-
1
-
-
0036788082
-
Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states
-
Watkins LR, Maier SF: Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 2002;82:981-1011.
-
(2002)
Physiol Rev
, vol.82
, pp. 981-1011
-
-
Watkins, L.R.1
Maier, S.F.2
-
3
-
-
0026335130
-
New roles for glia
-
Barres BA: New roles for glia. J Neurosci 1991;11:3685-3694.
-
(1991)
J Neurosci
, vol.11
, pp. 3685-3694
-
-
Barres, B.A.1
-
5
-
-
0031600021
-
Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition
-
Maier, SF, Watkins LR: Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 1998;105:83-107.
-
(1998)
Psychol Rev
, vol.105
, pp. 83-107
-
-
Maier, S.F.1
Watkins, L.R.2
-
7
-
-
0024159821
-
Biological basis of the behavior of sick animals
-
Hart BL: Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988;12:123-137.
-
(1988)
Neurosci Biobehav Rev
, vol.12
, pp. 123-137
-
-
Hart, B.L.1
-
9
-
-
0001447393
-
Endogenous pain facilitatory systems: Anti-analgesia and hyperalgesia
-
Maier SF, Wiertelak EP, Watkins LR: Endogenous pain facilitatory systems: anti-analgesia and hyperalgesia. Am Pain Soc J 1992;1:191-198.
-
(1992)
Am Pain Soc J
, vol.1
, pp. 191-198
-
-
Maier, S.F.1
Wiertelak, E.P.2
Watkins, L.R.3
-
10
-
-
0033656015
-
The pain of being sick: Implications of immune-to-brain communication for understanding pain
-
Watkins LR, Maier SF: The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000;51:29-57.
-
(2000)
Annu Rev Psychol
, vol.51
, pp. 29-57
-
-
Watkins, L.R.1
Maier, S.F.2
-
11
-
-
0022607883
-
Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats
-
McCarthy DO, Kluger MJ, Vander AJ: Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats. Physiol Behav 1986;36:745-749.
-
(1986)
Physiol Behav
, vol.36
, pp. 745-749
-
-
McCarthy, D.O.1
Kluger, M.J.2
Vander, A.J.3
-
12
-
-
0023732794
-
Central effects of TNF alpha on thermogenesis and fever in the rat
-
Rothwell NJ: Central effects of TNF alpha on thermogenesis and fever in the rat. Biosci Rep 1988;8:345-352.
-
(1988)
Biosci Rep
, vol.8
, pp. 345-352
-
-
Rothwell, N.J.1
-
13
-
-
0030840882
-
Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
-
Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF: Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 1997;71:225-235.
-
(1997)
Pain
, vol.71
, pp. 225-235
-
-
Watkins, L.R.1
Martin, D.2
Ulrich, P.3
Tracey, K.J.4
Maier, S.F.5
-
14
-
-
0028857633
-
Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: Evidence for vagal mediation of immune-brain communication
-
Watkins LR, Goehler LE, Relton JK, Tartaglia N, Silbert L, Martin D, Maier SF: Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett 1995;183:27-31.
-
(1995)
Neurosci Lett
, vol.183
, pp. 27-31
-
-
Watkins, L.R.1
Goehler, L.E.2
Relton, J.K.3
Tartaglia, N.4
Silbert, L.5
Martin, D.6
Maier, S.F.7
-
15
-
-
0027301614
-
Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin
-
Maier SF, Wiertelak EP, Martin D, Watkins LR: Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res 1993;623:321-324.
-
(1993)
Brain Res
, vol.623
, pp. 321-324
-
-
Maier, S.F.1
Wiertelak, E.P.2
Martin, D.3
Watkins, L.R.4
-
16
-
-
0028805882
-
Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states
-
Watkins LR, Maier SF, Goehler LE: Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 1995;63:289-302.
-
(1995)
Pain
, vol.63
, pp. 289-302
-
-
Watkins, L.R.1
Maier, S.F.2
Goehler, L.E.3
-
17
-
-
0028220867
-
Neurocircuitry of illness-induced hyperalgesia
-
Watkins LR, Wiertelak EP, Goehler LE, Mooney-Heiberger K, Martinez J, Furness L, Smith KP, Maier SF: Neurocircuitry of illness-induced hyperalgesia. Brain Res 1994;639:283-299.
-
(1994)
Brain Res
, vol.639
, pp. 283-299
-
-
Watkins, L.R.1
Wiertelak, E.P.2
Goehler, L.E.3
Mooney-Heiberger, K.4
Martinez, J.5
Furness, L.6
Smith, K.P.7
Maier, S.F.8
-
18
-
-
0031049046
-
Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias
-
Wiertelak EP, Roemer B, Maier SF, Watkins LR: Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Res 1997;748:143-150.
-
(1997)
Brain Res
, vol.748
, pp. 143-150
-
-
Wiertelak, E.P.1
Roemer, B.2
Maier, S.F.3
Watkins, L.R.4
-
19
-
-
0024255828
-
Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
-
Graeber MB, Streit WJ, Kreutzberg GW: Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J Neurosci Res 1988;21:18-24.
-
(1988)
J Neurosci Res
, vol.21
, pp. 18-24
-
-
Graeber, M.B.1
Streit, W.J.2
Kreutzberg, G.W.3
-
20
-
-
0025043120
-
Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation
-
Hajos F, Csillik B, Knyihar-Csillik E: Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation. Neurosci Lett 1990;117:8-13.
-
(1990)
Neurosci Lett
, vol.117
, pp. 8-13
-
-
Hajos, F.1
Csillik, B.2
Knyihar-Csillik, E.3
-
21
-
-
0024401761
-
Transection or electrical stimulation of the hypoglossal nerve increases glial fibrillary acidic protein immunoreactivity in the hypoglossal nucleus
-
Hall LL, Borke RC, Anders JJ: Transection or electrical stimulation of the hypoglossal nerve increases glial fibrillary acidic protein immunoreactivity in the hypoglossal nucleus. Brain Res 1989;490:157-161.
-
(1989)
Brain Res
, vol.490
, pp. 157-161
-
-
Hall, L.L.1
Borke, R.C.2
Anders, J.J.3
-
22
-
-
0014977043
-
Neuroglial proliferation in the hypoglossal nucleus after nerve injury
-
Sjostrand J: Neuroglial proliferation in the hypoglossal nucleus after nerve injury. Exp Neurol 1971;30:178-189.
-
(1971)
Exp Neurol
, vol.30
, pp. 178-189
-
-
Sjostrand, J.1
-
23
-
-
0024201984
-
Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus
-
Tetzlaff W, Graeber MB, Bisby MA, Kreutzberg GW: Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus. Glia 1988;1:90-95.
-
(1988)
Glia
, vol.1
, pp. 90-95
-
-
Tetzlaff, W.1
Graeber, M.B.2
Bisby, M.A.3
Kreutzberg, G.W.4
-
24
-
-
0026051875
-
Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury
-
Garrison CJ, Dougherty PM, Kajander KC, Carlton SM: Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 1991;565:1-7.
-
(1991)
Brain Res
, vol.565
, pp. 1-7
-
-
Garrison, C.J.1
Dougherty, P.M.2
Kajander, K.C.3
Carlton, S.M.4
-
25
-
-
0027944898
-
GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801
-
Garrison CJ, Dougherty PM, Carlton SM: GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801. Exp Neurol 1994;129:237-243.
-
(1994)
Exp Neurol
, vol.129
, pp. 237-243
-
-
Garrison, C.J.1
Dougherty, P.M.2
Carlton, S.M.3
-
26
-
-
0001802513
-
Transport of neuroactive amino acids in astrocytes
-
Kettenmann H, Ransom BR (eds): New York, Oxford University Press
-
Schousboe A, Westergaard N: Transport of neuroactive amino acids in astrocytes; in Kettenmann H, Ransom BR (eds): Neuroglia. New York, Oxford University Press, 1995, pp 246-258.
-
(1995)
Neuroglia
, pp. 246-258
-
-
Schousboe, A.1
Westergaard, N.2
-
27
-
-
0027050133
-
Glial modulation of neural excitability mediated by extracellular pH: A hypothesis
-
Ransom BR: Glial modulation of neural excitability mediated by extracellular pH: a hypothesis. Prog Brain Res 1992;94:37-46.
-
(1992)
Prog Brain Res
, vol.94
, pp. 37-46
-
-
Ransom, B.R.1
-
28
-
-
0030222037
-
Microglia: A sensor for pathological events in the CNS
-
Kreutzberg GW: Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996;19:312-318.
-
(1996)
Trends Neurosci
, vol.19
, pp. 312-318
-
-
Kreutzberg, G.W.1
-
29
-
-
0030697366
-
Reactive astrocytes: Cellular and molecular cues to biological function
-
Ridet JL, Malhotra SK, Privat A, Gage FH: Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 1997;20:570-577.
-
(1997)
Trends Neurosci
, vol.20
, pp. 570-577
-
-
Ridet, J.L.1
Malhotra, S.K.2
Privat, A.3
Gage, F.H.4
-
30
-
-
0026024802
-
Substance P-induced release of prostaglandins from astrocytes: Regional specialisation and correlation with phosphoinositol metabolism
-
Marriott DR, Wilkin GP, Wood JN: Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism. J Neurochem 1991;56:259-265.
-
(1991)
J Neurochem
, vol.56
, pp. 259-265
-
-
Marriott, D.R.1
Wilkin, G.P.2
Wood, J.N.3
-
31
-
-
24544456955
-
Mapping fractalkine and its receptor (CX3CR1) in a rat model of sciatic inflammatory neuropathy (SIN)
-
Verge G, Milligan ED, Twining C, Maier SF, Watkins LR, Foster AC, Naeve GS: Mapping fractalkine and its receptor (CX3CR1) in a rat model of sciatic inflammatory neuropathy (SIN). Proc Soc Neurosci 2002;28.
-
(2002)
Proc Soc Neurosci
, vol.28
-
-
Verge, G.1
Milligan, E.D.2
Twining, C.3
Maier, S.F.4
Watkins, L.R.5
Foster, A.C.6
Naeve, G.S.7
-
32
-
-
0030580559
-
Connexin-43 in rat spinal cord: Localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions
-
Ochalski, PA, Frankenstein UN, Hertzberg EL, Nagy JI: Connexin-43 in rat spinal cord: localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions. Neuroscience 1997;76:931-945.
-
(1997)
Neuroscience
, vol.76
, pp. 931-945
-
-
Ochalski, P.A.1
Frankenstein, U.N.2
Hertzberg, E.L.3
Nagy, J.I.4
-
33
-
-
0038162256
-
Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain
-
Zhu X, Conklin D, Eisenach JC: Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain 2003;104:15-23.
-
(2003)
Pain
, vol.104
, pp. 15-23
-
-
Zhu, X.1
Conklin, D.2
Eisenach, J.C.3
-
34
-
-
0242300734
-
Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury
-
Zhu X, Eisenach JC: Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Anesthesiology 2003;99:1175-1179.
-
(2003)
Anesthesiology
, vol.99
, pp. 1175-1179
-
-
Zhu, X.1
Eisenach, J.C.2
-
35
-
-
0031239164
-
Use of fluorocitrate and fluoroacetate in the study of brain metabolism
-
Fonnum F, Johnsen A, Hassel B: Use of fluorocitrate and fluoroacetate in the study of brain metabolism. Glia 1997;21:106-113.
-
(1997)
Glia
, vol.21
, pp. 106-113
-
-
Fonnum, F.1
Johnsen, A.2
Hassel, B.3
-
36
-
-
0023226069
-
An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: The use of fluorocitrate
-
Paulsen RE, Contestabile A, Villani L, Fonnum F: An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluorocitrate. J Neurochem 1987;48:1377-1385.
-
(1987)
J Neurochem
, vol.48
, pp. 1377-1385
-
-
Paulsen, R.E.1
Contestabile, A.2
Villani, L.3
Fonnum, F.4
-
37
-
-
0037320840
-
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
-
Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S, Tracey K, Martin D, Maier SF, Watkins LR: Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci 2003;23:1026-1040.
-
(2003)
J Neurosci
, vol.23
, pp. 1026-1040
-
-
Milligan, E.D.1
Twining, C.2
Chacur, M.3
Biedenkapp, J.4
O'Connor, K.5
Poole, S.6
Tracey, K.7
Martin, D.8
Maier, S.F.9
Watkins, L.R.10
-
38
-
-
0035871357
-
Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines
-
Milligan ED, O'Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR: Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci 2001;21:2808-2819.
-
(2001)
J Neurosci
, vol.21
, pp. 2808-2819
-
-
Milligan, E.D.1
O'Connor, K.A.2
Nguyen, K.T.3
Armstrong, C.B.4
Twining, C.5
Gaykema, R.P.6
Holguin, A.7
Martin, D.8
Maier, S.F.9
Watkins, L.R.10
-
39
-
-
0034615875
-
Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120
-
Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR: Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res 2000;861:105-116.
-
(2000)
Brain Res
, vol.861
, pp. 105-116
-
-
Milligan, E.D.1
Mehmert, K.K.2
Hinde, J.L.3
Harvey, L.O.4
Martin, D.5
Tracey, K.J.6
Maier, S.F.7
Watkins, L.R.8
-
40
-
-
0028027868
-
The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
-
Meller ST, Dykstra C, Grzybycki D, Murphy S, Gebhart GF: The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 1994;33:1471-1478.
-
(1994)
Neuropharmacology
, vol.33
, pp. 1471-1478
-
-
Meller, S.T.1
Dykstra, C.2
Grzybycki, D.3
Murphy, S.4
Gebhart, G.F.5
-
41
-
-
0035876916
-
Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
-
Tikka TM, Koistinaho JE: Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 2001;166:7527-7533.
-
(2001)
J Immunol
, vol.166
, pp. 7527-7533
-
-
Tikka, T.M.1
Koistinaho, J.E.2
-
42
-
-
0035871840
-
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
-
Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J: Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 2001;21:2580-2588.
-
(2001)
J Neurosci
, vol.21
, pp. 2580-2588
-
-
Tikka, T.1
Fiebich, B.L.2
Goldsteins, G.3
Keinanen, R.4
Koistinaho, J.5
-
43
-
-
0019292911
-
Pharmacotherapeutics of the newer tetracyclines
-
Aronson AL: Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 1980;176:1061-1068.
-
(1980)
J Am Vet Med Assoc
, vol.176
, pp. 1061-1068
-
-
Aronson, A.L.1
-
44
-
-
0025875557
-
Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs
-
Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR: Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991;2:297-321.
-
(1991)
Crit Rev Oral Biol Med
, vol.2
, pp. 297-321
-
-
Golub, L.M.1
Ramamurthy, N.S.2
McNamara, T.F.3
Greenwald, R.A.4
Rifkin, B.R.5
-
45
-
-
0026018690
-
Suppression of human neutrophil functions by tetracyclines
-
Gabler WL, Creamer HR: Suppression of human neutrophil functions by tetracyclines. J Periodontal Res 1991;26:52-58.
-
(1991)
J Periodontal Res
, vol.26
, pp. 52-58
-
-
Gabler, W.L.1
Creamer, H.R.2
-
46
-
-
0026447407
-
Comparison of doxycycline and a chemically modified tetracycline inhibition of leukocyte functions
-
Gabler WL, Smith J, Tsukuda NL: Comparison of doxycycline and a chemically modified tetracycline inhibition of leukocyte functions. Res Commun Chem Pathol Pharmacol 1992;78:151-160.
-
(1992)
Res Commun Chem Pathol Pharmacol
, vol.78
, pp. 151-160
-
-
Gabler, W.L.1
Smith, J.2
Tsukuda, N.L.3
-
47
-
-
0030450402
-
A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
-
USA
-
Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB: A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 1996;93:14014-14019.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 14014-14019
-
-
Amin, A.R.1
Attur, M.G.2
Thakker, G.D.3
Patel, P.D.4
Vyas, P.R.5
Patel, R.N.6
Patel, I.R.7
Abramson, S.B.8
-
48
-
-
0030832313
-
Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines
-
Amin AR, Patel RN, Thakker GD, Lowenstein CJ, Attur MG, Abramson SB: Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett 1997;410:259-264.
-
(1997)
FEBS Lett
, vol.410
, pp. 259-264
-
-
Amin, A.R.1
Patel, R.N.2
Thakker, G.D.3
Lowenstein, C.J.4
Attur, M.G.5
Abramson, S.B.6
-
49
-
-
0031018687
-
Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics
-
Whiteman M, Halliwell B: Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics. Free Radic Res 1997;26:49-56.
-
(1997)
Free Radic Res
, vol.26
, pp. 49-56
-
-
Whiteman, M.1
Halliwell, B.2
-
50
-
-
0034761723
-
Treatment of early seropositive rheumatoid arthritis: A two-year, double-blind comparison of minocycline and hydroxychloroquine
-
O'Dell JR, Blakely KW, Mallek JA, Eckhoff PJ, Leff RD, Wees SJ, Sems KM, Fernandez AM, Palmer WR, Klassen LW, Paulsen GA, Haire CE, Moore GF: Treatment of early seropositive rheumatoid arthritis: a two-year, double-blind comparison of minocycline and hydroxychloroquine. Arthritis Rheum 2001;44:2235-2241.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 2235-2241
-
-
O'Dell, J.R.1
Blakely, K.W.2
Mallek, J.A.3
Eckhoff, P.J.4
Leff, R.D.5
Wees, S.J.6
Sems, K.M.7
Fernandez, A.M.8
Palmer, W.R.9
Klassen, L.W.10
Paulsen, G.A.11
Haire, C.E.12
Moore, G.F.13
-
51
-
-
0028280174
-
Minocycline in active rheumatoid arthritis: A double-blind, placebo-controlled trial
-
Kloppenburg M, Breedveld FC, Terwiel JP, Mallee C, Dijkmans BA: Minocycline in active rheumatoid arthritis: a double-blind, placebo-controlled trial. Arthritis Rheum 1994;37:629-636.
-
(1994)
Arthritis Rheum
, vol.37
, pp. 629-636
-
-
Kloppenburg, M.1
Breedveld, F.C.2
Terwiel, J.P.3
Mallee, C.4
Dijkmans, B.A.5
-
52
-
-
0037622717
-
Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
-
Raghavendra V, Tanga F, DeLeo JA: Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther 2003;306:624-630.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 624-630
-
-
Raghavendra, V.1
Tanga, F.2
DeLeo, J.A.3
-
53
-
-
2442485722
-
Selective inhibition of spinal cord microglial activation attenuates mechanical allodynia in rat models of pathological pain
-
in press
-
Ledeboer A, Sloane E, Chacur M, Milligan ED, Maier SF, Watkins LR: Selective inhibition of spinal cord microglial activation attenuates mechanical allodynia in rat models of pathological pain. Proc Soc Neurosci 2003;29:in press.
-
(2003)
Proc Soc Neurosci
, vol.29
-
-
Ledeboer, A.1
Sloane, E.2
Chacur, M.3
Milligan, E.D.4
Maier, S.F.5
Watkins, L.R.6
-
54
-
-
0141921513
-
Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: Genetic, pharmacological and developmental aspects
-
Wolf G, Yirmiya R, Goshen I, Iverfeldt K, Holmlund L, Takeda K, Shavit Y: Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 2003;104:471-480.
-
(2003)
Pain
, vol.104
, pp. 471-480
-
-
Wolf, G.1
Yirmiya, R.2
Goshen, I.3
Iverfeldt, K.4
Holmlund, L.5
Takeda, K.6
Shavit, Y.7
-
55
-
-
0001997918
-
Development of microglia
-
Kettenmann H, Ransom BR (eds): New York, Oxford University Press
-
Fedoroff S: Development of microglia; in Kettenmann H, Ransom BR (eds): Neuroglia. New York, Oxford University Press, 1995, pp 162-181.
-
(1995)
Neuroglia
, pp. 162-181
-
-
Fedoroff, S.1
-
56
-
-
0042968804
-
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
-
Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 2003;424:778-783.
-
(2003)
Nature
, vol.424
, pp. 778-783
-
-
Tsuda, M.1
Shigemoto-Mogami, Y.2
Koizumi, S.3
Mizokoshi, A.4
Kohsaka, S.5
Salter, M.W.6
Inoue, K.7
-
57
-
-
26244442300
-
-
Garland Publishing, New York
-
Janeway CA, Travers P, Walport M, Shlomchik M: Immunobiology, ed 5. Garland Publishing, New York, 2001.
-
(2001)
Immunobiology, Ed 5
-
-
Janeway, C.A.1
Travers, P.2
Walport, M.3
Shlomchik, M.4
-
58
-
-
0027768570
-
Cytokine regulation of metalloproteinase gene expression
-
Mauviel A: Cytokine regulation of metalloproteinase gene expression. J Cell Biochem 1993;53:288-295.
-
(1993)
J Cell Biochem
, vol.53
, pp. 288-295
-
-
Mauviel, A.1
-
59
-
-
0024399071
-
IL-1 induces rapid phosphorylation of the IL-1 receptor
-
Gallis B, Prickett KS, Jackson J, Slack J, Schooley K, Sims JE, Dower SK: IL-1 induces rapid phosphorylation of the IL-1 receptor. J Immunol 1989;143:3235-3240.
-
(1989)
J Immunol
, vol.143
, pp. 3235-3240
-
-
Gallis, B.1
Prickett, K.S.2
Jackson, J.3
Slack, J.4
Schooley, K.5
Sims, J.E.6
Dower, S.K.7
-
61
-
-
0033874108
-
Proinflammatory cytokines
-
Dinarello CA: Proinflammatory cytokines. Chest 2000;118:503-508.
-
(2000)
Chest
, vol.118
, pp. 503-508
-
-
Dinarello, C.A.1
-
62
-
-
0032570035
-
Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: Potential role of IL-6 in neuropathic pain
-
Arruda JL, Colburn RW, Rickman AJ, Rutkowski MD, DeLeo JA: Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain. Brain Res Mol Brain Res 1998;62:228-235.
-
(1998)
Brain Res Mol Brain Res
, vol.62
, pp. 228-235
-
-
Arruda, J.L.1
Colburn, R.W.2
Rickman, A.J.3
Rutkowski, M.D.4
DeLeo, J.A.5
-
63
-
-
0035888956
-
Quantification of neural tissue injury in a rat radiculopathy model: Comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons
-
Winkelstein BA, Rutkowski MD, Weinstein JN, DeLeo JA: Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons. J Neurosci Methods 2001;111:49-57.
-
(2001)
J Neurosci Methods
, vol.111
, pp. 49-57
-
-
Winkelstein, B.A.1
Rutkowski, M.D.2
Weinstein, J.N.3
DeLeo, J.A.4
-
64
-
-
0035888084
-
Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
-
Winkelstein BA, Rutkowski MD, Sweitzer SM, Pahl JL, DeLeo JA: Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J Comp Neurol 2001;439:127-139.
-
(2001)
J Comp Neurol
, vol.439
, pp. 127-139
-
-
Winkelstein, B.A.1
Rutkowski, M.D.2
Sweitzer, S.M.3
Pahl, J.L.4
DeLeo, J.A.5
-
65
-
-
12144289036
-
HIV-1 gp120-induced spinal proinflammatory cytokine production and low threshold mechanical allodynia are mediated by nitric oxide
-
Holguin A, O'Connor K, Hansen MK, Milligan ED, Cheepsunthorn P, Braymann C, Cochran K, Biedenkapp J, Martin D, Maier SF, Watkins LR: HIV-1 gp120-induced spinal proinflammatory cytokine production and low threshold mechanical allodynia are mediated by nitric oxide. Brain Behav Immun 2002;16:191.
-
(2002)
Brain Behav Immun
, vol.16
, pp. 191
-
-
Holguin, A.1
O'Connor, K.2
Hansen, M.K.3
Milligan, E.D.4
Cheepsunthorn, P.5
Braymann, C.6
Cochran, K.7
Biedenkapp, J.8
Martin, D.9
Maier, S.F.10
Watkins, L.R.11
-
66
-
-
0037195594
-
Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: Considerations for persistent pain
-
Winkelstein BA, DeLeo JA: Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: considerations for persistent pain. Brain Res 2002;956:294-301.
-
(2002)
Brain Res
, vol.956
, pp. 294-301
-
-
Winkelstein, B.A.1
DeLeo, J.A.2
-
67
-
-
0029783630
-
Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model
-
DeLeo JA, Colburn RW, Nichols M, Malhotra A: Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J Interferon Cytokine Res 1996;16:695-700.
-
(1996)
J Interferon Cytokine Res
, vol.16
, pp. 695-700
-
-
DeLeo, J.A.1
Colburn, R.W.2
Nichols, M.3
Malhotra, A.4
-
68
-
-
0034657820
-
Spinal glial activation and cytokine expression after lumbar root injury in the rat
-
Hashizume H, DeLeo JA: Colburn RW, Weinstein JN: Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine 2000;25:1206-1217.
-
(2000)
Spine
, vol.25
, pp. 1206-1217
-
-
Hashizume, H.1
DeLeo, J.A.2
Colburn, R.W.3
Weinstein, J.N.4
-
69
-
-
0030751245
-
Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy
-
DeLeo JA, Colburn RW, Rickman AJ: Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy. Brain Res 1997;759:50-57.
-
(1997)
Brain Res
, vol.759
, pp. 50-57
-
-
DeLeo, J.A.1
Colburn, R.W.2
Rickman, A.J.3
-
70
-
-
0033594738
-
Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat
-
Sweitzer SM, Colburn RW, Rutkowski M, DeLeo JA: Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res 1999;829:209-221.
-
(1999)
Brain Res
, vol.829
, pp. 209-221
-
-
Sweitzer, S.M.1
Colburn, R.W.2
Rutkowski, M.3
Deleo, J.A.4
-
71
-
-
0034955577
-
Dib, Hyperalgesic effect of intrathecally administered interleukin-1 in rats
-
Falchi M, Ferrara F, Gharib CB: Dib, Hyperalgesic effect of intrathecally administered interleukin-1 in rats. Drugs Exp Clin Res 2001;27:97-101.
-
(2001)
Drugs Exp Clin Res
, vol.27
, pp. 97-101
-
-
Falchi, M.1
Ferrara, F.2
Gharib, C.B.3
-
72
-
-
0033835476
-
Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat
-
Reeve AJ, Patel S, Fox A, Walker K, Urban L: Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. Eur J Pain 2000;4:247-257.
-
(2000)
Eur J Pain
, vol.4
, pp. 247-257
-
-
Reeve, A.J.1
Patel, S.2
Fox, A.3
Walker, K.4
Urban, L.5
-
73
-
-
0003032172
-
Brain cytokines and pain
-
Watkins LR, Maier SF (eds): Basel, Birkhäuser
-
Oka T, Hori T: Brain cytokines and pain; in Watkins LR, Maier SF (eds): Cytokines and Pain. Basel, Birkhäuser, 1999, pp 183-204.
-
(1999)
Cytokines and Pain
, pp. 183-204
-
-
Oka, T.1
Hori, T.2
-
74
-
-
0035857748
-
Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
-
Sweitzer S, Martin D, DeLeo JA: Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 2001;103:529-539.
-
(2001)
Neuroscience
, vol.103
, pp. 529-539
-
-
Sweitzer, S.1
Martin, D.2
DeLeo, J.A.3
-
76
-
-
19944432904
-
Chronic constriction injury induced pathological pain states are controlled long term via intrathecal administration of a non-viral vector (NVV) encoding the anti-inflammatory cytokine interleukin-10 (IL-10)
-
Sloane EM, Langer SE, Milligan ED, Wieseler-Frank J, Mahoney J, Levkoff L, Cruz P, Flotte TR, Leinwant L, Maier SF, Watkins LR: Chronic constriction injury induced pathological pain states are controlled long term via intrathecal administration of a non-viral vector (NVV) encoding the anti-inflammatory cytokine interleukin-10 (IL-10). Proc Am Pain Soc, 2004.
-
(2004)
Proc Am Pain Soc
-
-
Sloane, E.M.1
Langer, S.E.2
Milligan, E.D.3
Wieseler-Frank, J.4
Mahoney, J.5
Levkoff, L.6
Cruz, P.7
Flotte, T.R.8
Leinwant, L.9
Maier, S.F.10
Watkins, L.R.11
-
77
-
-
0034613224
-
Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain
-
Arruda JL, Sweitzer S, Rutkowski MD, DeLeo JA: Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res 2000;879:216-225.
-
(2000)
Brain Res
, vol.879
, pp. 216-225
-
-
Arruda, J.L.1
Sweitzer, S.2
Rutkowski, M.D.3
DeLeo, J.A.4
-
78
-
-
0347169249
-
Glia: A novel drug discovery target for clinical pain
-
Watkins LR, Maier SF: Glia: a novel drug discovery target for clinical pain. Nature Rev Drug Discovery 2003;2:973-985.
-
(2003)
Nature Rev Drug Discovery
, vol.2
, pp. 973-985
-
-
Watkins, L.R.1
Maier, S.F.2
-
79
-
-
0025216634
-
Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord
-
Hornfeldt CS, Larson AA: Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord. Eur J Pharmacol 1990;179:307-313.
-
(1990)
Eur J Pharmacol
, vol.179
, pp. 307-313
-
-
Hornfeldt, C.S.1
Larson, A.A.2
-
80
-
-
0035018058
-
Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
-
Sweitzer SM, Schubert P, DeLeo JA: Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 2001;297:1210-1217.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 1210-1217
-
-
Sweitzer, S.M.1
Schubert, P.2
DeLeo, J.A.3
-
81
-
-
0345701254
-
Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
-
Schafers M, Svensson CI, Sommer C, Sorkin LS: Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 2003;23:2517-2521.
-
(2003)
J Neurosci
, vol.23
, pp. 2517-2521
-
-
Schafers, M.1
Svensson, C.I.2
Sommer, C.3
Sorkin, L.S.4
-
82
-
-
0037705314
-
p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
-
Jin SX, Zhuang ZY, Woolf CJ, Ji RR: p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 2003;23:4017-4022.
-
(2003)
J Neurosci
, vol.23
, pp. 4017-4022
-
-
Jin, S.X.1
Zhuang, Z.Y.2
Woolf, C.J.3
Ji, R.R.4
-
83
-
-
0037147689
-
Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury
-
Kim SY, Bae JC, Kim JY, Lee HL, Lee KM, Kim DS, Cho HJ: Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury. Neuroreport 2002;13:2483-2486.
-
(2002)
Neuroreport
, vol.13
, pp. 2483-2486
-
-
Kim, S.Y.1
Bae, J.C.2
Kim, J.Y.3
Lee, H.L.4
Lee, K.M.5
Kim, D.S.6
Cho, H.J.7
-
84
-
-
0141767048
-
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
-
Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL: Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing J Neurochem 2003;86:1534-1544.
-
(2003)
J Neurochem
, vol.86
, pp. 1534-1544
-
-
Svensson, C.I.1
Marsala, M.2
Westerlund, A.3
Calcutt, N.A.4
Campana, W.M.5
Freshwater, J.D.6
Catalano, R.7
Feng, Y.8
Protter, A.A.9
Scott, B.10
Yaksh, T.L.11
-
85
-
-
0042267829
-
Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia
-
Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL: Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport 2003;14:1153-1157.
-
(2003)
Neuroreport
, vol.14
, pp. 1153-1157
-
-
Svensson, C.I.1
Hua, X.Y.2
Protter, A.A.3
Powell, H.C.4
Yaksh, T.L.5
-
87
-
-
26244454974
-
Inflammatory and chronic constriction injury-induced pain states are controlled by spinal delivery of viral and non-viral vectors encoding the anti-inflammatory gene, interleukin-10 (IL10)
-
Milligan ED, Langer SE, Sloane E, Chacur M, Wieseler-Frank J, Frank M, Flotte TR, Cruz P, Leinwand L, Maier SF, Watkins LR: Inflammatory and chronic constriction injury-induced pain states are controlled by spinal delivery of viral and non-viral vectors encoding the anti-inflammatory gene, interleukin-10 (IL10). Proc Soc Neurosci, 2003, p 29.
-
(2003)
Proc Soc Neurosci
, pp. 29
-
-
Milligan, E.D.1
Langer, S.E.2
Sloane, E.3
Chacur, M.4
Wieseler-Frank, J.5
Frank, M.6
Flotte, T.R.7
Cruz, P.8
Leinwand, L.9
Maier, S.F.10
Watkins, L.R.11
-
88
-
-
0037333298
-
Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE
-
Ledeboer A, Wierinckx A, Bol JG, Floris S, Renardel de Lavalette C, De Vries HE, van den Berg TK, Dijkstra CD, Tilders FJ, van dam AM: Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE. J Neuroimmunol 2003;136:94-103.
-
(2003)
J Neuroimmunol
, vol.136
, pp. 94-103
-
-
Ledeboer, A.1
Wierinckx, A.2
Bol, J.G.3
Floris, S.4
Renardel De Lavalette, C.5
De Vries, H.E.6
Van Den Berg, T.K.7
Dijkstra, C.D.8
Tilders, F.J.9
Van Dam, A.M.10
-
89
-
-
26244454594
-
Gene therapy using naked plasmid DNA coding the anti-inflammatory gene, interleukin-10 (IL10): Repeated injections lead to long-term pain control in chronic constriction injury (CCI) rats
-
Milligan, ED, Langer SE, Sloane E, Wieseler-Frank J, Frank M, Levkoff L, Mahoney J, Chavez R, Forsayeth J, Cruz P, Flotte TR, Leinwand L, Maier SF, Watkins LR: Gene therapy using naked plasmid DNA coding the anti-inflammatory gene, interleukin-10 (IL10): repeated injections lead to long-term pain control in chronic constriction injury (CCI) rats. Proc Am Pain Soc, 2004.
-
(2004)
Proc Am Pain Soc
-
-
Milligan, E.D.1
Langer, S.E.2
Sloane, E.3
Wieseler-Frank, J.4
Frank, M.5
Levkoff, L.6
Mahoney, J.7
Chavez, R.8
Forsayeth, J.9
Cruz, P.10
Flotte, T.R.11
Leinwand, L.12
Maier, S.F.13
Watkins, L.R.14
|