Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: Role of IRS phosphorylation

Life Sciences

Volumn 77, Issue 24, 2005, Pages 3068-3077

  Zhang, Qin ^a   Carter, Edward A ^a   Ma, Bang Yi ^a   White, Morris ^b   Fischman, Alan J ^a   Tompkins, Ronald G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Akt kinase; Burn injury; Insulin receptor substrate 1; Insulin resistance; SAPK JNK

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; SERINE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; ENZYME ACTIVITY; INSULIN RESISTANCE; LIMB; MOUSE; NONHUMAN; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BURNS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HINDLIMB; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 26444436274     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.02.034     Document Type: Article

References (25)

1. G.l. Carlson Insulin resistance in sepsis British Journal of Surgery 90 3 2003 259 260
2. C.J. Carlson, M.F. White, and C.M. Rondinonea Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation Biochemical and Biophysical Research Communications 316 2 2004 533 539
3. S.F. Clark, J.C. Molero, and D.E. James Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance The Journal of Biological Chemistry 275 6 2000 3819 3826
4. J.P. de Bandt, S. Chollet-Martin, A. Hernvann, N. Lioret, L.D. du Roure, S.K. Lim, M. Vaubourdolle, J. Guechot, R. Saizy, and J. Giboudeau Cytokine response to burn injury: relationship with protein metabolism Journal of Trauma, Injury, Infection, and Critical Care 36 5 1994 624 628
5. K. De Fea, and R.A. Roth Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase The Journal of Biological Chemistry 272 50 1997 31400 31406
6. T. Haruta, T. Uno, J. Kawahara, A. Takano, K. Egawa, P.M. Sharma, J.M. Olefsky, and M. Kobayashi A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1 Molecular Endocrinology 14 6 2000 783 794
7. R. Hemi, K. Paz, N. Wertheim, A. Karasik, Y. Zick, and H. Kanety Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins The Journal of Biological Chemistry 277 11 2002 8961 8969
8. T.L. Hilder, J.C.L. Toub, R.E. Grindeland, C.E. Wade, and L.M. Graves Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle FEBS Letters 553 1-2 2003 63 67
9. G.S. Hotamisligil The role of TNFα and TNF receptors in obesity and insulin resistance Journal of Internal Medicine 245 6 1999 621 625
10. G.S. Hotamisligil, P. Peraldi, A. Budavari, R. Ellis, M.F. White, and B.M. Spiegelman IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Science 271 5249 1996 665 668
11. T. Ikezu Analysis of thermal injury-induced insulin resistance in rodents The Journal of Biological Chemistry 272 40 1997 25289 25295
12. B.B. Kahn, and J.S. Flier Obesity and insulin resistance The Journal of Clinical Investigation 106 4 2000 473 481
13. H. Kanety, R. Feinstein, M.Z. Papa, R. Hemi, and A. Karasik Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1(IRS-1) The Journal of Biological Chemistry 270 40 1995 23780 23784
14. D. Le Roith, and Y. Zick Recent advances in our understanding of insulin action and insulin resistance Diabetes Care 24 3 2001 588 597
15. S. Matthaei, M. Stumvoll, M. Kellerer, and H.U. Haring Pathophysiology and pharmacological treatment of insulin resistance Endocrine Reviews 21 6 2000 585 618
16. I. Mothe, and E. Van Obberghen Phosphorylation of insulin receptor substrate-1 on multiple serine residues 612, 632, 662, and 731, modulates insulin action The Journal of Biological Chemistry 271 19 1996 11222 11227
17. T.M. Pawlik, E.A. Carter, B.P. Bode, A.J. Fischman, and R.G. Tompkins Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport International Journal of Molecular Medicine 12 4 2003 541 548
18. K. Paz, R. Hemi, D. LeRoith, A. Karasik, E. Elhanany, H. Kanety, and Y. Zick A molecular basis for insulin resistance: elevated Serine/Threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation The Journal of Biological Chemistry 272 47 1997 29911 29918
19. T.M. Pederson, D.L. Kramer, and C.M. Rondinone Serine/Threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation Diabetes 50 1 2001 24 31
20. L. Rui, V. Aguirre, J.K. Kim, G.I. Shulman, A. Lee, A. Corbould, A. Dunaif, and M.F. White Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways The Journal of Clinical Investigation 107 2 2001 181 189
21. M.G. Schwacha, and I.H. Chaudry The cellular basis of post-burn immunosuppression: macrophages and mediators International Journal of Molecular Medicine 10 3 2002 239 243
22. J.F. Tanti, T. Gremeaux, E. van Obberghen, and Y. Le Marchand-Brustel Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling The Journal of Biological Chemistry 269 8 1994 6051 6057
23. A. Virkamaki, K. Ueki, and C.R. Kahn Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance The Journal of Clinical Investigation 103 7 1999 931 943
24. R. Zhande, J.J. Mitchell, J. Wu, and X.J. Sun Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1 Molecular and Cellular Biology 22 4 2002 1016 1026
25. Y. Zick Insulin resistance: a phosphorylation-based uncoupling of insulin signaling Trends in Cell Biology 11 11 2001 437 441