Decreased serum leptin levels in primary biliary cirrhosis: A link between metabolism and autoimmunity?

Annals of the New York Academy of Sciences

Volumn 1051, Issue , 2005, Pages 211-217

  Rieger, Roman ^a   Oertelt, Sabine ^a   Selmi, Carlo ^a,b   Invernizzi, Pietro ^b   Podda, Mauro ^b   Gershwin, M Eric ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmune disease; Leptin; Primary biliary cirrhosis

Indexed keywords

AUTOANTIBODY; CYTOKINE; LEPTIN;

ADULT; AGED; AUTOIMMUNITY; CHOLESTASIS; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE SEVERITY; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOOD INTAKE; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; INTRAHEPATIC BILE DUCT; LIVER CIRRHOSIS; LIVER FAILURE; LIVER FIBROSIS; LIVER METABOLISM; PRIMARY BILIARY CIRRHOSIS; T LYMPHOCYTE;

EID: 25444526350     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1361.124     Document Type: Conference Paper

References (28)

1. FRIEDMAN, J.M. & J.L. HALAAS. 1998. Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
2. CALDEFIE-CHEZET, F., A. POULIN & M.P. VASSON. 2003. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic. Res. 37: 809-814.
3. MANCUSO, P. et al. 2002. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J. Immunol. 168: 4018-4024.
4. HOWARD, J.K. et al. 1999. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest. 104: 1051-1059.
5. LORD, G.M. et al. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 394: 897-901.
6. TIAN, Z., et al. 2002. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem. Biophys. Res. Commun. 298: 297-302.
7. LA CAVA, A. & G. MATARESE. 2004. The weight of leptin in immunity. Nat. Rev. Immunol. 4: 371-379.
8. ZARKESH-ESFAHANI, H. et al. 2004. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J. Immunol. 172: 1809-1814.
9. GERSHWIN, M.E. et al. 2000. Primary biliary cirrhosis: an orchestrated immune response against epithelial cells. Immunol. Rev. 174: 210-225.
10. ISHIBASHI, H. et al. 2003. T cell immunity and primary biliary cirrhosis. Autoimmun. Rev. 2: 19-24.
11. BREIDERT, M. et al. 2004. Ghrelin/leptin-imbalance in patients with primary biliary cirrhosis. Exp. Clin. Endocrinol. Diabetes 112: 123-126.
12. GARCIA-SUAREZ, C. et al. 2004. [Plasma leptin levels in patients with primary biliary cirrhosis and their relationship with degree of fibrosis]. Gastroenterol. Hepatol. 27: 47-50.
13. KAPLAN, M.M. 1996. Primary biliary cirrhosis. N. Engl. J. Med. 335: 1570-1580.
14. LUDWIG, J., E.R. DICKSON & G.S. MCDONALD. 1978. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch. A. Pathol. Anat. Histol. 379: 103-112.
15. SITARAMAN, S. et al. 2004. Colonic leptin: source of a novel proinflammatory cytokine involved in IBD. FASEB J. 18: 696-698.
16. SERA, N. et al. 2000. Thyroid hormones influence serum leptin levels in patients with Graves' disease during suppression of beta-adrenergic receptors. Thyroid 10: 641-646.
17. BIDECI, A., P. CINAZ & F. S. EZGU. 2002. Leptin levels in children with insulin dependent diabetes mellitus. Turk. J. Pediatr. 44: 211-214.
18. BOKAREWA, M. et al. 2003. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann. Rheum. Dis. 62: 952-956.
19. GARCIA-GONZALEZ, A. et al. 2002. Serum leptin levels in women with systemic lupus erythematosus. Rheumatol. Int. 22: 138-141.
20. HOPPIN, A.G. et al. 1998. Serum leptin in children and young adults with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 26: 500-505.
21. YATURU, S., S. PRADO & S.R. GRIMES. 2004. Changes in adipocyte hormones leptin, resistin, and adiponectin in thyroid dysfunction. J. Cell. Biochem. 93: 491-496.
22. MYERS, S.E. et al. 2004. Pubertal changes in serum leptin levels in adolescents with type 1 diabetes mellitus: a controlled longitudinal study. J. Pediatr. Endocrinol. Metab. 17: 1653-1662.
23. ANDERS, H.J. et al. 1999. Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism. 48: 745-748.
24. DI LEO, V. et al. 2003. Gastroduodenal and intestinal permeability in primary biliary cirrhosis. Eur. J. Gastroenterol. Hepatol. 15: 967-973.
25. LANSPA, S.J. et al. 1985. Pathogenesis of steatorrhea in primary biliary cirrhosis. Hepatology 5: 837-842.
26. GREEN, J.H., P.N. BRAMLEY & M.S. LOSOWSKY. 1991. Are patients with primary biliary cirrhosis hypermetabolic? A comparison between patients before and after liver transplantation and controls. Hepatology 14: 464-472.
27. SUGDEN, M.C. & M.J. HOLNESS. 2003. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am. J. Physiol. Endocrinol. Metab. 284: E855-E862.
28. GIBNEY, E. et al. 1997. Total energy expenditure in patients with small-cell lung cancer: results of a validated study using the bicarbonate-urea method. Metabolism 46: 1412-1417.