Bupivacaine inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells

British Journal of Anaesthesia

Volumn 88, Issue 6, 2002, Pages 864-866

  Friederich, P ^a   Benzenberg, D ^b   Urban, B W ^b,c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Anaesthetics local; Complications; Complications, seizure; Side effects

Indexed keywords

BUPIVACAINE; LOCAL ANESTHETIC AGENT; POTASSIUM CHANNEL BLOCKING AGENT;

ARTICLE; CLINICAL PROTOCOL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVULSION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ELECTROENCEPHALOGRAM; HUMAN; HUMAN CELL; IC 50; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROBLASTOMA CELL; NEUROTOXICITY; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; SEIZURE;

EID: 0036273270     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/88.6.864     Document Type: Article

References (10)

1. Regional anesthesia and local anesthetic-induced systemic toxicity: Seizure frequency and accompanying cardiovascular changes
2. Severe hypoxia and acidosis following local anesthetic-induced convulsions
3. + channels
4. Contributions of Kv3 channels to neuronal excitability
5. Kv3.1 expression in human neuroblastoma SH-SY5Y cells
6. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
7. Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations
8. Voltage-dependent inhibition of RCKI K+ channels by phenol, p-cresol, and benzyl alcohol
9. Pharmacokinetics of local anaesthetics
10. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog