Influence of cyclic intravenous pamidronate on proinflammatory monocytic cytokine profiles and bone density in rheumatoid arthritis treated with low dose prednisolone and methotrexate

Clinical and Experimental Rheumatology

Volumn 19, Issue 1, 2001, Pages 13-20

  Van Offel, J F ^a   Schuerwegh, A J ^a   Bridts, C H ^a   Bracke, P G ^a   Stevens, W J ^a   De Clerk, L S ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Apoptosis; Bisphosphonates; Cytokines; Inflammation; Monocytes; Necrosis; Osteoporosis; Pamidronate; Rheumatoid arthritis

Indexed keywords

ANABOLIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; CYTOKINE; DACTINOMYCIN; FLUORIDE; FOLIC ACID; INTERLEUKIN 1; INTERLEUKIN 6; METHOTREXATE; PAMIDRONIC ACID; PENICILLIN G; PREDNISOLONE; PROPIDIUM IODIDE; STEROID; STREPTOMYCIN; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BONE DENSITY; BONE MASS; CELL LINE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; EVALUATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MEASUREMENT; MONOCYTE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SPINE;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; BONE DENSITY; C-REACTIVE PROTEIN; CYTOKINES; DIPHOSPHONATES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; MALE; METHOTREXATE; MIDDLE AGED; MONOCYTES; PREDNISOLONE; PROSPECTIVE STUDIES; RANDOM ALLOCATION;

EID: 0035093204     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Osteoporosis in rheumatoid arthritis
2. Rheumatoid arthritis and osteoporosis
3. Osteoporosis in rheumatoid arthritis - The clinical view point
4. Bone mass measurement and bone metabolism in rheumatoid arthritis: A review
5. What is the impact of osteoporosis?
6. Intermittent etidronate therapy to prevent corticosteroid induced osteoporosis
7. Alendronate for the prevention and treatment of glucocorticoid induced osteoporosis
8. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
9. Modified disease activity scores include twenty-eight-joint counts
10. Prediction of progression of radiologic damage in newly diagnosed rheumatoid arthritis
11. Flow cytometrical determination of interleukin-1β, interluekin-6 and tumor necrosis factor-α in monocytes of rheumatoid arthritis patients; relation with parameters of osteoporosis
12. Growth inhibition of macrophage-like and other cell types by liposome-encapsulated, calcium-bound, and free bisphosphonates in vitro
13. Radiographic changes in early rheumatoid disease
14. Measurement of hand bone mineral content by dual x-ray absorptiometry: Development of the method, and its application in normal volunteers and in patients with rheumatoid arthritis
15. Longitudinal study of hand bone densitometry in rheumatoid arthritis
16. Generalised bone loss in patients with early rheumatoid arthritis occurs early and relates to disease activity
17. Bone mineral density in patients with recent onset rheumatoid arthritis: Influence of disease activity and functional capacity
18. The effect of glucocorticoids on joint destruction in rheumatoid arthritis
19. Joint destruction after glucocorticoids are withdrawn in early rheumatoid arthritis
20. Primary prevention of glucocorticoid-induced osteoporosis with intermittent intravenous pamidronate: A randomized trial
21. Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three year randomised, double blind trial
22. Nitrogen containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
23. Heterocycle containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: Evidence from structure-activity relationships in J774 macrophages
24. Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
25. Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity
26. Cytokines in rheumatoid arthritis
27. Cytokine and cytokine inhibitors or antagonists in rheumatoid arthritis
28. Synovial tissue macrophages and joint erosions in rheumatoid arthritis
29. Interleukin-1 beta, hand and foot bone mineral content and the development of joint erosions in rheumatoid arthritis
30. NE-58095: A diphosphonate which prevents bone erosion and preserves joint architecture in experimental arthritis
31. Demonstration of novel anti-arthritic and anti-inflammatory effects of diphosphonates
32. Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes
33. Effect of clodronate on established adjuvant arthritis
34. Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: A double blind placebo controlled study
35. The effect of alendronate on cytokine production, adhesion molecule expression and transendothelial migration of human blood mononuclear cells
36. An in vitro and in vivo study of cytokines in the acute phase response associated with bisphosphonates
37. Evaluation of bone turnover and osteoclastic cytokines in early rheumatoid arthritis treated with alendronate