Esterase activity of human organotypic cornea construct (HCC) as in vitro model for permeation studies;Esteraseaktivität eines organotypischen humanen kornea-konstrukts (HCC) als in-vitro-modell für permeationsuntersuchungen. Originalien

Ophthalmologe

Volumn 102, Issue 10, 2005, Pages 971-980

  Meyer, L ^a   Bednarz, J ^b   Muller Goymann C C ^a   Reichl, S ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Esterase activity; Human cornea construct; Hydrocortisone acetate; In vitro model

Indexed keywords

ACETIC ACID DERIVATIVE; ESTERASE; HYDROCORTISONE ACETATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA CELL; CORNEA EPITHELIUM; DIFFUSION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; METABOLIC RATE; NONHUMAN;

AGED; ANIMALS; BIOLOGICAL AVAILABILITY; CELLS, CULTURED; CORNEA; CORNEAL STROMA; ENDOTHELIUM, CORNEAL; EPITHELIUM, CORNEAL; ESTERASES; HUMANS; HYDROCORTISONE; MICROSCOPY, PHASE-CONTRAST; MIDDLE AGED; OPHTHALMIC SOLUTIONS; ORGAN CULTURE TECHNIQUES; PERMEABILITY; PRODRUGS; SWINE; TIME FACTORS; TISSUE DONORS;

EID: 26444541616     PISSN: 0941293X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00347-005-1200-z     Document Type: Article

References (30)

1. Anand BS, Mitra AK (2002) Mechanism of corneal permeation of L-valyl ester of acyclovir: targeting the oligopeptide transporter on the rabbit cornea. Pharm Res 19:1194-1202
2. Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H (1995) An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 36:614-621
3. Babiole M, Wilhelm F, Schoch C (2001) In vitro permeation of unoprostone isopropyl and its metabolism in the isolated pig eye. J Ocul Pharmacol Ther 17:159-172
4. Baker JE, Fabrick JA, Zhu KY (1998) Characterization of esterases in malathion-resistant and susceptible strains of the pteromalid parsitoid Anisopteromalus calandrae. Insect Biochemistry and Molecular Biology 28:1039-1050
5. Bednarz J, Teifel M, Friedl P, Engelmann K (2000) Immortalization of human corneal endothelial cells using electroporation protocol optimized for human corneal endothelial and human retinal pigment epithelial cells. Acta Ophthalmol Scand 78:130-136
6. Bertelmann E, Knapp S, Rieck P, Keipert S, Hartmann C, Pleyer U (2003) Transcorneal-paracorneal penetration route for topical application of drugs to the eye. Mycophenolate mofetil as a model substance. Ophthalmologe 100:696-701
7. Böhnke M (1991) Corneal preservation in organ culture. Current Opinion in Ophthalmology 2:432-442
8. Burstein NL, Anderson JA (1985) Corneal penetration and ocular bioavailability of drugs. J Ocular Pharmacol 1:309-326
9. Chang J, Basu SK, Lee VHL (2000) Air-interface condition promotes the formation of tight corneal epithelial cell layers for drug transport studies. Pharm Res 17:670-676
10. Coupland SE, Penfold PL, Billson FA (1994) Hydrolases of anterior segment tissues in the normal human, pig and rat eye: a comparative study. Graefes Arch Clin Exp Ophthalmol 232:182-191
11. Doane MG, Jensen AD, Dohlmann CH (1978) Penetration routes of topically applied eye medications. Am J Ophthalmol 85:383-386
12. Goskonda VR, Khan MA, Hutak CM, Reddy IK (1999) Permeability characteristics of novel mydriatic agents using an in vitro cell culture model that utilizes SIRC rabbit corneal cells. J Pharm Sci 88:180-184
13. Griffith M, Osborne R, Munger R, Xiong X, Doillon CJ, Laycock NL, Hakim M, Song Y, Watsky MA (1999) Functional human corneal equivalents constructed from cell lines. Science 286:2169-2172
14. Kawazu K, Shiono H, Tanioka H, Ota A, Ikuse T, Takashina H, Kawashima Y (1998) Beta adrenergic antagonist permeation across cultured rabbit corneal epithelial cells grown on permeable supports. Curr Eye Res 17:125-131
15. Lee VH (1983) Esterase activities in adult rabbit eyes. J Pharm Sci 72:239-244
16. Lee VH, Morimoto KW, Stratford RE (1982) Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability. Biopharm Drug Dispos 3:291-300
17. Minami Y, Sugihara H, Oono S (1993) Reconstruction of cornea in threedimensional collagen gel matrix culture. Invest Ophthalmol Vis Sci 34:2316-2324
18. Nakamura M, Shirasawa E, Hikida M (1993) Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride. Ophthalmic Res 25:46-51
19. Offord EA, Sharif NA, Mace K, Tromvoukis Y, Spillare EA, Avanti O, Howe WE, Pfeifer AM (1999) Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci 40:1091-1101
20. Rahul V, Dhananjay P, Hongwu G (2001) Transport of acyclovir ester prod rugs through rabbit cornea and SIRC-rabbit corneal epithelial cell line. J Pharm Sci 90:1505-1515
21. Reichl S, Müller-Goymann CC (2001) Development of an organotypical cornea construct as an in vitro model for permeation studies. Ophthalmologe 98:853-858
22. Reichl S, Bednarz J, Müller-Goymann CC (2004) Human corneal equivalent as cell culture model for in vitro drug permeation studies. Br J Ophthalmol 88:560-565
23. Reichl S, Döhring S, Bednarz J, Müller-Goymann CC (2004) Human Cornea Construct HCC - an alternative for In-vitro-permeation studies? A comparison with human donor corneas. Eur J Pharm Biopharm (in press)
24. Smith VA, El-Rakhawy A, Easty DL (2001) Matrix metalloproteinase 2 activation in cultured corneas. Ophthalmic Res 33:1-6
25. Schneider AI, Maier-Reif K, Graeve T (1999) Constructing an in vitro cornea from cultures of the three specific corneal cell types. In Vitro Cell Dev Biol Anim 35:515-526
26. Scholz M, Lin JE, Lee VHL, Keipert S (2002) Pilocarpine permeability across ocular tissues and cell cultures: influence of formulation parameters. J Ocul Pharmacol Ther 18:455-468
27. Tegtmeyer S, Papantoniou I, Müller-Goymann CC (2001) Reconstruction of an in vitro cornea and its use for drug permeation studies from different formulations containing pilocarpine hydrochloride. Eur J Pharm Biopharm 51:119-125
28. Tirucherai GS, Dias C, Mitra AK (2003) Corneal permeation of ganciclovir: mechanism of ganciclovir permeation enhancement by acyl ester prodrug design. J Ocul Pharmacol Ther 18:535-548
29. Toropainen E, Ranta V, Talvitie A, Suhonen P, Urtti A (2001) Culture model of human corneal epithelium for prediction of ocular drug absorption. Invest Ophthalmol Vis Sci 42:2942-2948
30. Toropainen E, Ranta VP, Vellonen KS, Palmgren J, Talvitie A, Laavola M, Suhonen P, Hamalainen KM, Auriola S, Urtti A (2003) Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. Eur J Pharm Sci 20:99-106