메뉴 건너뛰기




Volumn 38, Issue 3, 2005, Pages 300-306

The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective

Author keywords

Dimethyl dimethoxy biphenyl dicarboxylate; Glutathione peroxidase; Glutathione S transferase; Reduced glutathione; Tamoxifen; Thiobarbituric acid reactive substance

Indexed keywords

BIPHENYL DERIVATIVE; DICARBOXYLIC ACID; TAMOXIFEN;

EID: 25444471536     PISSN: 12258687     EISSN: 12258687     Source Type: Journal    
DOI: 10.5483/bmbrep.2005.38.3.300     Document Type: Article
Times cited : (63)

References (54)
  • 1
    • 0034645736 scopus 로고    scopus 로고
    • Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal womwn
    • Akcay, T., Dinner, Y., Kayali, R., Colgar, U., Oral, E. and Cakatay, U. (2000) Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal womwn. J. Toxicol. Environ. Health 59, 1-5.
    • (2000) J. Toxicol. Environ. Health , vol.59 , pp. 1-5
    • Akcay, T.1    Dinner, Y.2    Kayali, R.3    Colgar, U.4    Oral, E.5    Cakatay, U.6
  • 2
    • 0036488531 scopus 로고    scopus 로고
    • Endocrine responsive breast cancer and strategies for combating resistance
    • Ali, S. and Coombes, R. C. (2002) Endocrine responsive breast cancer and strategies for combating resistance. Nat. Rev. Cancer 2, 101-112.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 101-112
    • Ali, S.1    Coombes, R.C.2
  • 3
    • 10744233292 scopus 로고    scopus 로고
    • The effect of exemestane on serum lipids profile in postmenopausal women with metastatic breast cancer
    • Atalay, G., Dirix, L., Biganzoli, L., Beex, L., Nooij, M., Cameron, D. and Lohrisch, C. (2004) The effect of exemestane on serum lipids profile in postmenopausal women with metastatic breast cancer. Ann. Oncol. 15, 211-217.
    • (2004) Ann. Oncol. , vol.15 , pp. 211-217
    • Atalay, G.1    Dirix, L.2    Biganzoli, L.3    Beex, L.4    Nooij, M.5    Cameron, D.6    Lohrisch, C.7
  • 4
    • 0028263871 scopus 로고
    • Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen-induced hepatocarcinogenesis in rats
    • Athoupa, M., Hirsimaki, P., Parssinen, R. and Mantyla, E. (1994) Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen-induced hepatocarcinogenesis in rats. Carcinogenesis 15, 863-868.
    • (1994) Carcinogenesis , vol.15 , pp. 863-868
    • Athoupa, M.1    Hirsimaki, P.2    Parssinen, R.3    Mantyla, E.4
  • 5
    • 0035059625 scopus 로고    scopus 로고
    • Metabolism of DDB by human liver microsomal cytochrome P450: Probable involvement of CYP3A and CYP1A2
    • Baek, M. S., Kim, J. Y., Myung, S. W., Yim, Y. H., Jeong, J. H. and Kim, D. H. (2001) Metabolism of DDB by human liver microsomal cytochrome P450: probable involvement of CYP3A and CYP1A2. Drug Metab. Dispos. 29, 381-388.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 381-388
    • Baek, M.S.1    Kim, J.Y.2    Myung, S.W.3    Yim, Y.H.4    Jeong, J.H.5    Kim, D.H.6
  • 6
    • 29844456352 scopus 로고
    • Traditional indications of DDB
    • Medica, M. (eds), Eastland Press, Seattle, USA
    • Bensky, D. and Gamble A. (1993) Traditional indications of DDB; in Chinese Herbal Medicine, Medica, M. (eds), pp. 110-112, Eastland Press, Seattle, USA.
    • (1993) Chinese Herbal Medicine , pp. 110-112
    • Bensky, D.1    Gamble, A.2
  • 7
    • 0034995019 scopus 로고    scopus 로고
    • On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminobenzene in CF1 mice
    • Caballero, F., Gerez, E., Oliveri, L., Falcolff, N., Battle, A. and Vazquez, E. (2001) On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminobenzene in CF1 mice. Int. J. Biochem. Cell. Biol. 33, 681-690.
    • (2001) Int. J. Biochem. Cell. Biol. , vol.33 , pp. 681-690
    • Caballero, F.1    Gerez, E.2    Oliveri, L.3    Falcolff, N.4    Battle, A.5    Vazquez, E.6
  • 8
    • 0000757141 scopus 로고
    • Catalase activity
    • Greenwald, R. A. (ed.), CRC press, Boca Raton, USA
    • Clairborne, A. (1985) Catalase activity; in Handbook of Methods for Oxygen Radical Research, Greenwald, R. A. (ed.), p. 383, CRC press, Boca Raton, USA.
    • (1985) Handbook of Methods for Oxygen Radical Research , pp. 383
    • Clairborne, A.1
  • 9
    • 0030812209 scopus 로고    scopus 로고
    • CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver
    • Dehal, S. S. and Kupfer, D. (1997) CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver, Cancer Res. 57, 3402-3406.
    • (1997) Cancer Res. , vol.57 , pp. 3402-3406
    • Dehal, S.S.1    Kupfer, D.2
  • 10
    • 0033017135 scopus 로고    scopus 로고
    • Cytochrome P450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: Involvement of catechols in covalent binding to hepatic proteins
    • Dehal, S. S. and Kupfer, D. (1999) Cytochrome P450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab. Dispos. 27, 681-688.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 681-688
    • Dehal, S.S.1    Kupfer, D.2
  • 11
    • 0036239630 scopus 로고    scopus 로고
    • Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen
    • Desai, P., Nallani, S., Sane, R., Moore, L., Goodwin, B., Buckley, D. and Buckley, A. (2002) Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen. Drug Metab. Dispos. 30, 608-612.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 608-612
    • Desai, P.1    Nallani, S.2    Sane, R.3    Moore, L.4    Goodwin, B.5    Buckley, D.6    Buckley, A.7
  • 12
    • 0028265343 scopus 로고
    • Is there a significant role for lipid peroxidation in the causation of malignancy and for antioxidants in cancer prevention
    • Diplock, A. T., Rice, C. A. and Burdon, R. H. (1994) Is there a significant role for lipid peroxidation in the causation of malignancy and for antioxidants in cancer prevention. Cancer. Res. 54, 1952-1956.
    • (1994) Cancer Res. , vol.54 , pp. 1952-1956
    • Diplock, A.T.1    Rice, C.A.2    Burdon, R.H.3
  • 13
    • 0025980382 scopus 로고    scopus 로고
    • Tumour promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis
    • Dragon, Y. P., Xu, Y. D. and Pilot, H. C. (1998) Tumour promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis. Prev. Med. 20, 15-26.
    • (1998) Prev. Med. , vol.20 , pp. 15-26
    • Dragon, Y.P.1    Xu, Y.D.2    Pilot, H.C.3
  • 14
    • 3042934967 scopus 로고
    • Tissue sulfahydryl groups
    • Ellman, G. L. (1959) Tissue sulfahydryl groups. Arch. Biochem. Biophys. 82, 70-77.
    • (1959) Arch. Biochem. Biophys. , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 15
    • 0028925204 scopus 로고
    • Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver
    • Emile, F. N., Dragan, Y. P., Colin, R. J., Jordan, V. C. and Pitot, H. C. (1995) Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver. Cancer Res. 55, 1780-1786.
    • (1995) Cancer Res. , vol.55 , pp. 1780-1786
    • Emile, F.N.1    Dragan, Y.P.2    Colin, R.J.3    Jordan, V.C.4    Pitot, H.C.5
  • 16
    • 0026925559 scopus 로고
    • Protective effects of dimethyl-4,4′ dimethoxy-5,6,5′, 6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate on damages of isolated rat hepatocytes induced by carbon tetrachloride and D-galactosamine
    • Fu, T. and Liu, G. (1992) Protective effects of dimethyl-4,4′ dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′- dicarboxylate on damages of isolated rat hepatocytes induced by carbon tetrachloride and D-galactosamine. Biomed. Environ. Sci. 5, 185-194.
    • (1992) Biomed. Environ. Sci. , vol.5 , pp. 185-194
    • Fu, T.1    Liu, G.2
  • 17
    • 0016275313 scopus 로고
    • Glutathione-S-transferases. The first enzymatic step in mercaptouric acid formation
    • Habig, W. H., Pabst, M. J. and Jakoby, W. B. (1974) Glutathione-S- transferases. The first enzymatic step in mercaptouric acid formation. J. Biol. Chem. 249, 7130-7139.
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 18
    • 0026606580 scopus 로고
    • Induction of covalent DNA adducts in rodents by tamoxifen
    • Han, Y. and Liehr, J. G. (1992) Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res. 52, 1360-1363.
    • (1992) Cancer Res. , vol.52 , pp. 1360-1363
    • Han, Y.1    Liehr, J.G.2
  • 19
    • 0027428568 scopus 로고
    • Major difference in the hepatocarcinogenecity and DNA adduct forming ability between toremifene and tamoxifen in female rats
    • Hard, G. C., Iatropoulos, M. J., Jordan, K., Kaltenberg, O. P., Imondi, A. R. and Williams, G. M. (1993) Major difference in the hepatocarcinogenecity and DNA adduct forming ability between toremifene and tamoxifen in female rats. Cancer Res. 53, 4534-4541.
    • (1993) Cancer Res. , vol.53 , pp. 4534-4541
    • Hard, G.C.1    Iatropoulos, M.J.2    Jordan, K.3    Kaltenberg, O.P.4    Imondi, A.R.5    Williams, G.M.6
  • 20
    • 0034026317 scopus 로고    scopus 로고
    • Genotoxic effects of the novel antiestrogenic FC-1271a in comparison to tamoxifen and toremifene
    • Hellmann-Blumberg, U., Taras, T. L., Wurz, G. T. and DeGreorio, M. W. (2000) Genotoxic effects of the novel antiestrogenic FC-1271a in comparison to tamoxifen and toremifene. Breast Cancer Res. Treat. 60, 63-70.
    • (2000) Breast Cancer Res. Treat. , vol.60 , pp. 63-70
    • Hellmann-Blumberg, U.1    Taras, T.L.2    Wurz, G.T.3    DeGreorio, M.W.4
  • 21
    • 0028979277 scopus 로고
    • DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro
    • Hemminki, K., Widlak, P. and Hou, S. M. (1995) DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro. Carcinogenesis 16, 1661-1664.
    • (1995) Carcinogenesis , vol.16 , pp. 1661-1664
    • Hemminki, K.1    Widlak, P.2    Hou, S.M.3
  • 22
    • 29844457950 scopus 로고
    • Antibacterial effect of DDB
    • Oriental Healing Arts Institute, Long Beach, USA
    • Hong, Y. H. (1986) Antibacterial effect of DDB; in Oriental Materia Medica: A Concise Guide, p. 65, Oriental Healing Arts Institute, Long Beach, USA.
    • (1986) Oriental Materia Medica: A Concise Guide , pp. 65
    • Hong, Y.H.1
  • 23
    • 0033997704 scopus 로고    scopus 로고
    • Differential effects of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice
    • Ip, S. P., Yiu, H. Y. and Ko, K. M. (2000) Differential effects of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice. Mol. Cell Biochem. 205, 111-114.
    • (2000) Mol. Cell Biochem. , vol.205 , pp. 111-114
    • Ip, S.P.1    Yiu, H.Y.2    Ko, K.M.3
  • 24
    • 0037364074 scopus 로고    scopus 로고
    • Tamoxifen: A most unlikely pioneering medicine
    • Jordan, V. C. (2003) Tamoxifen: a most unlikely pioneering medicine. Natl. Rev. Drug. Discov. 2, 205-213.
    • (2003) Natl. Rev. Drug Discov. , vol.2 , pp. 205-213
    • Jordan, V.C.1
  • 26
    • 0035193605 scopus 로고    scopus 로고
    • Characterization of the Selectivity and Mechanism of Cytochrome P450 Inhibition by Dimethyl-4,4′-dimethoxy-5,6,5′,6′- dimethylenedioxybiphenyl-2,2′-dicarboxylate
    • Kim, J., Back, M., Lee, S., Kim, S., Dong, M., Kim, B. and Kim, D. (2001) Characterization of the Selectivity and Mechanism of Cytochrome P450 Inhibition by Dimethyl-4,4′-dimethoxy-5,6,5′,6′- dimethylenedioxybiphenyl-2,2′-dicarboxylate, Drug Metab. Dispos. 29, 1555-1560.
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1555-1560
    • Kim, J.1    Back, M.2    Lee, S.3    Kim, S.4    Dong, M.5    Kim, B.6    Kim, D.7
  • 27
    • 0344457182 scopus 로고    scopus 로고
    • Effect of dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) on chemical induced liver injury
    • Kim, S. N., Kim, S. Y., Yim, S. Y., Lee, W. Y., Ham, K. S., Kim, S. K., Yoon, M. Y. and Kim, Y. C. (1999) Effect of dimethyl-4,4′-dimethoxy-5,6, 5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) on chemical induced liver injury. Biol. Pharm. Bull. 22, 93-95.
    • (1999) Biol. Pharm. Bull. , vol.22 , pp. 93-95
    • Kim, S.N.1    Kim, S.Y.2    Yim, S.Y.3    Lee, W.Y.4    Ham, K.S.5    Kim, S.K.6    Yoon, M.Y.7    Kim, Y.C.8
  • 28
    • 0028340473 scopus 로고
    • Induction of tamoxifen-4-hydroxylation by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD), beta-naphthoflavone (beta NF), and phenobarbital (PB) in avian liver: Identification of P450 TCDDAA as catalyst of 4-hydroxylation induced by TCDD and beta NF
    • Kupfer, D., Mani, C., Lee, C. and Rifkind, A. (1994) Induction of tamoxifen-4-hydroxylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), beta-naphthoflavone (beta NF), and phenobarbital (PB) in avian liver: identification of P450 TCDDAA as catalyst of 4-hydroxylation induced by TCDD and beta NF. Cancer Res. 54, 3140-3144.
    • (1994) Cancer Res. , vol.54 , pp. 3140-3144
    • Kupfer, D.1    Mani, C.2    Lee, C.3    Rifkind, A.4
  • 29
    • 0025310518 scopus 로고
    • Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant
    • Letteron, P., Labbe, G., Degott, C., Berson, A., Fromenty, B., Delaforge, M., Larrey, D. and Pessayre, D. (1990) Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem. Pharmacol. 39, 2027-2034.
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 2027-2034
    • Letteron, P.1    Labbe, G.2    Degott, C.3    Berson, A.4    Fromenty, B.5    Delaforge, M.6    Larrey, D.7    Pessayre, D.8
  • 30
    • 0025146116 scopus 로고
    • Scavenging effects on active oxygen radicals by schizandrins with different structures and configurations
    • Li, X. J., Zhao, B. L., Liu, G. T. and Xin, W. J. (1990) Scavenging effects on active oxygen radicals by schizandrins with different structures and configurations. Free Radic. Biol. Med. 9, 99-104.
    • (1990) Free Radic. Biol. Med. , vol.9 , pp. 99-104
    • Li, X.J.1    Zhao, B.L.2    Liu, G.T.3    Xin, W.J.4
  • 31
    • 0026366116 scopus 로고
    • Bioactivity of neolignans from fructus Schizandrae
    • Li, X. Y. (1991) Bioactivity of neolignans from fructus Schizandrae. Mem. Inst. Oswaldo Cruz. 86, 31-37.
    • (1991) Mem. Inst. Oswaldo Cruz , vol.86 , pp. 31-37
    • Li, X.Y.1
  • 32
    • 0024946962 scopus 로고
    • Pharmacological actions and clinical use of fructus Schizandrae
    • Liu, G. T. (1989) Pharmacological actions and clinical use of fructus Schizandrae. Chin. Med. J. 102, 740-749.
    • (1989) Chin. Med. J. , vol.102 , pp. 740-749
    • Liu, G.T.1
  • 33
    • 0017986237 scopus 로고
    • Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds
    • Liu, C. S., Fang, S. D., Huang, M. F., Kao, Y. L. and Hsu, J. S. (1978) Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds. Sci. Sin. 21, 483-502.
    • (1978) Sci. Sin. , vol.21 , pp. 483-502
    • Liu, C.S.1    Fang, S.D.2    Huang, M.F.3    Kao, Y.L.4    Hsu, J.S.5
  • 34
    • 2442607924 scopus 로고    scopus 로고
    • Tamoxifen induces the expression of maspin through estrogen receptor alpha
    • Liu, Z., Shi, H. Y., Nawaz, Z. and Zhang, M. (2004) Tamoxifen induces the expression of maspin through estrogen receptor alpha. Cancer Lett. 209, 55-65.
    • (2004) Cancer Lett. , vol.209 , pp. 55-65
    • Liu, Z.1    Shi, H.Y.2    Nawaz, Z.3    Zhang, M.4
  • 35
    • 0026096606 scopus 로고
    • Effect of dibenzo[a,c]cyclootene lignans isolated from fructus Schizandrae on lipid peroxidation and anti-oxidative enzyme activity
    • Lu, H. and Liu, G. T. (1991) Effect of dibenzo[a,c]cyclootene lignans isolated from fructus Schizandrae on lipid peroxidation and anti-oxidative enzyme activity. Chem. Biol. Interact. 78, 77-84.
    • (1991) Chem. Biol. Interact. , vol.78 , pp. 77-84
    • Lu, H.1    Liu, G.T.2
  • 36
    • 0021322170 scopus 로고
    • Oxygen and carbon centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro
    • McCay, P. B., Lai, E. K., Poyer, J. L., Dubose, C. M. and Janzen, E. C. (1984) Oxygen and carbon centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro. J. Biol. Chem. 259, 2135-2143.
    • (1984) J. Biol. Chem. , vol.259 , pp. 2135-2143
    • McCay, P.B.1    Lai, E.K.2    Poyer, J.L.3    Dubose, C.M.4    Janzen, E.C.5
  • 37
    • 12244279556 scopus 로고    scopus 로고
    • The effects of estrogen and raloxifene treatment on the antioxidant enzymes and nitrite-nitrate levels in brain cortex of ovarictomized rats
    • Oge, A., Sezer, E. D., Ozgonul, M., Bayraktar, F. and Sozmen, E. Y. (2003) The effects of estrogen and raloxifene treatment on the antioxidant enzymes and nitrite-nitrate levels in brain cortex of ovarictomized rats. Neurosci. 338, 217-220.
    • (2003) Neurosci. , vol.338 , pp. 217-220
    • Oge, A.1    Sezer, E.D.2    Ozgonul, M.3    Bayraktar, F.4    Sozmen, E.Y.5
  • 38
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric reaction
    • Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric reaction. Anal. Biochem. 95, 351-358.
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 40
    • 0035871677 scopus 로고    scopus 로고
    • Effects of aging on the susceptibility to the toxic effects of cyclosporine A in rats. Changes in liver glutathione and antioxidant enzymes
    • Palomero, J., Galan, A. I., Munoz, M. E., Tunon, M. J., Gonzalez-Gallego, J. and Jimenez, R. (2001) Effects of aging on the susceptibility to the toxic effects of cyclosporine A in rats. Changes in liver glutathione and antioxidant enzymes. Free Rad. Biol. Med. 30, 836-845.
    • (2001) Free Rad. Biol. Med. , vol.30 , pp. 836-845
    • Palomero, J.1    Galan, A.I.2    Munoz, M.E.3    Tunon, M.J.4    Gonzalez-Gallego, J.5    Jimenez, R.6
  • 42
    • 29844439031 scopus 로고
    • Microassay of glutathione peroxidase by reduced phase HPLC
    • Qi-Change, X., Lin, L., Degao, W. and Gen-Jun, X. (1987) Microassay of glutathione peroxidase by reduced phase HPLC. Chromatogram 9, 11-14.
    • (1987) Chromatogram , vol.9 , pp. 11-14
    • Qi-Change, X.1    Lin, L.2    Degao, W.3    Gen-Jun, X.4
  • 44
    • 0030033913 scopus 로고    scopus 로고
    • Antiatherogenic effects of adjuvant antiestrogens: A randomized trial comparing the effects of tamoxifen on plasma lipid levels in postmenopausal women
    • Saarto, T., Blomqvist, C., Ehnholm, C., Taskinen, M. R. and Elomaa, I. (1996) Antiatherogenic effects of adjuvant antiestrogens: a randomized trial comparing the effects of tamoxifen on plasma lipid levels in postmenopausal women. J. Clin. Oncol. 14, 429-433.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 429-433
    • Saarto, T.1    Blomqvist, C.2    Ehnholm, C.3    Taskinen, M.R.4    Elomaa, I.5
  • 45
    • 29844448798 scopus 로고    scopus 로고
    • A novel mechanism by which retinamide inhibits breast cancer growth: The production of nitric oxide
    • Simeone, A. M., Ekmikciolu, S., Grimm, E. A. and Tari, A. M. (2002) A novel mechanism by which retinamide inhibits breast cancer growth: the production of nitric oxide. Mol. Cancer Ther. 1, 1366.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 1366
    • Simeone, A.M.1    Ekmikciolu, S.2    Grimm, E.A.3    Tari, A.M.4
  • 46
    • 0032184873 scopus 로고    scopus 로고
    • Chinese herbs: A clinical review of astragalus, ligusticum, and schizandrae
    • Sinclair, S., (1998) Chinese herbs: a clinical review of astragalus, ligusticum, and schizandrae. Altern. Med. Rev. 3, 338-344.
    • (1998) Altern. Med. Rev. , vol.3 , pp. 338-344
    • Sinclair, S.1
  • 49
    • 0037387183 scopus 로고    scopus 로고
    • Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system
    • Stefano, G. B., Cadet, P., Mantione, K., Cho, J. J., Jones, D. and Zhu, W. (2003) Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system. Endocrinology 144, 1234-1240.
    • (2003) Endocrinology , vol.144 , pp. 1234-1240
    • Stefano, G.B.1    Cadet, P.2    Mantione, K.3    Cho, J.J.4    Jones, D.5    Zhu, W.6
  • 50
    • 0027308685 scopus 로고
    • The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat
    • Williams, G. M., Iatropoulos, M. J., Djordjevic, M. V. and Kaltenberg, O. P. (1993). The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis 14, 315-317.
    • (1993) Carcinogenesis , vol.14 , pp. 315-317
    • Williams, G.M.1    Iatropoulos, M.J.2    Djordjevic, M.V.3    Kaltenberg, O.P.4
  • 52
    • 0036915408 scopus 로고    scopus 로고
    • A proposed mechanism of tamoxifen in breast cancer prevention
    • Yu, F. L. and Bender, W. (2002) A proposed mechanism of tamoxifen in breast cancer prevention. Cancer Detect. Prev. 26, 370-375.
    • (2002) Cancer Detect. Prev. , vol.26 , pp. 370-375
    • Yu, F.L.1    Bender, W.2
  • 53
    • 0023237374 scopus 로고
    • Biphenyl-dimethyl dicarboxylate in treating and preventing hepatitis due to drug poisoning
    • Yu, H. Q., Yang, X. U., Zang, Y. X. and Shi, J. Z. (1987) Biphenyl-dimethyl dicarboxylate in treating and preventing hepatitis due to drug poisoning. Chinese Med. J. Peking. 100, 122-123.
    • (1987) Chinese Med. J. Peking , vol.100 , pp. 122-123
    • Yu, H.Q.1    Yang, X.U.2    Zang, Y.X.3    Shi, J.Z.4
  • 54
    • 29844436992 scopus 로고    scopus 로고
    • Antioxidant properties of biphenyl dimethyl dicarboxylate, silymarin and garlic homogenates in carbon tetrachloride-induced rat liver injury
    • Zohny, S., Kandil, E., Moselhy, S. and Mohamed, E. (2001) Antioxidant properties of biphenyl dimethyl dicarboxylate, silymarin and garlic homogenates in carbon tetrachloride-induced rat liver injury. Egy. J. Biochem. Mol. Biol. 20, 47-62.
    • (2001) Egy. J. Biochem. Mol. Biol. , vol.20 , pp. 47-62
    • Zohny, S.1    Kandil, E.2    Moselhy, S.3    Mohamed, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.