Bisphosphonates Induce Osteoblasts to Secrete an Inhibitor of Osteoclast-Mediated Resorption

Endocrinology

Volumn 137, Issue 6, 1996, Pages 2324-2333

  Vitté, Claire ^a,b   Fleisch, Herbert ^a   Guenther, Harald L ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; IBANDRONIC ACID;

ANIMAL CELL; ARTICLE; BONE METABOLISM; BONE MINERAL; CALCIUM METABOLISM; CELL FUNCTION; ENZYME SYNTHESIS; MULTINUCLEAR CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SECRETION; RAT; SKIN FIBROBLAST;

ACID PHOSPHATASE; ALENDRONATE; ANIMALS; BONE RESORPTION; CELL LINE; CULTURE MEDIA, CONDITIONED; DIPHOSPHONATES; ENDOPEPTIDASES; HEAT; ISOENZYMES; KINETICS; MOLECULAR WEIGHT; OSTEOBLASTS; OSTEOCLASTS; RATS; RATS, WISTAR;

EID: 0029934545     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.6.8641182     Document Type: Article

References (52)

1. Fleisch H, Russell RGC, Francis MD 1969 Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science 165:1262-1264
2. Fleisch H 1995 Bisphosphonates in Bone Disease. From the Laboratory to the Patient. Parthenon, New York and London, pp 9-176
3. Fleisch H 1993 Bisphosphonates: mechanisms of action and clinical use. In: Mundy GR, Martin TJ (eds) Handbook of Experimental Pharmacology. Physiology and Pharmacology of Bone. Springer-Verlag, Berlin, vol 107:377-418
4. Kanis JA 1991 Drug used for treatment of Paget's disease. In: Kanis JA (ed) Pathophysiology and Treatment of Paget's Disease of Bone. Dunitz, London, pp 159-216
5. Fleisch H 1991 Bisphosphonates: pharmacology and use in the treatment of tumor-induced hypercalemia and metastatic bone disease. Drugs 42:919-944
6. Valkema R, Vismans F-JFE, Papapoulos SE, Pauwels EKJ, Bijvoet OLM 1989 Maintained improvement in calcium balance and bone mineral content in patients with osteoporosis treated with the bisphosphonate APD. Bone Miner 5:183-192
7. Reginster JY, Lecart MP, Deroisy R, Sarlet N, Denis D, Ethgen D, Collate J, Franchimont P 1989 Prevention of postmenopausal bone loss by tiludronate. Lancet 2:1469-1471
8. Storm T, Thamsborg G, Steinichem T, Genant HK, Soerensen OH 1990 Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322:1265-1271
9. Watts NB, Harris ST, Genant HK, Wasnich RD, Miller PD, Jackson RD, Licata AA, Ross P, Woodson GC, Yanover MJ, Mysiw WJ, Kohse L, Rao MB, Steiger P, Richmond B, Chesnut CH 1990 Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. N Engl J Med 323:73-79
10. Jung A, Bisaz S, Fleisch H 1973 The binding of pyrophosphate and two bisphosphonates to hydroxyapatite crystals. Calcif Tissue Res 11:269-280
11. 14C]citric acid. Calcif Tissue Int 52:21-25
12. Van Beek E, Hoekstra M, Van de Ruit M, Löwick C, Papapoulos S 1994 Structural requirements for bisphosphonate actions in vitro. J Bone Miner Res 9:1875-1882
13. 2 MDP) on the tibeal epiphysis and metaphysis of rats. Calcif Tissue Res 11:196-214
14. 2MDP-coated bone. Bone Miner 6:33-43
15. Carano A, Teitelbaum SL, Konsek JD, Schlesinger PH, Blair HC 1990 Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro. J Clin Invest 85:456-461
16. Selender K, Lehenkari P, Väänänen HK 1994 The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int 55:368-375
17. Sato MW, Grasser W, Endo N, Akins R, Simmons H, Tompson DD, Golub E, Rodan GA 1991 Bisphosphonate action: alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:2095-2105
18. Sato MW, Grasser W 1990 Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected microscopy. J Bone Miner Res 5:31-40
19. Mühlbauer RC, Bauss F, Schenk R, Janner M, Bosis E, Strein K, Fleisch H 1991 BM 21.0955, a potent new bisphosphonate to inhibit bone resorption. J Bone Miner Res 9:1003-1011
20. Sahni M, Guenther HL, Fleisch H, Collin P, Martin TJ 1993 Bisphosphonates act on rat resorption through the mediation of osteoblasts. J Clin Invest 91:2004-2011
21. Yu X, Scholler J, Foget NT 1994 Pre-treatment of an osteoblast-like cell line with bisphosphonates inhibits its PTH-stimulated induction of osteoclastic bone resorption. J Bone Miner Res [Suppl 1] 9:S232 (Abstract)
22. Nishikawa M, Akutsu T, Y Katayama Y, Yasutomo Y, Kado S, Kugai N, Yamamoto M, Nagata N 1995 Bisphosphonates act on osteoblastic cells and inhibit osteoclastic cell formation in mouse marrow culture. Bone 18:9-14
23. Passeri G, Girasole G, Ulietti V, Giuliani N, Pedrazzoni M, Sartoni I, Jilka RL, Manolagas SC 1994 Bisphosphonates inhibit IL-6 production by human osteoblastic cells MG-63. J Bone Miner Res [Suppl 1] 9:S230 (Abstract)
24. Ishii T, Saito T, Morimoto K, Takeuchi Y, Asano S, Kumegawa M, Ogata E, Matsumoto T 1993 Estrogen stimulates the elaboration of cell / matrix surface-associated inhibitory factor of osteoclastic bone resorption from osteoblastic cells. Biochem Biophys Res Commun 191:495-502
25. McSheehy PMJ, Chambers TJ 1986 Osteoblast-like cells in the presence of parathyroid hormone release soluble factors that stimulate osteoclastic bone resorption. Endocrinology 119:1654-1659
26. 3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption. J Clin Invest 80:425-429
27. Thomson BM, Saklatvala J, Chambers TJ 1987 Osteoblasts mediate interleukin-1 stimulation of bone resorption by rat osteoclasts. J Exp Med 164:104-112
28. Thomson BM, Mundy GR, Chambers TJ 1987 Tumor necrosis factor α and β induce osteoblastic cells to stimulate osteoblastic bone resorption. J Immunol 138:775-779
29. Perry HM, Skogen W, Chappel J, Kahn A, Wilner G Teitelbaum SL 1989 Partial characterization of a parathyroid hormone stimulated resorption factor(s) from osteoblast-like cells. Endocrinology 125:2075-2082
30. Morris KA, Mitnick ME, Weir ME, Horowitz H, Kreider BL Isogna L 1990 The parathyroid hormone-related protein stimulates human osteoblast-like cells to secrete a 9000 dalton bone resorbing protein. Endocrinology 126:1783-1785
31. 3. Endocrinology 131:1181-1187
32. Guenther HL, Hofstetter W, Stutzer A, Mühlbauer R, Fleisch H 1989 Evidence for a heterogeneity of the osteoblastic phenotype determined with clonal rat bone cells established from transforming growth factor-β-induced cell colonies grown anchorage independently in semisolid medium. Endocrinology 125:2092-2102
33. McSheehy PMJ, Chambers TJ 1987 Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 118:824-828
34. Felix R, Fleisch H 1979 Increase in alkaline phosphatase activity in calvaria cells cultures with diphosphonates. Biochem J 183:73-81
35. Salomon Y 1979 Adenylate cyclase assay. Adv Cyclic Nucleotide Res 10:35-55
36. Guenther HL, Felix R, Fleisch H 1984 Comparative study of deflazacort, a new synthetic corticosteroid and dexamethasone on the synthesis of collagen in different rat bone cell populations and rabbit articular chondrocytes. Calcif Tissue Int 36:145-152
37. Flanagan AM, Chambers TJ 1991 Inhibition of bone resorption by bisphosphonates: interactions between bisphosphonates, osteoclasts, and bone. Calcif Tissue Int 49:407-415
38. Ohya K, Yamada S, Felix R, Fleisch H 1985 Effect of bisphosphonates on prostaglandin synthesis by rat bone cells and mouse calvaria in culture. Clin Sci (Lond) 69:403-411
39. 3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium. Calcif Tissue Int 42:248-254
40. Chambers TJ, 1980 Diphosphonates inhibit bone resorption in macrophages in vitro. J Pathol 132:255-262
41. Cecchini MG, Felix R, Fleisch H Cooper PH 1987 Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages. J Bone Miner Res 2:135-142
42. Cecchini MG, Fleisch H 1990 Bisphosphonates in vitro specifically inhibit among the hematopoietic series, the development of the mouse mononuclear phagocyte lineage. J Bone Miner Res 5:1019-1027
43. Tsuchimoto M, Azuma A, Higuchi O, Sugimoto I, Hiruta N, Kiyoki M, Yamamoto I 1994 Alendronate modulates osteogenesis of human osteoblastic cells in vitro. Jpn J Pharmcol 66:25-33
44. Fenton AJ, Martin TJ, Nicholson GC 1993 Long-term culture of disaggregated rat osteoclasts: inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP(107-139). J Cell Physiol 155:1-7
45. Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF 1995 Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-1487
46. Hughes DE, MacDonald BR, Russell RGG, Gowen M 1989 Inhibition of osteoclast-like cell formation by bisphosphonates in long term culture of human bone marrow. J Clin Invest 83:1930-1935
47. Kukita A, Kukita K, Hata K, Kurisu K, Kohashi O 1993 Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells. Bone Miner 23:113-127
48. Van Beek E, Van der Wee-Pals L, Van de Ruit M, Nijweide P, Papapoulos S, Löwik C 1993 Leukemia inhibitory factor inhibits osteoclastic resorption, growth, mineralization and alkaline phosphatase activity in fetal mouse metacarpal bones in culture. J Bone Miner Res 8:191-198
49. Gowen M, Nedwin GE, Mundy GR 1986 Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma. J Bone Miner Res 1:469-473
50. Nakano Y, Watanabe K, Morimoto I, Okada Y, Ura K, Sato K, Kasano K, Nakamura T, Eto S 1994 Interleukin-4 inhibits spontaneous and parathyroid hormone-related protein-stimulated osteoclast formation in mice. J Bone Miner Res 9:1533-1539
51. Riancho JA, Zarrabeita MT, Gonzalez-Macias M 1993 Interleukin-4 modulates osteoclast differentiation and inhibits the formation of resorption pits in mouse osteoclast cultures. Biochem Biophys Res Commun 196:678-685
52. Guenther HL, Hofstetter W, Moseley JM, Gillespie MT, Suda N, Martin TJ 1995 Evidence for the synthesis of parathyroid hormone-related protein (PTHrP) by nontransformed clonal rat osteoblastic cells in vitro. Bone 16:341-347