Protective effect of nicotinamide on neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation

Journal of Biomedical Science

Volumn 11, Issue 4, 2004, Pages 472-481

  Shen, Chiung Chyi ^a   Huang, Hsueh Meei ^a,b   Ou, Hsiu Chung ^a   Chen, Huan Lian ^a   Chen, Wen Chi ^a   Jeng, Kee Ching ^a  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; c fos; Caspase 3; Hypoxia reoxygenation; Nicotinamide; Oxygen glucose deprivation; Reactive oxygen species

Indexed keywords

CASPASE 3; GLUCOSE; LACTATE DEHYDROGENASE; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROPROTECTIVE AGENT; NICOTINAMIDE; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CALCIUM TRANSPORT; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME RELEASE; HYPOGLYCEMIA; HYPOXIA; IMMUNOFLUORESCENCE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; ANOXIA; APOPTOSIS; BRAIN ISCHEMIA; CALCIUM; CASPASE 3; CASPASES; CELLS, CULTURED; CEREBRAL CORTEX; GLUCOSE; L-LACTATE DEHYDROGENASE; MODELS, BIOLOGICAL; NEURONS; NIACINAMIDE; OXYGEN; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION;

EID: 2642550638     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000077897     Document Type: Article

References (44)

1. Ayoub IA, Lee EJ, Ogilvy CS, Beal MF, Maynard KI. Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats. Neurosci Lett 259:21-24;1999.
2. 10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate. Ann Neurol 36:882-888;1994.
3. Boulu RG, Mesenge C, Charriaut-Marlangue C, Verrecchia C, Plotkine M. Neuronal death: Potential role of the nuclear enzyme, poly (ADP-ribose) polymerase. Bull Acad Natl Med 185:555-563;2001.
4. Braslavskii VE, Shchavelev VA, Kryzhanovskii GN, Nikushkin EV, Germanov SB. Effect of nicotinamide on focal and generalized epileptic activity in the cerebral cortex. Biull Eksp Biol Med 94:39-42;1982.
5. Chan PH. Role of oxidants in ischemic brain damage. Stroke 27:1124-1129;1996.
6. Charriaut-Marlangue C, Margaill I, Represa A, Popovici T, Plotkine M, Ben-Ari Y. Apoptosis and necrosis after reversible focal ischemia: An in situ DNA fragmentation analysis. J Cereb Blood Flow Metab 16:186-194;1996.
7. Chen CF, Wang D, Hwang CP, Liu HW, Wei J, Lee RP, Chen HI. The protective effect of niacinamide on ischemia-reperfusion-induced liver injury. J Biomed Sci 8:446-452;2001.
8. 2 injury. J Neurochem 82:19-29;2002.
9. + precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate. Cell Death Differ 7:314-326;2000.
10. Decker P, Muller S. Modulating poly (ADP-ribose) polymerase activity: Potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr Pharm Biotechnol 3:275-283;2002.
11. Eliasson MJL, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 3:1089-1095;1997.
12. Ellis RE, Yuan JY, Horvitz HR. Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698;1991.
13. Endres M, Wang ZQ, Namura S, Waeber C, Moskowitz MA. Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab 17:1143-1151;1997.
14. Fujimura M, Morita-Fujimura Y, Kawase M, Copin JC, Calagui B, Epstein CJ, Chan PH. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci 19:3414-3422;1999.
15. Fujimura M, Tominaga T, Yoshimoto T. Nicotinamide inhibits inducible nitric oxide synthase mRNA in primary rat glial cells. Neurosci Lett 228:107-110;1997.
16. Gale EA. Theory and practice of nicotinamide trials in pre-type 1 diabetes. J Pediatr Endocrinol Metab 9:375-379;1996.
17. Gorman AM, Bonfoco E, Zhivotovsky B, Orrenius S, Ceccatelli S. Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells. Eur J Neurosci 11:1067-1072;1999.
18. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450;1985.
19. Gubits RM, Burke RE, Casey-McIntosh G, Bandele A, Munell F. Immediate early gene induction after neonatal hypoxia-ischemia. Brain Res Mol Brain Res 18:228-238;1993.
20. Hou RC, Huang HM, Tzen JT, Jeng KC. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. J Neurosci Res 74:123-133;2003.
21. Huang HM, Ou HC, Xu H, Chen HL, Fowler C, Gibson GE Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death. J Neurosci Res 74:309-317;2003.
22. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265:1883-1885;1994.
23. Huang ZS, Chiang TL, Lee TK. Stroke prevalence in Taiwan. Findings from the 1994 National Health Interview Survey. Stroke 28:1579-1584;1997.
24. Hung TP, Chen ST. Cerebral hemorrhage in Taiwan (in Chinese). J Formos Med Assoc 92: S161-S168;1993.
25. Kamat JP, Devasagayam TP. Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria. Redox Rep 4:179-184;1999.
26. + prevents apoptosis in the mouse brain induced by tertiary-butyl hydroperoxide. Neurosci Lett 206:5-8;1996.
27. Kumar S. ICE-like proteases in apoptosis. Trends Biochem Sci 20:198-202;1995.
28. Lee MM, Hseih MT, Kuo JS, Yeh FT, Huang HM. Magnolol protects cortical neuronal cells from chemical hypoxia in rats. Neuroreport 9:3451-3456;1998.
29. Lewen A, Matz P, Chan PH. Free radical pathways in CNS injury. J Neurotrauma 17:871-890;2000.
30. Lin SH, Vincent A, Shaw T, Maynard KI, Maiese K. Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death. J Cereb Blood Flow Metab 20:1380-1391;2000.
31. 3) improves neurologic outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats. Stroke 31:1679-1685;2000.
32. Mukherjee SK, Klaidman LK, Yasharel R, Adams JD Jr. Increased brain NAD prevents neuronal apoptosis in vivo. Eur J Pharmacol 330:27-34;1997.
33. Oorschot DE, Black MJ, Rangi F, Scarr E. Is Fos protein expressed by dying striatal neurons after immature hypoxic-ischemic brain injury? Exp Neurol 161:227-233;2000.
34. Pacifici RE, Davies KJ. Protein, lipid and DNA repair systems in oxidative stress: The free-radical theory of aging revisited. Gerontology 37:166-180;1991.
35. Rheaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sekaly RP, Denis F. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J 16:6346-6354;1997.
36. 3) reduces the infarct volume following permanent focal cerebral ischemia in female Sprague-Dawley and Wistar rats. Neurosci Lett 281:111-114;2000.
37. Szabo C. DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite. Free Radic Biol Med 21:855-869;1996.
38. Szabo C, Dawson VL. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 19:287-298;1998.
39. Takahashi K, Greenberg JH, Jackson P, Maclin K, Zhang J. Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J Cereb Blood Flow Metab 17:1137-1142;1997.
40. Wallis RA, Panizzon KL, Girard JM. Traumatic neuroprotection with inhibitors of nitric oxide and ADP-ribosylation. Brain Res 710:169-177;1996.
41. Wan FJ, Lin HC, Kang BH, Tseng CJ, Tung CS. D-amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment. Brain Res Bull 50:167-171;1999.
42. Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, Hong JS, Jeng KCG. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci 16:2102-2112;2002.
43. Yang J, Klaidman LK, Chang ML, Kem S, Sugawara T, Chan P, Adams JD. Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model. Pharmacol Biochem Behav 73:901-910;2002.
44. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275:1129-1132;1997.