Cross-talk between snurportin1 subdomains

Molecular Biology of the Cell

Volumn 16, Issue 10, 2005, Pages 4660-4671

  Ospina, Jason K ^a   Gonsalvez, Graydon B ^a   Bednenko, Janna ^b   Darzynkiewicz, Edward ^c   Gerace, Larry ^b   Matera, A Gregory ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; GUANOSINE DERIVATIVE; KARYOPHERIN ALPHA; KARYOPHERIN BETA; LEPTOMYCIN B; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; SNURPORTIN 1; TRIMETHYLGUANOSINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOREGULATION; BIOGENESIS; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; COILED BODY; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOTONEURON; NONHUMAN; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; BETA KARYOPHERINS; COILED BODIES; CONSERVED SEQUENCE; FATTY ACIDS, UNSATURATED; HELA CELLS; HUMANS; KARYOPHERINS; MOLECULAR SEQUENCE DATA; MOTOR NEURONS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RNA CAP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 26244433138     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-04-0316     Document Type: Article

References (61)

1. Adam, E.J., and Adam, S. A. (1994). Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope. J. Cell Biol. 125, 547-555.
2. Adam, S. A., and Gerace, L. (1991). Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell 66, 837-847.
3. Adam, S. A., Marr, R. S., and Gerace, L. (1990). Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111, 807-816.
4. Andrade, M. A., Petosa, C., O'Donoghue, S. I., Muller, C. W., and Bork, P. (2001). Comparison of ARM and HEAT protein repeats. J. Mol. Biol. 309, 1-18.
5. Askjaer, P., Jensen, T. H., Nilsson, J., Englmeier, L., and Kjems, J. (1998). The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. J. Biol. Chem. 273, 33414-33422.
6. Bednenko, J., Cingolani, G., and Gerace, L. (2003). Importin-β contains a COOH-terminal nucleoporin binding region important for nuclear transport. J. Cell Biol. 162, 391-401.
7. Boulon, S., Verheggen, C., Jady, B. E., Girard, C., Pescia, C., Paul, C., Ospina, J. K., Kiss, T., Matera, A. G., Bordonne, R., and Bertrand, E. (2004). PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli. Mol. Cell 16, 777-787.
8. Cingolani, G., Petosa, C., Weis, K., and Muller, C. W. (1999). Structure of importing bound to the IBB domain of importin-α. Nature 399, 221-229.
9. Conti, E., Uy, M., Leighton, L., Blobel, G., and Kuriyan, J. (1998). Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94, 193-204.
10. Dreyfuss, G., Kim, V. N., and Kataoka, N. (2002). Messenger-RNA-binding proteins and the messages they carry. Nat. Rev. Mol. Cell Biol. 3, 195-205.
11. Fechter, P., and Brownlee, G. G. (2005). Recognition of mRNA cap structures by viral and cellular proteins. J. Gen. Virol. 86, 1239-1249.
12. Fischer, U., Sumpter, V., Sekine, M., Satoh, T., and Lührmann, R. (1993). Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap. EMBO J. 12, 573-583.
13. Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I. W. (1997). CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90, 1051-1060.
14. Frey, M. R., and Matera, A. G. (1995). Coiled Bodies Contain U7 Small Nuclear RNA and Associate with Specific DNA Sequences in Interphase Cells. Proc. Natl. Acad. Sci. USA 92, 5915-5919.
15. Fried, H., and Kutay, U. (2003). Nucleocytoplasmic transport: taking an inventory. Cell Mol. Life Sci. 60, 1659-1688.
16. Görlich, D., Henklein, P., Laskey, R. A., and Hartmann, E. (1996). A 41 amino acid motif in importin-α confers binding to importin-beta and hence transit into the nucleus. EMBO J. 15, 1810-1817.
17. Görlich, D., and Mattaj, I. (1996). Nucleocytoplasmic transport. Science 271, 1513-1518.
18. Harel, A., and Forbes, D. J. (2004). Importin β: conducting a much larger cellular symphony. Mol. Cell 16, 319-330.
19. Harreman, M. T., Cohen, P. E., Hodel, M. R., Truscott, G. J., Corbett, A. H., and Hodel, A. E. (2003a). Characterization of the auto-inhibitory sequence within the N-terminal domain of importin alpha. J. Biol. Chem. 278, 21361-21369.
20. Harreman, M. T., Hodel, M. R., Fanara, P., Hodel, A. E., and Corbett, A. H. (2003b). The auto-inhibitory function of importin alpha is essential in vivo. J. Biol. Chem. 278, 5854-5863.
21. Hieda, M., Tachibana, T., Yokoya, F., Kose, S., Imamoto, N., and Yoneda, Y. (1999). A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells. J. Cell Biol. 144, 645-655.
22. Huber, J., Cronshagen, U., Kadokura, M., Marshallsay, C., Wada, T., Sekine, M., and Lührmann, R. (1998). Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. EMBO J. 17, 4114-4126.
23. Huber, J., Dickmanns, A., and Lührmann, R. (2002). The importin-β binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J. Cell Biol. 156, 467-479.
24. Izaurralde, E., Kutay, U., von Kobbe, C., Mattaj, I. W., and Gorlich, D. (1997). The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J. 16, 6535-6547.
25. Jarmolowski, A., Boelens, W. C., Izaurralde, E., and Mattaj, I. W. (1994). Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124, 627-635.
26. Kiss, T. (2004). Biogenesis of small nuclear RNPs. J. Cell Sci. 117, 5949-5951.
27. Klebe, C., Nishimoto, T., and Wittinghofer, F. (1993). Functional expression in Escherichia coli of the mitotic regulator proteins p24ran and p45rcc1 and fluorescence measurements of their interaction. Biochemistry 32, 11923-11928.
28. Kobe, B. (1999). Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin α. Nat. Struct. Biol. 6, 388-397.
29. Kudo, N., Wolff, B., Sekimoto, T., Schreiner, E. P., Yoneda, Y., Yanagida, M., Horinouchi, S., and Yoshida, M. (1998). Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242, 540-547.
30. Marshallsay, C., and Lührmann, R. (1994). In vitro nuclear import of snRNPs: cytosolic factors mediate m3G-cap dependence of U1 and U2 snRNP transport. EMBO J. 13, 222-231.
31. Masuyama, K., Taniguchi, I., Kataoka, N., and Ohno, M. (2004). RNA length defines RNA export pathway. Genes Dev. 18, 2074-2085.
32. Meister, G., Eggert, C., and Fischer, U. (2002). SMN-mediated assembly of RNPs: a complex story. Trends Cell Biol. 12, 472-478.
33. Moroianu, J., Blobel, G., and Radu, A. (1995). Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc. Natl. Acad. Sci. USA 92, 2008-2011.
34. Mosammaparast, N., and Pemberton, L. F. (2004). Karyopherins: from nuclear-transport mediators to nuclear-function regulators. Trends Cell Biol. 14, 547-556.
35. Mouaikel, J., Bujnicki, J. M., Tazi, J., and Bordonne, R. (2003). Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase. Nucleic Acids Res. 31, 4899-4909.
36. Mouaikel, J., Verheggen, C., Bertrand, E., Tazi, J., and Bordonne, R. (2002). Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. Mol. Cell 9, 891-901.
37. Narayanan, U., Achsel, T., Lührmann, R., and Matera, A. G. (2004). Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein. Mol. Cell 16, 223-234.
38. Narayanan, U., Ospina, J. K., Frey, M. R., Hebert, M. D., and Matera, A. G. (2002). SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin β. Hum. Mol. Genet. 11, 1785-1795.
39. Nesic, D., Tanackovic, G., and Krämer, A. (2004). A role for Cajal bodies in the final steps of U2 snRNP biogenesis. J. Cell Sci. 117, 4423-4433.
40. Nilsson, J., Askjaer, P., and Kjems, J. (2001). A role for the basic patch and the C terminus of RanGTP in regulating the dynamic interactions with importin β, CRM1 and RanBP1. J. Mol. Biol. 305, 231-243.
41. Ohno, M., Segref, A., Bachi, A., Wilm, M., and Mattaj, I. W. (2000). PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell 202, 187-198.
42. Ossareh-Nazari, B., Bachelerie, F., and Dargemont, C. (1997). Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278, 141-144.
43. Palacios, I., Hetzer, M., Adam, S. A., and Mattaj, I. W. (1997). Nuclear import of U snRNPs requires importin β. EMBO J. 16, 6783-6792.
44. Pante, N. (2004). Nuclear pore complex structure: unplugged and dynamic pores. Dev. Cell 7, 780-781.
45. Paraskeva, E., Izaurralde, E., Bischoff, F. R., Huber, J., Kutay, U., Hartmann, E., Lührmann, R., and Gorlich, D. (1999). CRM1-mediated recycling of snurportin 1 to the cytoplasm. J. Cell Biol. 145, 255-264.
46. Pellizzoni, L., Yong, J., and Dreyfuss, G. (2002). Essential role for the SMN complex in the specificity of snRNP assembly. Science 298, 1775-1779.
47. Petosa, C., Schoehn, G., Askjaer, P., Bauer, U., Moulin, M., Steuerwald, U., Soler-Lopez, M., Baudin, F., Mattaj, I. W., and Muller, C. W. (2004). Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol. Cell 16, 761-775.
48. Quiocho, F. A., Hu, G., and Gershon, P. D. (2000). Structural basis of mRNA cap recognition by proteins. Curr. Opin. Struct. Biol. 10, 78-86.
49. Rout, M. P., and Aitchison, J. D. (2001). The nuclear pore complex as a transport machine. J. Biol. Chem. 276, 16593-16596.
50. Segault, V., Will, C. L., Sproat, B. S., and Lührmann, R. (1995). In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs. EMBO J. 14, 4010-4021.
51. Sleeman, J. E., and Lamond, A. I. (1999). Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr. Biol. 9, 1065-1074.
52. Strasser, A., Dickmanns, A., Lührmann, R., and Ficner, R. (2005). Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J. 24, 2235-2243.
53. Strasser, A., Dickmanns, A., Schmidt, U., Penka, E., Urlaub, H., Sekine, M., Lührmann, R., and Ficner, R. (2004). Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1. Acta Crystallogr. D. Biol. Crystallogr. 60, 1628-1631.
54. Sumpter, V., Kahrs, A., Fischer, U., Kornstadt, U., and Lührmann, R. (1992). In vitro reconstitution of U1 and U2 snRNPs from isolated proteins and snRNA. Mol. Biol. Rep. 16, 229-240.
55. Suntharalingam, M., and Wente, S. R. (2003). Peering through the pore: nuclear pore complex structure, assembly, and function. Dev. Cell 4, 775-789.
56. Tanackovic, G., and Krämer, A. (2005). Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo. Mol. Biol. Cell 26, 1366-1377.
57. Verheggen, C., Lafontaine, D. L., Samarsky, D., Mouaikel, J., Blanchard, J. M., Bordonne, R., and Bertrand, E. (2002). Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments. EMBO J. 21, 2736-2745.
58. Weis, K., Mattaj, I., and Lamond, A. (1995). Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science 268, 1049-1053.
59. Will, C. L., and Lührmann, R. (2001). Spliceosomal UsnRNP biogenesis, structure and function. Curr. Opin. Cell Biol. 13, 290-301.
60. Will, C. L., Urlaub, H., Achsel, T., Gentzel, M., Wilm, M., and Lührmann, R. (2002). Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J. 21, 4978-4988.
61. Yong, J., Golembe, T. J., Battle, D. J., Pellizzoni, L., and Dreyfuss, G. (2004). snRNAs contain specific SMN-binding domains that are essential for snRNP assembly. Mol. Cell Biol. 24, 2747-2756.