TGF-β1 induction of the adenine nucleotide translocator I in astrocytes occurs through Smads and Sp I transcription factors

BMC Neuroscience

Volumn 5, Issue , 2004, Pages

  Law, Alick K T ^a   Gupta, Deepak ^a   Levy, Shawn ^a   Wallace, Douglas C ^a   McKeon, Robert J ^b   Buck, Charles R ^a,c  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ORIDIS Biomed GmbH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ISOPROTEIN; NUCLEAR PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1; DNA BINDING PROTEIN; PYROXYLIN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE; SMAD4 PROTEIN, MOUSE; TGFB1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; ASTROCYTE; BASE PAIRING; BRAIN CORTEX; BRAIN INJURY; CELL SURVIVAL; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC CODE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; IMPLANT; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ADENINE NUCLEOTIDE TRANSLOCATOR 1; ANIMALS; ASTROCYTES; BINDING SITES; CELLS, CULTURED; CEREBRAL CORTEX; COLLODION; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; IMPLANTS, EXPERIMENTAL; MICE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2642532891     PISSN: 14712202     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2202-5-1     Document Type: Article

References (65)

1. Meyer-Puttlitz B, Junker E, Margolis RU, Margolis RK: Chondroitin sulfate proteoglycans in the developing central nervous system. II. Immunocytochemical localization of neurocan and phosphacan. J Comp Neurol 1996, 366:44-54.
2. Yamada H, Fredette B, Shitara K, Hagihara K, Miura R, Ranscht B, Stallcup WB, Yamaguchi Y: The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons. J Neurosci 1997, 17:7784-7795.
3. Oohira A, Matsui F, Watanabe E, Kushima Y, Maeda N: Developmentally regulated expression of a brain specific species of chondroitin sulfate proteoglycan, neurocan, identified with a monoclonal antibody IG2 in the rat cerebrum. Neuroscience 1994, 60:145-157.
4. Asher RA, Scheibe RJ, Keiser HD, Bignami A: On the existence of a cartilage-like proteoglycan and link proteins in the central nervous system. Glia 1995, 13:294-308.
5. McKeon RJ, Jurynec MJ, Buck CR: The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci 1999, 19:10778-10788.
6. Buck CR, Jurynec MJ, Gupta DK, Law AK, Bilger J, Wallace DC, McKeon RJ: Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. Exp Neurol 2003, 181:149-158.
7. Schultheiss HP, Schulze K, Dorner A: Significance of the adenine nucleotide translocator in the pathogenesis of viral heart disease. Mol Cell Biochem 1996, 163-164:319-327.
8. Dörner A, Schultheiss HP: The myocardial expression of the adenine nucleotide translocator isoforms is specifically altered in dilated cardiomyopathy. Herz 2000, 25:176-180.
9. Kaukonen J, Juselius JK, Tiranti V, Kyttala A, Zeviani M, Comi GP, Keranen S, Peltonen L, Suomalainen A: Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 2000, 289:782-785.
10. Graham BH, Waymire KG, Cottrell B, Trounce IA, MacGregor GR, Wallace DC: A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet 1997, 16:226-234.
11. Powell SJ, Medd SM, Runswick MJ, Walker JE: Two bovine genes for mitochondrial ADP/ATP translocase expressed differences in various tissues. Biochemistry 1989, 28:866-873.
12. Cozens AL, Runswick MJ, Walker JE: DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J Mol Biol 1989, 206:261-280.
13. Shinohara Y, Kamida M, Yamazaki N, Terada H: Isolation and characterization of cDNA clones and a genomic clone encoding rat mitochondrial adenine nucleotide translocator. Biochim Biophys Acta 1993, 1152:192-196.
14. Lawson JE, Douglas MG: Separate genes encode functionally equivalent ADP/ATP carrier proteins in Saccharomyces cerevisiae. Isolation and analysis of AAC2. J Biol Chem 1988, 263:14812-14818.
15. O'Malley K, Pratt P, Robertson J, Lilly M, Douglas MG: Selection of the nuclear gene for the mitochondrial adenine nucleotide translocator by genetic complementation of the op1 mutation in yeast. J Biol Chem 1982, 257:2097-2103.
16. Baker A, Leaver CJ: Isolation and sequence analysis of a cDNA encoding the ATP/ADP translocator of Zea mays L. Nucleic Acids Res 1985, 13:5857-5867.
17. Dörner A, Olesch M, Giessen S, Pauschinger M, Schultheiss HP: Transcription of the adenine nucleotide translocase isoforms in various types of tissues in the rat. Biochim Biophys Acta 1999, 1417:16-24.
18. Levy SE, Chen YS, Graham BH, Wallace DC: Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes. Gene 2000, 254:57-66.
19. Lunardi J, Hurko O, Engel WK, Attardi G: The multiple ADP/ATP translocase genes are differentially expressed during human muscle development. J Biol Chem 1992, 267:15267-15270.
20. Stepien G, Torroni A, Chung AB, Hodge JA, Wallace DC: Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation. J Biol Chem 1992, 267:14592-14597.
21. Chung AB, Stepien G, Haraguchi Y, Li K, Wallace DC: Transcriptional control of nuclear genes for the mitochondrial muscle ADP/ATP translocator and the ATP synthase beta subunit. Multiple factors interact with the OXBOX/REBOX promoter sequences. J Biol Chem 1992, 267:21154-21161.
22. Li K, Hodge JA, Wallace DC: OXBOX, a positive transcriptional element of the heart-skeletal muscle ADP/ATP translocator gene. J Biol Chem 1990, 265:20585-20588.
23. Too CK, Giles A, Wilkinson M: Estrogen stimulates expression of adenine nucleotide translocator ANT1 messenger RNA in female rat hearts. Mol Cell Endocrinol 1999, 150:161-167.
24. Law SW, Apostolakis EM, Samora PJ, O'Malley BW, Clark JH: Hormonal regulation of hypothalamic gene expression: identification of multiple novel estrogen induced genes. J Steroid Biochem Mol Biol 1994, 51:131-136.
25. Massagué J: TGF-beta signal transduction. Annu Rev Biochem 1998, 67:753-791.
26. Hartsough MT, Mulder KM: Transforming growth factor-beta signaling in epithelial cells. Pharmacol Ther 1997, 75:21-41.
27. Mulder KM: Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev 2000, 11:23-35.
28. Yakymovych I, Ten Dijke P, Heldin CH, Souchelnytskyi S: Regulation of Smad signaling by protein kinase C. Faseb J 2001, 15:553-555.
29. Itoh S, Itoh F, Goumans MJ, Ten Dijke P: Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 2000, 267:6954-6967.
30. Pardali K, Kurisaki A, Moren A, ten Dijke P, Kardassis D, Moustakas A: Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factorbeta. J Biol Chem 2000, 275:29244-29256.
31. Moustakas A, Kardassis D: Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci U S A 1998, 95:6733-6738.
32. Lai CF, Feng X, Nishimura R, Teitelbaum SL, Avioli LV, Ross FP, Cheng SL: Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling. J Biol Chem 2000, 275:36400-36406.
33. Inagaki Y, Nemoto T, Nakao A, Dijke Pt, Kobayashi K, Takehara K, Greenwel P: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription. J Biol Chem 2001, 276:16573-16579.
34. Datta PK, Blake MC, Moses HL: Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J Biol Chem 2000, 275:40014-40019.
35. Krohn K, Rozovsky I, Wals P, Teter B, Anderson CP, Finch CE: Glial fibrillary acidic protein transcription responses to transforming growth factor-beta1 and interleukin-1beta are mediated by a nuclear factor-1-like site in the near-upstream promoter. J Neurochem 1999, 72:1353-1361.
36. Docagne F, Nicole O, Marti HH, MacKenzie ET, Buisson A, Vivien D: Transforming growth factor-beta1 as a regulator of the serpins/t-PA axis in cerebral ischemia. Faseb J 1999, 13:1315-1324.
37. Ihn H, LeRoy EC, Trojanowska M: Oncostatin M stimulates transcription of the human alpha2(I) collagen gene via the Sp1/Sp3-binding site. J Biol Chem 1997, 272:24666-24672.
38. Tone M, Powell MJ, Tone Y, Thompson SA, Waldmann H: IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J Immunol 2000, 165:286-291.
39. Treichel JA, Reddington M, Kreutzberg GW: Regulation of plasminogen activator inhibitor-1 mRNA accumulation by basic fibroblast growth factor and transforming growth factor-beta1 in cultured rat astrocytes. J Neurochem 1998, 71:1944-1952.
40. Poncelet AC, Schnaper HW: Sp1 and Smad proteins cooperate to mediate transforming growth factor- beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem 2001, 276:6983-6992.
41. Zhang W, Ou J, Inagaki Y, Greenwel P, Ramirez F: Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription. J Biol Chem 2000, 275:39237-39245.
42. Feng XH, Lin X, Derynck R: Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. Embo J 2000, 19:5178-5193.
43. Massagué J, Chen YG: Controlling TGF-beta signaling [In Process Citation]. Genes Dev 2000, 14:627-644.
44. Satoh M, Sugino H, Yoshida T: Activin promotes astrocytic differentiation of a multipotent neural stem cell line and an astrocyte progenitor cell line from murine central nervous system. Neurosci Lett 2000, 284:143-146.
45. Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL: MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 1996, 85:489-500.
46. Jayaraman L, Massagú J: Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway. J Biol Chem 2000, 275:40710-40717.
47. Pratt BM, McPherson JM: TGF-beta in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases. Cytokine Growth Factor Rev 1997, 8:267-292.
48. Flanders KC, Ren RF, Lippa CF: Transforming growth factorbetas in neurodegenerative disease. Prog Neurobiol 1998, 54:71-85.
49. Rich JN, Zhang M, Datto MB, Bigner DD, Wang XF: Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem 1999, 274:35053-35058.
50. Amara FM, Junaid A, Clough RR, Liang B: TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization. Brain Res Mol Brain Res 1999, 71:42-49.
51. Reilly JF, Maher PA, Kumari VG: Regulation of astrocyte GFAP expression by TGF-beta1 and FGF-2. Glia 1998, 22:202-210.
52. Laping NJ, Morgan TE, Nichols NR, Rozovsky I, Young-Chan CS, Zarow C, Finch CE: Transforming growth factor-beta 1 induces neuronal and astrocyte genes: tubulin alpha 1, glial fibrillary acidic protein and clusterin. Neuroscience 1994, 58:563-572.
53. Silberstein FC, De Simone R, Levi G, Aloisi F: Cytokine-regulated expression of platelet-derived growth factor gene and protein in cultured human astrocytes. J Neurochem 1996, 66:1409-1417.
54. Faber-Elman A, Solomon A, Abraham JA, Marikovsky M, Schwartz M: Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation. J Clin Invest 1996, 97:162-171.
55. Buisson A, Nicole O, Docagne F, Sartelet H, Mackenzie ET, Vivien D: Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1. Faseb J 1998, 12:1683-1691.
56. Asher RA, Morgenstern DA, Fidler PS, Adcock KH, Oohira A, Braistead JE, Levine JM, Margolis RU, Rogers JH, Fawcett JW: Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J Neurosci 2000, 20:2427-2438.
57. Rauch U, Grimpe B, Kulbe G, Arnold-Ammer I, Beier DR, Fassler R: Structure and chromosomal localization of the mouse neurocan gene. Genomics 1995, 28:405-410.
58. Eddleston M, Mucke L: Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 1993, 54:15-36
59. Gomes FC, Paulin D, Moura Neto V: Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation. Braz J Med Biol Res 1999, 32:619-631.
60. Giraud S, Bonod-Bidaud C, Wesolowski-Louvel M, Stepien G: Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria. J Mol Biol 1998, 281:409-418.
61. Luciakova K, Hodny Z, Barath P, Nelson BD: In vivo mapping of the human adenine nucleotide translocator-2 (ANT2) promoter provides support for regulation by a pair of proximal Sp1- activating sites and an upstream silencer element. Biochem J 2000, 352 Pt 2:519-523.
62. McKeon RJ, Hoke A, Silver J: Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars. Exp Neurol 1995, 136:32-43.
63. Rudge JS, Smith GM, Silver J: An in vitro model of wound healing in the CNS: analysis of cell reaction and interaction at different ages. Exp Neurol 1989, 103:1-16.
64. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.
65. Ibrahim NM, Marinovic AC, Price SR, Young LG, Frohlich O: Pitfall of an internal control plasmid: response of Renilla luciferase (pRL-TK) plasmid to dihydrotestosterone and dexamethasone. Biotechniques 2000, 29:782-784.