Syntheses and antifilarial profile of 5-amino and 5,8-diamino-isoquinoline derivatives: A new class of antifilarial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 22, 1996, Pages 2623-2628

  Srivastava, Sanjay K ^a   Chauhan, P M S ^a   Agarwal, S K ^a   Bhaduri, A P ^a   Singh, S N ^a   Fatma, Nigar ^a   Chatterjee, R K ^a   Bose, Chhanda ^a   Srivastava, V M L ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOISOQUINOLINE DERIVATIVE; 5,8 DIAMINOISOQUINOLINE DERIVATIVE; ANTIFILARIAL AGENT; DIETHYLCARBAMAZINE; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACANTHAMOEBA; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; DRUG SYNTHESIS; FILARIASIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN;

ACANTHAMOEBA; ACANTHOCHEILONEMA VITEAE; ANIMALIA; ONCHOCERCIDAE; RODENTIA;

EID: 0030593885     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00458-1     Document Type: Article

References (16)

1. 1. CDRI communication No. 5557
2. 2. TDR / CTD / FIL / PENAN / 94.1 1994.
3. 3. Chauhan, P.M.S.; Singh, S.N.; Chattarjee, R. K. Indian J. Chem. 1993, 32B, 858.
4. 4. Chauhan, P.M.S.; Chattarjee, R. K. Indian J. Chem. 1994, 33B, 32.
5. 5. Campbell, W.C. Parasitology Today, 1985, 1, 10.
6. 6. Elslager, E.F.; Perricone, S.C.; Tendick, F.H. J. Med. Chem. 1969, 12, 965.
7. 7. Loiseau, P.M.; Depreux, P. Annals. Trop. Med. Parasitol. 1993, 87, 469.
8. 8. Craig, J.J.; Cass, W.E. J. Am. Chem. Soc. 1942, 64, 783.
9. 9. Mathison, I.W.; Morgan, P. J. Org. Chem. 1974, 39, 3211.
10. 3): δ 3.00-3.20(m, 4H), 3.60-3.80(m, 4H), 4.30(s, 1H), 6.30-6.80(m, 4H), 7.52-7.58(m, 2H), 7.80-8.20(m, 2H), 8.35(s, 1H), 8.70(s, 1H).
11. 11. Worms, M.J.; Jerry, R.J.; Terry, A. J. Parasit. 1961, 47, 963.
12. 12. Bose, C.; Chattarjee, R.K.; Srivastava, V.M.L. Indian J. Exp. Biol. 1994, 32, 431.
13. 13. Bose, C.; Chattarjee, R.K.; Srivastava, V.M.L. Med. Sci. Res. 1996 (in press).
14. 14. Hawking, F. Adv. Pharmacol. Chemother. 1979, 16, 130.
15. 15. Van den Bossche, H. In "Hand Book of Experimental Pharmacology", Vol. 77, Eds. Vanden Bossche, H.; Thienpont, D. and Janssens, P.G. Spring Verlag, Heidelberg, 1985, pp. 125.
16. 16. Friedman, P.A. and Platzer, E.G. Biochim. Biophys. Acta, 1978, 544, 605.