Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: In vitro and in vivo evaluation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 61, Issue 3, 2005, Pages 171-180

  Lagarce, Frederic ^a,b   Faisant, Nathalie ^a   Desfontis, Jean Claude ^c   Marescaux, Laurent ^c   Gautier, Freddy ^c   Richard, Joel ^b   Menei, Philippe ^a,d   Benoit, Jean Pierre ^a  

^a INSERM   (France)

^b Ethypharm   (France)

^c UPSP 5304 Laboratoire de Physiopathologie animale et de Pharmacologie fonctionnelle   (France)

^d ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

Baclofen; Burst effect; Intrathecal administration; PLGA microsphere; Polymer gel

Indexed keywords

BACLOFEN; CARBOXYMETHYLCELLULOSE; MEDISORB; MICROSPHERE; POLOXAMER; POLYGLACTIN; RINGER LACTATE SOLUTION;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; GEL; HEAT SENSITIVITY; HUMAN; MICROENCAPSULATION; NONHUMAN; SUSPENSION; SUSTAINED RELEASE FORMULATION;

BACLOFEN; GELS; INJECTIONS, SPINAL; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; SOLUBILITY; SUSPENSIONS;

EID: 26444562934     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.04.004     Document Type: Article

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