Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus

Pharmaceutical Research

Volumn 20, Issue 5, 2003, Pages 720-727

  Kusuhara, Hiroyuki ^a   He, Zhonggui ^a   Nagata, Yoshinori ^a   Nozaki, Yoshitane ^a   Ito, Takashi ^b   Masuda, Hiroyuki ^b   Meier, Peter J ^c   Abe, Takaaki ^d   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Daiichi Pharmaceutical   (Japan)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Blood CSF barrier; Choroid plexus; Efflux transport; Oatp; Organic anion

Indexed keywords

4 AMINOHIPPURIC ACID; CIMETIDINE; CORTICOSTERONE; DICLOFENAC; DIGOXIN; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; GLIBENCLAMIDE; IBUPROFEN; INDOMETACIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; PENICILLIN G; PROBENECID; QUININE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CHOROID PLEXUS; DNA TRANSFECTION; ENZYME SPECIFICITY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT KINETICS; WESTERN BLOTTING;

ANIMALS; CHOROID PLEXUS; ESTRADIOL; GENE EXPRESSION REGULATION; LLC-PK1 CELLS; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SWINE;

EID: 0037406304     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023473216759     Document Type: Article

References (26)

1. B. Gao and P. J. Meier. organic anion transport across the choroid plexus. Microsc. Res. Tech. 52:60-64 (2001).
2. R. Spector. Drug transport in the mammalian central nervous system: multiple complex systems. Pharmacol. 60:58-73 (2000).
3. J. F. Ghersi-Egea and N. Strazielle. Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus. Microsc. Res. Tech. 52:83-88 (2001).
4. H. Kusuhara and Y. Sugiyama. Efflux transport systems for drugs at the blood-brain barrier and blood- cerebrospinal fluid barrier (Part 2). Drug Discov. Today 6:206-212 (2001).
5. H. Kusuhara and Y. Sugiyama. Efflux transport systems for drugs at the blood-brain barrier and blood- cerebrospinal fluid barrier (Part 1). Drug Discov. Today 6:150-156 (2001).
6. H. Kusuhara and Y. Sugiyama. Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J. Control. Release 78:43-54 (2002).
7. M. Haselbach, J. Wegener, S. Decker, C. Engelbertz, and H. J. Galla. Porcine Choroid plexus epithelial cells in culture: regulation of barrier properties and transport processes. Microsc. Res. Tech. 52:137-152 (2001).
8. N. Strazielle and J. F. Ghersi-Egea. Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. J. Neurosci. 19:6275-6289 (1999).
9. J. Nishino, H. Suzuki, D. Sugiyama, T. Kitazawa, K. Ito, M. Hanano, and Y. Sugiyama. Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein. J. Pharmacol. Exp. Ther. 290:289-294 (1999).
10. T. Kitazawa, K. Hosoya, T. Takahashi, Y. Sugiyama, and T. Terasaki. In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier. J. Pharm. Pharmacol. 52:281-288 (2000).
11. Y. Nagata, H. Kusuhara, H. Endou, and Y. Sugiyama. Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol. Pharmacol. 61:982-988 (2002).
12. R. H. Angeletti, P. M. Novikoff, S. R. Juvvadi, J. M. Fritschy, P. J. Meier, and A. W. Wolkoff. The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc. Natl. Acad. Sci. USA 94:283-286 (1997).
13. H. Suzuki, T. Terasaki, and Y. Sugiyama. Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv. Drug Deliv. Rev. 25:257-285 (1997).
14. H. Ishizuka, K. Konno, H. Naganuma, K. Nishimura, H. Kouzuki, H. Suzuki, B. Stieger, P. J. Meier, and Y. Sugiyama. Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 287:37-42 (1998).
15. T. N. Abu-Zahra, A. W. Wolkoff, R. B. Kim, and K. S. Pang. Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab. Dispos. 28:801-806 (2000).
16. P. J. Meier, U. Eckhardt, A. Schroeder, B. Hagenbuch, and B. Stieger. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26:1667-1677 (1997).
17. M. Muller and P. L. Jansen. Molecular aspects of hepatobiliary transport. Am. J. Physiol. 272:G1285-G1303 (1997).
18. C. Reichel, B. Gao, J. Van Montfoort, V. Cattori, C. Rahner, B. Hagenbuch, B. Stieger, T. Kamisako, and P. J. Meier. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 117:688-695 (1999).
19. P. J. Meier and B. Stieger. Bile salt transporters. Annu. Rev. Physiol. 64:635-661 (2002).
20. V. Cattori, J. E. van Montfoort, B. Stieger, L. Landmann, D. K. Meijer, K. H. Winterhalter, P. J. Meier, and B. Hagenbuch. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 443:188-195 (2001).
21. T. Abe, M. Kakyo, T. Tokui, R. Nakagomi, T. Nishio, D. Nakai, H. Nomura, M. Unno, M. Suzuki, T. Naitoh, S. Matsuno, and H. Yawo. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 274:17159-17163 (1999).
22. H. C. Walters, A. L. Craddock, H. Fusegawa, M. C. Willingham, and P. A. Dawson. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am. J. Physiol. 279:G1188-G1200 (2000).
23. N. Li, D. P. Hartley, N. J. Cherrington, and C. D. Klaassen. Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. J. Pharmacol. Exp. Ther. 301:551-560 (2002).
24. D. Sugiyama, H. Kusuhara, Y. Shitara, T. Abe, P. J. Meier, T. Sekine, H. Endou, H. Suzuki, and Y. Sugiyama. Characterization of the efflux transport of 17beta-estradiol-D-17beta- glucuronide from the brain across the blood-brain barrier. J. Pharmacol. Exp. Ther. 298:316-322 (2001).
25. H. Suzuki, Y. Sawada, Y. Sugiyama, T. Iga, and M. Hanano. Transport of cimetidine by the rat choroid plexus in vitro. J. Pharmacol. Exp. Ther. 239:927-935 (1986).
26. K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno. A pharmacokinetic analysis program (multi) for microcomputer. J. Pharmacobiodyn. 4:879-885 (1981).