The promise of prostaglandins: Have they fulfilled their potential as therapeutic targets for the delay of preterm birth?

Journal of the Society for Gynecologic Investigation

Volumn 12, Issue 7, 2005, Pages 466-478

  Olson, David M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cyclooxygenase; Indomethacin; Nonsteroidal anti inflammatory drugs; Prostaglandin H synthase; Prostaglandin receptors

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; INDOMETACIN; MELOXICAM; MIFEPRISTONE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; SULINDAC; VALDECOXIB;

BRAIN HEMORRHAGE; CLINICAL TRIAL; GASTROINTESTINAL TOXICITY; HEART INFARCTION; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MYOMETRIUM; NECROTIZING ARTERITIS; NONHUMAN; OLIGOHYDRAMNIOS; PATENT DUCTUS ARTERIOSUS; PREMATURE LABOR; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PULMONARY HYPERTENSION; REVIEW; SHEEP; SIDE EFFECT; STROKE;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2 INHIBITORS; FEMALE; HUMANS; PREGNANCY; PREMATURE BIRTH; PROSTAGLANDINS; RECEPTORS, PROSTAGLANDIN;

EID: 25844446158     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsgi.2005.06.004     Document Type: Review

References (151)

1. G.C. Liggins, R.J. Fairclough, S.A. Grieves, J.Z. Kendall, B.S. Knox The mechanism of initiation of parturition in the ewe Recent Prog Horm Res 29 1973 111 159
2. G.S. Berkowitz, E. Papiernik Epidemiology of preterm birth Epidemiol Rev 15 1993 414 443
3. J.M. Moutquin, E. Papiernik Can we lower the rate of preterm birth? 1990 Bull Society of Obstetricians and Gynaecologists of Canada, September, 19-20
4. H. Canada Canadian Perinatal Health Report, 2003 2003 Minister of Public Works and Government Sources Canada Ottawa, Canada
5. R.L. Goldenberg The management of preterm labor Obstet Gynecol 100 2002 1020 1037
6. M.S. Kramer, K. Demissie, H. Yang, R.W. Platt, R. Sauve, R. Liston The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System JAMA 284 2000 843 849
7. J. Magill-Evans, M.J. Harrison, J. Van der Zalm, G. Holdgrafer Cognitive and language development of healthy preterm infants at 10 years of age Phys Occup Ther Pediatr 22 2002 41 56
8. C. Boiti, D. Zampini, M. Zerani, G. Guelfi, A. Gobbetti Prostaglandin receptors and role of G protein-activated pathways on corpora lutea of pseudopregnant rabbit in vitro J Endocrinol 168 2001 141 151
9. C.L. Roberts, C.S. Algert, B. Peat, D.J. Henderson-Smart Trends in place of birth for preterm infants in New South Wales, 1992-2001 J Paediatr Child Health 40 2004 139 143
10. K.S. Joseph, M.S. Kramer, S. Marcoux Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994 N Engl J Med 339 1998 1434 1439
11. M.S. Kramer, R. Platt, H. Yang Secular trends in preterm birth A hospital-based cohort study JAMA 280 1998 1849 1854
12. Prematurity Research Expansion and Education for Mothers who deliver Infants Early Act of 2003. 3350 USC.
13. J.R. Challis, D.M. Olson Parturition E. Knobil J. Neill The Physiology of Reproduction 1988 Raven New York, NY 2177 2216
14. J.R. Niebyl, D.A. Blake, R.D. White The inhibition of premature labor with indomethacin Am J Obstet Gynecol 136 1980 1014 1019
15. H. Zuckerman, E. Shalev, G. Gilad, E. Katzuni Further study of the inhibition of premature labor by indomethacin. Part I J Perinat Med 12 1984 19 23
16. M.A. Alano, E. Ngougmna, E.M. Ostrea Jr, G.G. Konduri Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn Pediatrics 107 2001 519 523
17. M.E. Norton, J. Merrill, B.A. Cooper, J.A. Kuller, R.I. Clyman Neonatal complications after the administration of indomethacin for preterm labor N Engl J Med 329 1993 1602 1607
18. B. Kirshon, K.J. Moise Jr, G. Mari, R. Willis Long-term indomethacin therapy decreases fetal urine output and results in oligohydramnios Am J Perinatol 8 1991 86 88
19. B.S. Kaplan, I. Restaino, D.S. Raval, R.P. Gottlieb, J. Bernstein Renal failure in the neonate associated with in utero exposure to non-steroidal anti-inflammatory agents Pediatr Nephrol 8 1994 700 704
20. R. Krishna, K.W. Riggs, E. Kwan Clearance and disposition of indometacin in chronically instrumented fetal lambs following a 3-day continuous intravenous infusion J Pharm Pharmacol 54 2002 801 808
21. D.F. Anderson, T.M. Phernetton, J.H. Rankin The measurement of placental drug clearance in near-term sheep Indomethacin J Pharmacol Exp Ther 213 1980 100 104
22. W.H. Harris, G.R. Van Petten Placental transfer of indomethacin in the rabbit and sheep Can J Physiol Pharmacol 59 1981 342 346
23. K.J. Moise Jr, C.N. Ou, B. Kirshon, L.E. Cano, C. Rognerud, R.J. Carpenter Jr Placental transfer of indomethacin in the human pregnancy Am J Obstet Gynecol 162 1990 549 554
24. D.W. Rurak, M.R. Wright, J.E. Axelson Drug disposition and effects in the fetus J Dev Physiol 15 1991 33 44
25. Z. Smieja, T. Zakar, J.C. Walton, D.M. Olson Prostaglandin endoperoxide synthase kinetics in human amnion before and after labor at term and following preterm labor Placenta 14 1993 163 175
26. F.J. Teixeira, T. Zakar, J. Hirst, F. Guo, G. Machin, D.M. Olson Prostaglandin endoperoxide H synthase (PGHS) activity increases with gestation and labour in human amnion J Lipid Mediat 6 1993 515 523
27. F.J. Teixeira, T. Zakar, J.J. Hirst Prostaglandin endoperoxide-H synthase (PGHS) activity and immunoreactive PGHS-1 and PGHS-2 levels in human amnion throughout gestation, at term, and during labor J Clin Endocrinol Metab 78 1994 1396 1402
28. W.L. Xie, J.G. Chipman, D.L. Robertson, R.L. Erikson, D.L. Simmons Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing Proc Natl Acad Sci U S A 88 1991 2692 2696
29. J.J. Hirst, F.J. Teixeira, T. Zakar, D.M. Olson Prostaglandin endoperoxide H synthase II mRNA and immunoreactive protein levels in human amnion and deciduas. 3rd European Congress on Prostaglandins in Reproduction 1993 Edinburgh, Scotland
30. M.D. Mitchell, L. Barley, D. Collmer, D.J. Dudley, M.S. Trautman An evaluation of cyclooxygenases I and II in human gestational tissues using polymerase chain reaction (PCR) 1993 Annual Meeting of the Endocrine Society. Las Vegas, NV
31. D.M. Slater, L.C. Berger, R. Newton, G.E. Moore, P.R. Bennett Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term Am J Obstet Gynecol 172 1995 77 82
32. M.S. Trautman, S.S. Edwin, D. Collmer, D.J. Dudley, D. Simmons, M.D. Mitchell Prostaglandin H synthase-2 in human gestational tissues Regulation in amnion Placenta 17 1996 239 245
33. D.M. Slater, W.J. Dennes, J.S. Campa, L. Poston, P.R. Bennett Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy Mol Hum Reprod 5 1999 880 884
34. J.E. Mijovic, T. Zakar, T.K. Nairn, D.M. Olson Prostaglandin-endoperoxide H synthase-2 expression and activity increases with term labor in human chorion Am J Physiol 272 1997 E832 E840
35. J.E. Mijovic, T. Zakar, T.K. Nairn, D.M. Olson Prostaglandin endoperoxide H synthase (PGHS) activity and PGHS-1 and -2 messenger ribonucleic acid abundance in human chorion throughout gestation and with preterm labor J Clin Endocrinol Metab 83 1998 1358 1367
36. J.E. Mijovic, T. Zakar, J. Angelova, D.M. Olson Prostaglandin endoperoxide H synthase mRNA expression in the human amnion and decidua during pregnancy and in the amnion at preterm labour Mol Hum Reprod 5 1999 182 187
37. J.J. Hirst, J.E. Mijovic, T. Zakar, D.M. Olson Prostaglandin endoperoxide H synthase-1 and -2 mRNA levels and enzyme activity in human decidua at term labor J Soc Gynecol Investig 5 1998 13 20
38. J.J. Hirst, F.J. Teixeira, T. Zakar, D.M. Olson Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset J Clin Endocrinol Metab 80 1995 517 523
39. F. Potestio, T. Zakar, D.M. Olson Glucocorticoids stimulate prostaglandin synthesis in human amnion cells by a receptor-mediated mechanism J Clin Endocrinol Metab 67 1988 1205 1210
40. T. Zakar, D.M. Olson The action of epidermal growth factor on human amnion prostaglandin E2 output Can J Physiol Pharmacol 66 1988 769 775
41. T. Zakar, D.M. Olson Stimulation of human amnion prostaglandin E2 production by activators of protein kinase-C J Clin Endocrinol Metab 67 1988 915 923
42. T. Zakar, D.M. Olson Dexamethasone stimulates arachidonic acid conversion to prostaglandin E2 in human amnion cells J Dev Physiol 12 1989 269 272
43. T. Zakar, E.A. MacLeod, D.M. Olson Glucocorticoid stimulation of amnion cell prostaglandin synthesis Suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C Biochim Biophys Acta 1136 1992 161 168
44. M.D. Mitchell, R.M. Silver, D. Carlton An interleukin-1 beta-inducible cyclooxygenase in human amnion 1992 8th International Conference on Prostaglandins and Related Compounds. Montreal, Canada
45. J.A. Mitchell, S. Larkin, T.J. Williams Cyclooxygenase-2 Regulation and relevance in inflammation Biochem Pharmacol 50 1995 1535 1542
46. W.L. Smith, D.L. DeWitt Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs Semin Nephrol 15 1995 179 194
47. H.R. Herschman Regulation of prostaglandin synthase-1 and prostaglandin synthase-2 Cancer Metast Rev 13 1994 241 256
48. M. Goppelt-Struebe Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression Prostaglandins Leukot Essent Fatty Acids 52 1995 213 222
49. T. Zakar, J.J. Hirst, J.E. Mijovic, D.M. Olson Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells Endocrinology 136 1995 1610 1619
50. T. Zakar, J.E. Mijovic, K.M. Eyster, D. Bhardwaj, D.M. Olson Regulation of prostaglandin H2 synthase-2 expression in primary human amnion cells by tyrosine kinase dependent mechanisms Biochim Biophys Acta 1391 1998 37 51
51. W.R. Hansen, T. Sato, M.D. Mitchell Tumour necrosis factor-alpha stimulates increased expression of prostaglandin endoperoxide H synthase type 2 mRNA in amnion-derived WISH cells J Mol Endocrinol 20 1998 221 231
52. S. Potter, W.R. Hansen, J.A. Keelan, M.D. Mitchell Characterization of the amnion-derived AV3 cell line for use as a model for investigation of prostaglandin-cytokine interactions in human amnion Prostaglandins Leukot Essent Fatty Acids 61 1999 373 379
53. J. Mijovic, T. Zakar, T. Nairn, D.M. Olson Prostaglandin-endoperoxide H synthase-2 expression and activity increases with term labor in human chorion Am J Physiol 272 1997 E832 E840
54. T.D. Warner, F. Giuliano, I. Vojnovic, A. Bukasa, J.A. Mitchell, J.R. Vane Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity a full in vitro analysis Proc Natl Acad Sci U S A 96 1999 7563 7568
55. K.J. McKeown, J.R. Challis, C. Small Altered fetal pituitary-adrenal function in the ovine fetus treated with RU486 and meloxicam, an inhibitor of prostaglandin synthase-II Biol Reprod 63 2000 1899 1904
56. P.L. Grigsby, K.R. Poore, J.J. Hirst, G. Jenkin Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist Am J Obstet Gynecol 183 2000 649 657
57. J.E. Dinchuk, B.D. Car, R.J. Focht Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II Nature 378 1995 406 409
58. M. Komhoff, J.L. Wang, H.F. Cheng Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development Kidney Int 57 2000 414 422
59. M.E. Wlodek, R. Harding, G.D. Thorburn Effects of inhibition of prostaglandin synthesis on flow and composition of fetal urine, lung liquid, and swallowed fluid in sheep Am J Obstet Gynecol 170 1994 186 195
60. S.J. Williams, I.C. McMillen, D.B. Zaragoza, D.M. Olson Placental restriction increases the expression of prostaglandin endoperoxide G/H synthase-2 and EP2 mRNA in the fetal sheep kidney during late gestation Pediatr Res 52 2002 879 885
61. B.M. Brenner, D.L. Garcia, S. Anderson Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1 1988 335 347
62. D.M. Olson, J.E. Mijovic, D.B. Zaragoza, J.L. Cook Prostaglandin endoperoxide H synthase type 1 and type 2 messenger ribonucleic acid in human fetal tissues throughout gestation and in the newborn infant Am J Obstet Gynecol 184 2001 169 174
63. R.J. Sawdy, S. Lye, N.M. Fisk, P.R. Bennett A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor Am J Obstet Gynecol 188 2003 1046 1051
64. K.M. Groom, A.H. Shennan, B.A. Jones, P. Seed, P.R. Bennett Tocox - A randomised double blind placebo controlled trial to assess the safety of the use of rofecoxib (a COX-2 specific PG inhibitor) for the prevention of preterm delivery in women at high risk J Soc Gynecol Investig 10 2003 307A
65. J.A. Loudon, K.M. Groom, P.R. Bennett Prostaglandin inhibitors in preterm labour Best Pract Res Clin Obstet Gynaecol 17 2003 731 744
66. J.R. Vane, T.D. Warner Nomenclature for COX-2 inhibitors Lancet 356 2000 1373 1374
67. J. Couzin Withdrawal of Vioxx casts a shadow over COX-2 inhibitors Science 306 2004 384 385
68. J. Couzin Nail-biting time for trials of COX-2 drugs Science 306 2004 1673 1675
69. R.S. Eisenberg Learning the value of drugs - Is Rofecoxib a regulatory success story? N Engl J Med 352 2005 1285 1287
70. M. Wadman The safety catch Nature 434 2005 554 556
71. J.M. Drazen COX-2 inhibitors - A lesson in unexpected problems N Engl J Med 352 2005 1131 1132
72. B. Sibbald Pfizer to withdraw valdecoxib (Bextra) at Health Canada's request eCMAJ 172 2005 e1
73. J. Lenzer Pfizer is asked to suspend sales of painkiller BMJ 330 2005 862
74. D. Young FDA ponders future of NSAIDs Am J Health Syst Pharm 62 2005 997 1000
75. C. Vanchieri Vioxx withdrawal alarms cancer prevention researchers J Natl Cancer Inst 96 2004 1734 1735
76. C. Vanchieri Researchers plan to continue to study COX-2 inhibitors in cancer treatment and prevention J Natl Cancer Inst 97 2005 552 553
77. J.E. Mijovic, T. Zakar, D.B. Zaragoza, D.M. Olson Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice J Perinat Med 30 2002 297 300
78. T. Zakar, J.E. Mijovic, D.M. Olson Prostaglandin endoperoxide H synthase-2 expression in human amnion cells Involvement of tyrosine kinases in the regulation Adv Exp Med Biol 433 1997 415 418
79. T. Zakar, J.E. Mijovic, D. Bhardwaj, D.M. Olson Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells Can J Physiol Pharmacol 77 1999 138 142
80. R. Romero, M. Emamian, M. Wan, R. Quintero, J.C. Hobbins, M.D. Mitchell Prostaglandin concentrations in amniotic fluid of women with intra-amniotic infection and preterm labor Am J Obstet Gynecol 157 1987 1461 1467
81. R.L. Goldenberg, J.C. Hauth, W.W. Andrews Intrauterine infection and preterm delivery N Engl J Med 342 2000 1500 1507
82. R. Romero, Y.K. Wu, M. Mazor, J.C. Hobbins, M.D. Mitchell Amniotic fluid prostaglandin E2 in preterm labor Prostaglandins Leukot Essent Fatty Acids 34 1988 141 145
83. M.D. Mitchell, A.P. Flint, J. Bibby Plasma concentrations of prostaglandins during late human pregnancy Influence of normal and preterm labor J Clin Endocrinol Metab 46 1978 947 951
84. S.M. Sellers, M.D. Mitchell, J.G. Bibby, A.B. Anderson, A.C. Turnbull A comparison of plasma prostaglandin levels in term and preterm labour Br J Obstet Gynaecol 88 1981 362 366
85. K.G. Allen, M.A. Harris The role of n-3 fatty acids in gestation and parturition Exp Biol Med (Maywood) 226 2001 498 506
86. J.A. McGregor, K.G. Allen, M.A. Harris The omega-3 story Nutritional prevention of preterm birth and other adverse pregnancy outcomes Obstet Gynecol Surv 56 2001 S1 S13
87. S.F. Olsen, H.S. Hansen, T.I. Sorensen Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation Lancet 2 1986 367 369
88. S.F. Olsen, J.D. Sorensen, N.J. Secher Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration Lancet 339 1992 1003 1007
89. S.F. Olsen, N.J. Secher, A. Tabor, T. Weber, J.J. Walker, C. Gluud Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team Br J Obstet Gyencol 107 2000 382 395
90. J.R. Challis, J.E. Patrick The production of prostaglandins and thromboxanes in the feto-placental unit and their effects on the developing fetus Semin Perinatol 4 1980 23 33
91. F. Coceani, I. Bishai, E. White, E. Bodach, P.M. Olley Action of prostaglandins, endoperoxides, and thromboxanes on the lamb ductus arteriosus Am J Physiol 234 1978 H117 H122
92. D.M. Olson, S.J. Lye, J.R. Challis Prostaglandin concentrations in ovine maternal and fetal tissues at late gestation Pediatr Res 20 1986 83 86
93. C.R. Pace-Asciak, G. Rangaraj Distribution of prostaglandin biosynthetic pathways in organs and tissues of the fetal lamb Biochim Biophys Acta 528 1978 512 514
94. D.M. Olson, J.E. Mijovic, D.W. Sadowsky Control of human parturition Semin Perinatol 19 1995 52 63
95. J. Senior, R. Sangha, G.S. Baxter, K. Marshall, J.K. Clayton In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium Br J Pharmacol 107 1992 215 221
96. J. Senior, K. Marshall, R. Sangha, J.K. Clayton In vitro characterization of prostanoid receptors on human myometrium at term pregnancy Br J Pharmacol 108 1993 501 506
97. M.L. Casey, P.C. MacDonald Human parturition Distinction between the initiation of parturition and the onset of labor Semin Reprod Endocrinol 11 1993 272 284
98. M.J. Keirse, M. Thiery, W. Parewijck, M.D. Mitchell Chronic stimulation of uterine prostaglandin synthesis during cervical ripening before the onset of labor Prostaglandins 25 1983 671 682
99. W.A. Noort, B. van Bulck, A. Vereecken, F.A. de Zwart, M.J. Keirse Changes in plasma levels of PGF2 alpha and PGI2 metabolites at and after delivery at term Prostaglandins 37 1989 3 12
100. M. Takagi, S. Fujimoto, M. Ohtani Bovine retained placenta hormonal concentrations in fetal and maternal placenta Placenta 23 2002 429 437
101. J.O. Lindell, H. Kindahl Exogenous prostaglandin F2 alpha promotes uterine involution in the cow Acta Vet Scand 24 1983 269 274
102. F.N. Thompson, R.D. Page, C.B. Cook, A.B. Caudle Prostaglandin F2 alpha metabolite levels in normal and uterine-infected postpartum cows Vet Res Commun 11 1987 503 507
103. F. Regassa, D.E. Noakes Acute phase protein response of ewes and the release of PGFM in relation to uterine involution and the presence of intrauterine bacteria Vet Rec 144 1999 502 506
104. U. Ulug, S. Goldman, I. Ben-Shlomo, E. Shalev Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes The effect of prostaglandin F(2alpha) and indomethacin Mol Hum Reprod 7 2001 1187 1193
105. W.Y. Chan Uterine and placental prostaglandins and their modulation of oxytocin sensitivity and contractility in the parturient uterus Biol Reprod 29 1983 680 688
106. B.F. Mitchell, B. Schmid Oxytocin and its receptor in the process of parturition J Soc Gynecol Investig 8 2001 122 133
107. M. Baguma-Nibasheka, P.W. Nathanielsz In vivo administration of nimesulide, a selective PGHS-2 inhibitor, increases in vitro myometrial sensitivity to prostaglandins while lowering sensitivity to oxytocin J Soc Gynecol Investig 5 1998 296 299
108. R.E. Garfield, D. Merrett, A.K. Grover Gap junction formation and regulation in myometrium Am J Physiol 239 1980 C217 C228
109. W.X. Wu, N. Unno, X.H. Ma, P.W. Nathanielsz Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep Endocrinology 139 1998 3096 3103
110. I. Kennedy, R.A. Coleman, P.P. Humphrey, G.P. Levy, P. Lumley Studies on the characterisation of prostanoid receptors A proposed classification Prostaglandins 24 1982 667 689
111. R.A. Coleman, W.L. Smith, S. Narumiya International Union of Pharmacology classification of prostanoid receptors properties, distribution, and structure of the receptors and their subtypes Pharmacol Rev 46 1994 205 229
112. M. Hirata, Y. Hayashi, F. Ushikubi Cloning and expression of cDNA for a human thromboxane A2 receptor Nature 349 1991 617 620
113. F. Ushikubi, M. Nakajima, M. Hirata, M. Okuma, M. Fujiwara, S. Narumiya Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets J Biol Chem 264 1989 16496 16501
114. S. Narumiya, Y. Sugimoto, F. Ushikubi Prostanoid receptors Structures, properties, and functions Physiol Rev 79 1999 1193 1226
115. K.L. Pierce, T.J. Bailey, P.B. Hoyer, D.W. Gil, D.F. Woodward, J.W. Regan Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor J Biol Chem 272 1997 883 887
116. Y. Ishii, K. Sakamoto Suppression of protein kinase C signaling by the novel isoform for bovine PGF(2alpha) receptor Biochem Biophys Res Commun 285 2001 1 8
117. K.L. Pierce, J.W. Regan Prostanoid receptor heterogeneity through alternative mRNA splicing Life Sci 62 1998 1479 1483
118. M. Abramovitz, Y. Boie, T. Nguyen Cloning and expression of a cDNA for the human prostanoid FP receptor J Biol Chem 269 1994 2632 2636
119. G. Asboth, S. Phaneuf, A.L. Lopez Bernal Prostaglandin E receptors in myometrial cells Acta Physiol Hung 85 1997 39 50
120. S. Matsumoto, M. Katoh, S. Saito, T. Watanabe, Y. Masuho Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA Biochim Biophys Acta 1354 1997 159 170
121. J. Brodt-Eppley, L. Myatt Prostaglandin receptors in lower segment myometrium during gestation and labor Obstet Gynecol 93 1999 89 93
122. J. Senior, K. Marshall, R. Sangha, G.S. Baxter, J.K. Clayton In vitro characterization of prostanoid EP-receptors in the non-pregnant human myometrium Br J Pharmacol 102 1991 747 753
123. G.N. Europe-Finner, S. Phaneuf, A.M. Tolkovsky, S.P. Watson, A. Lopez Bernal Down-regulation of G alpha s in human myometrium in term and preterm labor A mechanism for parturition J Clin Endocrinol Metab 79 1994 1835 1839
124. G.C.S. Smith, W.X. WU, P.W. Nathanielsz Baboon labour is associated with a decreased uterine prostanoid EP2 receptor expression J Soc Gynecol Investig 6 1999 128A 129A
125. C.C. Docherty, A. Sathananthan, L.A. Fraine, B. Davis, P.W. Nathanielsz Altered PG receptor function in murine myometrium around the time of parturition J Soc Gynecol Investig 6 1999 160A
126. H.Y. Al-Matubsi, J. Brodt-Eppley, D.J. MacPhee, S.J. Lye, L. Myatt Expression of the contratile prostaglandin F receptor in rat myometrium in late gestation, labour and post-partum J Soc Gynecol Investig. Chicago, IL 2000 129A Abstract
127. J. Brodt-Eppley, L. Myatt Changes in expression of contractile FP and relaxatory EP2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartum Biol Reprod 59 1998 878 883
128. Y.L. Dong, C. Yallampalli Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus Biol Reprod 62 2000 533 539
129. W.X. Wu, X.H. Ma, T. Yoshizato, N. Shinozuka, P.W. Nathanielsz Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor Endocrinology 140 1999 5712 5718
130. G.C. Smith, W.X. Wu, P.W. Nathanielsz Effects of gestational age and labor on expression of prostanoid receptor genes in baboon uterus Biol Reprod 64 2001 1131 1137
131. D.J. Crankshaw, R. Dyal Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contractility of the human lower uterine segment in vitro Can J Physiol Pharmacol 72 1994 870 874
132. T.L. Armer, P. Duff Intraamniotic infection in patients with intact membranes and preterm labor Obstet Gynecol Surv 46 1991 589 593
133. R. Romero, B.H. Yoon, M. Mazor The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes Am J Obstet Gynecol 169 1993 805 816
134. D. Slater, W. Dennes, R. Sawdy, V. Allport, P. Bennett Expression of cyclo-oxygenase types-1 and -2 in human fetal membranes throughout pregnancy J Mol Endocrinol 22 1999 125 130
135. A.R. Belt, J.J. Baldassare, M. Molnar, R. Romero, F. Hertelendy The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells Am J Obstet Gynecol 181 1999 359 366
136. K. Narko, O. Ritvos, A. Ristimaki Induction of cyclooxygenase-2 and prostaglandin F2alpha receptor expression by interleukin-1beta in cultured human granulosa-luteal cells Endocrinology 138 1997 3638 3644
137. M. Molnar, F. Hertelendy PGF2 alpha and PGE2 binding to rat myometrium during gestation, parturition, and postpartum Am J Physiol 258 1990 E740 E747
138. D. Srinivasan, H. Fujino, J.W. Regan Differential internalization of the prostaglandin F2 alpha receptor isoforms Role of protein kinase C and clathrin J Pharmacol Exp Ther 302 2002 219 224
139. K. Sakamoto, T. Ezashi, K. Miwa Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor Adv Prostaglandin Thromboxane Leukot Res 23 1995 259 261
140. Y. Sugimoto, K. Hasumoto, T. Namba Cloning and expression of a cDNA for mouse prostaglandin F receptor J Biol Chem 269 1994 1356 1360
141. P.E. Graves, K.L. Pierce, T.J. Bailey Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum Endocrinology 136 1995 3430 3436
142. R. Betz, J. Lagercrantz, D. Kedra, J.P. Dumanski, A. Nordenskjold Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene Biochem Biophys Res Commun 254 1999 413 416
143. K. Hasumoto, Y. Sugimoto, M. Gotoh Characterization of the mouse prostaglandin F receptor gene A transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary Genes Cells 2 1997 571 580
144. T. Ezashi, K. Sakamoto, K. Miwa, E. Okuda-Ashitaka, S. Ito, O. Hayaishi Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor Gene 190 1997 271 278
145. F. Neuschafer-Rube, U. Moller, G.P. Puschel Structure of the 5′-flanking region of the rat prostaglandin F(2alpha) receptor gene and its transcriptional control functions in hepatocytes Biochem Biophys Res Commun 278 2000 278 285
146. 2α receptor gene Biochim Biophys Acta 2003 doi:10.1016/j. bbaexp.2003.11.004
147. K.G. Peri, C. Quiniou, X. Hou THG113 A novel selective FP antagonist that delays preterm labor Semin Perinatol 26 2002 389 397
148. R. Leiser, P. Kaufmann Placental structure In a comparative aspect Exp Clin Endocrinol 102 1994 122 134
149. A.R. Beaudoin Embryology and teratology H.J. Baker J.R. Lindsey S.H. Weisbroth The Laboratory Rat 1980 Academic Press Orlando, FL 75 101
150. Insights on Western Canada: A socio-economic report. The Conference Board of Canada, 2003; Ottawa, Ontario, Canada.
151. Moutquin JM, Lalonde A. The cost of prematurity in Canada. Preterm Birth Prevention Conference Report and Background Papers, 1998; Ottawa, Ontario, Canada.