Inhibition of Kv4.3/KChIP2.2 channels by bupivacaine and its modulation by the pore mutation Kv4.3V401I

Anesthesiology

Volumn 103, Issue 4, 2005, Pages 796-804

  Solth, Anna ^a   Siebrands, Cornelia C ^a   Friederich, Patrick ^b  

^a Institute for Neural Signal Transduction   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; COMPLEMENTARY DNA; LEVOBUPIVACAINE; LOCAL ANESTHETIC AGENT; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL; COMPLEX FORMATION; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; GENE; HEART MUSCLE CELL; KCHIP2 GENE; MOLECULAR MECHANICS; NONHUMAN; PATCH CLAMP; POTASSIUM CHANNEL KV4.3; POTASSIUM CURRENT; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WILD TYPE;

EID: 26244468710     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200510000-00018     Document Type: Article

References (35)

1. Dixon JE, Shi W, Wang HS, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D: Role of the Kv4.3 K+ channel in ventricular muscle: A molecular correlate for the transient outward current. Circ Res 1996; 79:659-68
2. Nerbonne JM: Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol 2000; 525:285-98
3. Näbauer M, Beuckelmann DJ, Erdmann E: Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 1993; 73:386-94
4. Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF: Molecular basis of transient outward potassium current downregulation in human heart failure: A decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 1998; 98:1383-93
5. Jeck C, Pinto J, Boyden P: Transient outward currents in subendocardial Purkinje myocytes surviving in the infarcted heart. Circulation 1995; 92:465-73
6. Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V III, Houser SR, Tomasellei GF: Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: Insights into molecular composition of ventricular Ito. Am J Physiol Heart Circ Physiol 2004; 286:602-9
7. Rosati B, Grau F, Rodriguez S, Li H, Nerbonne JM, McKinnon D: Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol 2003; 548:815-22
8. Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D: Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 2001; 533:119-25
9. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattson KI, Strassle BW, Trimmer JS: Modulation of A-type potassium channels by a family of calcium sensors. Nature 2000; 403:553-6
10. Guo W, Li H, Aimond F, Johns DC, Rhodes KJ, Trimmer T, Nerbonne JM: Role of heteromultimers in the generation of myocardial transient outward K+ currents. Circ Res 2002; 90:586-93
11. Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D: Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem 2001; 276:23888-94
12. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyen-Tran VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR: A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell 2001; 107:801-13
13. Wang S, Patel SP, Qu Y, Hua P, Strauss HC, Morales MJ: Kinetic properties of Kv4.3 and their modulation by KChIP2b. Biochem Biophys Res Commun 2002; 295:223-9
14. Kasten GW: Amide local anesthetic alterations of effective refractory period temporal dispersion: Relationship to ventricular arrhythmias. ANESTHESIOLOGY 1986; 65:61-6
15. Scott DB, Lee A, Fagan D, Bowler GM, Bloomfield P, Lundh R: Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989; 69:563-9
16. Knudsen K, Beckman Suurkula M, Blomberg S, Sjovall J, Edvardsson N: Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997; 78:507-14
17. Franqueza L, Longobardo M, Vicente J, Delpon E, Tamkun MM, Tamargo J, Snyders DJ, Valenzuela C: Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels. Circ Res 1997; 81:1053-64
18. Lipka LJ, Jiang M, Tseng GN: Differential effects of bupivacaine on cardiac K channels: Role of channel inactivation and subunit composition in drug-channel interaction. J Cardiovasc Electrophysiol 1998; 9:727-42
19. Franqueza L, Valenzuela C, Eck J, Tamkun MM, Tamargo J, Snyders DJ: Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line. Cardiovasc Res 1999; 41:212-9
20. Gonzalez T, Longobardo M, Caballero R, Delpon E, Tamargo J, Valenzuela C: Effects of bupivacaine and a novel local anesthetic, 1QB-9302, on human cardiac K+ channels. J Pharmacol Exp Ther 2001; 296:573-83
21. Gonzalez T, Arias C, Caballero R, Moreno I, Delpon E, Tamargo J, Valenzuela C: Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: Stereoselective bupivacaine block. Br J Pharmacol 2002; 137:1269-79
22. Gonzalez T, Navarro-Polanco R, Arias C, Caballero R, Moreno I, Delpon E, Tamargo J, Tamkun MM, Valenzuela C: Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels. Mol Pharmacol 2002; 62:1456-63
23. Friederich P, Solth A, Schillemeit S, Isbrandt D: Local anaesthetic sensitivities of cloned HERG channels from human heart: Comparison with HERG/MiRP1 and HERG/MiRP1 T8A. Br J Anaesth 2004; 92:93-101
24. Friederich P, Solth A: Interaction of ropivacaine with cloned cardiac Kv4.3/KChIP2.2 complexes. ANESTHESIOLOGY 2004; 101:1347-56
25. Courtney KR, Kendig JJ: Bupivacaine is an effective potassium channel blocker in heart. Biochim Biophys Acta 1988; 939:163-6
26. Castle NA: Bupivacaine inhibits the transient outward K+ current but not the inward rectifier in rat ventricular myocytes. J Pharmacol Exp Ther 1990; 255:1038-46
27. Isbrandt D, Leicher T, Waldschutz R, Zhu X, Luhmann U, Michel U, Sauter K, Pongs O: Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents 1(TO) and 1(SA). Genomics 2000; 64:144-54
28. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patchclamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391:85-100
29. Armstrong CM: Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons. J Gen Physiol 1969; 54:553-75
30. Zhoti M, Morais-Cabral JH, Mann S, MacKinnon R: Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 2001; 411:657-61
31. Friederich P, Benzenberg D, Urban BW: Bupivacaine inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells. Br J Anaesth 2002; 88:864-6
32. Nilsson J, Madeja M, Arhem P: Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action. Mol Pharmacol 2003; 63:1417-29
33. Beck EJ, Bowlby M, An WF, Rhodes KJ, Covarrubias M: Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. J Physiol 2002; 538:691-706
34. Jerng HH, Shahidullah M, Covarrubias M: Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore. J Gen Physiol 1999; 113:641-60
35. Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, Bähring R: N-type inactivation features of Kv4.2 channel gating. Biophys J 2004; 86:210-23