IL-13 and adenosine: Partners in a molecular dance?

Journal of Clinical Investigation

Volumn 112, Issue 3, 2003, Pages 329-331

  Grünig, Gabriele ^a,b  

^a St Luke's Roosevelt Hospital ^*  (United States)

^b ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 13; STAT6 PROTEIN; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ASTHMA; INFLAMMATION; LUNG FIBROSIS; LUNG INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; HUMAN; INJURY; LUNG; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY; T LYMPHOCYTE;

ADENOSINE; ANIMALS; ASTHMA; HUMANS; INFLAMMATION; INTERLEUKIN-13; LUNG; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 85047689880     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI19392     Document Type: Review

References (15)

1. Blackburn, M.R., et al. 2003. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J. Clin. Invest. 112:332-344. doi:10.1172/JC1200316815.
2. Van Den Berge, M., et al. 2001. PC(20) adenosine 5′-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine. Am. J. Respir. Crit. Care Med. 163:1546-1550.
3. Blackburn, M.R., et al. 2000. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J. Exp. Med. 192:159-170.
4. Wills-Karp, M., et al. 1998. Interleukin-13: central mediator of allergic asthma. Science. 282:2258-2261.
5. Zhu, Z., et al. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103:779-788.
6. Grunig, G., et al. 1998. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 282:2261-2263.
7. Graves, P.E., et al. 2000. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J. Allergy Clin. Immunol. 105:506-513.
8. Howard, T.D., et al. 2002. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am. J. Hum. Genet. 70:230-236.
9. Lee, J.H., et al. 2001. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am. J. Respir. Cell Mol. Biol. 25:474-485.
10. Linden, J. 2001. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu. Rev. Pharmacol. Toxicol. 41:775-787.
11. Fozard, J.R., and Hannon, J.P. 2000. Species differences in adenosine receptor-mediated bronchoconstrictor responses. Clin. Exp. Allergy 30:1213-1220.
12. Apasov, S.G., Blackburn, M.R., Kellems, R.E., Smith, P.T., and Sitkovsky, M.V. 2001. Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J. Clin. Invest. 108:131-141. doi:10.1172/JCI200110360.
13. Forr, M.M., et al. 2001. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity. 15:985-995.
14. Vargaftig, B.B., and Singer, M. 2003. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am. J. Respir. Cell Mol. Biol. 28:410-419.
15. Wood, N., et al. 2003. Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J. Exp. Med. 197:703-709.