-
1
-
-
0037483895
-
The global burden of disease 2000 project: Aims, methods and data sources
-
No. 36. Geneva, World Health Organization
-
Murray CJL, Lopez AD, Mathers CD, Stein C. The global burden of disease 2000 project: aims, methods and data sources. Global Programme on Evidence for Health Policy -Discussion Papers, No. 36. Geneva, World Health Organization (2001).
-
(2001)
Global Programme on Evidence for Health Policy - Discussion Papers
-
-
Murray, C.J.L.1
Lopez, A.D.2
Mathers, C.D.3
Stein, C.4
-
2
-
-
0037458552
-
Atrial fibrillation as a contributing cause of death and Medicare hospitalization - United States, 1999
-
Atrial fibrillation as a contributing cause of death and Medicare hospitalization - United States, 1999. MMWR 52, 128-131 (2003).
-
(2003)
MMWR
, vol.52
, pp. 128-131
-
-
-
3
-
-
0038548084
-
Public health and aging: Hospitalizations for stroke among adults aged 65 years or over - United States, 2000
-
Public health and aging: hospitalizations for stroke among adults aged 65 years or over - United States, 2000. MMWR 52, 586-589 (2003).
-
(2003)
MMWR
, vol.52
, pp. 586-589
-
-
-
4
-
-
0003775053
-
Heart disease and stroke statistics - 2003 update
-
American Heart Association
-
American Heart Association. Heart disease and stroke statistics - 2003 update (2002).
-
(2002)
-
-
-
5
-
-
0025779484
-
Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
-
Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 22, 983-988 (1991).
-
(1991)
Stroke
, vol.22
, pp. 983-988
-
-
Wolf, P.A.1
Abbott, R.D.2
Kannel, W.B.3
-
6
-
-
0035810152
-
Atrial fibrillation
-
Falk RH. Atrial fibrillation. N. Engl. J. Med. 344, 1067-1078 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1067-1078
-
-
Falk, R.H.1
-
7
-
-
0037322578
-
Atrial fibrillation and the prothrombotic state in the elderly: The Rotterdam Study
-
Conway DS, Heeringa J, Van Der Kuip DA et al. Atrial fibrillation and the prothrombotic state in the elderly: the Rotterdam Study. Stroke 34, 413-417 (2003).
-
(2003)
Stroke
, vol.34
, pp. 413-417
-
-
Conway, D.S.1
Heeringa, J.2
Van Der Kuip, D.A.3
-
8
-
-
0030818521
-
Nonvalvular atrial fibrillation: Evidence for a prothrombotic state
-
Kahn SR, Solymoss S, Flegel KM. Nonvalvular atrial fibrillation: evidence for a prothrombotic state. Can. Med. Assoc. J. 157, 673-681 (1997).
-
(1997)
Can. Med. Assoc. J.
, vol.157
, pp. 673-681
-
-
Kahn, S.R.1
Solymoss, S.2
Flegel, K.M.3
-
9
-
-
0038417537
-
Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation
-
Conway DS, Pearce LA, Chin BS, Hart RG, Lip GY. Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation. Circulation 107, 3141-3145 (2003).
-
(2003)
Circulation
, vol.107
, pp. 3141-3145
-
-
Conway, D.S.1
Pearce, L.A.2
Chin, B.S.3
Hart, R.G.4
Lip, G.Y.5
-
10
-
-
0027505093
-
Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
-
EAFT (European Atrial Fibrillation Trial Study Group)
-
EAFT (European Atrial Fibrillation Trial Study Group). Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 342, 1255-1262 (1993).
-
(1993)
Lancet
, vol.342
, pp. 1255-1262
-
-
-
11
-
-
0035128599
-
Antithrombotic therapy in atrial fibrillation
-
Albers GW, Dalen JE, Laupacis A et al. Antithrombotic therapy in atrial fibrillation. Chest 119, 194S-206S (2001).
-
(2001)
Chest
, vol.119
-
-
Albers, G.W.1
Dalen, J.E.2
Laupacis, A.3
-
12
-
-
0033866204
-
Functional outcome in stroke patients with atrial fibrillation
-
Karatas M, Dilek A, Erkan H et al. Functional outcome in stroke patients with atrial fibrillation. Arch. Phys. Med. Rehabil. 81, 1025-1029 (2000).
-
(2000)
Arch. Phys. Med. Rehabil.
, vol.81
, pp. 1025-1029
-
-
Karatas, M.1
Dilek, A.2
Erkan, H.3
-
13
-
-
0037221236
-
Atrial fibrillation is associated with severe acute ischemic stroke
-
Dulli DA, Stanko H, Levine RL. Atrial fibrillation is associated with severe acute ischemic stroke. Neuroepidemiology 22, 118-123 (2003).
-
(2003)
Neuroepidemiology
, vol.22
, pp. 118-123
-
-
Dulli, D.A.1
Stanko, H.2
Levine, R.L.3
-
14
-
-
0036843745
-
Atrial fibrillation, stroke and acute antithrombotic therapy: Analysis of randomized clinical trials
-
Hart RG, Palacio S, Pearce LA. Atrial fibrillation, stroke and acute antithrombotic therapy: analysis of randomized clinical trials. Stroke 33, 2722-2727 (2002).
-
(2002)
Stroke
, vol.33
, pp. 2722-2727
-
-
Hart, R.G.1
Palacio, S.2
Pearce, L.A.3
-
15
-
-
0028921708
-
Prevalence, age distribution and gender of patients with atrial fibrillation. Analysis and implications
-
Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution and gender of patients with atrial fibrillation. Analysis and implications. Arch. Intern. Med. 155, 469-473 (1995).
-
(1995)
Arch. Intern. Med.
, vol.155
, pp. 469-473
-
-
Feinberg, W.M.1
Blackshear, J.L.2
Laupacis, A.3
Kronmal, R.4
Hart, R.G.5
-
16
-
-
0038375709
-
Prevalence of five common clinical abnormalities in very elderly people: Population based cross sectional study
-
de Craen AJ, Gussekloo J, Teng YK, Macfarlane PW, Westendorp RG. Prevalence of five common clinical abnormalities in very elderly people: population based cross sectional study. Br. Med. J. 327, 131-132 (2003).
-
(2003)
Br. Med. J.
, vol.327
, pp. 131-132
-
-
de Craen, A.J.1
Gussekloo, J.2
Teng, Y.K.3
Macfarlane, P.W.4
Westendorp, R.G.5
-
17
-
-
0043164965
-
Increasing trends in hospitalization for atrial fibrillation in the United States, 1985 through 1999: Implications for primary prevention
-
Wattigney WA, Mensah GA, Croft JB. Increasing trends in hospitalization for atrial fibrillation in the United States, 1985 through 1999: implications for primary prevention. Circulation 108, 711-716 (2003).
-
(2003)
Circulation
, vol.108
, pp. 711-716
-
-
Wattigney, W.A.1
Mensah, G.A.2
Croft, J.B.3
-
18
-
-
0004035658
-
-
United Nations. ESA/P/WP.165. United Nations, NY, USA
-
United Nations. World Population Prospects. The 2002 Revision. ESA/P/WP.165. United Nations, NY, USA (2001).
-
(2001)
World Population Prospects. The 2002 Revision
-
-
-
19
-
-
0037629032
-
The prevalence of atrial fibrillation in incident stroke cases and matched population controls in Rochester, Minnesota: Changes over three decades
-
Tsang TS, Petty GW, Barnes ME et al. The prevalence of atrial fibrillation in incident stroke cases and matched population controls in Rochester, Minnesota: changes over three decades. J. Am. Coll. Cardiol. 42, 93-100 (2003).
-
(2003)
J. Am. Coll. Cardiol.
, vol.42
, pp. 93-100
-
-
Tsang, T.S.1
Petty, G.W.2
Barnes, M.E.3
-
20
-
-
0035155445
-
ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation
-
Fuster V, Ryden LE, Asinger RW et al. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to develop guidelines for the management of patients with atrial fibrillation) developed in collaboration with the North American Society of Pacing and Electrophysiology. Eur. Heart J. 22, 1852-1923 (2001).
-
(2001)
Eur. Heart J.
, vol.22
, pp. 1852-1923
-
-
Fuster, V.1
Ryden, L.E.2
Asinger, R.W.3
-
21
-
-
0032497292
-
Impact of atrial fibrillation on the risk of death: The Framingham Heart Study
-
Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 98, 946-952 (1998).
-
(1998)
Circulation
, vol.98
, pp. 946-952
-
-
Benjamin, E.J.1
Wolf, P.A.2
D'Agostino, R.B.3
Silbershatz, H.4
Kannel, W.B.5
Levy, D.6
-
22
-
-
0028244264
-
Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials
-
Atrial Fibrillation Investigators
-
Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Arch. Intern. Med. 154, 1449-1457 (1994).
-
(1994)
Arch. Intern. Med.
, vol.154
, pp. 1449-1457
-
-
-
23
-
-
0033527355
-
Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: A meta-analysis
-
Hart RG, Benavente O, McBride R, Pearce LA. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann. Intern. Med. 131, 492-501 (1999).
-
(1999)
Ann. Intern. Med.
, vol.131
, pp. 492-501
-
-
Hart, R.G.1
Benavente, O.2
McBride, R.3
Pearce, L.A.4
-
24
-
-
0035128503
-
Oral anticoagulants: Mechanism of action, clinical effectiveness and optimal therapeutic range
-
Hirsh J, Dalen J, Anderson DR et al. Oral anticoagulants: mechanism of action, clinical effectiveness and optimal therapeutic range. Chest 119, S8-S21 (2001).
-
(2001)
Chest
, vol.119
-
-
Hirsh, J.1
Dalen, J.2
Anderson, D.R.3
-
25
-
-
0030707669
-
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis
-
Elg M, Gustafsson D, Deinum J. The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis. Thromb. Haemost. 78, 1286-1292 (1997).
-
(1997)
Thromb. Haemost.
, vol.78
, pp. 1286-1292
-
-
Elg, M.1
Gustafsson, D.2
Deinum, J.3
-
26
-
-
0033135457
-
Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rat
-
Elg M, Gustafsson D, Carlsson S. Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rat. Thromb. Res. 94, 187-197 (1999).
-
(1999)
Thromb. Res.
, vol.94
, pp. 187-197
-
-
Elg, M.1
Gustafsson, D.2
Carlsson, S.3
-
27
-
-
0028576943
-
Interactions of warfarin with drugs and food
-
Wells PS, Holbrook AM, Crowther NR, Hirsh J. Interactions of warfarin with drugs and food. Ann. Intern. Med. 121, 676-683 (1994).
-
(1994)
Ann. Intern. Med.
, vol.121
, pp. 676-683
-
-
Wells, P.S.1
Holbrook, A.M.2
Crowther, N.R.3
Hirsh, J.4
-
28
-
-
0033608466
-
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
-
Aithal GP, Day CP, Kesteven PJ, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet 353, 717-719 (1999).
-
(1999)
Lancet
, vol.353
, pp. 717-719
-
-
Aithal, G.P.1
Day, C.P.2
Kesteven, P.J.3
Daly, A.K.4
-
29
-
-
0036194038
-
The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin
-
Tabrizi AR, Zehnbauer BA, Borecki IB et al. The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin. J. Am. Coll. Surg. 194, 267-273 (2002).
-
(2002)
J. Am. Coll. Surg.
, vol.194
, pp. 267-273
-
-
Tabrizi, A.R.1
Zehnbauer, B.A.2
Borecki, I.B.3
-
31
-
-
0035909047
-
Clinical predictors of prolonged delay in return of the international normalized ratio to within the therapeutic range after excessive anticoagulation with warfarin
-
Hylek EM, Regan S, Go AS et al. Clinical predictors of prolonged delay in return of the international normalized ratio to within the therapeutic range after excessive anticoagulation with warfarin. Ann. Intern. Med. 135, 393-400 (2001).
-
(2001)
Ann. Intern. Med.
, vol.135
, pp. 393-400
-
-
Hylek, E.M.1
Regan, S.2
Go, A.S.3
-
32
-
-
0035125403
-
Managing oral anticoagulant therapy
-
Ansell J, Hirsh J, Dalen J et al. Managing oral anticoagulant therapy. Chest 119, S22-S38 (2001).
-
(2001)
Chest
, vol.119
-
-
Ansell, J.1
Hirsh, J.2
Dalen, J.3
-
33
-
-
0042387879
-
Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation
-
Hylek EM, Go AS, Chang Y et al. Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation. N. Engl. J. Med. 349, 1019-1026 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1019-1026
-
-
Hylek, E.M.1
Go, A.S.2
Chang, Y.3
-
34
-
-
0034627893
-
Why do patients with atrial fibrillation not receive warfarin?
-
Bungard TJ, Ghali WA, Teo KK, McAlister FA, Tsuyuki RT. Why do patients with atrial fibrillation not receive warfarin? Arch. Intern. Med. 160, 41-46 (2000).
-
(2000)
Arch. Intern. Med.
, vol.160
, pp. 41-46
-
-
Bungard, T.J.1
Ghali, W.A.2
Teo, K.K.3
McAlister, F.A.4
Tsuyuki, R.T.5
-
35
-
-
0030473468
-
Failure to prescribe warfarin to patients with nonrheumatic atrial fibrillation
-
Antani MR, Beyth RJ, Covinsky KE et al. Failure to prescribe warfarin to patients with nonrheumatic atrial fibrillation. J. Gen. Intern. Med. 11, 713-720 (1996).
-
(1996)
J. Gen. Intern. Med.
, vol.11
, pp. 713-720
-
-
Antani, M.R.1
Beyth, R.J.2
Covinsky, K.E.3
-
36
-
-
0027965628
-
Anticoagulation in atrial fibrillation. Does efficacy in clinical trials translate into effectiveness in practice?
-
Gottlieb LK, Salem-Schatz S. Anticoagulation in atrial fibrillation. Does efficacy in clinical trials translate into effectiveness in practice? Arch. Intern. Med. 154, 1945-1953 (1994).
-
(1994)
Arch. Intern. Med.
, vol.154
, pp. 1945-1953
-
-
Gottlieb, L.K.1
Salem-Schatz, S.2
-
37
-
-
0030964477
-
Atrial fibrillation and stroke prevention with warfarin in the long-term care setting
-
Gurwritz JH, Monette J, Rochon PA, Eckler MA, Avorn J. Atrial fibrillation and stroke prevention with warfarin in the long-term care setting. Arch. Intern. Med. 157, 978-984 (1997).
-
(1997)
Arch. Intern. Med.
, vol.157
, pp. 978-984
-
-
Gurwritz, J.H.1
Monette, J.2
Rochon, P.A.3
Eckler, M.A.4
Avorn, J.5
-
38
-
-
0033958893
-
Can warfarin randomized trials be reproduced in 'real life'? Adherence to warfarin guidelines for intensity of anticoagulation in a university-based warfarin clinic
-
Malik AK, Taylor AJ. Can warfarin randomized trials be reproduced in 'real life'? Adherence to warfarin guidelines for intensity of anticoagulation in a university-based warfarin clinic. South Med. J. 93, 58-61 (2000).
-
(2000)
South Med. J.
, vol.93
, pp. 58-61
-
-
Malik, A.K.1
Taylor, A.J.2
-
39
-
-
0035128439
-
New anticoagulant drugs
-
Weitz JI, Hirsh J. New anticoagulant drugs. Chest 119, S95-S107 (2001).
-
(2001)
Chest
, vol.119
-
-
Weitz, J.I.1
Hirsh, J.2
-
40
-
-
0035159740
-
Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study
-
Abraham E, Reinhart K, Svoboda P et al. Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study. Crit. Care Med. 29, 2081-2089 (2001).
-
(2001)
Crit. Care Med.
, vol.29
, pp. 2081-2089
-
-
Abraham, E.1
Reinhart, K.2
Svoboda, P.3
-
41
-
-
0035800075
-
Dose-response study of recombinant Factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
-
Lee A, Agnelli G, Buller H et al. Dose-response study of recombinant Factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation 104, 74-78 (2001).
-
(2001)
Circulation
, vol.104
, pp. 74-78
-
-
Lee, A.1
Agnelli, G.2
Buller, H.3
-
42
-
-
0035522304
-
Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery
-
Bauer KA, Eriksson BI, Lassen MR, Turpie AG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. N. Engl. J. Med. 345, 1305-1310 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1305-1310
-
-
Bauer, K.A.1
Eriksson, B.I.2
Lassen, M.R.3
Turpie, A.G.4
-
43
-
-
0037150191
-
First experience with direct Factor Xa inhibition in patients with stable coronary disease: A pharmacokinetic and pharmacodynamic evaluation
-
Dyke CK, Becker RC, Kleiman NS et al. First experience with direct Factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation. Circulation 105, 2385-2391 (2002).
-
(2002)
Circulation
, vol.105
, pp. 2385-2391
-
-
Dyke, C.K.1
Becker, R.C.2
Kleiman, N.S.3
-
44
-
-
0033957888
-
Nonpeptide Factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics
-
Wong PC, Quan ML, Crain EJ et al. Nonpeptide Factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics. J. Pharmacol. Exp. Ther. 292, 351-357 (2000).
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.292
, pp. 351-357
-
-
Wong, P.C.1
Quan, M.L.2
Crain, E.J.3
-
45
-
-
0031888018
-
Biochemical and pharmacological characterization of YM-60828, a newly synthesized and orally-active inhibitor of human Factor Xa
-
Taniuchi Y, Sakai Y, Hisamichi N et al. Biochemical and pharmacological characterization of YM-60828, a newly synthesized and orally-active inhibitor of human Factor Xa. Thromb. Haemost. 79, 543-548 (1998).
-
(1998)
Thromb. Haemost.
, vol.79
, pp. 543-548
-
-
Taniuchi, Y.1
Sakai, Y.2
Hisamichi, N.3
-
46
-
-
0035125405
-
Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy and safety
-
Hirsh J, Warkentin TE, Shaughnessy SG et al. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy and safety. Chest 119, S64-S94 (2001).
-
(2001)
Chest
, vol.119
-
-
Hirsh, J.1
Warkentin, T.E.2
Shaughnessy, S.G.3
-
47
-
-
17644442033
-
Orally administered heparin for preventing deep venous thrombosis
-
Gonze MD, Manord JD, Leone-Bay A et al. Orally administered heparin for preventing deep venous thrombosis. Am. J. Surg. 176, 176-178 (1998).
-
(1998)
Am. J. Surg.
, vol.176
, pp. 176-178
-
-
Gonze, M.D.1
Manord, J.D.2
Leone-Bay, A.3
-
48
-
-
0034612268
-
Orally administered unfractionated heparin with carrier agent is therapeutic for deep venous thrombosis
-
Gonze MD, Salartash K, Sternbergh WC III et al. Orally administered unfractionated heparin with carrier agent is therapeutic for deep venous thrombosis. Circulation 101, 2658-2661 (2000).
-
(2000)
Circulation
, vol.101
, pp. 2658-2661
-
-
Gonze, M.D.1
Salartash, K.2
Sternbergh III, W.C.3
-
50
-
-
0030722727
-
A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement
-
Eriksson BI, Wille-Jorgensen P, Kalebo P et al. A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement. N. Engl. J. Med. 337, 1329-1335 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1329-1335
-
-
Eriksson, B.I.1
Wille-Jorgensen, P.2
Kalebo, P.3
-
51
-
-
0031793581
-
New treatment options for heparin-induced thrombocytopenia
-
Ortel TL, Chong BH. New treatment options for heparin-induced thrombocytopenia. Semin. Hematol. 35, 26-34 (1998).
-
(1998)
Semin. Hematol.
, vol.35
, pp. 26-34
-
-
Ortel, T.L.1
Chong, B.H.2
-
52
-
-
0035836541
-
Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia
-
Lewis BE, Wallis DE, Berkowitz SD et al. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 103, 1838-1843 (2001).
-
(2001)
Circulation
, vol.103
, pp. 1838-1843
-
-
Lewis, B.E.1
Wallis, D.E.2
Berkowitz, S.D.3
-
54
-
-
19244378454
-
Discovery and development of the novel potent orally-active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): Coapplication of structure-based design and rapid multiple analogue synthesis on solid support
-
Brady SF, Stauffer KJ, Lumma WC et al. Discovery and development of the novel potent orally-active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on solid support. J. Med. Chem. 41, 401-406 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 401-406
-
-
Brady, S.F.1
Stauffer, K.J.2
Lumma, W.C.3
-
55
-
-
0034526532
-
The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis
-
McClanahan TB, Hicks GW, Ignasiak DP et al. The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis. J. Thromb. Thrombol. 10, 277-284 (2000).
-
(2000)
J. Thromb. Thrombol.
, vol.10
, pp. 277-284
-
-
McClanahan, T.B.1
Hicks, G.W.2
Ignasiak, D.P.3
-
56
-
-
19244385909
-
Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor
-
Oh YS, Yuri M, Hwang SY et al. Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. Bioorg. Med. Chem. Lett. 8, 631-634 (1998).
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 631-634
-
-
Oh, Y.S.1
Yuri, M.2
Hwang, S.Y.3
-
57
-
-
0036628436
-
BIBR-1048 Boehringer Ingelheim
-
Mungall D. BIBR-1048 Boehringer Ingelheim. Curr. Opin. Investig. Drugs 3, 905-907 (2002).
-
(2002)
Curr. Opin. Investig. Drugs
, vol.3
, pp. 905-907
-
-
Mungall, D.1
-
58
-
-
0141750717
-
Oral direct thrombin inhibitors in clinical development
-
Gustafsson D. Oral direct thrombin inhibitors in clinical development. J. Intern. Med. 254, 322-334 (2003).
-
(2003)
J. Intern. Med.
, vol.254
, pp. 322-334
-
-
Gustafsson, D.1
-
59
-
-
0141849427
-
Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism, following total hip replacement. A randomized, double-blind study
-
Colwell CW, Berkowitz SD, Davidson BL et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism, following total hip replacement. A randomized, double-blind study. J. Thromb. Haemost. 1, 2119-2130 (2003).
-
(2003)
J. Thromb. Haemost.
, vol.1
, pp. 2119-2130
-
-
Colwell, C.W.1
Berkowitz, S.D.2
Davidson, B.L.3
-
60
-
-
0037048939
-
Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: The METHRO II randomised trial
-
Eriksson BI, Bergqvist D, Kalebo P et al. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. Lancet 360, 1441-1447 (2002).
-
(2002)
Lancet
, vol.360
, pp. 1441-1447
-
-
Eriksson, B.I.1
Bergqvist, D.2
Kalebo, P.3
-
61
-
-
0037329702
-
Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement: The METHRO III study
-
Eriksson BI, Agnelli G, Cohen AT et al. Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO III study. Thromb. Haemost. 89, 288-296 (2003).
-
(2003)
Thromb. Haemost.
, vol.89
, pp. 288-296
-
-
Eriksson, B.I.1
Agnelli, G.2
Cohen, A.T.3
-
62
-
-
0037108825
-
Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial
-
Francis CW, Davidson BL, Berkowitz SD et al. Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial. Ann. Intern. Med. 137, 648-655 (2002).
-
(2002)
Ann. Intern. Med.
, vol.137
, pp. 648-655
-
-
Francis, C.W.1
Davidson, B.L.2
Berkowitz, S.D.3
-
63
-
-
0742284689
-
The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: The EXPRESS study
-
Eriksson BI, Agnelli G, Cohen AT et al. The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: the EXPRESS study. J. Thromb. Haemost. 1(12), 2490-2496 (2003).
-
(2003)
J. Thromb. Haemost.
, vol.1
, Issue.12
, pp. 2490-2496
-
-
Eriksson, B.I.1
Agnelli, G.2
Cohen, A.T.3
-
64
-
-
0035829034
-
Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: A Phase II dose-finding study
-
Heit JA, Colwell CW, Francis CW et al. Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a Phase II dose-finding study. Arch. Intern. Med. 161, 2215-2221 (2001).
-
(2001)
Arch. Intern. Med.
, vol.161
, pp. 2215-2221
-
-
Heit, J.A.1
Colwell, C.W.2
Francis, C.W.3
-
65
-
-
0142151552
-
Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement
-
Francis CW, Berkowitz SD, Comp PC et al. Comparison of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism after Total Knee Replacement. N. Engl. J. Med. 349, 1703-1712 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1703-1712
-
-
Francis, C.W.1
Berkowitz, S.D.2
Comp, P.C.3
-
66
-
-
0041829444
-
Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomised controlled trial
-
Wallentin L, Wilcox RG, Weaver WD et al. Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomised controlled trial. Lancet 362, 789-797 (2003).
-
(2003)
Lancet
, vol.362
, pp. 789-797
-
-
Wallentin, L.1
Wilcox, R.G.2
Weaver, W.D.3
-
67
-
-
0041694480
-
Ximelagatran compared with warfarin for prevention of thromboembolism in patients with nonvalvular atrial fibrillation: Rationale, objectives and design of a pair of clinical studies and baseline patient characteristics (SPORTIF III and V)
-
and the Executive Steering Committee on behalf of the SPORTIF III and V Study Investigators
-
Halperin JL and the Executive Steering Committee on behalf of the SPORTIF III and V Study Investigators. Ximelagatran compared with warfarin for prevention of thromboembolism in patients with nonvalvular atrial fibrillation: rationale, objectives and design of a pair of clinical studies and baseline patient characteristics (SPORTIF III and V). Am. Heart. J. 146, 431-438 (2003).
-
(2003)
Am. Heart J.
, vol.146
, pp. 431-438
-
-
Halperin, J.L.1
-
68
-
-
0038185371
-
Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: A dose-guiding, tolerability and safety study
-
Petersen P, Grind M, Adler J. Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability and safety study. J. Am. Coll. Cardiol. 41, 1445-1451 (2003).
-
(2003)
J. Am. Coll. Cardiol.
, vol.41
, pp. 1445-1451
-
-
Petersen, P.1
Grind, M.2
Adler, J.3
-
69
-
-
0345414673
-
Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvularatrial fibrillation (SPORTIF III): Randomised controlled trial
-
Executive Steering Committee on behalf of the SPORTIF III Investigators
-
Executive Steering Committee on behalf of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvularatrial fibrillation (SPORTIF III): randomised controlled trial. Lancet 362, 1691-1698 (2003).
-
(2003)
Lancet
, vol.362
, pp. 1691-1698
-
-
-
70
-
-
0242361090
-
Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation and in healthy subjects
-
Wolzt M, Wollbratt M, Svensson M, Wahlander K, Grind M, Eriksson UG. Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation and in healthy subjects. Eur. J. Clin. Pharmacol. 59, 537-543 (2003).
-
(2003)
Eur. J. Clin. Pharmacol.
, vol.59
, pp. 537-543
-
-
Wolzt, M.1
Wollbratt, M.2
Svensson, M.3
Wahlander, K.4
Grind, M.5
Eriksson, U.G.6
-
71
-
-
0035251672
-
The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: Intestinal absorption properties, biochemical and pharmacodynamic effects
-
Gustafsson D, Nystrom J, Carlsson S et al. The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects. Thromb. Res. 101, 171-181 (2001).
-
(2001)
Thromb. Res.
, vol.101
, pp. 171-181
-
-
Gustafsson, D.1
Nystrom, J.2
Carlsson, S.3
-
72
-
-
0037669041
-
The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: A mini-review
-
Gustafsson D, Elg M. The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review. Thromb. Res. 109(Suppl. 1), S9-S15 (2003).
-
(2003)
Thromb. Res.
, vol.109
, Issue.SUPPL. 1
-
-
Gustafsson, D.1
Elg, M.2
-
73
-
-
0038513109
-
Effects of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran and dalteparin on the endogenous thrombolin potential in venous blood from healthy male subject
-
Boström SL, Hansson GF, Kjaer M, Sarich TC. Effects of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran and dalteparin on the endogenous thrombolin potential in venous blood from healthy male subject. Blood Coagul. Fibrinolysis 14, 457-462 (2003).
-
(2003)
Blood Coagul. Fibrinolysis
, vol.14
, pp. 457-462
-
-
Boström, S.L.1
Hansson, G.F.2
Kjaer, M.3
Sarich, T.C.4
-
74
-
-
0036007936
-
Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects
-
Sarich TC, Eriksson UG, Mattsson C et al. Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects. Thromb. Haemost. 87, 300-305 (2002).
-
(2002)
Thromb. Haemost.
, vol.87
, pp. 300-305
-
-
Sarich, T.C.1
Eriksson, U.G.2
Mattsson, C.3
-
75
-
-
0013432360
-
Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects
-
Eriksson UG, Bredberg U, Gislen K et al. Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects. Eur. J. Clin. Pharmacol. 59, 35-43 (2003).
-
(2003)
Eur. J. Clin. Pharmacol.
, vol.9
, pp. 35-43
-
-
Eriksson, U.G.1
Bredberg, U.2
Gislen, K.3
-
76
-
-
0037454036
-
Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects
-
Sarich TC, Wolzt M, Eriksson UG et al. Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects. J. Am. Coll. Cardiol. 41, 557-564 (2003).
-
(2003)
J. Am. Coll. Cardiol.
, vol.41
, pp. 557-564
-
-
Sarich, T.C.1
Wolzt, M.2
Eriksson, U.G.3
-
77
-
-
0037256123
-
Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor
-
Johansson LC, Frison L, Logren U et al. Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor. Clin. Pharmacokin. 42, 381-392 (2003).
-
(2003)
Clin. Pharmacokin.
, vol.42
, pp. 381-392
-
-
Johansson, L.C.1
Frison, L.2
Logren, U.3
-
78
-
-
0038526281
-
No influence of ethnic origin on the pharmacokinetics and pharmacodynamics of melagatran following oral administration of ximelagatran, a novel oral direct thrombin inhibitor, to healthy male volunteers
-
Johansson L, Andersson M, Fager G, Gustafsson D, Eriksson U. No influence of ethnic origin on the pharmacokinetics and pharmacodynamics of melagatran following oral administration of ximelagatran, a novel oral direct thrombin inhibitor, to healthy male volunteers. Clin. Pharmacokinet. 42, 475-484 (2003).
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 475-484
-
-
Johansson, L.1
Andersson, M.2
Fager, G.3
Gustafsson, D.4
Eriksson, U.5
-
79
-
-
0037512328
-
No influence of obesity on the pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran
-
Sarich TC, Teng R, Peters GR et al. No influence of obesity on the pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran. Clin. Pharmacokinet. 42, 485-492 (2003).
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 485-492
-
-
Sarich, T.C.1
Teng, R.2
Peters, G.R.3
-
80
-
-
0344062615
-
Effects of the oral direct thrombin inhibitor ximelagatran on P-selectin expression and thrombin generation in atrial fibrillation
-
Wolzt M, Boström SL, Svensson M et al. Effects of the oral direct thrombin inhibitor ximelagatran on P-selectin expression and thrombin generation in atrial fibrillation. Pathophysiol. Haemost. Thromb. 33, 68-74 (2003).
-
(2003)
Pathophysiol. Haemost. Thromb.
, vol.33
, pp. 68-74
-
-
Wolzt, M.1
Boström, S.L.2
Svensson, M.3
-
81
-
-
0042623846
-
Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions
-
Bredberg E, Andersson TB, Frison L et al. Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions. Clin. Pharmacokinet. 42, 765-777 (2003).
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 765-777
-
-
Bredberg, E.1
Andersson, T.B.2
Frison, L.3
-
82
-
-
0742284686
-
No influence of alcohol intake on the pharmacokinetics or pharmacodynamics of the oral direct thrombin inhibitor, ximelagatran, in healthy volunteers
-
Johansson S, Schützer K-M, Kessler E, Eriksson UG. No influence of alcohol intake on the pharmacokinetics or pharmacodynamics of the oral direct thrombin inhibitor, ximelagatran, in healthy volunteers. J. Thromb. Haemost. 1, 1991 (2003).
-
(2003)
J. Thromb. Haemost.
, vol.1
, pp. 1991
-
-
Johansson, S.1
Schützer, K.-M.2
Kessler, E.3
Eriksson, U.G.4
-
83
-
-
2642580397
-
No clinically significant interaction between ximelagatran, an oral direct thrombin inhibitor and amiodarone
-
(In Press)
-
Teng R, Sarich TC, Eriksson UG et al. No clinically significant interaction between ximelagatran, an oral direct thrombin inhibitor and amiodarone. Eur. Heart J. (2003) (In Press).
-
(2003)
Eur. Heart J.
-
-
Teng, R.1
Sarich, T.C.2
Eriksson, U.G.3
-
84
-
-
0042913361
-
Pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, are not influenced by acetylsalicylic acid
-
Fager G, Cullberg M, Eriksson-Lepkowska M, Frison L, Eriksson UG. Pharmacokinetics and pharmacodynamics of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, are not influenced by acetylsalicylic acid. Eur. J. Clin. Pharmacol. 59, 283-289 (2003).
-
(2003)
Eur. J. Clin. Pharmacol.
, vol.59
, pp. 283-289
-
-
Fager, G.1
Cullberg, M.2
Eriksson-Lepkowska, M.3
Frison, L.4
Eriksson, U.G.5
-
85
-
-
0042122764
-
Influence of severe renal impairment on the pharmacokinetics and pharmacodynamics of oral ximelagatran and sc. melagatran
-
Eriksson UG, Johansson S, Attman PO et al. Influence of severe renal impairment on the pharmacokinetics and pharmacodynamics of oral ximelagatran and sc. melagatran. Clin. Pharmacokin. 42, 743-753 (2003).
-
(2003)
Clin. Pharmacokin.
, vol.42
, pp. 743-753
-
-
Eriksson, U.G.1
Johansson, S.2
Attman, P.O.3
-
86
-
-
0037499163
-
Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving sc. melagatran and oral ximelagatran: A population model analysis
-
Eriksson U, Mandema J, Karlsson M et al. Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving sc. melagatran and oral ximelagatran: a population model analysis. Clin. Pharmacokinet. 42, 687-701 (2003).
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 687-701
-
-
Eriksson, U.1
Mandema, J.2
Karlsson, M.3
-
87
-
-
0038230252
-
Predictable pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor, in nonvalvular atrial fibrillation patients receiving long-term treatment
-
Eriksson UG, Bååthe S, Hamrén B et al. Predictable pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor, in nonvalvular atrial fibrillation patients receiving long-term treatment. Pathophysiol Haemost. Thromb. 32, 56 (2002).
-
(2002)
Pathophysiol. Haemost. Thromb.
, vol.32
, pp. 56
-
-
Eriksson, U.G.1
Bååthe, S.2
Hamrén, B.3
-
88
-
-
0024543543
-
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation
-
for the Copenhagen AFASAK study
-
Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B for the Copenhagen AFASAK study. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. Lancet 1, 175-179 (1989).
-
(1989)
Lancet
, vol.1
, pp. 175-179
-
-
Petersen, P.1
Boysen, G.2
Godtfredsen, J.3
Andersen, E.D.4
Andersen, B.5
-
89
-
-
0025914693
-
Stroke Prevention in Atrial Fibrillation Study. Final results
-
Stroke Prevention in Atrial Fibrillation Investigators
-
Stroke Prevention in Atrial Fibrillation Investigators. Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation 84, 527-539 (1991).
-
(1991)
Circulation
, vol.84
, pp. 527-539
-
-
-
90
-
-
0025241137
-
The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation
-
The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators
-
The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N. Engl. J. Med. 323, 1505-1511 (1990).
-
(1990)
N. Engl. J. Med.
, vol.323
, pp. 1505-1511
-
-
-
91
-
-
0347060679
-
A 2-year follow-up of ximelagatran as an oral anticoagulant for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
-
Petersen P. A 2-year follow-up of ximelagatran as an oral anticoagulant for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Neurology 58, A477 (2002).
-
(2002)
Neurology
, vol.58
-
-
Petersen, P.1
-
92
-
-
0033593072
-
Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study
-
Go AS, Hylek EM, Borowsky LH et al. Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study. Ann. Intern. Med. 131, 927-934 (1999).
-
(1999)
Ann. Intern. Med.
, vol.131
, pp. 927-934
-
-
Go, A.S.1
Hylek, E.M.2
Borowsky, L.H.3
|