Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on Ras in human hepatic stellate cells

Hepatology

Volumn 31, Issue 1, 2000, Pages 131-140

  Carloni, Vlnicio ^a   Plnzani, Massimo ^a   Glusti, Sabrina ^a   Romanelli, Roberto G ^a   Parola, Maurizio ^b   Bellomo, Glorgio ^c   Failli, Paola ^a   Hamilton, Andrew D ^d   Sebti, Said M ^e,f   Laffi, Giacomo ^a   Gentilini, Paolo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d YALE UNIVERSITY   (United States)

^e H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; RAS PROTEIN;

ARTICLE; CALCIUM CELL LEVEL; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; LIVER CELL; ONCOGENE RAS; PRIORITY JOURNAL; STELLATE CELL;

EID: 17544384148     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510310121     Document Type: Article

References (15)

1. Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993;328:1828-1835.
2. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 1995;66:387-412.
3. Pinzani M, Milani S, Herbst H, DeFranco R, Grappone C, Gentilini A, Pellegrini G, et al. Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol 1996;148:785-800.
4. Claesson-Welsh L. Platelet-derived growth factor receptor signals. J Biol Chem 1994;269:32023-32026.
5. Kundra V, Escobedo JA, Kazlauskas A, Kun Kim H, Rhee SG, Williams LT, Zetter BR. Regulation of chemotaxis by the platelet-derived growth factor receptor-β. Nature 1994:367:474-476.
6. Arvidsson AK, Rupp E, Nanberg E, Downward J, Ronnstrand L, Wennstrom S, Schlessinger J, et al. Tyr-716 in the platelet derived growth factor β-receptor kinase insert is involved in GRB2 binding and Ras activation. Mol Cell Biol 1994;14:6715-6726.
7. Ilie D, Damski CH, Yamamoto T. Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci 1997;110:401-407.
8. FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. J Biol Chem 1994;269:704-710.
9. Abedi H, Dawes K, Zachary E. Differential effects of platelet-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbit aortic vascular smooth muscle cells and Swiss 3T3 fibroblasts. J Biol Chem 1995;270:11367-11376.
10. Carloni V, Romanelli RG, Pinzani M, Laffi G, Gentilini P. Focal adhesion kinase and phospholipase Cγ involvement in adhesion and migration of human hepatic stellate cells. Gastroenterology 1997;112:522-531.
11. Denhardt DT. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiple signaling. Biochem J 1996;318:729-747.
12. Zhang FL, Kirschmeier P, Carr D, James L, Bond RW, Wang L, Patton R, et al. Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for famesyl protein transferase and geranylgeranyl protein transferase type 1. J Biol Chem 1997;272:10232-10239.
13. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 1997;89:457-467.
14. Casini A, Pinzani M, Milani S, Grappone C, Galli G, Jezequel AM, Schuppan D, et al. Regulation of transforming growth factor-βl in human fat-storing cells. Gastroenterology 1993;105:522-531.
15. McGuire TF, QianY, Vagt A, Hamilton AD, Sebti SM. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. J Biol Chem 1996;271:27402-27407.