Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent

Wound Repair and Regeneration

Volumn 10, Issue 5, 2002, Pages 336-340

  Liu, Yawei ^a   Kalén, Anders ^a   Risto, Olof ^a   Wahlström, Ola ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

NITROBLUE TETRAZOLIUM; PLATELET DERIVED GROWTH FACTOR; THROMBOCYTE CONCENTRATE; TRANSFORMING GROWTH FACTOR BETA;

ACIDITY; ALKALINITY; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CULTURE MEDIUM; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FIBROBLAST; HUMAN; MACROMOLECULE; PRIORITY JOURNAL; WESTERN BLOTTING; WOUND HEALING IMPAIRMENT;

BLOOD PLATELETS; BLOTTING, WESTERN; CELL DIVISION; COLLAGEN TYPE I; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; HUMANS; HYDROGEN-ION CONCENTRATION; PLATELET-DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0036427196     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2002.10510.x     Document Type: Article

References (30)

1. Martin P. Wound healing: Aiming for perfect skin regeneration. Science 1997;276:75-81.
2. Bartold PM, Raben A. Growth factor modulation of fibroblasts in simulated wound healing. J Peridont Res 1996;31:205-16.
3. Bennett NT, Schultz GS. Growth factors and wound healing. Biochemical properties of growth factors and their receptors. Am J Surg 1993;165:728-37.
4. Chufa HE, Hughes MA, Cherry GW, Arnold F. Effects of chronic wound fluid on the bioactivity of PDGF in serum-free medium and its direct effect on fibroblast growth. Wound Rep Reg 1999;7:97-105.
5. Graves DT, Cochran DL. Mesenchymal cell growth factors. Crit Rev Oral Biol Med 1990;1:17-36.
6. Guerne PA, Sublet A, Lotz M. Growth factor responsiveness of human articular chondrocytes: Distinct profiles in primary chondrocytes, subcultered chondrocytes and fibroblasts. J Cell Phys 1994;158:476-84.
7. Katz MH, Alvarez AF, Kirsner RS, Eaglstein WH, Falanga VC. Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J Am Acad Dermatol 1991;25:1054-8.
8. Marx RE, Carlson ER, Eichstaedt RM, Schimmelse SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-46.
9. Staiano-Coico L, Higgins PJ, Schwartz SB, Zimm AJ, Goncalves J. Wound fluids: A reflection of the state of healing. Ostomy/Wound Manage 2000;46(Suppl. 1):85S-93S.
10. Vogt PM, Lehnhardt M, Wagner D, Jansen V, Krieg M, Steinau HU. Determination of endogenous growth factors in human wound fluid. Temporal presence and profiles of secretion. Plast Reconstr Surg 1998;102:117-23.
11. Vogt PM, Drucke D, Muhlberger T, Homan HH, Steinau HU. Klinischer einsatz von wachstumfactoren und zytokinen in der wundheilung. Centr Chir 2000;125(Suppl. 1):65-8.
12. Bennett NT, Schultz GS. Growth factors and wound healing. Part II. Role in normal and chronic wound healing. Am J Surg 1993;166:74-81.
13. Hollinger J, Wong MEK. The integrated process of hard tissue regeneration with special emphasis on fracture healing. Oral Surg Oral Med Oral Pathol Oral Radiol Oral Endod 1996;82:594-606.
14. Chakkalakal DA, Mashoof AA, Novak J, Strates BS, McGuire MH. Mineralization and pH relationship in healing skeletal defects grafted with demineralized bone matrix. J Biomed Mat Res 1994;28:14-39-43.
15. Edlow DE, Sheldon WH. The pH of inflammatory exudates. Proc Soc Exp Biol Med 1971;137:1328-32.
16. Heuwinkel R, Schneider HM, Störkel S. Der gewebs-pH als stimulans desmaler knochenneubildung. Unfallheilkunde 1980;83:577-85.
17. Newman RJ, Duthie RB, Martin JO. Nuclear magnetic resonance studies of fracture repair. Clin Orthop 1985;198:297-303.
18. Newman RJ, Francis MJ, Duthie RB. Nuclear magnetic resonance studies of experimentally induced delayed fracture union. Clin Orthop 1987;216:253-61.
19. Swenson O, Lloyd Claff C. Changes in the hydrogen ion concentration of healing fractures. Proc Soc Exp Biol Med 1946;61:151-4.
20. Knighton DR, Fiegel VD, Austin LL, Ciresi KF, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg 1986;204:322-30.
21. Knighton DR, Ciresi K, Fiegel VD, Schumerth S, Butler E, Cerra F. Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet 1990;170:56-60.
22. Holloway GA, Steed DL, Demarco MJ, Masumoto T, Moosa HH, Webster MW, Bunt TJ, Polansky M. A randomized controlled multicenter dose response trial of activated platelet supernatant, topical CT-102 in chronic, nonhealing diabetic wounds. Wounds 1993;5:198-206.
23. Steed DL, Goslen JB, Holloway GA, Malone JM, Webster MW. Randomized prospective double-blind trial in healing chronic diabetic foot ulcers (CT-102 activated platelet supernatant, topical versus placebo). Diabetes Care 1992;15:1598-604.
24. Pricolo VE, Caldwell MD, Mastrofrancesco B, Mills CD. Modulatory activities of wound fluid on fibroblast proliferation and collagen synthesis. J Surg Res 1990;48:534-8.
25. Leveen HH, Falk G, Borek B, Diaz C, Lynfield Y, Wynkoop BJ, Mabunda GA, Rubricius JL, Christoudias GC. Chemical acidification of wounds. Ann Surg 1973;178:745-53.
26. Lengheden A, Jansson L. pH effects on experimental wound healing of human fibroblasts in vitro. Eur J Oral Sci 1995;103:148-55.
27. Lynch SE, Nixon JC, Colvin RB, Antoniades HN. Role of PDGF in wound healing: Synergistic effects with other growth factors. Proc Natl Acad Sci USA 1987;84:7696-700.
28. Jennings J, Mohan S. Heterogeneity of latent transforming growth factor-β isolated from bone matrix proteins. Endocrinology 1990;126:1014-21.
29. Varga J, Jimenez SA. Stimulation of normal fibroblast collagen production and processing by transforming growth factor-beta. Biochem Biophys Res Commun 1986;138:974-80.
30. Varga J, Rosenbloom J, Jimenez SA. Transforming growth factor-β (TGF-β) causes a persistent increase in steady-state amounts of type I and Type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 1987;247:597-604.