Persistence of decreased T-helper cell function in industrial workers 20 years after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Environmental Health Perspectives

Volumn 104, Issue 4, 1996, Pages 422-426

  Tonn, Torsten ^a   Esser, Charlotte ^a,c   Schneider, E Marion ^a   Steinmann Steiner Haldenstätt, Wolfgang ^b   Gleichmann, Ernst ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b BAYER AG   (Germany)

^c Med Inst of Environmental Hygiene   (Germany)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Allogeneic response; Immunosuppression; Lymphocyte subsets; Mitogen stimulation

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ADULT; ARTICLE; B LYMPHOCYTE; BODY BURDEN; CLINICAL ARTICLE; FOLLOW UP; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENCE; INDUSTRIAL WORKER; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029982254     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104422     Document Type: Article

References (28)

1. Poland A, Knutson JC. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons; examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 22:517-554 (1982).
2. Holsapple MP, Snyder NK, Wood SC, Morris DL. A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence:1991 update. Toxicology 69:219-255 (1991).
3. Faith RE, Luster MI. Investigations on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on parameters of various immune functions. Ann NY Acad Sci 320:564-571 (1979).
4. Dooley RK, Holsapple MP. Elucidation of cellular targets responsible for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody responses: I. The role of the B lymphocyte. Immunopharmacology 16:167-180 (1988).
5. Swanson H, Bradfield CA. The AH-receptor: genetics, structure and function. Pharmacogenetics 3:213-230 (1993).
6. Sutter TR, Greenlee WF. Classification of members of the Ah gene battery. Chemosphere 25:223-226 (1992).
7. Neubert R, Stahlmann R, Korte M, van Loveren H, Vos JG, Webb JR, Golor G, Helge H, Neubert D. Effects of small doses of dioxins on the immune system of marmosets and rats. Ann NY Acad Sci 686:662-686 (1993).
8. Patterson DG Jr, Hampton L, Lapeza CR Jr, Belser WT, Green V, Alexander L, Needham LL. High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-tetrachlorodibenro-p-dioxin. Anal Chem 59:2000-2005 (1987).
9. Schrey P, Wittsiepe J, Ewers U, Exner M, Selenka F. Age-related increase of PCDD/F-levels in human blood - a study with 95 unexposed persons from Germany. Organohalogen Compounds 9:261-267 (1992).
10. Pawelec G, Wernet P, Rehbein A, Balko I, Schneider EM. Alloproliferative human T cell clones primed and cultured in vitro lose proliferative and gain suppressive activity with age. Hum Immunol 10:135-142 (1984).
11. Pawelec G, Schneider EM, Wernet P. Cloned human T lymphocytes with lymphostimulatory capacity preferentially activate suppressor cells. Eur J Immunol 14:335-340 (1984).
12. Clark D, Gauldie J, Szewczuk MR, Sweeney G. Enhanced suppressor cell activity as a mechanism of immunosuppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Soc Exp Biol Med 168:290-299 (1981).
13. Morris DL, Snyder NK, Gokani V, Blair RE, Holsapple MP. Enhanced suppression of humoral immunity in DBA/2 mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 112: 128-132 (1992).
14. Stehr PA, Stein G, Webb K, Schramm W, Gedney WD, Donnell HD, Ayres S, Falk H. A pilot epidemiologic study of possible health effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin contaminations in Missouri. Arch Environ Health 41:16-22 (1987).
15. Knutson AP. Immunologic effects of TCDD exposure in humans. Bull Environ Contam Toxicol 33:673-681 (1984).
16. Tognoni G, Bonaccorsi A. Epidemiological problems with TCDD (a critical review). Drug Metab Rev 13:447-469 (1982).
17. Kochmann S, Cazabat JBA, Lavand F, Lorton C, Rappe C. Phenotypical dissection of immunoregulatory T cell subsets in humans after furan exposure. Chemosphere 15:9-12 (1986).
18. Jennings AM, Wild G, Ward JD, Ward AM: Immunological abnormalities 17 years after accidental exposure to 2,3,7,8-TCDD. Br Med J 45:701-704 (1988).
19. Pocchiari F, Silano V, Zampieri A. Human health effects from accidental release of tetrachlorodibenzo-p-dioxin. Ann NY Acad Sci 320:311-320 (1979).
20. Wolfe WH, Michalek JE, Miner JC. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. I. Physical health. J Am Med Assoc 264:1824-1831 (1990).
21. Zober MA, Ott MG, Päfke O, Senft K, Germann C. Morbidity study of extruder personnel with potential exposure to brominated dioxins and furans. I. Results of blood monitoring and immunological tests. Br J Ind Med 49:532-544 (1992).
22. Webb KB, Evans RG, Knutsen AP, Roodman ST, Roberts DW, Schramm WF, Andrews JS, Needham LL, Patterson DG. Medical evaluation of subjects with known body levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Toxicol Environ Health 28:183-193 (1989).
23. Neubert R, Golor G, Helge Hans, Neubert D. Risk assessment for possible effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related substances on components and functions of the immune system. Exp Clin Immunogenet 11:163-171 (1994).
24. Neubert D, Neubert R, Stahlmann R, Helge H. Immunotoxicology and pharmacology. Braz J Med Biol Res 22:1457-1473 (1989).
25. Esser C, Welzel M. Ontogenetic development of murine fetal thymocytes is accelerated by 3,3′,4,4′-tetrachlorobiphenyl. Int J Immunopharmacol 13:841-852 (1993).
26. Lai ZW, Kremer J, Gleichmann E, Esser C. 3,3′,4,4′tetrachlorobiphenyl inhibits proliferation of immature thymocytes in fetal thymus organ culture. Scand J Immunol 39:480-488 (1994).
27. Klein J. Immunology. Oxford:Blackwell Scientific Publications, 1990
28. Neubert R, Maskow L, Webb J, Jacob-Müller U, Nogueira AC, Delgado I, Helge H, Neubert D. Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system. I. Blood cell receptors in volunteers with moderately increased body burdens. Life Sci 53:2007-2018 (1993).