A proposed mechanism of tamoxifen in breast cancer prevention

Cancer Detection and Prevention

Volumn 26, Issue 5, 2002, Pages 370-375

  Yu, Fu Li ^a   Bender, Wanda ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

17 Estradiol epoxide; Breast cancer prevention; DNA binding; Estrone epoxide; RNA synthesis; Tamoxifen

Indexed keywords

ANTINEOPLASTIC AGENT; EPOXIDE; ESTRADIOL; ESTRONE; RNA; TAMOXIFEN;

ANIMAL; ARTICLE; BIOSYNTHESIS; BREAST TUMOR; DNA ADDUCT; FEMALE; HUMAN; LIVER; METABOLISM; RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; BREAST NEOPLASMS; DNA ADDUCTS; EPOXY COMPOUNDS; ESTRADIOL; ESTRONE; FEMALE; HUMANS; LIVER; RATS; RNA; TAMOXIFEN;

EID: 0036915408     PISSN: 0361090X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-090X(02)00124-1     Document Type: Article

References (37)

1. Cole MP, Jones CTA, Todd IDH. A new antiestrogenic agent in late breast cancer. An early appraisal of ICI46474. Br J Cancer 1971;25:270-5.
2. National Institute of Health Consensus Development Panel. National institutes of health consensus development conference statement: Adjuvant therapy for breast cancer. J Natl Cancer Inst 2001;93:979-89.
3. Jordan VC, Dowse LJ. Tamoxifen as an antitumor agent: Effect on estrogen binding. J Endocrinol 1976;68:297-303.
4. Lerner LJ, Jordan VC. Development of antiestrogens and their use in breast cancer: Eighth Cain Memorial Award lecture. Cancer Res 1990;50:4177-89.
5. Fisher B, Costantino JP, Wickerham DL, et al. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 1998;90:1371-88.
6. Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: An overview of randomized trials. Lancet 1998;351:1451-67.
7. Phillips DH. Understanding the genotoxicity of tamoxifen. Carcinogenesis 2001;22:839-49.
8. White INH. The tamoxifen dilemma. Carcinogenesis 1999;22:1153-969.
9. King CM. Tamoxifen and the induction of cancer. Carcinogenesis 1995;16:1449-54.
10. Weisburger EK. Metabolism and activation of chemical carcinogens. Mol Cell Biochem 1980;32:95-104.
11. Miller EC, Miller JA. Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules. Cancer 1981;47:2327-45.
12. Farber E. Cellular biochemistry of the stepwise development of cancer with chemicals: G.H.A. Clowes memorial lecture. Cancer Res 1984;44:5463-74.
13. Harris CC. Chemical and physical carcinogenesis: Advances and perspective for the 1990s. Cancer Res 1991:51(Suppl):5023s-44s.
14. Hemminki K. DNA adducts, mutations and cancer. Carcinogenesis 1993;14:2007-12.
15. Dipple A. DNA adducts of chemical carcinogens. Carcinogenesis 1995;16:437-41.
16. Gottardis MM, Robison SP, Satyaswaroop PG, et al. Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res 1988;48:812-5.
17. Rutqvist LE, Johansson H, Signomklao T, et al. Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. J Natl Cancer Inst 1995;87:645-51.
18. Curtis RE, Boice Jr JD, Shriner DA, et al. Second cancers after adjuvant tamoxifen therapy for breast cancer. J Natl Cancer Inst 1996;88:832-4.
19. 1: The ultimate carcinogenic species. J Am Chem Soc 1988;110:7929-31.
20. 1 epoxide. J Am Chem Soc 1994;116:1603-8869.
21. 1-8,9-epoxide. Carcinogenesis 1994;15:1737-41.
22. 1-8,9-epoxide-DNA adducts on transcription of a supF gene fragment. Cancer Lett 1996;109:77-83.
23. Park KK, Surh YJ, Stewart BC, et al. Synthesis and properties of vinyl-carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate. Biochem Biophys Res Commun 1990;169:1094-8.
24. Park KK, Sohn Y, Liem A, et al. The electrophilic and tumorigenic activities of phenol and 4-nitrophenyl vinyl ethers and their epoxide metabolites. Carcinogenesis 1997;18:431-7.
25. Adam W, Chan YY, Cremer D, et al. Spectral and chemical properties of dimethyldioxirane as determined by experiment and ab initio calculations. J Org Chem 1987;52:2800-3.
26. Yu FL, Bender W. Activation of 17β-estradiol and estrone by dimethyldioxirane and inhibition of rat liver nuclear and nucleolar RNA synthesis in vitro. Carcinogenesis 1996;17:1957-61.
27. Yu FL, Wang MY, Li DH, et al. Evidence for the DNA binding and adduct formation of estrone and 17β-estradiol after dimethyldioxirane activation. Chem Biol Interact 1998;110:173-87.
28. Yu FL, Bender W, Zheng WY, et al. The transcriptional effects and DNA-binding specificities of 17β-estradiol after dimethyldioxirane activation. Carcinogenesis 1998;19:1127-31.
29. Yu FL, Zheng WY, Wang MY. The effect of 17β-estradiol-DNA adducts on the replication of exon #5 of the human tumor suppressor gene p53. FEBS Lett 1999;454:7-10.
30. Yu FL, Wang MY, Bender W. A hypothesis on breast cancer. In: Ioannidou-Mouzaka L, Agnantis NJ, Lopez DM, editors. Proceedings of the 22nd Congress of the International Association for Breast Cancer Research, Sept. 19-24, 1998 Athens, Greece.
31. Yu FL, Wang MY, Bender W. Evidence for an initiation mechanism of 17β-estradiol carcinogenesis. In: Li JJ, Daling J, Li SA, editors. Hormonal Carcinogenesis III. New York (NY): Springer-Verlag; 2001, p. 444-50.
32. Busby WF, Wogan GN. Aflatoxins. In: Searle CE, editor. Chemical Carcinogens. 2nd Ed. ACS Monograph 182. Washington (DC): American Chemical Society; 1984, p. 945-1136.
33. Phillips DH, Hewer A, White INH, et al. Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats. Carcinogenesis 1994;15:793-5.
34. Davies AM, Martin EA, Jones RM, et al. Peroxidase activation of tamoxifen and toremifene resulting DNA damage and covalently bond protein adduct. Carcinogenesis 1995;16:539-45.
35. Yu FL, Bender W. Studies on the isolated transcriptionally active and inactive chromatin fractions from rat liver nuclei. J Biochem Biophys Methods 1995;30:21-36.
36. Feigelson HS, Henderson BE. Estrogens and breast cancer. Carcinogenesis 1996;17:2279-84.
37. Menard S, Aiello P, Tagliabue E, et al. Tamoxifen chemoprevention of a hormone-independent tumor in the proto-neu transgenic mice model. Cancer Res 2000;60:273-5.