Can warfarin randomized trials be reproduced in 'real life'? Adherence to warfarin guidelines for intensity of anticoagulation in a university based warfarin clinic

Southern Medical Journal

Volumn 93, Issue 1, 2000, Pages 58-61

  Malik, Anwar K ^a   Taylor, Allen J ^a  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

WARFARIN;

ADOLESCENT; ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; CEREBROVASCULAR DISEASE; CLINICAL PRACTICE; HEART ATRIUM ARRHYTHMIA; HEART VALVE PROSTHESIS; HUMAN; HYPERCOAGULABILITY; INTERNATIONAL STANDARD UNIT; MAJOR CLINICAL STUDY; PRACTICE GUIDELINE; PROTHROMBIN TIME; THROMBOEMBOLISM; TREATMENT INDICATION;

EID: 0033958893     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007611-200093010-00011     Document Type: Article

References (22)

1. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation, analysis of pooled data from five randomized controlled trials. Arch Intern Med 1994; 154:1449-1457
2. Stafford RS, Singer DE: Recent national patterns of warfarin use in atrial fibrillation. Circulation 1998; 97:1231-1233
3. Hylek EM, Skates SJ, Sheehan MA, et al: An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation. N Engl J Med 1996; 335:540-546
4. Brass LM, Krumholz HM, Scinto JM, et al: Warfarin use among patients with atrial fibrillation. Stroke 1997; 28:2382-2389
5. The Stroke Prevention in Atrial Fibrillation Investigators: Bleeding during antithrombotic therapy in patients with atrial fibrillation. Arch Intern Med 1996; 156:409-416
6. Landefeld CS, Beyth RJ: Anticoagulant-related bleeding: clinical epidemiology, prediction, and prevention. Am J Med 1993; 95:315-328
7. Fihn SD, Callahan CM, Martin DC, et al: The risk for and severity of bleeding complications in elderly patients treated with warfarin. the National Consortium of Anticoagulation Clinics. Ann Intern Med 1996; 124:970-979
8. Bussey HI, Force RW, Bianco TM, et al: Reliance on prothrombin time ratios causes significant errors in anticoagulation therapy. Arch Intern Med 1992; 152:278-282
9. Hirsh J: Optimal intensity and monitoring warfarin. Am J Cardiol 1995; 75:39B-42B
10. Hirsh J, Dalen JE, Deykin D, et al: Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 1992; 102:312S-326S
11. Petersen P, Boysen G, Godtfredsen J, et al: Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. the Copenhagen AFASAK study. Lancet 1989; 1:175-179
12. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators: The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Engl J Med 1990; 323:1505-1511
13. Stroke Prevention in Atrial Fibrillation Study: final results. Circulation 1991; 84:527-539
14. Stroke Prevention in Atrial Fibrillation II Study. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation. Lancet 1994; 343:687-691
15. Gitter MJ, Jaeger TM, Petterson TM, et al: Bleeding and thromboembolism during anticoagulant therapy: a population-based study in Rochester, Minnesota. Mayo Clin Proc 1995; 70:725-733
16. Gottlieb LK, Salem-Schatz S: Anticoagulation in atrial fibrillation. does efficacy in clinical trials translate into effectiveness in practice? Arch Intern Med 1994; 154:1945-1953
17. Andrews TC, Peterson DW, Doeppenschmidt D, et al: Complications of warfarin therapy monitored by the International Normalized Ratio versus the prothrombin time ratio. Clin Cardiol 1995; 18:80-82
18. Hylek EM, Heiman H, Skates SJ, et al: Acetaminophen and other risk factors for excessive warfarin anticoagulation. JAMA 1998; 279:657-662
19. Hylek EM, Singer DE: Risk factors for intracranial hemorrhage in outpatients taking warfarin. Ann Intern Med 1994; 120:897-902
20. Cannegieter SC, Rosendaal FR, Wintzen AR, et al: Optimal oral anticoagulant therapy in patients with mechanical heart valves. N Engl J Med 1995; 333:11-17
21. White RH, Hong R, Venook AP, et al: Initiation of warfarin therapy: comparison of physician dosing with computer-assisted dosing. J Gen Intern Med 1987; 2:141-148
22. Abbrecht PH, O'Leary TJ, Behrendt DM: Evaluation of a computer-assisted method for individualized anticoagulation: retrospective and prospective studies with a pharmacodynamic model. Clin Pharmacol Ther 1982; 32:129-136