메뉴 건너뛰기




Volumn 14, Issue 4, 2005, Pages 166-174

Central proinflammatory cytokines and pain enhancement

Author keywords

Allodynia; Astrocyte; Hyperalgesia; Interleukin 1; Interleukin 6; Microglia; Pain facilitation; Proinflammatory cytokines; Sickness behavior; Tumor necrosis factor alpha

Indexed keywords

CYTOKINE; INTERLEUKIN 10;

EID: 26244444488     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087655     Document Type: Review
Times cited : (173)

References (89)
  • 1
    • 0036788082 scopus 로고    scopus 로고
    • Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states
    • Watkins LR, Maier SF: Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 2002;82:981-1011.
    • (2002) Physiol Rev , vol.82 , pp. 981-1011
    • Watkins, L.R.1    Maier, S.F.2
  • 3
    • 0026335130 scopus 로고
    • New roles for glia
    • Barres BA: New roles for glia. J Neurosci 1991;11:3685-3694.
    • (1991) J Neurosci , vol.11 , pp. 3685-3694
    • Barres, B.A.1
  • 4
    • 0033739738 scopus 로고    scopus 로고
    • Neuronal and glial cell biology
    • Barres BA, Barde Y: Neuronal and glial cell biology. Curr Opin Neurobiol 2000;10:642-648.
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 642-648
    • Barres, B.A.1    Barde, Y.2
  • 5
    • 0031600021 scopus 로고    scopus 로고
    • Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition
    • Maier, SF, Watkins LR: Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 1998;105:83-107.
    • (1998) Psychol Rev , vol.105 , pp. 83-107
    • Maier, S.F.1    Watkins, L.R.2
  • 7
    • 0024159821 scopus 로고
    • Biological basis of the behavior of sick animals
    • Hart BL: Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988;12:123-137.
    • (1988) Neurosci Biobehav Rev , vol.12 , pp. 123-137
    • Hart, B.L.1
  • 9
    • 0001447393 scopus 로고
    • Endogenous pain facilitatory systems: Anti-analgesia and hyperalgesia
    • Maier SF, Wiertelak EP, Watkins LR: Endogenous pain facilitatory systems: anti-analgesia and hyperalgesia. Am Pain Soc J 1992;1:191-198.
    • (1992) Am Pain Soc J , vol.1 , pp. 191-198
    • Maier, S.F.1    Wiertelak, E.P.2    Watkins, L.R.3
  • 10
    • 0033656015 scopus 로고    scopus 로고
    • The pain of being sick: Implications of immune-to-brain communication for understanding pain
    • Watkins LR, Maier SF: The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000;51:29-57.
    • (2000) Annu Rev Psychol , vol.51 , pp. 29-57
    • Watkins, L.R.1    Maier, S.F.2
  • 11
    • 0022607883 scopus 로고
    • Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats
    • McCarthy DO, Kluger MJ, Vander AJ: Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats. Physiol Behav 1986;36:745-749.
    • (1986) Physiol Behav , vol.36 , pp. 745-749
    • McCarthy, D.O.1    Kluger, M.J.2    Vander, A.J.3
  • 12
    • 0023732794 scopus 로고
    • Central effects of TNF alpha on thermogenesis and fever in the rat
    • Rothwell NJ: Central effects of TNF alpha on thermogenesis and fever in the rat. Biosci Rep 1988;8:345-352.
    • (1988) Biosci Rep , vol.8 , pp. 345-352
    • Rothwell, N.J.1
  • 13
    • 0030840882 scopus 로고    scopus 로고
    • Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
    • Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF: Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 1997;71:225-235.
    • (1997) Pain , vol.71 , pp. 225-235
    • Watkins, L.R.1    Martin, D.2    Ulrich, P.3    Tracey, K.J.4    Maier, S.F.5
  • 14
    • 0028857633 scopus 로고
    • Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: Evidence for vagal mediation of immune-brain communication
    • Watkins LR, Goehler LE, Relton JK, Tartaglia N, Silbert L, Martin D, Maier SF: Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett 1995;183:27-31.
    • (1995) Neurosci Lett , vol.183 , pp. 27-31
    • Watkins, L.R.1    Goehler, L.E.2    Relton, J.K.3    Tartaglia, N.4    Silbert, L.5    Martin, D.6    Maier, S.F.7
  • 15
    • 0027301614 scopus 로고
    • Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin
    • Maier SF, Wiertelak EP, Martin D, Watkins LR: Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res 1993;623:321-324.
    • (1993) Brain Res , vol.623 , pp. 321-324
    • Maier, S.F.1    Wiertelak, E.P.2    Martin, D.3    Watkins, L.R.4
  • 16
    • 0028805882 scopus 로고
    • Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states
    • Watkins LR, Maier SF, Goehler LE: Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 1995;63:289-302.
    • (1995) Pain , vol.63 , pp. 289-302
    • Watkins, L.R.1    Maier, S.F.2    Goehler, L.E.3
  • 18
    • 0031049046 scopus 로고    scopus 로고
    • Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias
    • Wiertelak EP, Roemer B, Maier SF, Watkins LR: Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Res 1997;748:143-150.
    • (1997) Brain Res , vol.748 , pp. 143-150
    • Wiertelak, E.P.1    Roemer, B.2    Maier, S.F.3    Watkins, L.R.4
  • 19
    • 0024255828 scopus 로고
    • Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
    • Graeber MB, Streit WJ, Kreutzberg GW: Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J Neurosci Res 1988;21:18-24.
    • (1988) J Neurosci Res , vol.21 , pp. 18-24
    • Graeber, M.B.1    Streit, W.J.2    Kreutzberg, G.W.3
  • 20
    • 0025043120 scopus 로고
    • Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation
    • Hajos F, Csillik B, Knyihar-Csillik E: Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation. Neurosci Lett 1990;117:8-13.
    • (1990) Neurosci Lett , vol.117 , pp. 8-13
    • Hajos, F.1    Csillik, B.2    Knyihar-Csillik, E.3
  • 21
    • 0024401761 scopus 로고
    • Transection or electrical stimulation of the hypoglossal nerve increases glial fibrillary acidic protein immunoreactivity in the hypoglossal nucleus
    • Hall LL, Borke RC, Anders JJ: Transection or electrical stimulation of the hypoglossal nerve increases glial fibrillary acidic protein immunoreactivity in the hypoglossal nucleus. Brain Res 1989;490:157-161.
    • (1989) Brain Res , vol.490 , pp. 157-161
    • Hall, L.L.1    Borke, R.C.2    Anders, J.J.3
  • 22
    • 0014977043 scopus 로고
    • Neuroglial proliferation in the hypoglossal nucleus after nerve injury
    • Sjostrand J: Neuroglial proliferation in the hypoglossal nucleus after nerve injury. Exp Neurol 1971;30:178-189.
    • (1971) Exp Neurol , vol.30 , pp. 178-189
    • Sjostrand, J.1
  • 23
    • 0024201984 scopus 로고
    • Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus
    • Tetzlaff W, Graeber MB, Bisby MA, Kreutzberg GW: Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus. Glia 1988;1:90-95.
    • (1988) Glia , vol.1 , pp. 90-95
    • Tetzlaff, W.1    Graeber, M.B.2    Bisby, M.A.3    Kreutzberg, G.W.4
  • 24
    • 0026051875 scopus 로고
    • Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury
    • Garrison CJ, Dougherty PM, Kajander KC, Carlton SM: Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 1991;565:1-7.
    • (1991) Brain Res , vol.565 , pp. 1-7
    • Garrison, C.J.1    Dougherty, P.M.2    Kajander, K.C.3    Carlton, S.M.4
  • 25
    • 0027944898 scopus 로고
    • GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801
    • Garrison CJ, Dougherty PM, Carlton SM: GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801. Exp Neurol 1994;129:237-243.
    • (1994) Exp Neurol , vol.129 , pp. 237-243
    • Garrison, C.J.1    Dougherty, P.M.2    Carlton, S.M.3
  • 26
    • 0001802513 scopus 로고
    • Transport of neuroactive amino acids in astrocytes
    • Kettenmann H, Ransom BR (eds): New York, Oxford University Press
    • Schousboe A, Westergaard N: Transport of neuroactive amino acids in astrocytes; in Kettenmann H, Ransom BR (eds): Neuroglia. New York, Oxford University Press, 1995, pp 246-258.
    • (1995) Neuroglia , pp. 246-258
    • Schousboe, A.1    Westergaard, N.2
  • 27
    • 0027050133 scopus 로고
    • Glial modulation of neural excitability mediated by extracellular pH: A hypothesis
    • Ransom BR: Glial modulation of neural excitability mediated by extracellular pH: a hypothesis. Prog Brain Res 1992;94:37-46.
    • (1992) Prog Brain Res , vol.94 , pp. 37-46
    • Ransom, B.R.1
  • 28
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW: Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996;19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 29
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet JL, Malhotra SK, Privat A, Gage FH: Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 1997;20:570-577.
    • (1997) Trends Neurosci , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 30
    • 0026024802 scopus 로고
    • Substance P-induced release of prostaglandins from astrocytes: Regional specialisation and correlation with phosphoinositol metabolism
    • Marriott DR, Wilkin GP, Wood JN: Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism. J Neurochem 1991;56:259-265.
    • (1991) J Neurochem , vol.56 , pp. 259-265
    • Marriott, D.R.1    Wilkin, G.P.2    Wood, J.N.3
  • 32
    • 0030580559 scopus 로고    scopus 로고
    • Connexin-43 in rat spinal cord: Localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions
    • Ochalski, PA, Frankenstein UN, Hertzberg EL, Nagy JI: Connexin-43 in rat spinal cord: localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions. Neuroscience 1997;76:931-945.
    • (1997) Neuroscience , vol.76 , pp. 931-945
    • Ochalski, P.A.1    Frankenstein, U.N.2    Hertzberg, E.L.3    Nagy, J.I.4
  • 33
    • 0038162256 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain
    • Zhu X, Conklin D, Eisenach JC: Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain 2003;104:15-23.
    • (2003) Pain , vol.104 , pp. 15-23
    • Zhu, X.1    Conklin, D.2    Eisenach, J.C.3
  • 34
    • 0242300734 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury
    • Zhu X, Eisenach JC: Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Anesthesiology 2003;99:1175-1179.
    • (2003) Anesthesiology , vol.99 , pp. 1175-1179
    • Zhu, X.1    Eisenach, J.C.2
  • 35
    • 0031239164 scopus 로고    scopus 로고
    • Use of fluorocitrate and fluoroacetate in the study of brain metabolism
    • Fonnum F, Johnsen A, Hassel B: Use of fluorocitrate and fluoroacetate in the study of brain metabolism. Glia 1997;21:106-113.
    • (1997) Glia , vol.21 , pp. 106-113
    • Fonnum, F.1    Johnsen, A.2    Hassel, B.3
  • 36
    • 0023226069 scopus 로고
    • An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: The use of fluorocitrate
    • Paulsen RE, Contestabile A, Villani L, Fonnum F: An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluorocitrate. J Neurochem 1987;48:1377-1385.
    • (1987) J Neurochem , vol.48 , pp. 1377-1385
    • Paulsen, R.E.1    Contestabile, A.2    Villani, L.3    Fonnum, F.4
  • 39
    • 0034615875 scopus 로고    scopus 로고
    • Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120
    • Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR: Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res 2000;861:105-116.
    • (2000) Brain Res , vol.861 , pp. 105-116
    • Milligan, E.D.1    Mehmert, K.K.2    Hinde, J.L.3    Harvey, L.O.4    Martin, D.5    Tracey, K.J.6    Maier, S.F.7    Watkins, L.R.8
  • 40
    • 0028027868 scopus 로고
    • The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
    • Meller ST, Dykstra C, Grzybycki D, Murphy S, Gebhart GF: The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 1994;33:1471-1478.
    • (1994) Neuropharmacology , vol.33 , pp. 1471-1478
    • Meller, S.T.1    Dykstra, C.2    Grzybycki, D.3    Murphy, S.4    Gebhart, G.F.5
  • 41
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    • Tikka TM, Koistinaho JE: Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 2001;166:7527-7533.
    • (2001) J Immunol , vol.166 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 42
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J: Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 2001;21:2580-2588.
    • (2001) J Neurosci , vol.21 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 43
    • 0019292911 scopus 로고
    • Pharmacotherapeutics of the newer tetracyclines
    • Aronson AL: Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 1980;176:1061-1068.
    • (1980) J Am Vet Med Assoc , vol.176 , pp. 1061-1068
    • Aronson, A.L.1
  • 44
  • 45
    • 0026018690 scopus 로고
    • Suppression of human neutrophil functions by tetracyclines
    • Gabler WL, Creamer HR: Suppression of human neutrophil functions by tetracyclines. J Periodontal Res 1991;26:52-58.
    • (1991) J Periodontal Res , vol.26 , pp. 52-58
    • Gabler, W.L.1    Creamer, H.R.2
  • 46
    • 0026447407 scopus 로고
    • Comparison of doxycycline and a chemically modified tetracycline inhibition of leukocyte functions
    • Gabler WL, Smith J, Tsukuda NL: Comparison of doxycycline and a chemically modified tetracycline inhibition of leukocyte functions. Res Commun Chem Pathol Pharmacol 1992;78:151-160.
    • (1992) Res Commun Chem Pathol Pharmacol , vol.78 , pp. 151-160
    • Gabler, W.L.1    Smith, J.2    Tsukuda, N.L.3
  • 48
    • 0030832313 scopus 로고    scopus 로고
    • Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines
    • Amin AR, Patel RN, Thakker GD, Lowenstein CJ, Attur MG, Abramson SB: Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett 1997;410:259-264.
    • (1997) FEBS Lett , vol.410 , pp. 259-264
    • Amin, A.R.1    Patel, R.N.2    Thakker, G.D.3    Lowenstein, C.J.4    Attur, M.G.5    Abramson, S.B.6
  • 49
    • 0031018687 scopus 로고    scopus 로고
    • Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics
    • Whiteman M, Halliwell B: Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics. Free Radic Res 1997;26:49-56.
    • (1997) Free Radic Res , vol.26 , pp. 49-56
    • Whiteman, M.1    Halliwell, B.2
  • 52
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    • Raghavendra V, Tanga F, DeLeo JA: Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther 2003;306:624-630.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.2    DeLeo, J.A.3
  • 53
    • 2442485722 scopus 로고    scopus 로고
    • Selective inhibition of spinal cord microglial activation attenuates mechanical allodynia in rat models of pathological pain
    • in press
    • Ledeboer A, Sloane E, Chacur M, Milligan ED, Maier SF, Watkins LR: Selective inhibition of spinal cord microglial activation attenuates mechanical allodynia in rat models of pathological pain. Proc Soc Neurosci 2003;29:in press.
    • (2003) Proc Soc Neurosci , vol.29
    • Ledeboer, A.1    Sloane, E.2    Chacur, M.3    Milligan, E.D.4    Maier, S.F.5    Watkins, L.R.6
  • 54
    • 0141921513 scopus 로고    scopus 로고
    • Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: Genetic, pharmacological and developmental aspects
    • Wolf G, Yirmiya R, Goshen I, Iverfeldt K, Holmlund L, Takeda K, Shavit Y: Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 2003;104:471-480.
    • (2003) Pain , vol.104 , pp. 471-480
    • Wolf, G.1    Yirmiya, R.2    Goshen, I.3    Iverfeldt, K.4    Holmlund, L.5    Takeda, K.6    Shavit, Y.7
  • 55
    • 0001997918 scopus 로고
    • Development of microglia
    • Kettenmann H, Ransom BR (eds): New York, Oxford University Press
    • Fedoroff S: Development of microglia; in Kettenmann H, Ransom BR (eds): Neuroglia. New York, Oxford University Press, 1995, pp 162-181.
    • (1995) Neuroglia , pp. 162-181
    • Fedoroff, S.1
  • 58
    • 0027768570 scopus 로고
    • Cytokine regulation of metalloproteinase gene expression
    • Mauviel A: Cytokine regulation of metalloproteinase gene expression. J Cell Biochem 1993;53:288-295.
    • (1993) J Cell Biochem , vol.53 , pp. 288-295
    • Mauviel, A.1
  • 61
    • 0033874108 scopus 로고    scopus 로고
    • Proinflammatory cytokines
    • Dinarello CA: Proinflammatory cytokines. Chest 2000;118:503-508.
    • (2000) Chest , vol.118 , pp. 503-508
    • Dinarello, C.A.1
  • 62
    • 0032570035 scopus 로고    scopus 로고
    • Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: Potential role of IL-6 in neuropathic pain
    • Arruda JL, Colburn RW, Rickman AJ, Rutkowski MD, DeLeo JA: Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain. Brain Res Mol Brain Res 1998;62:228-235.
    • (1998) Brain Res Mol Brain Res , vol.62 , pp. 228-235
    • Arruda, J.L.1    Colburn, R.W.2    Rickman, A.J.3    Rutkowski, M.D.4    DeLeo, J.A.5
  • 63
    • 0035888956 scopus 로고    scopus 로고
    • Quantification of neural tissue injury in a rat radiculopathy model: Comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons
    • Winkelstein BA, Rutkowski MD, Weinstein JN, DeLeo JA: Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons. J Neurosci Methods 2001;111:49-57.
    • (2001) J Neurosci Methods , vol.111 , pp. 49-57
    • Winkelstein, B.A.1    Rutkowski, M.D.2    Weinstein, J.N.3    DeLeo, J.A.4
  • 64
    • 0035888084 scopus 로고    scopus 로고
    • Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
    • Winkelstein BA, Rutkowski MD, Sweitzer SM, Pahl JL, DeLeo JA: Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J Comp Neurol 2001;439:127-139.
    • (2001) J Comp Neurol , vol.439 , pp. 127-139
    • Winkelstein, B.A.1    Rutkowski, M.D.2    Sweitzer, S.M.3    Pahl, J.L.4    DeLeo, J.A.5
  • 66
    • 0037195594 scopus 로고    scopus 로고
    • Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: Considerations for persistent pain
    • Winkelstein BA, DeLeo JA: Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: considerations for persistent pain. Brain Res 2002;956:294-301.
    • (2002) Brain Res , vol.956 , pp. 294-301
    • Winkelstein, B.A.1    DeLeo, J.A.2
  • 67
    • 0029783630 scopus 로고    scopus 로고
    • Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model
    • DeLeo JA, Colburn RW, Nichols M, Malhotra A: Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J Interferon Cytokine Res 1996;16:695-700.
    • (1996) J Interferon Cytokine Res , vol.16 , pp. 695-700
    • DeLeo, J.A.1    Colburn, R.W.2    Nichols, M.3    Malhotra, A.4
  • 68
    • 0034657820 scopus 로고    scopus 로고
    • Spinal glial activation and cytokine expression after lumbar root injury in the rat
    • Hashizume H, DeLeo JA: Colburn RW, Weinstein JN: Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine 2000;25:1206-1217.
    • (2000) Spine , vol.25 , pp. 1206-1217
    • Hashizume, H.1    DeLeo, J.A.2    Colburn, R.W.3    Weinstein, J.N.4
  • 69
    • 0030751245 scopus 로고    scopus 로고
    • Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy
    • DeLeo JA, Colburn RW, Rickman AJ: Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy. Brain Res 1997;759:50-57.
    • (1997) Brain Res , vol.759 , pp. 50-57
    • DeLeo, J.A.1    Colburn, R.W.2    Rickman, A.J.3
  • 70
    • 0033594738 scopus 로고    scopus 로고
    • Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat
    • Sweitzer SM, Colburn RW, Rutkowski M, DeLeo JA: Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res 1999;829:209-221.
    • (1999) Brain Res , vol.829 , pp. 209-221
    • Sweitzer, S.M.1    Colburn, R.W.2    Rutkowski, M.3    Deleo, J.A.4
  • 71
    • 0034955577 scopus 로고    scopus 로고
    • Dib, Hyperalgesic effect of intrathecally administered interleukin-1 in rats
    • Falchi M, Ferrara F, Gharib CB: Dib, Hyperalgesic effect of intrathecally administered interleukin-1 in rats. Drugs Exp Clin Res 2001;27:97-101.
    • (2001) Drugs Exp Clin Res , vol.27 , pp. 97-101
    • Falchi, M.1    Ferrara, F.2    Gharib, C.B.3
  • 72
    • 0033835476 scopus 로고    scopus 로고
    • Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat
    • Reeve AJ, Patel S, Fox A, Walker K, Urban L: Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. Eur J Pain 2000;4:247-257.
    • (2000) Eur J Pain , vol.4 , pp. 247-257
    • Reeve, A.J.1    Patel, S.2    Fox, A.3    Walker, K.4    Urban, L.5
  • 73
    • 0003032172 scopus 로고    scopus 로고
    • Brain cytokines and pain
    • Watkins LR, Maier SF (eds): Basel, Birkhäuser
    • Oka T, Hori T: Brain cytokines and pain; in Watkins LR, Maier SF (eds): Cytokines and Pain. Basel, Birkhäuser, 1999, pp 183-204.
    • (1999) Cytokines and Pain , pp. 183-204
    • Oka, T.1    Hori, T.2
  • 74
    • 0035857748 scopus 로고    scopus 로고
    • Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
    • Sweitzer S, Martin D, DeLeo JA: Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 2001;103:529-539.
    • (2001) Neuroscience , vol.103 , pp. 529-539
    • Sweitzer, S.1    Martin, D.2    DeLeo, J.A.3
  • 77
    • 0034613224 scopus 로고    scopus 로고
    • Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain
    • Arruda JL, Sweitzer S, Rutkowski MD, DeLeo JA: Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res 2000;879:216-225.
    • (2000) Brain Res , vol.879 , pp. 216-225
    • Arruda, J.L.1    Sweitzer, S.2    Rutkowski, M.D.3    DeLeo, J.A.4
  • 78
    • 0347169249 scopus 로고    scopus 로고
    • Glia: A novel drug discovery target for clinical pain
    • Watkins LR, Maier SF: Glia: a novel drug discovery target for clinical pain. Nature Rev Drug Discovery 2003;2:973-985.
    • (2003) Nature Rev Drug Discovery , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 79
    • 0025216634 scopus 로고
    • Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord
    • Hornfeldt CS, Larson AA: Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord. Eur J Pharmacol 1990;179:307-313.
    • (1990) Eur J Pharmacol , vol.179 , pp. 307-313
    • Hornfeldt, C.S.1    Larson, A.A.2
  • 80
    • 0035018058 scopus 로고    scopus 로고
    • Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    • Sweitzer SM, Schubert P, DeLeo JA: Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 2001;297:1210-1217.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1210-1217
    • Sweitzer, S.M.1    Schubert, P.2    DeLeo, J.A.3
  • 81
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schafers M, Svensson CI, Sommer C, Sorkin LS: Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 2003;23:2517-2521.
    • (2003) J Neurosci , vol.23 , pp. 2517-2521
    • Schafers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 82
    • 0037705314 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin SX, Zhuang ZY, Woolf CJ, Ji RR: p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 2003;23:4017-4022.
    • (2003) J Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 83
    • 0037147689 scopus 로고    scopus 로고
    • Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury
    • Kim SY, Bae JC, Kim JY, Lee HL, Lee KM, Kim DS, Cho HJ: Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury. Neuroreport 2002;13:2483-2486.
    • (2002) Neuroreport , vol.13 , pp. 2483-2486
    • Kim, S.Y.1    Bae, J.C.2    Kim, J.Y.3    Lee, H.L.4    Lee, K.M.5    Kim, D.S.6    Cho, H.J.7
  • 85
    • 0042267829 scopus 로고    scopus 로고
    • Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia
    • Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL: Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport 2003;14:1153-1157.
    • (2003) Neuroreport , vol.14 , pp. 1153-1157
    • Svensson, C.I.1    Hua, X.Y.2    Protter, A.A.3    Powell, H.C.4    Yaksh, T.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.