Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 22, 2005, Pages 4910-4914

  Chu, Xin Jie ^a   Bartkovitz, David ^a   Danho, Waleed ^a   Swistok, Joseph ^a   Cheung, Adrian Wai Hing ^a   Kurylko, Grazyna ^a   Rowan, Karen ^a   Yeon, Mitch ^a   Franco, Lucia ^a   Qi, Lida ^a   Chen, Li ^a   Yagaloff, Keith ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; HISTIDINE; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PARTIAL AGONIST; PENTA 1 AMINO 4 PHENYLCYCLOHEXANE 1 CARBOXYLIC ACID DEXTRO PHENYLALANYLARGINYLTRYPTOPHANAMIDE; PENTA 1 AMINO 4 PHENYLCYCLOHEXANE 1 CARBOXYLIC ACID DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLGLYCINAMIDE; PENTA 2 AMINOTETRALINE 2 CARBOXYLIC ACID DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLGLYCINAMIDE; PENTAPEPTIDE; PEPTIDE DERIVATIVE; PHENYLQUINONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; LINEAR SYSTEM; SUBSTITUTION REACTION;

AMINO ACID SEQUENCE; CARBOXYLIC ACIDS; CYCLOHEXANES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 4; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 25844469596     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.012     Document Type: Article

References (21)

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