Tumor necrosis factor-α-induced changes in insulin-producing β-cells

Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology

Volumn 286, Issue 2, 2005, Pages 982-993

  Parkash, Jai ^a   Chaudhry, Muhammad A ^a   Rhoten, William B ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cells; Apoptosis; Bax; Bcl 2; Calbindin D28k; Insulin; Intracellular calcium; TNF

Indexed keywords

CALBINDIN; CALCIUM; CYTOKINE; INSULIN; IONOMYCIN; POTASSIUM CHLORIDE; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL DIVISION; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SYNTHESIS; LYMPHOCYTE; MACROPHAGE; MITOCHONDRION; NICK END LABELING; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

APOPTOSIS; CALCIUM SIGNALING; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; GENE EXPRESSION PROFILING; IN SITU NICK-END LABELING; INSULIN; INSULIN-SECRETING CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 26444446039     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ar.a.20229     Document Type: Article

References (65)

1. 2+ accumulation. Proc Natl Acad Sci USA 92:9328-9332.
2. Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA Jr. 1993. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med 177:57-68.
3. 28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase 3 activity. J Biol Chem 275:26328-26332.
4. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2:788-794.
5. Chang I, Kim S, Kim JY, Cho N, Kim YH, Kim HS, Lee MK, Kim KW, Lee MS. 2003. Nuclear factor kappaB protects pancreatic beta-cells from tumor necrosis factor-alpha-mediated apoptosis. Diabetes 52: 1169-1175.
6. Cheng B, Christakos S, Mattson MP. 1994. Tumor necrosis factor protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
7. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
8. Christakos S, Gabrielides C, Rhoten WB. 1989. Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology. Endocr Rev 10:3-26.
9. Christakos S, Liu Y. 2004. Biological actions and mechanism of action of calbindin in the process of apoptosis. J Steroid Biochem Mol Biol 89-90:401-404.
10. Darios F, Lambeng N, Troadec JD, Michel PP, Ruberg M. 2003. Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. J Neurochem 84:643-654.
11. Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. 2003. Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 81:455-470.
12. Dowd DR. 1995. Calcium regulation of apoptosis. Adv Second Messenger Phosphoprotein Res 30:255-280.
13. Eizirik DL, Flodstrom M, Karlsen AE, Welsh N. 1996. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39:875-890.
14. Flavell RA, Kratz A, Ruddle NH. 1996. The contribution of insulitis to diabetes development in tumor necrosis factor transgenic mice. Curr Top Microbiol Immunol 206:33-50.
15. 2+ as evidences in single pancreatic islets. J Biol Chem 268:22265-22268.
16. Grewal IS, Grewal KD, Wong FS, Picarella DE, Janeway CA Jr, Flavell RA. 1996. Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. Exp Med 184:1963-1974.
17. Hill DJ, Hogg J. 1998. Expression of insulin-like growth factors (IGFs) and their binding proteins (IGF BPs) during pancreatic development in rat, and modulation of IGF actions on rat islet DNA synthesis by IGF BPs. Adv Exp Med Biol 321:113-120.
18. Hill DJ, Petrik J, Arany E, McDonald TJ, Delovitch TL. 1999. Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice. J Endocrinol 161:153-165.
19. 28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity. Proc Natl Acad Sci USA 93:6796-6801.
20. Ishizuka N, Yagui K, Tokuyama Y, Yamada K, Suzuki Y, Miyazaki J, Hashimoto N, Makino H, Saito Y, Kanatsuka A. 1999. Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic beta cells. Metabolism 48:1485-1492.
21. Jacob CO, Aiso S, Michie SA, McDevitt HO, Acha-Orbea H. 1990. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. Proc Natl Acad Sci USA 87:968-972.
22. 2+ channels exposed to serum from patients with type I diabetes. Science 261: 86-90.
23. Kekow J, Ulrichs K, Muller-Ruchholtz W, Gross WL. 1988. Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay. Diabetes 37:321-326.
24. Kenchappa P, Yadav A, Singh G, Nandana S, Banerjee K. 2004. Rescue of TNFalpha-inhibited neuronal cells by IGF-1 involves Akt and c-Jun N-terminal kinases. J Neurosci Res 76:466-474.
25. Kroemer G, Reed JC. 2000. Mitochondrial control of cell death. Nat Med 6:513-519.
26. Lee HH, Dadgostar H, Cheng Q, Shu J, Cheng G. 1999. NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci USA 96: 9136-9141.
27. 28k. J Bone Miner Res 19:479-490.
28. Lowe WL Jr, Lasky SR, LeRoith D, Roberts CT Jr. 1988. Distribution and regulation of rat insulin-like growth factor I messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: evidence for differential processing and regulation in liver. Mol Endocrinol 2:528-535.
29. 28k alters calcium homeostasis and protects MCF-7 cells from apoptosis induction by TNFα. Strasbourg: Tenth Workshop on Vitamin D. p 212.
30. Mandrup-Poulsen T, Nerup J, Reimers JI, Pociot F, Andersen HU, Karlsen A, Bjerre U, Bergholdt R. 1996. Cytokines and the endocrine system: II, roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases. Eur J Endocrinol 134:21-30.
31. 2+. Oncogene 12:2259-2266.
32. Mattson MP. 1992. Calcium as sculptor and destroyer of neural circuitry. Exp Gerontol 27:29-49.
33. 28k in astrocytes: evidence for a cytoprotective response. J Neurosci Res 42:357-370.
34. Mattson MP, Mark RJ, Furukawa K, Bruce AJ. 1997a. Disruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom. Chem Res Toxicol 10:507-517.
35. Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L. 1997b. Cellular signaling role of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Res Rev 23:47-61.
36. McConkey DJ, Orrenius S. 1996. Signal transduction pathways in apoptosis. Stem Cells 14:619-631.
37. 28k have different domain organizations. Protein Sci 12:180-184.
38. Papakonstanti EA, Stournaras C. 2004. Tumor necrosis factor-{alpha} promotes survival of opossum kidney cells via cdc42-induced phospholipase C-{gamma}1 activation and actin filament redistribution. Mol Biol Cell 15:1273-1286.
39. 28k. Endocrine 18:221-229.
40. 28k protein. Int J Mol Med 13:3-11.
41. Phillips LS, Vassilopoulou-Sellin R. 1980. Somatomedins 302:371-380,438-446.
42. Picarella DE, Kratz A, Li CB, Ruddle N, Flavell RA. 1993. Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes: distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol 150:4136-4150.
43. 2+ and secretion. EMBO J 9:53-60.
44. Prehn JH, Bindokas VP, Marcuccilli CJ, Krajewski S, Reed JC, Miller RJ. 1994. Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons. Proc Natl Acad Sci USA 91:12599-12603.
45. Rabinovitch A, Suarez-Pinzon WL. 1998. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 55:1139-1149.
46. Rabinovitch A, Suarez-Pinzon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rajotte RV. 1999. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction. Diabetes 48:1223-1229.
47. 28k in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology 142:3649-3655.
48. 28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38). Proc Natl Acad Sci USA 94:1961-1966.
49. 2+ in butyrate-treated rat insulinoma cell line. Endocrine 2:989-995.
50. Rutgeerts P, Van Deventer S, Schreiber S. 2003. Review article: the expanding role of biological agents in the treatment of inflammatory bowel disease: focus on selective adhesion molecule inhibition. Aliment Pharmacol Ther 17:1435-1450.
51. Saito M, Korsmeyer SJ, Schlesinger PH. 2000. BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2:553-555.
52. Satoh J, Seino H, Abo T, Tanaka S, Shintani S, Ohta S, Tamura K, Sawai T, Nobunaga T, Oteki T, et al. 1989. Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice. J Clin Invest 84:1345-1348.
53. Satoh J, Seino H, Shintani S, Tanaka S, Ohteki T, Masuda T, Nobunaga T, Toyota T. 1990. Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha. J Immunol 145: 1395-1399.
54. Scearce LM, Brestelli JE, McWeeney SK, Lee CS, Mazzarelli J, Pinney DF, Pizarro A, Stoeckert CJ Jr, Clifton SW, Permutt MA, Brown J, Melton DA, Kaestner KH. 2002. Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes 51:1997-2004.
55. Schini VB, Catovsky S, Schray-Utz B, Busse R, Vanhoutte PM. 1994. Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells. Circ Res 74:24-32.
56. Sergeev I, Rhoten WB. 1998. Regulation of intracellular calcium in human breast cancer cells. Endocrine 9:321-327.
57. Shimizu S, Narita M, Tsujimoto Y. 1999. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399:483-487.
58. Stewart CE, Rotwein P. 1996. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. J Biol Chem 271:11330-11338.
59. Swenne I. 1982. The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic β-cells. Diabetes 31:754-760.
60. Thompson CB. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462.
61. Vander Heiden MG, Thompson CB. 1999. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol 1:E209-E216.
62. Wajant H, Pfizenmaier K, Scheurich P. 2003. Tumor necrosis factor signaling. Cell Death Differ 10:45-65.
63. 2+ current mediates cytokine-induced pancreatic β-cell death. Endocrinology 140:1200-1204.
64. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial. dysfunction and death. Science 292:727-730.
65. Xie K, Huang S, Wang Y, Beltran PJ, Juang SH, Dong Z, Reed JC, McDonnell TJ, McConkey DJ, Fidler IJ. 1996. Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis. Cancer Immunol Immunother 43:109-115.