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Volumn 36, Issue 2-3, 2004, Pages 98-107

Embryology of the upper limb: The molecular orchestration of morphogenesis

Author keywords

BMP; FGF; HOX genes; Limb anomalies; Limb development; Patterning; Review; SHH; Signal transduction; Transcription factors; WNT

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CELL NUCLEUS RECEPTOR; CELL SURFACE RECEPTOR; DNA; FIBROBLAST GROWTH FACTOR; FRIZZLED PROTEIN; GROWTH DIFFERENTIATION FACTOR 5; HELIX LOOP HELIX PROTEIN; NOTCH RECEPTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; WNT1 PROTEIN;

EID: 2642548296     PISSN: 07221819     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-817871     Document Type: Review
Times cited : (6)

References (65)
  • 1
    • 0035204194 scopus 로고    scopus 로고
    • BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb
    • Ahn K, Mishina Y, Hanks MC, Behringer RR, Crenshaw EB III: BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development 2001; 128: 4449-4461
    • (2001) Development , vol.128 , pp. 4449-4461
    • Ahn, K.1    Mishina, Y.2    Hanks, M.C.3    Behringer, R.R.4    Crenshaw III, E.B.5
  • 2
    • 0033506651 scopus 로고    scopus 로고
    • Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner
    • Asahara H, Dutta S, Kao HY, Evans RM, Montminy M: Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol 1999; 19: 8219-8225
    • (1999) Mol Cell Biol , vol.19 , pp. 8219-8225
    • Asahara, H.1    Dutta, S.2    Kao, H.Y.3    Evans, R.M.4    Montminy, M.5
  • 3
    • 0037093507 scopus 로고    scopus 로고
    • Three habits of highly effective signaling pathways: Principles of transcriptional control by developmental cell signaling
    • Barolo S, Posakony JW: Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling. Genes Dev 2002; 16; 1167-1181
    • (2002) Genes Dev , vol.16 , pp. 1167-1181
    • Barolo, S.1    Posakony, J.W.2
  • 4
    • 0037314332 scopus 로고    scopus 로고
    • Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge
    • Barrow JR, Thomas KR, Boussadia-Zahui O, Moore R, Kemler R, Capecchi MR, McMahon AP: Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev 2002; 17: 394-409
    • (2002) Genes Dev , vol.17 , pp. 394-409
    • Barrow, J.R.1    Thomas, K.R.2    Boussadia-Zahui, O.3    Moore, R.4    Kemler, R.5    Capecchi, M.R.6    McMahon, A.P.7
  • 5
    • 0035034042 scopus 로고    scopus 로고
    • A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-1
    • Brandau O, Meindl A, Fassler R, Aszodi A: A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-1. Dev Dyn 2001; 221: 72-80
    • (2001) Dev Dyn , vol.221 , pp. 72-80
    • Brandau, O.1    Meindl, A.2    Fassler, R.3    Aszodi, A.4
  • 7
    • 0028950248 scopus 로고
    • Hox genes and the evolution of vertebrate axial morphology
    • Burke AC, Nelson CE, Morgan BA, Tabin C: Hox genes and the evolution of vertebrate axial morphology. Development 1995; 121: 333-346
    • (1995) Development , vol.121 , pp. 333-346
    • Burke, A.C.1    Nelson, C.E.2    Morgan, B.A.3    Tabin, C.4
  • 9
    • 0029939199 scopus 로고    scopus 로고
    • Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus
    • Chang CP, Brocchieri L, Shen WF, Largman C, Cleary ML: Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol Cell Biol 1996; 16: 1734-1745
    • (1996) Mol Cell Biol , vol.16 , pp. 1734-1745
    • Chang, C.P.1    Brocchieri, L.2    Shen, W.F.3    Largman, C.4    Cleary, M.L.5
  • 10
    • 0028041418 scopus 로고
    • Ectopic expression of hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
    • Charité J, de Graaff W, Shen S, Deschamps J: Ectopic expression of hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell 1994; 78: 589-601
    • (1994) Cell , vol.78 , pp. 589-601
    • Charité, J.1    De Graaff, W.2    Shen, S.3    Deschamps, J.4
  • 11
    • 0034043442 scopus 로고    scopus 로고
    • The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development
    • Charité J, McFadden DG, Olson EN: The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development 2000; 127: 2461-2470
    • (2000) Development , vol.127 , pp. 2461-2470
    • Charité, J.1    McFadden, D.G.2    Olson, E.N.3
  • 13
    • 0031454063 scopus 로고    scopus 로고
    • Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants
    • Cygan JA, Johnson RL, McMahon AP: Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 1997; 124: 5021-5032
    • (1997) Development , vol.124 , pp. 5021-5032
    • Cygan, J.A.1    Johnson, R.L.2    McMahon, A.P.3
  • 14
    • 0034698302 scopus 로고    scopus 로고
    • Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling
    • Dahn RD, Fallon JF: Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling. Science 2000; 289: 438-441
    • (2000) Science , vol.289 , pp. 438-441
    • Dahn, R.D.1    Fallon, J.F.2
  • 15
    • 0024367398 scopus 로고
    • Differential expression of genes encoding a,b and g retinoic acid receptors and CRABP in the developing limbs of the mouse
    • Dolle P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P: Differential expression of genes encoding a,b and g retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature 1989; 342: 702-704
    • (1989) Nature , vol.342 , pp. 702-704
    • Dolle, P.1    Ruberte, E.2    Kastner, P.3    Petkovich, M.4    Stoner, C.M.5    Gudas, L.J.6    Chambon, P.7
  • 16
    • 0031752664 scopus 로고    scopus 로고
    • Vertebrate hox gene regulation: Clustering and/or colinearity?
    • Duboule D: Vertebrate hox gene regulation: clustering and/or colinearity? Curr Opin Genet Dev 1998; 8: 514-518
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 514-518
    • Duboule, D.1
  • 17
    • 0036682108 scopus 로고    scopus 로고
    • A re-examination of proximodistal patterning during vertebrate limb development
    • Dudley AT, Ros MA, Tabin CJ: A re-examination of proximodistal patterning during vertebrate limb development. Nature 2002; 418: 539-544
    • (2002) Nature , vol.418 , pp. 539-544
    • Dudley, A.T.1    Ros, M.A.2    Tabin, C.J.3
  • 18
    • 0034665885 scopus 로고    scopus 로고
    • csal1 is controlled by a combination of FGF and Wnt signals in developing limb buds
    • Farrell ER, Munsterberg AE: csal1 is controlled by a combination of FGF and Wnt signals in developing limb buds. Dev Biol 2000; 225: 447-458
    • (2000) Dev Biol , vol.225 , pp. 447-458
    • Farrell, E.R.1    Munsterberg, A.E.2
  • 19
  • 20
    • 0032869218 scopus 로고    scopus 로고
    • 1998 Warkany lecture: Signaling pathways in development
    • Gerhart J: 1998 Warkany lecture: Signaling pathways in development. Teratology 1999; 60: 226-239
    • (1999) Teratology , vol.60 , pp. 226-239
    • Gerhart, J.1
  • 22
    • 0030477866 scopus 로고    scopus 로고
    • The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: Implications for the mechanism of apical ridge formation
    • Grieshammer U, Minowada G, Pisenti JM, Abbott UK, Martin GR: The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation. Development 1996; 122: 3851-3861
    • (1996) Development , vol.122 , pp. 3851-3861
    • Grieshammer, U.1    Minowada, G.2    Pisenti, J.M.3    Abbott, U.K.4    Martin, G.R.5
  • 23
    • 0032701418 scopus 로고    scopus 로고
    • Expression pattern of Dkk-1 during mouse limb development
    • Grotewold L, Theil T, Ruther U: Expression pattern of Dkk-1 during mouse limb development. Mech Dev 1999; 89: 151-153
    • (1999) Mech Dev , vol.89 , pp. 151-153
    • Grotewold, L.1    Theil, T.2    Ruther, U.3
  • 24
    • 0028944665 scopus 로고
    • Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    • Halder G, Callaerts P, Gehring WJ: Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 1995; 267: 1788-1792
    • (1995) Science , vol.267 , pp. 1788-1792
    • Halder, G.1    Callaerts, P.2    Gehring, W.J.3
  • 25
    • 0028171254 scopus 로고
    • Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud
    • Helms J, Thaller C, Eichele G: Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud. Development 1994; 120: 3267-3274
    • (1994) Development , vol.120 , pp. 3267-3274
    • Helms, J.1    Thaller, C.2    Eichele, G.3
  • 26
    • 0026427261 scopus 로고
    • Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
    • Izpisua-Belmonte JC, Tickle C, Dolle P, Wolpert L, Duboule D: Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature 1991; 350: 585-589
    • (1991) Nature , vol.350 , pp. 585-589
    • Izpisua-Belmonte, J.C.1    Tickle, C.2    Dolle, P.3    Wolpert, L.4    Duboule, D.5
  • 27
    • 0030968579 scopus 로고    scopus 로고
    • Molecular models for vertebrate limb development
    • Johnson RL, Tabin CJ: Molecular models for vertebrate limb development. Cell 1997; 90: 979-990
    • (1997) Cell , vol.90 , pp. 979-990
    • Johnson, R.L.1    Tabin, C.J.2
  • 28
    • 0034541308 scopus 로고    scopus 로고
    • Involvement of frizzled-10 in Wnt-7a signaling during chick limb development
    • Kawakami Y, Wada N, Nishimatsu S, Nohno T: Involvement of frizzled-10 in Wnt-7a signaling during chick limb development. Dev Growth Differ 2000; 42: 561-569
    • (2000) Dev Growth Differ , vol.42 , pp. 561-569
    • Kawakami, Y.1    Wada, N.2    Nishimatsu, S.3    Nohno, T.4
  • 29
    • 0036403250 scopus 로고    scopus 로고
    • Different regulation of T-Box genes Tbx4 and Tbx5 during limb development and limb regeneration
    • Khan P, Linkhart B, Simon H: Different regulation of T-Box genes Tbx4 and Tbx5 during limb development and limb regeneration. Dev Biol 2002; 250: 383
    • (2002) Dev Biol , vol.250 , pp. 383
    • Khan, P.1    Linkhart, B.2    Simon, H.3
  • 31
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C: Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 2002; 418: 979-983
    • (2002) Nature , vol.418 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 32
    • 0031000392 scopus 로고    scopus 로고
    • Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation
    • Lu HC, Revelli JP, Goering L, Thaller C, Eichele G: Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development 1997; 124: 1643-1651
    • (1997) Development , vol.124 , pp. 1643-1651
    • Lu, H.C.1    Revelli, J.P.2    Goering, L.3    Thaller, C.4    Eichele, G.5
  • 33
    • 0029898760 scopus 로고    scopus 로고
    • Extra specificity from extradenticle:the partnership between HOX and PBX/EXD homeodomain proteins
    • Mann RS, Chan S-K: Extra specificity from extradenticle:the partnership between HOX and PBX/EXD homeodomain proteins. TIG 1996; 12: 258-262
    • (1996) TIG , vol.12 , pp. 258-262
    • Mann, R.S.1    Chan, S.-K.2
  • 34
    • 2642595047 scopus 로고    scopus 로고
    • The roles of FGFs in the early development of vertebrate limbs
    • Martin GR: The roles of FGFs in the early development of vertebrate limbs. Genes Dev 1998; 12: 1571-1586
    • (1998) Genes Dev , vol.12 , pp. 1571-1586
    • Martin, G.R.1
  • 35
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A: p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398: 708-713
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 37
    • 0036678603 scopus 로고    scopus 로고
    • Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
    • Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dolle P: Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. Development 2002; 129: 3563-3574
    • (2002) Development , vol.129 , pp. 3563-3574
    • Niederreither, K.1    Vermot, J.2    Schuhbaur, B.3    Chambon, P.4    Dolle, P.5
  • 38
    • 0036059099 scopus 로고    scopus 로고
    • Twist plays an essential role in FGF and SHH signal transduction during mouse limb development
    • O'Rourke MP, Soo K, Behringer RR, Hui CC, Tam PP: Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol 2002; 248: 143-156
    • (2002) Dev Biol , vol.248 , pp. 143-156
    • O'Rourke, M.P.1    Soo, K.2    Behringer, R.R.3    Hui, C.C.4    Tam, P.P.5
  • 39
    • 0007407122 scopus 로고    scopus 로고
    • Hox gene expression and regulation in the presumptive wing region of the chick lateral plate mesoderm
    • Abstract
    • Oberg KC, Eichele G: Hox gene expression and regulation in the presumptive wing region of the chick lateral plate mesoderm. Dev Biol 1999; 210: 228 (Abstract)
    • (1999) Dev Biol , vol.210 , pp. 228
    • Oberg, K.C.1    Eichele, G.2
  • 40
    • 0033386886 scopus 로고    scopus 로고
    • FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm, independent of its dorsoventral specification
    • Ohuchi H, Nakagawa T, Itoh N, Noji S: FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm, independent of its dorsoventral specification. Dev Growth Differ 1999; 41: 665-673
    • (1999) Dev Growth Differ , vol.41 , pp. 665-673
    • Ohuchi, H.1    Nakagawa, T.2    Itoh, N.3    Noji, S.4
  • 43
    • 0030602012 scopus 로고    scopus 로고
    • Surgical removal of limb bud. Sonic hedgehog results in posterior skeletal defects
    • Pagan SM, Ros MA, Tabin C, Fallon JF: Surgical removal of limb bud. Sonic hedgehog results in posterior skeletal defects. Dev Biol 1996; 180: 35-40
    • (1996) Dev Biol , vol.180 , pp. 35-40
    • Pagan, S.M.1    Ros, M.A.2    Tabin, C.3    Fallon, J.F.4
  • 44
    • 0028951117 scopus 로고
    • Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb
    • Parr BA, McMahon AP: Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 1995; 374: 350-353
    • (1995) Nature , vol.374 , pp. 350-353
    • Parr, B.A.1    McMahon, A.P.2
  • 45
    • 0030894303 scopus 로고    scopus 로고
    • Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and engrailed proteins
    • Peltenburg LT, Murre C: Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and engrailed proteins. Development 1997; 124: 1089-1098
    • (1997) Development , vol.124 , pp. 1089-1098
    • Peltenburg, L.T.1    Murre, C.2
  • 46
    • 24244468743 scopus 로고    scopus 로고
    • Genetic analysis of fgf gene function in the limb
    • Abstract
    • Peterson C, Martin G: Genetic analysis of fgf gene function in the limb. Dev Biol 2002; 247: LB35 (Abstract)
    • (2002) Dev Biol , vol.247
    • Peterson, C.1    Martin, G.2
  • 47
    • 0035199029 scopus 로고    scopus 로고
    • BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb
    • Pizette S, Abate-Shen C, Niswander L: BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 2001; 128: 4463-4474
    • (2001) Development , vol.128 , pp. 4463-4474
    • Pizette, S.1    Abate-Shen, C.2    Niswander, L.3
  • 48
    • 0033042804 scopus 로고    scopus 로고
    • BMPs negatively regulate structure and function of the limb apical ectodermal ridge
    • Pizette S, Niswander L: BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development 1999; 126: 883-894
    • (1999) Development , vol.126 , pp. 883-894
    • Pizette, S.1    Niswander, L.2
  • 49
    • 0028848301 scopus 로고
    • Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb
    • Riddle RD, Ensini M, Nelson C, Tsuchida T, Jessell TM, Tabin C: Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 1995; 83: 631-640
    • (1995) Cell , vol.83 , pp. 631-640
    • Riddle, R.D.1    Ensini, M.2    Nelson, C.3    Tsuchida, T.4    Jessell, T.M.5    Tabin, C.6
  • 50
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle RD, Johnson RL, Laufer E, Tabin C: Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 1993; 75: 1401-1416
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 53
    • 0029790405 scopus 로고    scopus 로고
    • The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions
    • Ros MA, Lopez-Martinez A, Simandl BK, Rodriguez C, Izpisua Belmonte JC, Dahn R, Fallon JF: The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions. Development 1996; 122: 2319-2330
    • (1996) Development , vol.122 , pp. 2319-2330
    • Ros, M.A.1    Lopez-Martinez, A.2    Simandl, B.K.3    Rodriguez, C.4    Izpisua Belmonte, J.C.5    Dahn, R.6    Fallon, J.F.7
  • 54
    • 0035087189 scopus 로고    scopus 로고
    • Differential tissue growth and patterns of cell death in mouse limb autopod morphogenesis
    • Salas-Vidal E, Valencia C, Covarrubias L: Differential tissue growth and patterns of cell death in mouse limb autopod morphogenesis. Dev Dyn 2001; 220: 295-306
    • (2001) Dev Dyn , vol.220 , pp. 295-306
    • Salas-Vidal, E.1    Valencia, C.2    Covarrubias, L.3
  • 57
    • 0034103657 scopus 로고    scopus 로고
    • Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
    • Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE Jr, Martin GR: Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet 2000; 25: 83-86
    • (2000) Nat Genet , vol.25 , pp. 83-86
    • Sun, X.1    Lewandoski, M.2    Meyers, E.N.3    Liu, Y.H.4    Maxson Jr., R.E.5    Martin, G.R.6
  • 58
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • Taipale J, Cooper MK, Maiti T, Beachy PA: Patched acts catalytically to suppress the activity of Smoothened. Nature 2002; 418: 892-897
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 59
    • 0034529367 scopus 로고    scopus 로고
    • Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development
    • Tavares AT, Tsukui T, Izpisua Belmonte JC: Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development. Development 2000; 127: 5133-5144
    • (2000) Development , vol.127 , pp. 5133-5144
    • Tavares, A.T.1    Tsukui, T.2    Izpisua Belmonte, J.C.3
  • 61
    • 0029563650 scopus 로고
    • Dorsal cell fate specified by chick Lmxl during vertebrate limb development
    • Vogel A, Rodriguez C, Warnken W, Izpisua Belmonte JC: Dorsal cell fate specified by chick Lmxl during vertebrate limb development. Nature 1995; 378: 716-720
    • (1995) Nature , vol.378 , pp. 716-720
    • Vogel, A.1    Rodriguez, C.2    Warnken, W.3    Izpisua Belmonte, J.C.4
  • 62
    • 0034928718 scopus 로고    scopus 로고
    • Differential response of Shh expression between chick forelimb and hindlimb buds by FGF-4
    • Wada N, Nohno T: Differential response of Shh expression between chick forelimb and hindlimb buds by FGF-4. Dev Dyn 2001; 221: 402-411
    • (2001) Dev Dyn , vol.221 , pp. 402-411
    • Wada, N.1    Nohno, T.2
  • 63
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang B, Fallon JF, Beachy PA: Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 2000; 100: 423-434
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 64
    • 0030726459 scopus 로고    scopus 로고
    • Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function
    • Xu PX, Cheng J, Epstein JA, Maas RL: Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proc Natl Acad Sci USA 1997; 94: 11974-11979
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11974-11979
    • Xu, P.X.1    Cheng, J.2    Epstein, J.A.3    Maas, R.L.4
  • 65
    • 0025820077 scopus 로고
    • Homeobox gene expression correlated with the bifurcation process of limb cartilage development
    • Yokouchi Y, Sasaki H, Kuroiwa A: Homeobox gene expression correlated with the bifurcation process of limb cartilage development. Nature 1991; 353: 443-445
    • (1991) Nature , vol.353 , pp. 443-445
    • Yokouchi, Y.1    Sasaki, H.2    Kuroiwa, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.