Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy

American Journal of Physiology - Renal Physiology

Volumn 287, Issue 3 56-3, 2004, Pages

  Breen, Christopher M ^a   Sykes, Destiny B ^a   Baehr, Carsten ^b   Fricker, Gert ^b   Miller, David S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Image analysis; Xenobiotic transport

Indexed keywords

DIGOXIN; ESTRONE SULFATE; FLUORESCEIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER; PROBENECID; TOXIN; VERLUKAST; XENOBIOTIC AGENT;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BILE FLOW; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPITHELIUM CELL; IMAGE ANALYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT; STEADY STATE; URINARY EXCRETION;

EID: 4143120956     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00045.2003     Document Type: Article

References (24)

1. Bode U, Magrath IT, Bleyer WA, Poplack DG, and Glauhiger DL. Active transport of methotrexate from cerebrospinal fluid in humans. Cancer Res 40: 2184-2187, 1980.
2. Breen CM, Sykes DB, Flicker G, and Miller DS. Confocal imaging of organic anion transport in intact rat choroid plexus. Am J Physiol Renal Physiol 282: F877-F885, 2002.
3. Bresler SE, Bresler VM, Kazbekov EN, Nikiforov AA, and Vasilieva NN. On the active transport of organic acids (fluorescein) in the choroid plexus of the rabbit. Biochim Biophys Acta 550: 110-119, 1979.
4. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, and Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59: 1277-1286, 2001.
5. Choudhuri S, Cherrington NJ, Li N, and Klaassen CD. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab Dispos 31: 1337-1345, 2003.
6. Gao B and Meier PJ. Organic anion transport across the choroid plexus. Microsc Res Tech 52: 60-64, 2001.
7. Gao B, Stieger B, Noe B, Fritschy JM, and Meier PJ. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J Histochem Cytochem 47: 1255-1264, 1999.
8. Ghersi-Egea JF and Strazielle N. Choroid plexus transporters for drugs, and other xenobiotics. J Drug Target 10: 353-357, 2002.
9. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274: 13675-13680, 1999.
10. Li L, Meier PJ, and Ballatori N. Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol Pharmacol 58: 335-340, 2000.
11. Nagata Y, Kusuhara H, Endou H, and Sugiyama Y. Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol 61: 982-988, 2002.
12. Noe B, Hagenbuch B, Stieger B, and Meier PJ. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94: 10346-10350, 1997.
13. Ohtsuki S, Takizawa T, Takanaga H, Terasaki N, Kitazawa T, Sasaki M, Abe T, Hosoya K, and Terasaki T. In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Mol Pharmacol 63: 532-537, 2003.
14. Pritchard JB, Sweet DH, Miller DS, and Waiden R. Mechanism of organic anion transport across the apical membrane of choroid plexus. J Biol Chem 274: 33382-33387, 1999.
15. Rao VV, Dalheimer JL, Bardgelt ME, Snyder AZ, Finch RA, Sartorelli AC, and Piwnica-Worms D. Choroid plexus epithelial expression of MDR1 P-glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal fluid drug-permeability barrier. Proc Natl Acad Sci USA 96: 3900-3905, 1999.
16. Russel FG, Masereeuw R, van Aubel RA. Molecular aspects of renal anionic drug transport. Annu Rev Physiol 64: 563-594, 2002.
17. Spector R. Inhibition of methotrexate transport from cerebrospinal fluid by probenecid. Cancer Treat Res 60: 913-916, 1976.
18. Sugiyama Y, Kusuhara H, and Suzuki H. Kinetic, and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain. J Control Release 62: 179-186, 1999.
19. + gradient. Am J Physiol Renal Physiol 284: F763-F769, 2003.
20. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nlgam SK. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 [Oat3 (Slc22a8)] knockout mice. J Biol Chem 277: 26934-26943, 2002.
21. Sykes D, Sweet DH, Lowes S, Nigam SK, Pritchard JB, and Miller DS. Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Am J Physiol Renal Physiol 286: F972-F978, 2004.
22. Terlouw SA, Graeff C, Smeets PH, Flicker G, Russel FG, Masereeuw R, and Miller DS. Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. J Pharmacol Exp Ther 301: 578-585, 2002.
23. Villalobos AR, Parmelee JT, and Renfro JL. Choline uptake across the ventricular membrane of neonate rat choroid plexus. Am J Physiol Cell Physiol 276: C1288-C1296, 1999.
24. Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, Scheper RJ,. Breimer DD, and Borst P. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105: 279-285, 2000.