    • 26644441590 scopus 로고    scopus 로고
    • I bisfosfonati: Gruppi di molecole con diversi effetti intracellulari e applicazioni cliniche
    • Zallone A, Faccio R, Zambonin G. I bisfosfonati: gruppi di molecole con diversi effetti intracellulari e applicazioni cliniche. Update on Bisfosfonati 1999; 6: 3-5.
    • (1999) Update on Bisfosfonati , vol.6 , pp. 3-5
    • Zallone, A.1    Faccio, R.2    Zambonin, G.3
  • 39
    • 0027284950 scopus 로고
    • Protein prenylation: A mediator of protein-protein interactions
    • Marshall C. Protein prenylation: a mediator of protein-protein interactions. Science 1993; 259: 1865-6.
    • (1993) Science , vol.259 , pp. 1865-1866
    • Marshall, C.1
  • 40
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang F, Casey PJ. Protein prenylation: molecular mechanisms and functional consequences. Ann Rev Biochem 1996; 65: 241-69.
    • (1996) Ann Rev Biochem , vol.65 , pp. 241-269
    • Zhang, F.1    Casey, P.J.2
  • 41
    • 0018595947 scopus 로고
    • Comparative antiinflammatory and bone protective effects of two bisphosphonates on rat adjuvant arthritis
    • Flora L. Comparative antiinflammatory and bone protective effects of two bisphosphonates on rat adjuvant arthritis. Arthritis Rheum 1979; 22: 240-6.
    • (1979) Arthritis Rheum , vol.22 , pp. 240-246
    • Flora, L.1
  • 43
    • 0034881399 scopus 로고    scopus 로고
    • Effects of low-dose, non.cytotoxix, itraarticular liposomal clodronate on development of erosions and proteoglican loss in established antigen-induced arthritis in rabbit
    • Ceponis A, Waris A, Mönkönnen J, Laasonen L, Hyttinen M, Solovieva SA, et al. Effects of low-dose, non.cytotoxix, itraarticular liposomal clodronate on development of erosions and proteoglican loss in established antigen-induced arthritis in rabbit. Arthritis Rheum 2001; 44: 1908-916.
    • (2001) Arthritis Rheum , vol.44 , pp. 1908-1916
    • Ceponis, A.1    Waris, A.2    Mönkönnen, J.3    Laasonen, L.4    Hyttinen, M.5    Solovieva, S.A.6
  • 44
    • 0029885195 scopus 로고    scopus 로고
    • Apoptosis of macrophages induced by liposome-mediaed intracellular delivery of clodronate and propamidime
    • Van Rooijen N, Sanders A, van den Berg TK. Apoptosis of macrophages induced by liposome-mediaed intracellular delivery of clodronate and propamidime. J Immunol Methods 1996; 193: 93-9.
    • (1996) J Immunol Methods , vol.193 , pp. 93-99
    • Van Rooijen, N.1    Sanders, A.2    Van Den Berg, T.K.3
  • 46
    • 0032899996 scopus 로고    scopus 로고
    • Contrasting effects od alendronate and clodronate on raw 264 macrophages: The role of a bisphosphonate metabolite
    • Makkonen N, Salmien A, Rogers MJ, Frith JC, Urtti A, Azhayeva E, et al. Contrasting effects od alendronate and clodronate on raw 264 macrophages: the role of a bisphosphonate metabolite. Eur J Pharm Sci 1999; 8: 109-18.
    • (1999) Eur J Pharm Sci , vol.8 , pp. 109-118
    • Makkonen, N.1    Salmien, A.2    Rogers, M.J.3    Frith, J.C.4    Urtti, A.5    Azhayeva, E.6
  • 47
    • 0027163599 scopus 로고
    • The effects of liposome-incapsulated and free clodronate on the growth of macrophage-like cells in vitro: The role of calcium and iron
    • Monkkonen J, Health TD. The effects of liposome-incapsulated and free clodronate on the growth of macrophage-like cells in vitro: the role of calcium and iron. Calcif Tissue Int 1993; 53: 139-46.
    • (1993) Calcif Tissue Int , vol.53 , pp. 139-146
    • Monkkonen, J.1    Health, T.D.2
  • 48
    • 0027762064 scopus 로고
    • Influence of dichloromethylene diphosphonate on reactive oxygen species production by human neutrophils
    • Serretti R, Core P, Muti S, Salaffi F. Influence of dichloromethylene diphosphonate on reactive oxygen species production by human neutrophils. Rheumatol Int 1993; 13: 135-8.
    • (1993) Rheumatol Int , vol.13 , pp. 135-138
    • Serretti, R.1    Core, P.2    Muti, S.3    Salaffi, F.4
  • 49
    • 0028926881 scopus 로고
    • Role of macrophage-like synovial lining cells in localization and expression of inflammation in type II collagen-induced arthritis
    • van Lent PL, Holthuysen AE vRN, vam de Putte LB, van der Berg WB. Role of macrophage-like synovial lining cells in localization and expression of inflammation in type II collagen-induced arthritis. Scand J Rheumatol 1995; 101(Suppl): 83-9.
    • (1995) Scand J Rheumatol , vol.101 , Issue.SUPPL. , pp. 83-89
    • Van Lent, P.L.1    Holthuysen, A.E.V.R.N.2    Vam De Putte, L.B.3    Van Der Berg, W.B.4
  • 51
    • 0036901126 scopus 로고    scopus 로고
    • Mechanisms of bisphosphonate effect on osteoclasts, tumor cell growth, and metastasis
    • Green JR, Clezardin P. Mechanisms of bisphosphonate effect on osteoclasts, tumor cell growth, and metastasis. Am J Clin Oncol 2002; 25(Suppl 1): S3-S9.
    • (2002) Am J Clin Oncol , vol.25 , Issue.SUPPL. 1
    • Green, J.R.1    Clezardin, P.2
  • 52
  • 53
    • 0023474969 scopus 로고
    • Progress in the understanding of inducible models of chronic arthritis
    • Breedveld FC, Trentham DE. Progress in the understanding of inducible models of chronic arthritis. Rheum Dis Clin 1987; 13: 531-44.
    • (1987) Rheum Dis Clin , vol.13 , pp. 531-544
    • Breedveld, F.C.1    Trentham, D.E.2
  • 57
    • 0029056655 scopus 로고
    • Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6, and TNF-alpha secretion from RAW 264 cells in vitro
    • Pennanen N, Lapinjoki S, Urtti A, Monkkonen J. Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6, and TNF-alpha secretion from RAW 264 cells in vitro. Pharm Res 1995; 12: 916-22.
    • (1995) Pharm Res , vol.12 , pp. 916-922
    • Pennanen, N.1    Lapinjoki, S.2    Urtti, A.3    Monkkonen, J.4
  • 59
    • 0027159490 scopus 로고
    • Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichlomethylene diphosphonate
    • Van Lent P, van den Berselaar L, van den Hoek A, van de Ende M, Dijkstra CD, Van Rooijen N. Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichlomethylene diphosphonate. Rheumatol Int 1993; 13: 21-30.
    • (1993) Rheumatol Int , vol.13 , pp. 21-30
    • Van Lent, P.1    Van Den Berselaar, L.2    Van Den Hoek, A.3    Van De Ende, M.4    Dijkstra, C.D.5    Van Rooijen, N.6
  • 60
    • 0036185343 scopus 로고    scopus 로고
    • Tumor Necrosis factor α-mediate joint destruction ins inhibited by targeting osteoclasts with protegerin
    • Redlich K, Hayer S, Maier A. Tumor Necrosis factor α-mediate joint destruction ins inhibited by targeting osteoclasts with protegerin. Arthritis Rheum 2002; 46: 785-92.
    • (2002) Arthritis Rheum , vol.46 , pp. 785-792
    • Redlich, K.1    Hayer, S.2    Maier, A.3
  • 62
    • 0037364369 scopus 로고    scopus 로고
    • Mechanisms of TNF-α and RANK-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
    • Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM. Mechanisms of TNF-α and RANK-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest 2003; 111: 821-31.
    • (2003) J Clin Invest , vol.111 , pp. 821-831
    • Ritchlin, C.T.1    Haas-Smith, S.A.2    Li, P.3    Hicks, D.G.4    Schwarz, E.M.5
  • 63
    • 0032703282 scopus 로고    scopus 로고
    • Evaluation of bone turnover and osteoclastic cytokines in early rheumatoid arthritis treated with alendronate
    • Cantatore FP, Acquista CA, Pipitone V. Evaluation of bone turnover and osteoclastic cytokines in early rheumatoid arthritis treated with alendronate. J Rheumatol 1999; 26: 2318-23.
    • (1999) J Rheumatol , vol.26 , pp. 2318-2323
    • Cantatore, F.P.1    Acquista, C.A.2    Pipitone, V.3
  • 64
    • 0035093204 scopus 로고    scopus 로고
    • Influence of cyclic intravenous pamidronate on proinflammatory monocytic cytokine profiles and bone density in rheumatoid arthritis trated with low dose prednisolone and methotrexate
    • Van Offel JF, Schuerwegh AJ, Bridts CH, Bracke PG, Stevens WJ, De Clerck LS. Influence of cyclic intravenous pamidronate on proinflammatory monocytic cytokine profiles and bone density in rheumatoid arthritis trated with low dose prednisolone and methotrexate. Clin Exp Rheum 2001; 19: 13-20.
    • (2001) Clin Exp Rheum , vol.19 , pp. 13-20
    • Van Offel, J.F.1    Schuerwegh, A.J.2    Bridts, C.H.3    Bracke, P.G.4    Stevens, W.J.5    De Clerck, L.S.6
  • 65
    • 0028109510 scopus 로고
    • Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: A double blind placebo controlled study
    • Eggelmejer F, Papapoulos SE, Henk C, et al. Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: a double blind placebo controlled study. J Rheumatol 1994; 21: 2016-20.
    • (1994) J Rheumatol , vol.21 , pp. 2016-2020
    • Eggelmejer, F.1    Papapoulos, S.E.2    Henk, C.3
  • 66
    • 0028059365 scopus 로고
    • Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis
    • Maccagno A, Di Giorgio E, Roldan EJA, Caballero LE, Perez Lloret A. Double blind radiological assessment of continuous oral pamidronic acid in patients with rheumatoid arthritis. J Rheumatol 1994; 23: 211-4.
    • (1994) J Rheumatol , vol.23 , pp. 211-214
    • Maccagno, A.1    Di Giorgio, E.2    Roldan, E.J.A.3    Caballero, L.E.4    Perez Lloret, A.5
  • 67
    • 0024544443 scopus 로고
    • Clinical, biochemical and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis
    • Ralston SH, Hacking L, Willocks L, Bruce F, Pitkeathly DA. Clinical, biochemical and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis. Ann Rheum Dis 1989; 48: 396-9.
    • (1989) Ann Rheum Dis , vol.48 , pp. 396-399
    • Ralston, S.H.1    Hacking, L.2    Willocks, L.3    Bruce, F.4    Pitkeathly, D.A.5
  • 69
    • 0036188770 scopus 로고    scopus 로고
    • A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis
    • Maksymowych WP, Jhangri GS, Fitzgerald AA, Leclerq S, Chiu P, Yah A, et al. A six-month randomized, controlled, double-blind, dose-response comparison of intravenous pamidronate (60 mg versus 10 mg) in the treatment of nonsteroidal antiinflammatory drug-refractory ankylosing spondylitis. Arthritis Rheum 2002; 46: 766-73.
    • (2002) Arthritis Rheum , vol.46 , pp. 766-773
    • Maksymowych, W.P.1    Jhangri, G.S.2    Fitzgerald, A.A.3    Leclerq, S.4    Chiu, P.5    Yah, A.6
  • 70
    • 0035171329 scopus 로고    scopus 로고
    • Clinical and radiological amelioration of refractory peripheral spondyloarthritis by pulse intravenous pamidronate therapy
    • Maksymowych WP, Lambert R, Jhangri GS, Leclerq S, Chiu P, Wong B, et al. Clinical and radiological amelioration of refractory peripheral spondyloarthritis by pulse intravenous pamidronate therapy. J Rheumatol 2001; 28: 144-55.
    • (2001) J Rheumatol , vol.28 , pp. 144-155
    • Maksymowych, W.P.1    Lambert, R.2    Jhangri, G.S.3    Leclerq, S.4    Chiu, P.5    Wong, B.6
  • 75
    • 0342460484 scopus 로고    scopus 로고
    • An in vitro and in vivo study of cytokines in the acute-phase response associated with bisphosphonates
    • Thiebaud D, Sauty A, Burkhardt P, Leuenberger P, Sitzler L, Green JR, et al. An in vitro and in vivo study of cytokines in the acute-phase response associated with bisphosphonates. Calcif Tissue Int 1997; 61: 386-92.
    • (1997) Calcif Tissue Int , vol.61 , pp. 386-392
    • Thiebaud, D.1    Sauty, A.2    Burkhardt, P.3    Leuenberger, P.4    Sitzler, L.5    Green, J.R.6
  • 76
    • 0023520871 scopus 로고
    • Paget's disease of bone: Early and late responses to three different with aminohydroxypropylidene bisphosphonate (APD)
    • Harinck HI, Papapoulos SE, Blanksma HJ, Vermey P, Bijuoet OL II. Paget's disease of bone: early and late responses to three different with aminohydroxypropylidene bisphosphonate (APD). BMJ 1987; 295: 1301-5.
    • (1987) BMJ , vol.295 , pp. 1301-1305
    • Harinck, H.I.1    Papapoulos, S.E.2    Blanksma, H.J.3    Vermey, P.4    Bijuoet II, O.L.5
  • 77
    • 0027296021 scopus 로고
    • Methylpentylaminopropylidenebisphosphonate (BM 21.0955): A new potent and safe bisphosphonate for the treatment of cancer-associated hypercalcemia
    • Wuster C, Schoter KH, Thiebaud D, Manegold C, Krahl D, Clemens MR, et al. Methylpentylaminopropylidenebisphosphonate (BM 21.0955): a new potent and safe bisphosphonate for the treatment of cancer-associated hypercalcemia. Bone Miner 1993; 22: 77-85.
    • (1993) Bone Miner , vol.22 , pp. 77-85
    • Wuster, C.1    Schoter, K.H.2    Thiebaud, D.3    Manegold, C.4    Krahl, D.5    Clemens, M.R.6
  • 79
    • 0025970833 scopus 로고
    • Intravenous aminobisphosphonate in Paget's disease: Clinical, biochemical, histomorphometric and radiological responses
    • Fenton AJ, Gutteridge DH, Kent GN, Price RI, Rettallak RW. Intravenous aminobisphosphonate in Paget's disease: clinical, biochemical, histomorphometric and radiological responses. Clin Endocrinol 1991; 34: 197-204.
    • (1991) Clin Endocrinol , vol.34 , pp. 197-204
    • Fenton, A.J.1    Gutteridge, D.H.2    Kent, G.N.3    Price, R.I.4    Rettallak, R.W.5
  • 80
    • 0029010690 scopus 로고
    • Interleukin-6 and the acute-phase response during treatment of patients with Paget's disease with the nitrogen-cotaining bisphosphonate dimethylaminohydroxypropylidene bisphosphonate
    • Schweitzer DH, Oostendorp-van de Ruit M, van der Pluijm G, Löwik CWGM, Papapoulos SE. Interleukin-6 and the acute-phase response during treatment of patients with Paget's disease with the nitrogen-cotaining bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. J bone Min Res 1995; 10: 956-62.
    • (1995) J Bone Min Res , vol.10 , pp. 956-962
    • Schweitzer, D.H.1    Oostendorp-Van De Ruit, M.2    Van Der Pluijm, G.3    Löwik, C.W.G.M.4    Papapoulos, S.E.5
  • 81
    • 0029986140 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy
    • Sauty A, Pecherstorfer M, Zimmer-Roth I, Fioroni P, Juillerat L, Markert M, et al. Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy.Bone 1996; 18: 133-9.
    • (1996) Bone , vol.18 , pp. 133-139
    • Sauty, A.1    Pecherstorfer, M.2    Zimmer-Roth, I.3    Fioroni, P.4    Juillerat, L.5    Markert, M.6
  • 83
    • 0025364167 scopus 로고
    • Treatment of Paget's disease of bone
    • Cantrill JA, Andersn DC. Treatment of Paget's disease of bone. Clin Endocrinol 1990; 32: 507-18.
    • (1990) Clin Endocrinol , vol.32 , pp. 507-518
    • Cantrill, J.A.1    Andersn, D.C.2
  • 84
    • 0005916684 scopus 로고
    • Bisphosphonate stimulate the production of cytokines by human peripheral blood mononuclear cells in vitro
    • Pioli G, Hughes DE, Milan A, Aarden L, Meager A, Chapman K, et al. Bisphosphonate stimulate the production of cytokines by human peripheral blood mononuclear cells in vitro. Calcif Tissue Int 1990; 46 (suppl 2): A54.
    • (1990) Calcif Tissue Int , vol.46 , Issue.SUPPL. 2
    • Pioli, G.1    Hughes, D.E.2    Milan, A.3    Aarden, L.4    Meager, A.5    Chapman, K.6
  • 87
    • 0027536485 scopus 로고
    • Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increse macrophages, granulocytes and osteoclasts in vivo
    • Endo Y, Nakamura M, Kikuchi T, Shinoda H, Takeda Y, Nitta Y, et al. Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increse macrophages, granulocytes and osteoclasts in vivo. Calcif Tissue Int 1993; 52: 248-54.
    • (1993) Calcif Tissue Int , vol.52 , pp. 248-254
    • Endo, Y.1    Nakamura, M.2    Kikuchi, T.3    Shinoda, H.4    Takeda, Y.5    Nitta, Y.6
  • 88
    • 0031660145 scopus 로고    scopus 로고
    • The effect of alendronate con cytokine production, adhesion molecule expression, and transendothelial migration of human peripheral blood mononuclear cells
    • Pietschmann P, Stohlawetz P, Brosch S, Steiner G, Smolen JS, Peterlik M. The effect of alendronate con cytokine production, adhesion molecule expression, and transendothelial migration of human peripheral blood mononuclear cells. Calcif Tissue Int 1998; 63: 325-30.
    • (1998) Calcif Tissue Int , vol.63 , pp. 325-330
    • Pietschmann, P.1    Stohlawetz, P.2    Brosch, S.3    Steiner, G.4    Smolen, J.S.5    Peterlik, M.6
  • 90
    • 0033430363 scopus 로고    scopus 로고
    • Partial chondroprotective effect of Zolendronate in a rabbit model of inflammatory arthritis
    • Podworny NV, Kandel RA, Renlund RC, Grynpas MD. Partial chondroprotective effect of Zolendronate in a rabbit model of inflammatory arthritis. J Rheumatol 1999; 26: 1972-82.
    • (1999) J Rheumatol , vol.26 , pp. 1972-1982
    • Podworny, N.V.1    Kandel, R.A.2    Renlund, R.C.3    Grynpas, M.D.4
  • 91
    • 0019134744 scopus 로고
    • Binding of the bone-seeking agent 99mTc-1-hydroxyethilydene-1,1- diphosphonic acid to cartilage and collagen in vitro and its stimulation by Er3+ and low pH
    • Evans CH, Mears DC. Binding of the bone-seeking agent 99mTc-1-hydroxyethilydene-1,1-diphosphonic acid to cartilage and collagen in vitro and its stimulation by Er3+ and low pH. Calcif Tissue Int 1980; 32: 91-4.
    • (1980) Calcif Tissue Int , vol.32 , pp. 91-94
    • Evans, C.H.1    Mears, D.C.2
  • 92
    • 0022358511 scopus 로고
    • Effect of bisphosphonates on production of interleukin 1-like acticity by macrophages and its effect on rabbit chondrocytes
    • Evequoz V, Trechsel U, Fleish H. Effect of bisphosphonates on production of interleukin 1-like acticity by macrophages and its effect on rabbit chondrocytes. Bone 1985; 6: 439-44.
    • (1985) Bone , vol.6 , pp. 439-444
    • Evequoz, V.1    Trechsel, U.2    Fleish, H.3
  • 93
    • 0019854630 scopus 로고
    • The effects of 1-hydroxyethane-1,1-diphosphonate and dicloro-methane- diphosphonate on collagen synthesis by rabbit articular chondrocytes and rat bone cells
    • Guenther HL, Guenther HE, Fleisch H. The effects of 1-hydroxyethane-1,1- diphosphonate and dicloro-methane-diphosphonate on collagen synthesis by rabbit articular chondrocytes and rat bone cells. Biochem J 1981; 196: 293-301.
    • (1981) Biochem J , vol.196 , pp. 293-301
    • Guenther, H.L.1    Guenther, H.E.2    Fleisch, H.3
  • 94
    • 0022379609 scopus 로고
    • Effects of 1-hydroxyethilene-1,1-diphosphonate and (chloro-4-phenyl)- thiomethylene bisphosphonic acid (SR 41319) on the mononuclear cell factor-mediated release of neutral proteinases by articular chindrocytes and synovial cells
    • Edmonds-Alt X, Breliere JC, Roncucci R. Effects of 1-hydroxyethilene-1,1- diphosphonate and (chloro-4-phenyl)-thiomethylene bisphosphonic acid (SR 41319) on the mononuclear cell factor-mediated release of neutral proteinases by articular chindrocytes and synovial cells. Biochem Pharmacol 1985; 34: 4043-9.
    • (1985) Biochem Pharmacol , vol.34 , pp. 4043-4049
    • Edmonds-Alt, X.1    Breliere, J.C.2    Roncucci, R.3


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