A method using biodegradable polylactides/polyethylene glycol for drug release with reduced initial burst

International Journal of Pharmaceutics

Volumn 182, Issue 1, 1999, Pages 93-100

  Huang, Yi You ^a   Chung, Tze Wen ^b   Tzeng, Tzeng Wen ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Biodegradable polymers; Drug release; Microencapsulation; PLA PEG

Indexed keywords

GELATIN; LIDOCAINE; MACROGOL; MICROSPHERE; POLYLACTIDE; POLYMER; PROPRANOLOL;

ARTICLE; DRUG RELEASE; FILM; MICROENCAPSULATION; PRIORITY JOURNAL;

ANTI-ARRHYTHMIA AGENTS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; COATED MATERIALS, BIOCOMPATIBLE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GELATIN; LACTATES; LIDOCAINE; MICROSPHERES; POLYETHYLENE GLYCOLS; PROPRANOLOL;

EID: 0032900007     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00060-5     Document Type: Article

References (16)

1. Cohn D., Younes H. Biodegradable PEO/PLA block copolymers. J. Biomed. Mater. Res. 22:1988;993-1009.
2. Flory, P.J., 1967. Principles of Polymer Chemistry, 6th Ed. New York, p. 605.
3. Gogolewski S., Jovanovic M., Perren S.M., Dillon J.G., Hughes M.K. Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA). J. Biomed. Mater. Res. 27:1993;1135-1148.
4. Gref R., Minamitake Y., Peracchia M.T. et al. Biodegradable long-circulating polymeric nanospheres. Science. 263:1994;1600-1603.
5. Gupta R.K., Alroy J., Alonso M.J., Langer R., Siber G.R. Chronic local tissue reactions, long-term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polymers. Vaccine. 15:1997;1716-1723.
6. 1H-NMR spectroscopy. Biomaterials. 18:1997;27-30.
7. Huang Y.Y., Chung T.W., Tzeng T.W. Drug release from PLA/PEG microparticulates. Int. J. Pharm. 156:1997;9-15.
8. Illum L., Jacobsen L.O., Muller R.H., Mak E., Davis S.S. Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages. Biomaterials. 8:1987;113-117.
9. Miyamoto S., Takaoka K., Okada T., Yoshikawa H., Hashimoto J., Suzuki S., Ono K. Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein. Clin. Orthop. 278:1992;274-282.
10. Miyamoto S., Takaoka K., Okada T. et al. Polylactic acid-polyethylene glycerol block copolymer-A new biodegradable synthetic carrier for bone morphogenetic protein. Clin. Orthop. Relat. Res. 294:1993;333-343.
11. Patel N., Padera R., Sander G.W. et al. Spatially controlled tissue engineering on biodegradable polymer surface. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 25:1998;109-110.
12. Po A.L., Mhando J.R. Formulation of sustained-release products: dissolution and diffusion-controlled release from gelatin films. Int. J. Pharm. 20:1984;87-98.
13. Mann S., Ozin G.A. Nature. 382:1996;313.
14. Sampath S.S., Garvin K., Robinson D.H. Preparation and characterization of biodegradable poly (L-lactic acid) gentamicin delivery systems. Int. J. Pharm. 78:1992;165-174.
15. Singh P.C., Stockar U. A simple penetration model for mass transfer in packed beds and strings of spheres. Chem. Eng. Proc. 35:1996;343-347.
16. Zhu K.J., Lin X., Yang S. Preparation, characterization and properties of polylactide(PLA)-poly(ethyleneglycol) (PEG) copolymers: a potential drug carrier. J. Appli. Polymer Sci. 39:1990;1-9.