Multiple components of 2,4-dichlorophenoxyacetic acid uptake by rat choroid plexus

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 1, 2005, Pages 136-143

  Lowes, Simon ^a   Sykes, Destiny ^a   Breen, Christopher M ^a   Ragone, Leigh J ^a   Miller, David S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; 4 AMINOHIPPURIC ACID; 5 HYDROXYINDOLEACETIC ACID; ESTRONE SULFATE; HERBICIDE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; PRASTERONE SULFATE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DRUG EFFECT; DRUG TRANSPORT; INTERMETHOD COMPARISON; KINETICS; LINEAR SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

2,4-DICHLOROPHENOXYACETIC ACID; ANIMALS; CHOROID PLEXUS; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, SPRAGUE-DAWLEY; SODIUM;

EID: 25644460010     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.087056     Document Type: Article

References (25)

1. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Matsuno S, Kondo H, et al. (1998) Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401.
2. Breen CM, Sykes DB, Baehr C, Fricker G, and Miller DS (2004) Fluoresceinmethotrexate transport in rat choroid plexus analyzed using confocal microscopy. Am J Physiol 287:F562-F569.
3. Breen CM, Sykes DB, Fricker G, and Miller DS (2002) Confocal imaging of organic anion transport in intact rat choroid plexus. Am J Physiol 282:F877-F885.
4. Choudhuri S, Cherrington NJ, Li N, and Klaassen CD (2003) Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab Dispos 31:1337-1345.
5. Ghersi-Egea JF and Strazielle N (2002) Choroid plexus transporters for drugs and other xenobiotics. J Drug Target 10:353-357.
6. Hasegawa M, Kusuhara H, Endou H, and Sugiyama Y (2003) Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther 305:1087-1097.
7. Kim CS and O'Tuama LA (1981) Choroid plexus transport of 2,4-dichlorophenoxyacetic acid: interaction with the organic acid carrier. Brain Res 224:209-212.
8. Kusuhara H, He Z, Nagata Y, Nozaki Y, Ito T, Masuda H, Meier PJ, Abe T, and Sugiyama Y (2003) Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus. Pharm Res (NY) 20:720-727.
9. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680.
10. Kusuhara H and Sugiyama Y (2004) Efflux transport systems for organic anions and cations at the blood-CSF barrier. Adv Drug Deliv Rev 56:1741-1763.
11. Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, et al. (2004) Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Mol Cell Biol 24:7612-7621.
12. Miller DS (2004) Confocal imaging of xenobiotic transport across the choroid plexus. Adv Drug Deliv Rev 56:1811-1824.
13. Nagata Y, Kusuhara H, Endou H, and Sugiyama Y (2002) Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol 61:982-988.
14. Nagata Y, Kusuhara H, Imaoka T, Endou H, and Sugiyama Y (2004) Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus. J Pharm Sci 93:2724-2732.
15. Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, and Terasaki T (2002) Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem 83:57-66.
16. Ohtsuki S, Takizawa T, Takanaga H, Terasaki N, Kitazawa T, Sasaki M, Abe T, Hosoya K, and Terasaki T (2003) In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Mol Pharmacol 63:532-537.
17. Pappenheimer JR, Heisey SR, and Jordan EF (1961) Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood. Am J Physiol 200:1-10.
18. Pritchard JB (1980) Accumulation of anionic pesticides by rabbit choroid plexus in vitro. J Pharmacol Exp Ther 212:354-359.
19. Pritchard JB and Miller DS (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73:765-796.
20. Pritchard JB, Sweet DH, Miller DS, and Walden R (1999) Mechanism of organic anion transport across the apical membrane of choroid plexus. J Biol Chem 274:33382-33387.
21. Sweet DH, Chan LM, Walden R, Yang XP, Miller DS, and Pritchard JB (2003) Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am J Physiol 284:F763-F769.
22. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943.
23. Sykes D, Sweet DH, Lowes S, Nigam SK, Pritchard JB, and Miller DS (2004) Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Am J Physiol 286:F972-F978.
24. Villalobos AR, Miller DS, and Renfro JL (2002) Transepithelial organic anion transport by shark choroid plexus. Am J Physiol 282:R1308-R1316.
25. Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, Scheper RJ, Breimer DD, and Borst P (2000) Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Investig 105:279-285.