Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: A phase 2 dose-finding study

Archives of Internal Medicine

Volumn 161, Issue 18, 2001, Pages 2215-2221

  Heit, J A ^a   Colwell, C W ^a   Francis, C W ^a   Ginsberg, J S ^a   Berkowitz, S D ^a   Whipple, J ^a   Peters, G ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DALTEPARIN; ENOXAPARIN; MELAGATRAN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; XIMELAGATRAN;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLEEDING; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; THROMBOEMBOLISM; TOTAL KNEE REPLACEMENT;

EID: 0035829034     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.161.18.2215     Document Type: Article

References (16)

1. Prevention of venous thromboembolism
2. Prevention of deep vein thrombosis after major knee surgery: A randomized, double-blind trial comparing a low molecular weight heparin fragment (enoxaparin) to placebo
3. RD heparin compared with warfarin for prevention of venous thromboembolic disease following total hip or knee arthroplasty
4. Prevention of venous thromboembolism after knee arthroplasty: A randomized, double-blind trial comparing enoxaparin with warfarin
5. Efficacy and safety of low molecular weight heparin (ardeparin sodium) compared to warfarin for prevention of venous thromboembolism following total knee replacement: A double-blind, dose-ranging study
6. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors
7. Prevention of thromboembolism with use of recombinant hirudin
8. Low molecular weight heparin: Biochemistry, pharmacology, perioperative prophylaxis regimens, and guidelines for regional anesthetic management
9. METHRO II: Dose-response study of the novel oral, direct thrombin inhibitor, H376/95, and its subcutaneous formulation melagatran, compared with dalteparin as thromboembolic prophylaxis after total hip or total knee replacement
10. Roentgen diagnosis of venous thrombosis in the leg
11. Percentage of inadequate phlebograms and observer agreement in thromboprophylactic multicenter trials using standardized methodology and central assessment
12. Pulmonary angiography, ventilation lung scanning and venography for clinically suspected pulmonary embolism with abnormal lung scan
13. Test for trend in proportions
14. Use of hirulog in the prevention of venous thrombosis after major hip or knee surgery
15. Prevention of deep-vein thrombosis after total hip replacement: Direct thrombin inhibition with recombinant hirudin, CGP 39393
16. A comparison of recombinant hirudin with low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement